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Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with all data for entry = 50041695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413456
PNG
(CHEMBL495028)
Show SMILES CN1CCN(Cc2cccc(c2)C(=O)NCc2cccc(c2)-c2cccc(CN3CCNCC3)c2)CC1
Show InChI InChI=1S/C31H39N5O/c1-34-15-17-36(18-16-34)24-27-7-4-10-30(21-27)31(37)33-22-25-5-2-8-28(19-25)29-9-3-6-26(20-29)23-35-13-11-32-12-14-35/h2-10,19-21,32H,11-18,22-24H2,1H3,(H,33,37)
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n/an/a 3.98n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413419
PNG
(CHEMBL493329)
Show SMILES C[C@H]1CN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CCN1 |r|
Show InChI InChI=1S/C27H29N3O3/c1-19-16-30(11-10-28-19)17-21-5-3-7-23(13-21)22-6-2-4-20(12-22)15-29-27(31)24-8-9-25-26(14-24)33-18-32-25/h2-9,12-14,19,28H,10-11,15-18H2,1H3,(H,29,31)/t19-/m0/s1
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n/an/a 5.01n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413426
PNG
(CHEMBL521986)
Show SMILES Fc1ccc(CNC(=O)c2ccc3OCOc3c2)cc1-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26FN3O3/c27-23-6-4-18(15-29-26(31)21-5-7-24-25(14-21)33-17-32-24)13-22(23)20-3-1-2-19(12-20)16-30-10-8-28-9-11-30/h1-7,12-14,28H,8-11,15-17H2,(H,29,31)
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413418
PNG
(CHEMBL493328)
Show SMILES CC1CN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CCN1
Show InChI InChI=1S/C27H29N3O3/c1-19-16-30(11-10-28-19)17-21-5-3-7-23(13-21)22-6-2-4-20(12-22)15-29-27(31)24-8-9-25-26(14-24)33-18-32-25/h2-9,12-14,19,28H,10-11,15-18H2,1H3,(H,29,31)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413452
PNG
(CHEMBL522020)
Show SMILES CC(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H29N3O2/c1-20(31)23-7-4-10-26(17-23)27(32)29-18-21-5-2-8-24(15-21)25-9-3-6-22(16-25)19-30-13-11-28-12-14-30/h2-10,15-17,28H,11-14,18-19H2,1H3,(H,29,32)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413450
PNG
(CHEMBL492978)
Show SMILES CCOc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H31N3O2/c1-2-32-26-11-5-10-25(18-26)27(31)29-19-21-6-3-8-23(16-21)24-9-4-7-22(17-24)20-30-14-12-28-13-15-30/h3-11,16-18,28H,2,12-15,19-20H2,1H3,(H,29,31)
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413444
PNG
(CHEMBL492374)
Show SMILES COC(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H29N3O3/c1-33-27(32)25-10-4-9-24(17-25)26(31)29-18-20-5-2-7-22(15-20)23-8-3-6-21(16-23)19-30-13-11-28-12-14-30/h2-10,15-17,28H,11-14,18-19H2,1H3,(H,29,31)
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413445
PNG
(CHEMBL494749)
Show SMILES CS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H29N3O3S/c1-33(31,32)25-10-4-9-24(17-25)26(30)28-18-20-5-2-7-22(15-20)23-8-3-6-21(16-23)19-29-13-11-27-12-14-29/h2-10,15-17,27H,11-14,18-19H2,1H3,(H,28,30)
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n/an/a 19.9n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413427
PNG
(CHEMBL522838)
Show SMILES COc1ccc(CNC(=O)c2ccc3OCOc3c2)cc1-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H29N3O4/c1-32-24-7-5-19(16-29-27(31)22-6-8-25-26(15-22)34-18-33-25)14-23(24)21-4-2-3-20(13-21)17-30-11-9-28-10-12-30/h2-8,13-15,28H,9-12,16-18H2,1H3,(H,29,31)
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50412734
PNG
