Found 65 hits Enz. Inhib. hit(s) with all data for entry = 50041784 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H4 receptor
(Rattus norvegicus (rat)) | BDBM50361015
(CHEMBL592379)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C21H25ClN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Binding affinity to rat histamine H4 receptor |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415482
(CHEMBL591011)Show SMILES CNS(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C16H23ClN6O2S/c1-18-26(24,25)10-5-19-15-13-11-12(17)3-4-14(13)20-16(21-15)23-8-6-22(2)7-9-23/h3-4,11,18H,5-10H2,1-2H3,(H,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415489
(CHEMBL591969)Show SMILES CN1CCN(CC1)c1nc(NCCS(N)(=O)=O)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C15H21ClN6O2S/c1-21-5-7-22(8-6-21)15-19-13-3-2-11(16)10-12(13)14(20-15)18-4-9-25(17,23)24/h2-3,10H,4-9H2,1H3,(H2,17,23,24)(H,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50361015
(CHEMBL592379)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C21H25ClN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415486
(CHEMBL592663)Show SMILES CN(c1ccccc1)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C22H27ClN6O2S/c1-27-11-13-29(14-12-27)22-25-20-9-8-17(23)16-19(20)21(26-22)24-10-15-32(30,31)28(2)18-6-4-3-5-7-18/h3-9,16H,10-15H2,1-2H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415494
(CHEMBL592434)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(I)ccc2n1 Show InChI InChI=1S/C21H25IN6O2S/c1-27-10-12-28(13-11-27)21-24-19-8-7-16(22)15-18(19)20(25-21)23-9-14-31(29,30)26-17-5-3-2-4-6-17/h2-8,15,26H,9-14H2,1H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412494
(CHEMBL452847 | VUF-10497)Show InChI InChI=1S/C18H20ClN5S/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415480
(CHEMBL591500)Show SMILES CCN(CC)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C19H29ClN6O2S/c1-4-26(5-2)29(27,28)13-8-21-18-16-14-15(20)6-7-17(16)22-19(23-18)25-11-9-24(3)10-12-25/h6-7,14H,4-5,8-13H2,1-3H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415500
(CHEMBL591496)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2c(cccc2n1)C(F)(F)F Show InChI InChI=1S/C22H25F3N6O2S/c1-30-11-13-31(14-12-30)21-27-18-9-5-8-17(22(23,24)25)19(18)20(28-21)26-10-15-34(32,33)29-16-6-3-2-4-7-16/h2-9,29H,10-15H2,1H3,(H,26,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 8.13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415485
(CHEMBL591250)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)N2CCOCC2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C19H27ClN6O3S/c1-24-5-7-25(8-6-24)19-22-17-3-2-15(20)14-16(17)18(23-19)21-4-13-30(27,28)26-9-11-29-12-10-26/h2-3,14H,4-13H2,1H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415484
(CHEMBL591249)Show SMILES CC1CCCCN1S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C21H31ClN6O2S/c1-16-5-3-4-9-28(16)31(29,30)14-8-23-20-18-15-17(22)6-7-19(18)24-21(25-20)27-12-10-26(2)11-13-27/h6-7,15-16H,3-5,8-14H2,1-2H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415499
(CHEMBL589746)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)cc(Cl)c2n1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-8-10-29(11-9-28)21-25-19-17(13-15(22)14-18(19)23)20(26-21)24-7-12-32(30,31)27-16-5-3-2-4-6-16/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| 12.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415481
(CHEMBL592188)Show SMILES CN(C)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C17H25ClN6O2S/c1-22(2)27(25,26)11-6-19-16-14-12-13(18)4-5-15(14)20-17(21-16)24-9-7-23(3)8-10-24/h4-5,12H,6-11H2,1-3H3,(H,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415498
