BindingDB PrimarySearch

Found 41 hits Enz. Inhib. hit(s) with all data for entry = 50041881
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14029 ((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	25.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14031 (5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...) Show SMILES O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	31.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417674 (CHEMBL1643361) Show SMILES Nc1nccc2cc(CNCCc3ccccc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	63.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14027 (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline \| 5-(1,4...) Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50417667 (CHEMBL1643574) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50417674 (CHEMBL1643361) Show SMILES Nc1nccc2cc(CNCCc3ccccc3)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM14031 (5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...) Show SMILES O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50417668 (CHEMBL1643368) Show SMILES Nc1nccc2cc(O[C@H]3CCCNC3)ccc12 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM14027 (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline \| 5-(1,4...) Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM14029 ((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.94E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from human ERG				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417667 (CHEMBL1643574) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417683 (CHEMBL1643573) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM14029 ((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417687 (CHEMBL1643356) Show SMILES CN(CCc1ccccc1)Cc1ccc2c(N)nccc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM14031 (5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...) Show SMILES O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417678 (CHEMBL1643365) Show SMILES Nc1nccc2cc(CNCc3cccc(Oc4ccccc4)c3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417670 (CHEMBL1643357) Show SMILES Nc1nccc2cc(CNCCOc3ccccc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14031 (5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...) Show SMILES O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417671 (CHEMBL1643358) Show SMILES Nc1nccc2cc(CNCCc3ccc(Cl)c(Cl)c3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	776	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417672 (CHEMBL1643359) Show SMILES Cc1ccc(CCNCc2ccc3c(N)nccc3c2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	813	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14029 ((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	871	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417673 (CHEMBL1643360) Show SMILES COc1ccc(CCNCc2ccc3c(N)nccc3c2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50417674 (CHEMBL1643361) Show SMILES Nc1nccc2cc(CNCCc3ccccc3)ccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417674 (CHEMBL1643361) Show SMILES Nc1nccc2cc(CNCCc3ccccc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM14027 (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline \| 5-(1,4...) Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417675 (CHEMBL1643362) Show SMILES Nc1nccc2cc(CNCCNc3ccccc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417676 (CHEMBL1643363) Show SMILES Nc1nccc2cc(CNCCc3cccc(c3)C(F)(F)F)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417677 (CHEMBL1643364) Show SMILES Nc1nccc2cc(CNCCc3ccncc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417681 (CHEMBL1643571) Show SMILES Nc1nccc2cc(O[C@@H]3CCCNC3)ccc12 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417668 (CHEMBL1643368) Show SMILES Nc1nccc2cc(O[C@H]3CCCNC3)ccc12 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
C-C motif chemokine 2 (Homo sapiens (Human))	BDBM14029 ((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of MCP1-mediated human THP cell migration				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM14027 (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline \| 5-(1,4...) Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417679 (CHEMBL1643366) Show SMILES Nc1nccc2cc(CNCc3ccc4ccccc4c3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417682 (CHEMBL1643572) Show SMILES Nc1nccc2cc(OC3CCNCC3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417684 (CHEMBL1643575) Show SMILES Nc1nccc2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417680 (CHEMBL1643367) Show SMILES Nc1nccc2cc(CNCc3ccccc3)ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
C-C motif chemokine 2 (Homo sapiens (Human))	BDBM14027 (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline \| 5-(1,4...) Show SMILES O=S(=O)(N1CCCNCC1)c1cccc2cnccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of MCP1-mediated human THP cell migration				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
C-C motif chemokine 2 (Homo sapiens (Human))	BDBM14031 (5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...) Show SMILES O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of MCP1-mediated human THP cell migration				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417669 (CHEMBL1643355) Show SMILES NCc1ccc2c(N)nccc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
C-C motif chemokine 2 (Homo sapiens (Human))	BDBM50417674 (CHEMBL1643361) Show SMILES Nc1nccc2cc(CNCCc3ccccc3)ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of MCP1-mediated human THP cell migration				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50417685 (CHEMBL1643576) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
MSD Curated by ChEMBL					Assay Description Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assay				Bioorg Med Chem Lett 21: 97-101 (2010) Article DOI: 10.1016/j.bmcl.2010.11.060 BindingDB Entry DOI: 10.7270/Q29W0GQK
MSD Curated by ChEMBL					More data for this Ligand-Target Pair