(CHEMBL493079)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C26H27N3O3/c30-26(23-7-8-24-25(15-23)32-18-31-24)28-16-19-3-1-5-21(13-19)22-6-2-4-20(14-22)17-29-11-9-27-10-12-29/h1-8,13-15,27H,9-12,16-18H2,(H,28,30)
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n/an/a 31.6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413425
PNG
(CHEMBL492701)
Show SMILES CC1CN(Cc2cccc(n2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CCN1
Show InChI InChI=1S/C26H28N4O3/c1-18-15-30(11-10-27-18)16-22-6-3-7-23(29-22)20-5-2-4-19(12-20)14-28-26(31)21-8-9-24-25(13-21)33-17-32-24/h2-9,12-13,18,27H,10-11,14-17H2,1H3,(H,28,31)
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n/an/a 39.8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413441
PNG
(CHEMBL494741)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)24-9-3-8-23(16-24)25(33)31-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-32-12-10-30-11-13-32/h1-9,14-16,30H,10-13,17-18H2,(H,31,33)
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413420
PNG
(CHEMBL493131)
Show SMILES C[C@@H]1CN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CCN1 |r|
Show InChI InChI=1S/C27H29N3O3/c1-19-16-30(11-10-28-19)17-21-5-3-7-23(13-21)22-6-2-4-20(12-22)15-29-27(31)24-8-9-25-26(14-24)33-18-32-25/h2-9,12-14,19,28H,10-11,15-18H2,1H3,(H,29,31)/t19-/m1/s1
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413433
PNG
(CHEMBL495172)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1cccc(c1)C#N
Show InChI InChI=1S/C26H26N4O/c27-17-20-4-1-9-25(14-20)26(31)29-18-21-5-2-7-23(15-21)24-8-3-6-22(16-24)19-30-12-10-28-11-13-30/h1-9,14-16,28H,10-13,18-19H2,(H,29,31)
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413474
PNG
(CHEMBL492802)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N4O/c27-17-20-7-9-23(10-8-20)26(31)29-18-21-3-1-5-24(15-21)25-6-2-4-22(16-25)19-30-13-11-28-12-14-30/h1-10,15-16,28H,11-14,18-19H2,(H,29,31)
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413435
PNG
(CHEMBL495180)
Show SMILES COc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H29N3O2/c1-31-25-10-4-9-24(17-25)26(30)28-18-20-5-2-7-22(15-20)23-8-3-6-21(16-23)19-29-13-11-27-12-14-29/h2-10,15-17,27H,11-14,18-19H2,1H3,(H,28,30)
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413414
PNG
(CHEMBL492988)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2C[C@@H]3C[C@H]2CN3)c1)c1ccc2OCOc2c1 |r|
Show InChI InChI=1S/C27H27N3O3/c31-27(22-7-8-25-26(11-22)33-17-32-25)29-13-18-3-1-5-20(9-18)21-6-2-4-19(10-21)15-30-16-23-12-24(30)14-28-23/h1-11,23-24,28H,12-17H2,(H,29,31)/t23-,24-/m0/s1
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413438
PNG
(CHEMBL492997)
Show SMILES Clc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H26ClN3O/c26-24-9-3-8-23(16-24)25(30)28-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-29-12-10-27-11-13-29/h1-9,14-16,27H,10-13,17-18H2,(H,28,30)
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413424
PNG
(CHEMBL492359)
Show SMILES Fc1ccc(cc1CN1CCNCC1)-c1cccc(CNC(=O)c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C26H26FN3O3/c27-23-6-4-20(13-22(23)16-30-10-8-28-9-11-30)19-3-1-2-18(12-19)15-29-26(31)21-5-7-24-25(14-21)33-17-32-24/h1-7,12-14,28H,8-11,15-17H2,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413446
PNG
(CHEMBL494950)
Show SMILES CN(C)c1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H32N4O/c1-30(2)26-11-5-10-25(18-26)27(32)29-19-21-6-3-8-23(16-21)24-9-4-7-22(17-24)20-31-14-12-28-13-15-31/h3-11,16-18,28H,12-15,19-20H2,1-2H3,(H,29,32)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413448
