Found 31 hits Enz. Inhib. hit(s) with all data for entry = 50040228 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391055
(CHEMBL2088399)Show InChI InChI=1S/C19H20N2O2S/c1-19(2,3)13-6-4-12(5-7-13)18(23)20-14-8-9-16-15(10-14)21-17(11-22)24-16/h4-10,22H,11H2,1-3H3,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391031
(CHEMBL2088393)Show InChI InChI=1S/C19H20N2O3S/c1-19(2,3)24-14-7-4-12(5-8-14)18(23)20-13-6-9-16-15(10-13)21-17(11-22)25-16/h4-10,22H,11H2,1-3H3,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391029
(CHEMBL2088391)Show InChI InChI=1S/C16H11F3N2O2S/c17-16(18,19)10-3-1-9(2-4-10)15(23)20-11-5-6-13-12(7-11)21-14(8-22)24-13/h1-7,22H,8H2,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391025
(CHEMBL2088398)Show InChI InChI=1S/C19H20N2OS/c1-12-20-16-11-15(9-10-17(16)23-12)21-18(22)13-5-7-14(8-6-13)19(2,3)4/h5-11H,1-4H3,(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391027
(CHEMBL2088401)Show InChI InChI=1S/C15H11BrN2O2S/c16-10-3-1-9(2-4-10)15(20)17-11-5-6-13-12(7-11)18-14(8-19)21-13/h1-7,19H,8H2,(H,17,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391032
(CHEMBL2088394)Show InChI InChI=1S/C18H18N2O3S/c1-11(2)23-14-6-3-12(4-7-14)18(22)19-13-5-8-16-15(9-13)20-17(10-21)24-16/h3-9,11,21H,10H2,1-2H3,(H,19,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391040
(CHEMBL2088406)Show SMILES OCc1nc2cc(NC(=O)c3ccc(OCC(F)(F)F)nc3)ccc2s1 Show InChI InChI=1S/C16H12F3N3O3S/c17-16(18,19)8-25-13-4-1-9(6-20-13)15(24)21-10-2-3-12-11(5-10)22-14(7-23)26-12/h1-6,23H,7-8H2,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391052
(CHEMBL2088419)Show InChI InChI=1S/C19H20N2O3S/c1-11(2)24-14-5-6-15(12(3)8-14)19(23)20-13-4-7-17-16(9-13)21-18(10-22)25-17/h4-9,11,22H,10H2,1-3H3,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391053
(CHEMBL2088420)Show InChI InChI=1S/C16H13BrN2O2S/c1-9-6-10(17)2-4-12(9)16(21)18-11-3-5-14-13(7-11)19-15(8-20)22-14/h2-7,20H,8H2,1H3,(H,18,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391037
(CHEMBL2088403)Show SMILES CC(C)(C)OCc1ccc(cc1)C(=O)Nc1ccc2sc(CO)nc2c1 Show InChI InChI=1S/C20H22N2O3S/c1-20(2,3)25-12-13-4-6-14(7-5-13)19(24)21-15-8-9-17-16(10-15)22-18(11-23)26-17/h4-10,23H,11-12H2,1-3H3,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391026
(CHEMBL2088400)Show InChI InChI=1S/C15H11ClN2O2S/c16-10-3-1-9(2-4-10)15(20)17-11-5-6-13-12(7-11)18-14(8-19)21-13/h1-7,19H,8H2,(H,17,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391039
(CHEMBL2088405)Show InChI InChI=1S/C19H20N4O2S/c24-12-18-22-15-10-14(5-6-16(15)26-18)21-19(25)13-4-7-17(20-11-13)23-8-2-1-3-9-23/h4-7,10-11,24H,1-3,8-9,12H2,(H,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391051
(CHEMBL2088418)Show InChI InChI=1S/C16H13ClN2O2S/c1-9-6-10(17)2-4-12(9)16(21)18-11-3-5-14-13(7-11)19-15(8-20)22-14/h2-7,20H,8H2,1H3,(H,18,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391041
(CHEMBL2088407)Show InChI InChI=1S/C14H11F3N4O2S/c1-21-9(5-11(20-21)14(15,16)17)13(23)18-7-2-3-10-8(4-7)19-12(6-22)24-10/h2-5,22H,6H2,1H3,(H,18,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 157 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391028
(CHEMBL2088390)Show InChI InChI=1S/C17H12N2O2S/c1-2-11-3-5-12(6-4-11)17(21)18-13-7-8-15-14(9-13)19-16(10-20)22-15/h1,3-9,20H,10H2,(H,18,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391054
(CHEMBL2088411)Show SMILES CC(O)c1nc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2s1 Show InChI InChI=1S/C20H22N2O2S/c1-12(23)19-22-16-11-15(9-10-17(16)25-19)21-18(24)13-5-7-14(8-6-13)20(2,3)4/h5-12,23H,1-4H3,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391038
(CHEMBL2088404)Show InChI InChI=1S/C15H10F3N3O2S/c16-15(17,18)12-4-1-8(6-19-12)14(23)20-9-2-3-11-10(5-9)21-13(7-22)24-11/h1-6,22H,7H2,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391036
