Found 35 hits Enz. Inhib. hit(s) with all data for entry = 50039964 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386955
(CHEMBL2048820)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C24H26ClN7OS/c1-17-12-31-14-19(28-23(31)34-17)10-22(33)30-8-4-24(5-9-30)15-29(16-24)13-18-2-3-20(11-21(18)25)32-26-6-7-27-32/h2-3,6-7,11-12,14H,4-5,8-10,13,15-16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386949
(CHEMBL2048814)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4Cl)-n4nccn4)C3)CC2)cc1 Show InChI InChI=1S/C25H28ClN5O3/c1-33-21-4-6-22(7-5-21)34-16-24(32)30-12-8-25(9-13-30)17-29(18-25)15-19-2-3-20(14-23(19)26)31-27-10-11-28-31/h2-7,10-11,14H,8-9,12-13,15-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386957
(CHEMBL2048822)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-c5ncccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C26H28N6OS/c1-19-14-32-16-22(29-25(32)34-19)13-23(33)31-11-7-26(8-12-31)17-30(18-26)15-20-3-5-21(6-4-20)24-27-9-2-10-28-24/h2-6,9-10,14,16H,7-8,11-13,15,17-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386948
(CHEMBL2048813)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-n4nccn4)C3)CC2)cc1 Show InChI InChI=1S/C25H29N5O3/c1-32-22-6-8-23(9-7-22)33-17-24(31)29-14-10-25(11-15-29)18-28(19-25)16-20-2-4-21(5-3-20)30-26-12-13-27-30/h2-9,12-13H,10-11,14-19H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386952
(CHEMBL2048817)Show SMILES CC(C)COc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2n[nH]c3ccccc23)cc1 Show InChI InChI=1S/C27H34N4O2/c1-20(2)17-33-22-9-7-21(8-10-22)16-30-18-27(19-30)11-13-31(14-12-27)26(32)15-25-23-5-3-4-6-24(23)28-29-25/h3-10,20H,11-19H2,1-2H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386953
(CHEMBL2048818)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(OCC(C)C)cc4Cl)C3)CC2)cn1 Show InChI InChI=1S/C26H34ClN3O4/c1-19(2)15-33-21-5-4-20(23(27)12-21)14-29-17-26(18-29)8-10-30(11-9-26)25(31)16-34-22-6-7-24(32-3)28-13-22/h4-7,12-13,19H,8-11,14-18H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386945
(CHEMBL2048810)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(OCC(C)C)cc4Cl)C3)CC2)cc1 Show InChI InChI=1S/C27H35ClN2O4/c1-20(2)16-33-24-5-4-21(25(28)14-24)15-29-18-27(19-29)10-12-30(13-11-27)26(31)17-34-23-8-6-22(32-3)7-9-23/h4-9,14,20H,10-13,15-19H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386958
(CHEMBL2048823)Show SMILES Clc1ccc2nc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5nccn5)C4)CC3)cn2c1 Show InChI InChI=1S/C25H26ClN7O/c26-20-3-6-23-29-21(16-32(23)15-20)13-24(34)31-11-7-25(8-12-31)17-30(18-25)14-19-1-4-22(5-2-19)33-27-9-10-28-33/h1-6,9-10,15-16H,7-8,11-14,17-18H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386951
(CHEMBL2048816)Show SMILES CC(C)COc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C27H33N3O2S/c1-20(2)17-32-22-9-7-21(8-10-22)16-29-18-27(19-29)11-13-30(14-12-27)26(31)15-25-28-23-5-3-4-6-24(23)33-25/h3-10,20H,11-19H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386959
(CHEMBL2048824)Show SMILES Clc1ccc2nc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-c5ncccn5)C4)CC3)cn2c1 Show InChI InChI=1S/C27H27ClN6O/c28-22-6-7-24-31-23(17-34(24)16-22)14-25(35)33-12-8-27(9-13-33)18-32(19-27)15-20-2-4-21(5-3-20)26-29-10-1-11-30-26/h1-7,10-11,16-17H,8-9,12-15,18-19H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386946
(CHEMBL2048811)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-c4nnc(C)o4)C3)CC2)cc1 Show InChI InChI=1S/C26H30N4O4/c1-19-27-28-25(34-19)21-5-3-20(4-6-21)15-29-17-26(18-29)11-13-30(14-12-26)24(31)16-33-23-9-7-22(32-2)8-10-23/h3-10H,11-18H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386954
(CHEMBL2048819)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5nccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C24H27N7OS/c1-18-13-30-15-20(27-23(30)33-18)12-22(32)29-10-6-24(7-11-29)16-28(17-24)14-19-2-4-21(5-3-19)31-25-8-9-26-31/h2-5,8-9,13,15H,6-7,10-12,14,16-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386950