PNG
(CHEMBL494752)
Show SMILES CC(=O)Nc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H30N4O2/c1-20(32)30-26-10-4-9-25(17-26)27(33)29-18-21-5-2-7-23(15-21)24-8-3-6-22(16-24)19-31-13-11-28-12-14-31/h2-10,15-17,28H,11-14,18-19H2,1H3,(H,29,33)(H,30,32)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413454
PNG
(CHEMBL494410)
Show SMILES Cc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H29N3O/c1-20-5-2-10-25(15-20)26(30)28-18-21-6-3-8-23(16-21)24-9-4-7-22(17-24)19-29-13-11-27-12-14-29/h2-10,15-17,27H,11-14,18-19H2,1H3,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413430
PNG
(CHEMBL494778)
Show SMILES O=S(=O)(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C25H27N3O4S/c29-33(30,23-7-8-24-25(15-23)32-18-31-24)27-16-19-3-1-5-21(13-19)22-6-2-4-20(14-22)17-28-11-9-26-10-12-28/h1-8,13-15,26-27H,9-12,16-18H2
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413471
PNG
(CHEMBL493939)
Show SMILES Fc1ccc(cc1CNC(=O)c1ccc2OCOc2c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26FN3O3/c27-23-6-4-20(19-3-1-2-18(12-19)16-30-10-8-28-9-11-30)13-22(23)15-29-26(31)21-5-7-24-25(14-21)33-17-32-24/h1-7,12-14,28H,8-11,15-17H2,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413469
PNG
(CHEMBL492756)
Show SMILES COc1ccc(cc1CN1CCNCC1)-c1cccc(CNC(=O)c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C27H29N3O4/c1-32-24-7-5-21(14-23(24)17-30-11-9-28-10-12-30)20-4-2-3-19(13-20)16-29-27(31)22-6-8-25-26(15-22)34-18-33-25/h2-8,13-15,28H,9-12,16-18H2,1H3,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413455
PNG
(CHEMBL494411)
Show SMILES CCc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H31N3O/c1-2-21-6-3-11-26(16-21)27(31)29-19-22-7-4-9-24(17-22)25-10-5-8-23(18-25)20-30-14-12-28-13-15-30/h3-11,16-18,28H,2,12-15,19-20H2,1H3,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413432
PNG
(CHEMBL495025)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1ccccc1C#N
Show InChI InChI=1S/C26H26N4O/c27-17-24-7-1-2-10-25(24)26(31)29-18-20-5-3-8-22(15-20)23-9-4-6-21(16-23)19-30-13-11-28-12-14-30/h1-10,15-16,28H,11-14,18-19H2,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413439
PNG
(CHEMBL492998)
Show SMILES Clc1ccc(cc1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H26ClN3O/c26-24-9-7-21(8-10-24)25(30)28-17-19-3-1-5-22(15-19)23-6-2-4-20(16-23)18-29-13-11-27-12-14-29/h1-10,15-16,27H,11-14,17-18H2,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413475
PNG
(CHEMBL494836)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCCNCC2)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H29N3O3/c31-27(24-8-9-25-26(16-24)33-19-32-25)29-17-20-4-1-6-22(14-20)23-7-2-5-21(15-23)18-30-12-3-10-28-11-13-30/h1-2,4-9,14-16,28H,3,10-13,17-19H2,(H,29,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413409
PNG
(CHEMBL494781)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C27H29N3O3/c1-29-10-12-30(13-11-29)18-21-5-3-7-23(15-21)22-6-2-4-20(14-22)17-28-27(31)24-8-9-25-26(16-24)33-19-32-25/h2-9,14-16H,10-13,17-19H2,1H3,(H,28,31)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413470
PNG
(CHEMBL492702)
Show SMILES CC1CN(Cc2ccc(s2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CCN1