(CHEMBL2088402)Show InChI InChI=1S/C18H18N2O3S/c1-2-23-11-12-3-5-13(6-4-12)18(22)19-14-7-8-16-15(9-14)20-17(10-21)24-16/h3-9,21H,2,10-11H2,1H3,(H,19,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391043
(CHEMBL2088409)Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc2sc(CNS(C)(=O)=O)nc2c1 Show InChI InChI=1S/C20H23N3O3S2/c1-20(2,3)14-7-5-13(6-8-14)19(24)22-15-9-10-17-16(11-15)23-18(27-17)12-21-28(4,25)26/h5-11,21H,12H2,1-4H3,(H,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391050
(CHEMBL2088417)Show InChI InChI=1S/C19H22N2OS/c1-19(2,3)14-6-4-13(5-7-14)11-20-15-8-9-17-16(10-15)21-18(12-22)23-17/h4-10,20,22H,11-12H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 833 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391042
(CHEMBL2088408)Show InChI InChI=1S/C19H21N3OS/c1-19(2,3)13-6-4-12(5-7-13)18(23)21-14-8-9-16-15(10-14)22-17(11-20)24-16/h4-10H,11,20H2,1-3H3,(H,21,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 987 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391033
(CHEMBL2088395)Show InChI InChI=1S/C19H20N2O3S/c1-19(2,3)24-14-6-4-5-12(9-14)18(23)20-13-7-8-16-15(10-13)21-17(11-22)25-16/h4-10,22H,11H2,1-3H3,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391046
(CHEMBL2088413)Show InChI InChI=1S/C18H18N2O2S/c1-12-2-4-13(5-3-12)8-9-19-18(22)14-6-7-16-15(10-14)20-17(11-21)23-16/h2-7,10,21H,8-9,11H2,1H3,(H,19,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391044
(CHEMBL2088410)Show SMILES CC(=O)NCc1nc2cc(NC(=O)c3ccc(cc3)C(C)(C)C)ccc2s1 Show InChI InChI=1S/C21H23N3O2S/c1-13(25)22-12-19-24-17-11-16(9-10-18(17)27-19)23-20(26)14-5-7-15(8-6-14)21(2,3)4/h5-11H,12H2,1-4H3,(H,22,25)(H,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391049
(CHEMBL2088416)Show SMILES OCc1nc2cc(ccc2s1)S(=O)(=O)NCc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C16H13F3N2O3S2/c17-16(18,19)11-3-1-2-10(6-11)8-20-26(23,24)12-4-5-14-13(7-12)21-15(9-22)25-14/h1-7,20,22H,8-9H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391048
(CHEMBL2088415)Show SMILES OCc1nc2cc(ccc2s1)S(=O)(=O)Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C15H11F3N2O3S2/c16-15(17,18)9-1-3-10(4-2-9)20-25(22,23)11-5-6-13-12(7-11)19-14(8-21)24-13/h1-7,20-21H,8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391030
(CHEMBL2088392)Show SMILES OCc1nc2cc(NC(=O)C3CCC(CC3)C(F)(F)F)ccc2s1 |(8.88,-26.24,;9.64,-27.58,;11.18,-27.58,;12.09,-26.34,;13.55,-26.82,;14.88,-26.04,;16.22,-26.8,;17.55,-26.03,;18.89,-26.79,;18.89,-28.33,;20.22,-26.02,;21.55,-26.79,;22.88,-26.02,;22.87,-24.47,;21.53,-23.71,;20.2,-24.49,;24.2,-23.7,;25.54,-24.46,;24.2,-22.16,;25.53,-22.91,;16.22,-28.35,;14.89,-29.13,;13.55,-28.35,;12.09,-28.83,)| Show InChI InChI=1S/C16H17F3N2O2S/c17-16(18,19)10-3-1-9(2-4-10)15(23)20-11-5-6-13-12(7-11)21-14(8-22)24-13/h5-7,9-10,22H,1-4,8H2,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391047
(CHEMBL2088414)Show InChI InChI=1S/C14H11BrN2O3S2/c15-9-1-4-11(5-2-9)22(19,20)17-10-3-6-13-12(7-10)16-14(8-18)21-13/h1-7,17-18H,8H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391045
(CHEMBL2088412)Show InChI InChI=1S/C19H20N2O2S/c1-19(2,3)13-5-7-14(8-6-13)20-18(23)12-4-9-16-15(10-12)21-17(11-22)24-16/h4-10,22H,11H2,1-3H3,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391035
(CHEMBL2088397)Show InChI InChI=1S/C20H21N3O3S/c24-13-19-22-17-11-16(5-6-18(17)27-19)21-20(25)15-3-1-14(2-4-15)12-23-7-9-26-10-8-23/h1-6,11,24H,7-10,12-13H2,(H,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50391034
(CHEMBL2088396)Show InChI InChI=1S/C20H23N3O2S/c1-3-23(4-2)12-14-5-7-15(8-6-14)20(25)21-16-9-10-18-17(11-16)22-19(13-24)26-18/h5-11,24H,3-4,12-13H2,1-2H3,(H,21,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assay |
Bioorg Med Chem Lett 22: 6205-11 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.018 BindingDB Entry DOI: 10.7270/Q29C6ZGB |
More data for this Ligand-Target Pair | |