Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Binding affinity to mGLUR2 | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Binding affinity to mGLUR3 | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi... | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi... | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50397661 (EGLUMEGAD) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at mGLUR2 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP production | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.07 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at mGLUR3 expressed in CHO cells | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at mGLUR2 expressed in CHO cells | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.58 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at human mGLUR3 assessed as inhibition of forskolin-stimulated cAMP production by cell-based assay | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.69 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at human mGLUR2 assessed as inhibition of forskolin-stimulated cAMP production by cell-based assay | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat)) | BDBM50397661 (EGLUMEGAD) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Agonist activity at mGLUR3 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP production | Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |