Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with all data for entry = 50040228   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391055 (CHEMBL2088399) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C19H20N2O2S/c1-19(2,3)13-6-4-12(5-7-13)18(23)20-14-8-9-16-15(10-14)21-17(11-22)24-16/h4-10,22H,11H2,1-3H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391031 (CHEMBL2088393) Show SMILES CC(C)(C)Oc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C19H20N2O3S/c1-19(2,3)24-14-7-4-12(5-8-14)18(23)20-13-6-9-16-15(10-13)21-17(11-22)25-16/h4-10,22H,11H2,1-3H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391029 (CHEMBL2088391) Show SMILES OCc1nc2cc(NC(=O)c3ccc(cc3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C16H11F3N2O2S/c17-16(18,19)10-3-1-9(2-4-10)15(23)20-11-5-6-13-12(7-11)21-14(8-22)24-13/h1-7,22H,8H2,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391025 (CHEMBL2088398) Show SMILES Cc1nc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2s1 Show InChI InChI=1S/C19H20N2OS/c1-12-20-16-11-15(9-10-17(16)23-12)21-18(22)13-5-7-14(8-6-13)19(2,3)4/h5-11H,1-4H3,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391027 (CHEMBL2088401) Show SMILES OCc1nc2cc(NC(=O)c3ccc(Br)cc3)ccc2s1 Show InChI InChI=1S/C15H11BrN2O2S/c16-10-3-1-9(2-4-10)15(20)17-11-5-6-13-12(7-11)18-14(8-19)21-13/h1-7,19H,8H2,(H,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391032 (CHEMBL2088394) Show SMILES CC(C)Oc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C18H18N2O3S/c1-11(2)23-14-6-3-12(4-7-14)18(22)19-13-5-8-16-15(9-13)20-17(10-21)24-16/h3-9,11,21H,10H2,1-2H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391040 (CHEMBL2088406) Show SMILES OCc1nc2cc(NC(=O)c3ccc(OCC(F)(F)F)nc3)ccc2s1 Show InChI InChI=1S/C16H12F3N3O3S/c17-16(18,19)8-25-13-4-1-9(6-20-13)15(24)21-10-2-3-12-11(5-10)22-14(7-23)26-12/h1-6,23H,7-8H2,(H,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391052 (CHEMBL2088419) Show SMILES CC(C)Oc1ccc(C(=O)Nc2ccc3sc(CO)nc3c2)c(C)c1 Show InChI InChI=1S/C19H20N2O3S/c1-11(2)24-14-5-6-15(12(3)8-14)19(23)20-13-4-7-17-16(9-13)21-18(10-22)25-17/h4-9,11,22H,10H2,1-3H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391053 (CHEMBL2088420) Show SMILES Cc1cc(Br)ccc1C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C16H13BrN2O2S/c1-9-6-10(17)2-4-12(9)16(21)18-11-3-5-14-13(7-11)19-15(8-20)22-14/h2-7,20H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391037 (CHEMBL2088403) Show SMILES CC(C)(C)OCc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C20H22N2O3S/c1-20(2,3)25-12-13-4-6-14(7-5-13)19(24)21-15-8-9-17-16(10-15)22-18(11-23)26-17/h4-10,23H,11-12H2,1-3H3,(H,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391026 (CHEMBL2088400) Show SMILES OCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2s1 Show InChI InChI=1S/C15H11ClN2O2S/c16-10-3-1-9(2-4-10)15(20)17-11-5-6-13-12(7-11)18-14(8-19)21-13/h1-7,19H,8H2,(H,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391039 (CHEMBL2088405) Show SMILES OCc1nc2cc(NC(=O)c3ccc(nc3)N3CCCCC3)ccc2s1 Show InChI InChI=1S/C19H20N4O2S/c24-12-18-22-15-10-14(5-6-16(15)26-18)21-19(25)13-4-7-17(20-11-13)23-8-2-1-3-9-23/h4-7,10-11,24H,1-3,8-9,12H2,(H,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391051 (CHEMBL2088418) Show SMILES Cc1cc(Cl)ccc1C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C16H13ClN2O2S/c1-9-6-10(17)2-4-12(9)16(21)18-11-3-5-14-13(7-11)19-15(8-20)22-14/h2-7,20H,8H2,1H3,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391041 (CHEMBL2088407) Show SMILES Cn1nc(cc1C(=O)Nc1ccc2sc(CO)nc2c1)C(F)(F)F Show InChI InChI=1S/C14H11F3N4O2S/c1-21-9(5-11(20-21)14(15,16)17)13(23)18-7-2-3-10-8(4-7)19-12(6-22)24-10/h2-5,22H,6H2,1H3,(H,18,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391028 (CHEMBL2088390) Show SMILES OCc1nc2cc(NC(=O)c3ccc(cc3)C#C)ccc2s1 Show InChI InChI=1S/C17H12N2O2S/c1-2-11-3-5-12(6-4-11)17(21)18-13-7-8-15-14(9-13)19-16(10-20)22-15/h1,3-9,20H,10H2,(H,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391054 (CHEMBL2088411) Show SMILES CC(O)c1nc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2s1 Show InChI InChI=1S/C20H22N2O2S/c1-12(23)19-22-16-11-15(9-10-17(16)25-19)21-18(24)13-5-7-14(8-6-13)20(2,3)4/h5-12,23H,1-4H3,(H,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	223	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391038 (CHEMBL2088404) Show SMILES OCc1nc2cc(NC(=O)c3ccc(nc3)C(F)(F)F)ccc2s1 Show InChI InChI=1S/C15H10F3N3O2S/c16-15(17,18)12-4-1-8(6-19-12)14(23)20-9-2-3-11-10(5-9)21-13(7-22)24-11/h1-6,22H,7H2,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	