Show InChI InChI=1S/C25H27N3O3S/c1-17-14-28(10-9-26-17)15-21-6-8-24(32-21)19-4-2-3-18(11-19)13-27-25(29)20-5-7-22-23(12-20)31-16-30-22/h2-8,11-12,17,26H,9-10,13-16H2,1H3,(H,27,29)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413449
PNG
(CHEMBL494953)
Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26F3N3O2/c27-26(28,29)34-24-9-3-8-23(16-24)25(33)31-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-32-12-10-30-11-13-32/h1-9,14-16,30H,10-13,17-18H2,(H,31,33)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413436
PNG
(CHEMBL495360)
Show SMILES COc1ccc(cc1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H29N3O2/c1-31-25-10-8-22(9-11-25)26(30)28-18-20-4-2-6-23(16-20)24-7-3-5-21(17-24)19-29-14-12-27-13-15-29/h2-11,16-17,27H,12-15,18-19H2,1H3,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413434
PNG
(CHEMBL524168)
Show SMILES COc1ccccc1C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H29N3O2/c1-31-25-11-3-2-10-24(25)26(30)28-18-20-6-4-8-22(16-20)23-9-5-7-21(17-23)19-29-14-12-27-13-15-29/h2-11,16-17,27H,12-15,18-19H2,1H3,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413413
PNG
(CHEMBL492987)
Show SMILES CN1CCCN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C28H31N3O3/c1-30-11-4-12-31(14-13-30)19-22-6-3-8-24(16-22)23-7-2-5-21(15-23)18-29-28(32)25-9-10-26-27(17-25)34-20-33-26/h2-3,5-10,15-17H,4,11-14,18-20H2,1H3,(H,29,32)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413442
PNG
(CHEMBL523712)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)24-9-7-21(8-10-24)25(33)31-17-19-3-1-5-22(15-19)23-6-2-4-20(16-23)18-32-13-11-30-12-14-32/h1-10,15-16,30H,11-14,17-18H2,(H,31,33)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413443
PNG
(CHEMBL494742)
Show SMILES Fc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H26FN3O/c26-24-9-3-8-23(16-24)25(30)28-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-29-12-10-27-11-13-29/h1-9,14-16,27H,10-13,17-18H2,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413437
PNG
(CHEMBL495361)
Show SMILES Clc1ccccc1C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H26ClN3O/c26-24-10-2-1-9-23(24)25(30)28-17-19-5-3-7-21(15-19)22-8-4-6-20(16-22)18-29-13-11-27-12-14-29/h1-10,15-16,27H,11-14,17-18H2,(H,28,30)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413451
PNG
(CHEMBL492391)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C31H31N3O2/c35-31(28-11-6-14-30(21-28)36-29-12-2-1-3-13-29)33-22-24-7-4-9-26(19-24)27-10-5-8-25(20-27)23-34-17-15-32-16-18-34/h1-14,19-21,32H,15-18,22-23H2,(H,33,35)
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413423
PNG
(CHEMBL522992)
Show SMILES COc1ccc(CN2CCNCC2)cc1-c1cccc(CNC(=O)c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C27H29N3O4/c1-32-24-7-5-20(17-30-11-9-28-10-12-30)14-23(24)21-4-2-3-19(13-21)16-29-27(31)22-6-8-25-26(15-22)34-18-33-25/h2-8,13-15,28H,9-12,16-18H2,1H3,(H,29,31)
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413410
PNG
(CHEMBL494996)
Show SMILES CCN1CCN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C28H31N3O3/c1-2-30-11-13-31(14-12-30)19-22-6-4-8-24(16-22)23-7-3-5-21(15-23)18-29-28(32)25-9-10-26-27(17-25)34-20-33-26/h3-10,15-17H,2,11-14,18-20H2,1H3,(H,29,32)
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n/an/a 1.58E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413453
PNG
(CHEMBL501486)
Show SMILES Oc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H27N3O2/c29-24-9-3-8-23(16-24)25(30)27-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-28-12-10-26-11-13-28/h1-9,14-16,26,29H,10-13,17-18H2,(H,27,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413447