(CHEMBL2048815)Show SMILES CCCOc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2ccc(OC)cc2)cn1 Show InChI InChI=1S/C25H33N3O3/c1-3-14-31-23-9-6-21(16-26-23)17-27-18-25(19-27)10-12-28(13-11-25)24(29)15-20-4-7-22(30-2)8-5-20/h4-9,16H,3,10-15,17-19H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 114 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386947
(CHEMBL2048812)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-n4cccn4)C3)CC2)cc1 Show InChI InChI=1S/C26H30N4O3/c1-32-23-7-9-24(10-8-23)33-18-25(31)29-15-11-26(12-16-29)19-28(20-26)17-21-3-5-22(6-4-21)30-14-2-13-27-30/h2-10,13-14H,11-12,15-20H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 152 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386956
(CHEMBL2048821)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5cccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C25H28N6OS/c1-19-14-30-16-21(27-24(30)33-19)13-23(32)29-11-7-25(8-12-29)17-28(18-25)15-20-3-5-22(6-4-20)31-10-2-9-26-31/h2-6,9-10,14,16H,7-8,11-13,15,17-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 206 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386942
(CHEMBL2048807)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc5OC(C)(C)CCc5c4)C3)CC2)cc1 Show InChI InChI=1S/C28H36N2O4/c1-27(2)11-10-22-16-21(4-9-25(22)34-27)17-29-19-28(20-29)12-14-30(15-13-28)26(31)18-33-24-7-5-23(32-3)6-8-24/h4-9,16H,10-15,17-20H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 408 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386944
(CHEMBL2048809)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccccc4Cl)C3)CC2)cc1 Show InChI InChI=1S/C23H27ClN2O3/c1-28-19-6-8-20(9-7-19)29-15-22(27)26-12-10-23(11-13-26)16-25(17-23)14-18-4-2-3-5-21(18)24/h2-9H,10-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 445 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386955
(CHEMBL2048820)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5Cl)-n5nccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C24H26ClN7OS/c1-17-12-31-14-19(28-23(31)34-17)10-22(33)30-8-4-24(5-9-30)15-29(16-24)13-18-2-3-20(11-21(18)25)32-26-6-7-27-32/h2-3,6-7,11-12,14H,4-5,8-10,13,15-16H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386949
(CHEMBL2048814)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4Cl)-n4nccn4)C3)CC2)cc1 Show InChI InChI=1S/C25H28ClN5O3/c1-33-21-4-6-22(7-5-21)34-16-24(32)30-12-8-25(9-13-30)17-29(18-25)15-19-2-3-20(14-23(19)26)31-27-10-11-28-31/h2-7,10-11,14H,8-9,12-13,15-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386954
(CHEMBL2048819)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5nccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C24H27N7OS/c1-18-13-30-15-20(27-23(30)33-18)12-22(32)29-10-6-24(7-11-29)16-28(17-24)14-19-2-4-21(5-3-19)31-25-8-9-26-31/h2-5,8-9,13,15H,6-7,10-12,14,16-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386953
(CHEMBL2048818)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(OCC(C)C)cc4Cl)C3)CC2)cn1 Show InChI InChI=1S/C26H34ClN3O4/c1-19(2)15-33-21-5-4-20(23(27)12-21)14-29-17-26(18-29)8-10-30(11-9-26)25(31)16-34-22-6-7-24(32-3)28-13-22/h4-7,12-13,19H,8-11,14-18H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386951
(CHEMBL2048816)Show SMILES CC(C)COc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C27H33N3O2S/c1-20(2)17-32-22-9-7-21(8-10-22)16-29-18-27(19-29)11-13-30(14-12-27)26(31)15-25-28-23-5-3-4-6-24(23)33-25/h3-10,20H,11-19H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386945
(CHEMBL2048810)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(OCC(C)C)cc4Cl)C3)CC2)cc1 Show InChI InChI=1S/C27H35ClN2O4/c1-20(2)16-33-24-5-4-21(25(28)14-24)15-29-18-27(19-29)10-12-30(13-11-27)26(31)17-34-23-8-6-22(32-3)7-9-23/h4-9,14,20H,10-13,15-19H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386957
(CHEMBL2048822)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-c5ncccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C26H28N6OS/c1-19-14-32-16-22(29-25(32)34-19)13-23(33)31-11-7-26(8-12-31)17-30(18-26)15-20-3-5-21(6-4-20)24-27-9-2-10-28-24/h2-6,9-10,14,16H,7-8,11-13,15,17-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386948