(CHEMBL589782)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Br)c(Cl)cc2n1 Show InChI InChI=1S/C21H24BrClN6O2S/c1-28-8-10-29(11-9-28)21-25-19-14-18(23)17(22)13-16(19)20(26-21)24-7-12-32(30,31)27-15-5-3-2-4-6-15/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415483
(CHEMBL591248)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)N2CCCC2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C19H27ClN6O2S/c1-24-9-11-25(12-10-24)19-22-17-5-4-15(20)14-16(17)18(23-19)21-6-13-29(27,28)26-7-2-3-8-26/h4-5,14H,2-3,6-13H2,1H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415497
(CHEMBL590995)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)c(Cl)cc2n1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-8-10-29(11-9-28)21-25-19-14-18(23)17(22)13-16(19)20(26-21)24-7-12-32(30,31)27-15-5-3-2-4-6-15/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415488
(CHEMBL601946)Show SMILES CN1CCN(CC1)c1nc(NCCS(C)(=O)=O)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C16H22ClN5O2S/c1-21-6-8-22(9-7-21)16-19-14-4-3-12(17)11-13(14)15(20-16)18-5-10-25(2,23)24/h3-4,11H,5-10H2,1-2H3,(H,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 26.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415501
(CHEMBL591711)Show SMILES CNS(=O)(=O)CCCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1 Show InChI InChI=1S/C17H25ClN6O2S/c1-19-27(25,26)11-3-6-20-16-14-12-13(18)4-5-15(14)21-17(22-16)24-9-7-23(2)8-10-24/h4-5,12,19H,3,6-11H2,1-2H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 33.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412516
(CHEMBL509852 | VUF-10515)Show InChI InChI=1S/C19H22ClN5S/c1-13-5-10-26-17(13)12-21-18-15-11-14(20)3-4-16(15)22-19(23-18)25-8-6-24(2)7-9-25/h3-5,10-11H,6-9,12H2,1-2H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 33.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412512
(CHEMBL509142 | VUF-10507)Show InChI InChI=1S/C18H20ClN5S/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 35.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412515
(CHEMBL452869 | VUF-10516)Show SMILES CN1CCN(CC1)c1nc(NCc2cc(C)cs2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C19H22ClN5S/c1-13-9-15(26-12-13)11-21-18-16-10-14(20)3-4-17(16)22-19(23-18)25-7-5-24(2)6-8-25/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415493
(CHEMBL589800)Show SMILES CN1CCN(CC1)c1nc(NCCc2ccc(cc2)[N+]([O-])=O)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C21H23ClN6O2/c1-26-10-12-27(13-11-26)21-24-19-7-4-16(22)14-18(19)20(25-21)23-9-8-15-2-5-17(6-3-15)28(29)30/h2-7,14H,8-13H2,1H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412513
(CHEMBL452848 | VUF-10498)Show InChI InChI=1S/C19H22ClN5S/c1-24-8-10-25(11-9-24)19-22-17-5-4-14(20)13-16(17)18(23-19)21-7-6-15-3-2-12-26-15/h2-5,12-13H,6-11H2,1H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 60.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 63.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415487
(CHEMBL608373)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccc(I)cc2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C21H24ClIN6O2S/c1-28-9-11-29(12-10-28)21-25-19-7-2-15(22)14-18(19)20(26-21)24-8-13-32(30,31)27-17-5-3-16(23)4-6-17/h2-7,14,27H,8-13H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 70.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397307
(CHEMBL489062 | VUF-10349)Show InChI InChI=1S/C14H18ClN5/c1-16-13-11-9-10(15)3-4-12(11)17-14(18-13)20-7-5-19(2)6-8-20/h3-4,9H,5-8H2,1-2H3,(H,16,17,18) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 79.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397292