PNG
(CHEMBL494951)
Show SMILES Nc1cccc(c1)C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C25H28N4O/c26-24-9-3-8-23(16-24)25(30)28-17-19-4-1-6-21(14-19)22-7-2-5-20(15-22)18-29-12-10-27-11-13-29/h1-9,14-16,27H,10-13,17-18,26H2,(H,28,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413429
PNG
(CHEMBL524031)
Show SMILES Fc1c(CNC(=O)c2ccc3OCOc3c2)cccc1-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26FN3O3/c27-25-21(15-29-26(31)20-7-8-23-24(14-20)33-17-32-23)5-2-6-22(25)19-4-1-3-18(13-19)16-30-11-9-28-10-12-30/h1-8,13-14,28H,9-12,15-17H2,(H,29,31)
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n/an/a 2.51E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413422
PNG
(CHEMBL538863)
Show SMILES C[N+]1(C)CCN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C28H31N3O3/c1-31(2)13-11-30(12-14-31)19-22-6-4-8-24(16-22)23-7-3-5-21(15-23)18-29-28(32)25-9-10-26-27(17-25)34-20-33-26/h3-10,15-17H,11-14,18-20H2,1-2H3/p+1
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n/an/a 2.51E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413428
PNG
(CHEMBL494131)
Show SMILES Cc1ccc(cc1CNC(=O)c1ccc2OCOc2c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C27H29N3O3/c1-19-5-6-22(21-4-2-3-20(13-21)17-30-11-9-28-10-12-30)14-24(19)16-29-27(31)23-7-8-25-26(15-23)33-18-32-25/h2-8,13-15,28H,9-12,16-18H2,1H3,(H,29,31)
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n/an/a 3.16E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413440
PNG
(CHEMBL494151)
Show SMILES FC(F)(F)c1ccccc1C(=O)NCc1cccc(c1)-c1cccc(CN2CCNCC2)c1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)24-10-2-1-9-23(24)25(33)31-17-19-5-3-7-21(15-19)22-8-4-6-20(16-22)18-32-13-11-30-12-14-32/h1-10,15-16,30H,11-14,17-18H2,(H,31,33)
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n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413417
PNG
(CHEMBL523012)
Show SMILES CC(=O)N1CCN(Cc2cccc(c2)-c2cccc(CNC(=O)c3ccc4OCOc4c3)c2)CC1
Show InChI InChI=1S/C28H29N3O4/c1-20(32)31-12-10-30(11-13-31)18-22-5-3-7-24(15-22)23-6-2-4-21(14-23)17-29-28(33)25-8-9-26-27(16-25)35-19-34-26/h2-9,14-16H,10-13,17-19H2,1H3,(H,29,33)
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n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413415
PNG
(CHEMBL492989)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(c1)C(=O)N1CCNCC1)c1ccc2OCOc2c1
Show InChI InChI=1S/C26H25N3O4/c30-25(21-7-8-23-24(15-21)33-17-32-23)28-16-18-3-1-4-19(13-18)20-5-2-6-22(14-20)26(31)29-11-9-27-10-12-29/h1-8,13-15,27H,9-12,16-17H2,(H,28,30)
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n/an/a 5.01E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50413411
PNG
(CHEMBL494997)
Show SMILES O=C(NCc1cccc(c1)-c1cccc(CN2CCCCC2)c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H28N2O3/c30-27(24-10-11-25-26(16-24)32-19-31-25)28-17-20-6-4-8-22(14-20)23-9-5-7-21(15-23)18-29-12-2-1-3-13-29/h4-11,14-16H,1-3,12-13,17-19H2,(H,28,30)
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n/an/a 6.31E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobili...


Bioorg Med Chem Lett 19: 1686-90 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.098
BindingDB Entry DOI: 10.7270/Q2639QZ5
More data for this
Ligand-Target Pair
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