(CHEMBL2048813)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-n4nccn4)C3)CC2)cc1 Show InChI InChI=1S/C25H29N5O3/c1-32-22-6-8-23(9-7-22)33-17-24(31)29-14-10-25(11-15-29)18-28(19-25)16-20-2-4-21(5-3-20)30-26-12-13-27-30/h2-9,12-13H,10-11,14-19H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386952
(CHEMBL2048817)Show SMILES CC(C)COc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2n[nH]c3ccccc23)cc1 Show InChI InChI=1S/C27H34N4O2/c1-20(2)17-33-22-9-7-21(8-10-22)16-30-18-27(19-30)11-13-31(14-12-27)26(32)15-25-23-5-3-4-6-24(23)28-29-25/h3-10,20H,11-19H2,1-2H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386958
(CHEMBL2048823)Show SMILES Clc1ccc2nc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5nccn5)C4)CC3)cn2c1 Show InChI InChI=1S/C25H26ClN7O/c26-20-3-6-23-29-21(16-32(23)15-20)13-24(34)31-11-7-25(8-12-31)17-30(18-25)14-19-1-4-22(5-2-19)33-27-9-10-28-33/h1-6,9-10,15-16H,7-8,11-14,17-18H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 204 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386942
(CHEMBL2048807)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc5OC(C)(C)CCc5c4)C3)CC2)cc1 Show InChI InChI=1S/C28H36N2O4/c1-27(2)11-10-22-16-21(4-9-25(22)34-27)17-29-19-28(20-29)12-14-30(15-13-28)26(31)18-33-24-7-5-23(32-3)6-8-24/h4-9,16H,10-15,17-20H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 211 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386944
(CHEMBL2048809)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccccc4Cl)C3)CC2)cc1 Show InChI InChI=1S/C23H27ClN2O3/c1-28-19-6-8-20(9-7-19)29-15-22(27)26-12-10-23(11-13-26)16-25(17-23)14-18-4-2-3-5-21(18)24/h2-9H,10-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 231 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386956
(CHEMBL2048821)Show SMILES Cc1cn2cc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-n5cccn5)C4)CC3)nc2s1 Show InChI InChI=1S/C25H28N6OS/c1-19-14-30-16-21(27-24(30)33-19)13-23(32)29-11-7-25(8-12-29)17-28(18-25)15-20-3-5-22(6-4-20)31-10-2-9-26-31/h2-6,9-10,14,16H,7-8,11-13,15,17-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 298 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386959
(CHEMBL2048824)Show SMILES Clc1ccc2nc(CC(=O)N3CCC4(CN(Cc5ccc(cc5)-c5ncccn5)C4)CC3)cn2c1 Show InChI InChI=1S/C27H27ClN6O/c28-22-6-7-24-31-23(17-34(24)16-22)14-25(35)33-12-8-27(9-13-33)18-32(19-27)15-20-2-4-21(5-3-20)26-29-10-1-11-30-26/h1-7,10-11,16-17H,8-9,12-15,18-19H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 321 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386950
(CHEMBL2048815)Show SMILES CCCOc1ccc(CN2CC3(C2)CCN(CC3)C(=O)Cc2ccc(OC)cc2)cn1 Show InChI InChI=1S/C25H33N3O3/c1-3-14-31-23-9-6-21(16-26-23)17-27-18-25(19-27)10-12-28(13-11-25)24(29)15-20-4-7-22(30-2)8-5-20/h4-9,16H,3,10-15,17-19H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386947
(CHEMBL2048812)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-n4cccn4)C3)CC2)cc1 Show InChI InChI=1S/C26H30N4O3/c1-32-23-7-9-24(10-8-23)33-18-25(31)29-15-11-26(12-16-29)19-28(20-26)17-21-3-5-22(6-4-21)30-14-2-13-27-30/h2-10,13-14H,11-12,15-20H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 442 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386946
(CHEMBL2048811)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-c4nnc(C)o4)C3)CC2)cc1 Show InChI InChI=1S/C26H30N4O4/c1-19-27-28-25(34-19)21-5-3-20(4-6-21)15-29-17-26(18-29)11-13-30(14-12-26)24(31)16-33-23-9-7-22(32-2)8-10-23/h3-10H,11-18H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50386943
(CHEMBL2048808)Show SMILES COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccccc4)C3)CC2)cc1 Show InChI InChI=1S/C23H28N2O3/c1-27-20-7-9-21(10-8-20)28-16-22(26)25-13-11-23(12-14-25)17-24(18-23)15-19-5-3-2-4-6-19/h2-10H,11-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA |
Bioorg Med Chem Lett 22: 4281-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.024
BindingDB Entry DOI: 10.7270/Q2P2705D |
More data for this
Ligand-Target Pair | |
Search and Browse