(CHEMBL454890 | VUF-10499)Show InChI InChI=1S/C18H20ClN5O/c1-23-5-7-24(8-6-23)18-21-16-3-2-14(19)10-15(16)17(22-18)20-11-13-4-9-25-12-13/h2-4,9-10,12H,5-8,11H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 89.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Rattus norvegicus (rat)) | BDBM50415489
(CHEMBL591969)Show SMILES CN1CCN(CC1)c1nc(NCCS(N)(=O)=O)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C15H21ClN6O2S/c1-21-5-7-22(8-6-21)15-19-13-3-2-11(16)10-12(13)14(20-15)18-4-9-25(17,23)24/h2-3,10H,4-9H2,1H3,(H2,17,23,24)(H,18,19,20) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Binding affinity to rat histamine H4 receptor |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412481
(CHEMBL453877 | VUF-10520)Show InChI InChI=1S/C17H19ClN6S/c1-23-5-7-24(8-6-23)17-21-14-3-2-12(18)10-13(14)16(22-17)20-11-15-19-4-9-25-15/h2-4,9-10H,5-8,11H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412504
(CHEMBL489070 | VUF-10513)Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(F)cc2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C20H21ClFN5/c1-26-8-10-27(11-9-26)20-24-18-7-4-15(21)12-17(18)19(25-20)23-13-14-2-5-16(22)6-3-14/h2-7,12H,8-11,13H2,1H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412482
(CHEMBL454891 | VUF-10559)Show InChI InChI=1S/C17H19ClN6S/c1-23-4-6-24(7-5-23)17-21-15-3-2-12(18)8-14(15)16(22-17)20-10-13-9-19-11-25-13/h2-3,8-9,11H,4-7,10H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 107 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412505
(CHEMBL448962 | VUF-10553)Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(cc2)C#N)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C21H21ClN6/c1-27-8-10-28(11-9-27)21-25-19-7-6-17(22)12-18(19)20(26-21)24-14-16-4-2-15(13-23)3-5-16/h2-7,12H,8-11,14H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412514
(CHEMBL452849 | VUF-10503)Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(C)o2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C19H22ClN5O/c1-13-3-5-15(26-13)12-21-18-16-11-14(20)4-6-17(16)22-19(23-18)25-9-7-24(2)8-10-25/h3-6,11H,7-10,12H2,1-2H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415495
(CHEMBL591013)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2n1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-8-10-29(11-9-28)21-25-18-14-15(22)13-17(23)19(18)20(26-21)24-7-12-32(30,31)27-16-5-3-2-4-6-16/h2-6,13-14,27H,7-12H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 151 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397300
(CHEMBL473302 | VUF-10351)Show InChI InChI=1S/C13H16ClN5/c1-18-4-6-19(7-5-18)13-16-11-3-2-9(14)8-10(11)12(15)17-13/h2-3,8H,4-7H2,1H3,(H2,15,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415492
(CHEMBL591027)Show SMILES CN1CCN(CC1)c1nc(NCCn2c(O)csc2=O)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C18H21ClN6O2S/c1-23-6-8-24(9-7-23)17-21-14-3-2-12(19)10-13(14)16(22-17)20-4-5-25-15(26)11-28-18(25)27/h2-3,10-11,26H,4-9H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 178 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412506
(CHEMBL523941 | VUF-10556)Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(F)c(F)c2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C20H20ClF2N5/c1-27-6-8-28(9-7-27)20-25-18-5-3-14(21)11-15(18)19(26-20)24-12-13-2-4-16(22)17(23)10-13/h2-5,10-11H,6-9,12H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 186 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412511
(CHEMBL454883 | VUF-10502)Show SMILES CN1CCN(CC1)c1nc(NCc2ccco2)c2cc(Cl)cc(C)c2n1 Show InChI InChI=1S/C19H22ClN5O/c1-13-10-14(20)11-16-17(13)22-19(25-7-5-24(2)6-8-25)23-18(16)21-12-15-4-3-9-26-15/h3-4,9-11H,5-8,12H2,1-2H3,(H,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 186 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415490