417	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391036 (CHEMBL2088402) Show SMILES CCOCc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C18H18N2O3S/c1-2-23-11-12-3-5-13(6-4-12)18(22)19-14-7-8-16-15(9-14)20-17(10-21)24-16/h3-9,21H,2,10-11H2,1H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391043 (CHEMBL2088409) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc2sc(CNS(C)(=O)=O)nc2c1 Show InChI InChI=1S/C20H23N3O3S2/c1-20(2,3)14-7-5-13(6-8-14)19(24)22-15-9-10-17-16(11-15)23-18(27-17)12-21-28(4,25)26/h5-11,21H,12H2,1-4H3,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	708	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391050 (CHEMBL2088417) Show SMILES CC(C)(C)c1ccc(CNc2ccc3sc(CO)nc3c2)cc1 Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)14-6-4-13(5-7-14)11-20-15-8-9-17-16(10-15)21-18(12-22)23-17/h4-10,20,22H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	833	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391042 (CHEMBL2088408) Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc2sc(CN)nc2c1 Show InChI InChI=1S/C19H21N3OS/c1-19(2,3)13-6-4-12(5-7-13)18(23)21-14-8-9-16-15(10-14)22-17(11-20)24-16/h4-10H,11,20H2,1-3H3,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	987	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391033 (CHEMBL2088395) Show SMILES CC(C)(C)Oc1cccc(c1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C19H20N2O3S/c1-19(2,3)24-14-6-4-5-12(9-14)18(23)20-13-7-8-16-15(10-13)21-17(11-22)25-16/h4-10,22H,11H2,1-3H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391046 (CHEMBL2088413) Show SMILES Cc1ccc(CCNC(=O)c2ccc3sc(CO)nc3c2)cc1 Show InChI InChI=1S/C18H18N2O2S/c1-12-2-4-13(5-3-12)8-9-19-18(22)14-6-7-16-15(10-14)20-17(11-21)23-16/h2-7,10,21H,8-9,11H2,1H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391044 (CHEMBL2088410) Show SMILES CC(=O)NCc1nc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2s1 Show InChI InChI=1S/C21H23N3O2S/c1-13(25)22-12-19-24-17-11-16(9-10-18(17)27-19)23-20(26)14-5-7-15(8-6-14)21(2,3)4/h5-11H,12H2,1-4H3,(H,22,25)(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391049 (CHEMBL2088416) Show SMILES OCc1nc2cc(ccc2s1)S(=O)(=O)NCc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C16H13F3N2O3S2/c17-16(18,19)11-3-1-2-10(6-11)8-20-26(23,24)12-4-5-14-13(7-12)21-15(9-22)25-14/h1-7,20,22H,8-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391048 (CHEMBL2088415) Show SMILES OCc1nc2cc(ccc2s1)S(=O)(=O)Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C15H11F3N2O3S2/c16-15(17,18)9-1-3-10(4-2-9)20-25(22,23)11-5-6-13-12(7-11)19-14(8-21)24-13/h1-7,20-21H,8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391030 (CHEMBL2088392) Show SMILES OCc1nc2cc(NC(=O)C3CCC(CC3)C(F)(F)F)ccc2s1 |(8.88,-26.24,;9.64,-27.58,;11.18,-27.58,;12.09,-26.34,;13.55,-26.82,;14.88,-26.04,;16.22,-26.8,;17.55,-26.03,;18.89,-26.79,;18.89,-28.33,;20.22,-26.02,;21.55,-26.79,;22.88,-26.02,;22.87,-24.47,;21.53,-23.71,;20.2,-24.49,;24.2,-23.7,;25.54,-24.46,;24.2,-22.16,;25.53,-22.91,;16.22,-28.35,;14.89,-29.13,;13.55,-28.35,;12.09,-28.83,)| Show InChI InChI=1S/C16H17F3N2O2S/c17-16(18,19)10-3-1-9(2-4-10)15(23)20-11-5-6-13-12(7-11)21-14(8-22)24-13/h5-7,9-10,22H,1-4,8H2,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391047 (CHEMBL2088414) Show SMILES OCc1nc2cc(NS(=O)(=O)c3ccc(Br)cc3)ccc2s1 Show InChI InChI=1S/C14H11BrN2O3S2/c15-9-1-4-11(5-2-9)22(19,20)17-10-3-6-13-12(7-10)16-14(8-18)21-13/h1-7,17-18H,8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391045 (CHEMBL2088412) Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc3sc(CO)nc3c2)cc1 Show InChI InChI=1S/C19H20N2O2S/c1-19(2,3)13-5-7-14(8-6-13)20-18(23)12-4-9-16-15(10-12)21-17(11-22)24-16/h4-10,22H,11H2,1-3H3,(H,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391035 (CHEMBL2088397) Show SMILES OCc1nc2cc(NC(=O)c3ccc(CN4CCOCC4)cc3)ccc2s1 Show InChI InChI=1S/C20H21N3O3S/c24-13-19-22-17-11-16(5-6-18(17)27-19)21-20(25)15-3-1-14(2-4-15)12-23-7-9-26-10-8-23/h1-6,11,24H,7-10,12-13H2,(H,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50391034 (CHEMBL2088396) Show SMILES CCN(CC)Cc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C20H23N3O2S/c1-3-23(4-2)12-14-5-7-15(8-6-14)20(25)21-16-9-10-18-17(11-16)22-19(13-24)26-18/h5-11,24H,3-4,12-13H2,1-2H3,(H,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay				Bioorg Med Chem Lett 22: 6205-11 (2012) Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB
					More data for this Ligand-Target Pair