(CHEMBL591970)Show SMILES CN(C(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C23H27ClN6O/c1-28-12-14-30(15-13-28)23-26-20-9-8-17(24)16-19(20)22(27-23)25-11-10-21(31)29(2)18-6-4-3-5-7-18/h3-9,16H,10-15H2,1-2H3,(H,25,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412510
(CHEMBL454882 | VUF-10500)Show InChI InChI=1S/C18H20FN5O/c1-23-6-8-24(9-7-23)18-21-16-5-4-13(19)11-15(16)17(22-18)20-12-14-3-2-10-25-14/h2-5,10-11H,6-9,12H2,1H3,(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 224 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397296
(CHEMBL490071 | VUF-10329)Show InChI InChI=1S/C20H22ClN5/c1-25-9-11-26(12-10-25)20-23-18-8-7-16(21)13-17(18)19(24-20)22-14-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3,(H,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 257 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415496
(CHEMBL602330)Show SMILES CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2ccc(Cl)c(Cl)c2n1 Show InChI InChI=1S/C21H24Cl2N6O2S/c1-28-10-12-29(13-11-28)21-25-19-16(7-8-17(22)18(19)23)20(26-21)24-9-14-32(30,31)27-15-5-3-2-4-6-15/h2-8,27H,9-14H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 309 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412503
(CHEMBL489464 | VUF-10505)Show SMILES COc1ccc(CNc2nc(nc3ccc(Cl)cc23)N2CCN(C)CC2)cc1 Show InChI InChI=1S/C21H24ClN5O/c1-26-9-11-27(12-10-26)21-24-19-8-5-16(22)13-18(19)20(25-21)23-14-15-3-6-17(28-2)7-4-15/h3-8,13H,9-12,14H2,1-2H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 363 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412517
(CHEMBL452870 | VUF-10511)Show SMILES CN1CCN(CC1)c1nc(NCc2nc(C)no2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C17H20ClN7O/c1-11-20-15(26-23-11)10-19-16-13-9-12(18)3-4-14(13)21-17(22-16)25-7-5-24(2)6-8-25/h3-4,9H,5-8,10H2,1-2H3,(H,19,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 372 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397293
(CHEMBL489664 | VUF-10455)Show InChI InChI=1S/C15H20ClN5O/c1-20-5-7-21(8-6-20)15-18-13-3-2-11(16)10-12(13)14(19-15)17-4-9-22/h2-3,10,22H,4-9H2,1H3,(H,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 437 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50415491
(CHEMBL603621)Show InChI InChI=1S/C17H23ClN6O/c1-12(25)19-5-6-20-16-14-11-13(18)3-4-15(14)21-17(22-16)24-9-7-23(2)8-10-24/h3-4,11H,5-10H2,1-2H3,(H,19,25)(H,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50412483
(CHEMBL509961 | VUF-10510)Show SMILES CN1CCN(CC1)c1nc(NCc2cc3ccccc3s2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C22H22ClN5S/c1-27-8-10-28(11-9-27)22-25-19-7-6-16(23)13-18(19)21(26-22)24-14-17-12-15-4-2-3-5-20(15)29-17/h2-7,12-13H,8-11,14H2,1H3,(H,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397294
(CHEMBL489271 | VUF-10509)Show SMILES CN1CCN(CC1)c1nc(NCc2ccc(N)cc2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C20H23ClN6/c1-26-8-10-27(11-9-26)20-24-18-7-4-15(21)12-17(18)19(25-20)23-13-14-2-5-16(22)6-3-14/h2-7,12H,8-11,13,22H2,1H3,(H,23,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 562 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
Histamine H4 receptor
(Homo sapiens (Human)) | BDBM50397297
(CHEMBL489061 | VUF-10508)Show InChI InChI=1S/C20H28ClN5/c1-25-9-11-26(12-10-25)20-23-18-8-7-16(21)13-17(18)19(24-20)22-14-15-5-3-2-4-6-15/h7-8,13,15H,2-6,9-12,14H2,1H3,(H,22,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffin Discoveries BV
Curated by ChEMBL
| Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells |
J Med Chem 53: 2390-400 (2010)
Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4 |
More data for this
Ligand-Target Pair | |
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