Found 11 hits Enz. Inhib. hit(s) with all data for entry = 50043979 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM92625
(Dimethoxyquinoline, 2)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cccn(Cc5ccccc5)c4=O)nc3)c2cc1OC Show InChI InChI=1S/C29H24N4O5/c1-36-25-15-22-23(16-26(25)37-2)30-13-12-24(22)38-20-10-11-27(31-17-20)32-28(34)21-9-6-14-33(29(21)35)18-19-7-4-3-5-8-19/h3-17H,18H2,1-2H3,(H,31,32,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50449315
(CHEMBL3125863)Show SMILES Fc1ccc(Cc2cnc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)s2)cc1F Show InChI InChI=1S/C21H16F2N4O2S/c22-15-6-5-12(10-16(15)23)9-13-11-24-21(30-13)27-19(28)8-7-18-25-17-4-2-1-3-14(17)20(29)26-18/h1-6,10-11H,7-9H2,(H,24,27,28)(H,25,26,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50449315
(CHEMBL3125863)Show SMILES Fc1ccc(Cc2cnc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)s2)cc1F Show InChI InChI=1S/C21H16F2N4O2S/c22-15-6-5-12(10-16(15)23)9-13-11-24-21(30-13)27-19(28)8-7-18-25-17-4-2-1-3-14(17)20(29)26-18/h1-6,10-11H,7-9H2,(H,24,27,28)(H,25,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of ZAP70 (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50449314
(CHEMBL3125862)Show SMILES O=c1[nH]c(CSc2nnc(NCC3CCCO3)s2)nc2sc(cc12)-c1ccccc1 Show InChI InChI=1S/C20H19N5O2S3/c26-17-14-9-15(12-5-2-1-3-6-12)29-18(14)23-16(22-17)11-28-20-25-24-19(30-20)21-10-13-7-4-8-27-13/h1-3,5-6,9,13H,4,7-8,10-11H2,(H,21,24)(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of ZAP70 (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50449314
(CHEMBL3125862)Show SMILES O=c1[nH]c(CSc2nnc(NCC3CCCO3)s2)nc2sc(cc12)-c1ccccc1 Show InChI InChI=1S/C20H19N5O2S3/c26-17-14-9-15(12-5-2-1-3-6-12)29-18(14)23-16(22-17)11-28-20-25-24-19(30-20)21-10-13-7-4-8-27-13/h1-3,5-6,9,13H,4,7-8,10-11H2,(H,21,24)(H,22,23,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50449315
(CHEMBL3125863)Show SMILES Fc1ccc(Cc2cnc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)s2)cc1F Show InChI InChI=1S/C21H16F2N4O2S/c22-15-6-5-12(10-16(15)23)9-13-11-24-21(30-13)27-19(28)8-7-18-25-17-4-2-1-3-14(17)20(29)26-18/h1-6,10-11H,7-9H2,(H,24,27,28)(H,25,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50449314
(CHEMBL3125862)Show SMILES O=c1[nH]c(CSc2nnc(NCC3CCCO3)s2)nc2sc(cc12)-c1ccccc1 Show InChI InChI=1S/C20H19N5O2S3/c26-17-14-9-15(12-5-2-1-3-6-12)29-18(14)23-16(22-17)11-28-20-25-24-19(30-20)21-10-13-7-4-8-27-13/h1-3,5-6,9,13H,4,7-8,10-11H2,(H,21,24)(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50449314
(CHEMBL3125862)Show SMILES O=c1[nH]c(CSc2nnc(NCC3CCCO3)s2)nc2sc(cc12)-c1ccccc1 Show InChI InChI=1S/C20H19N5O2S3/c26-17-14-9-15(12-5-2-1-3-6-12)29-18(14)23-16(22-17)11-28-20-25-24-19(30-20)21-10-13-7-4-8-27-13/h1-3,5-6,9,13H,4,7-8,10-11H2,(H,21,24)(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of FAK (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50449315
(CHEMBL3125863)Show SMILES Fc1ccc(Cc2cnc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)s2)cc1F Show InChI InChI=1S/C21H16F2N4O2S/c22-15-6-5-12(10-16(15)23)9-13-11-24-21(30-13)27-19(28)8-7-18-25-17-4-2-1-3-14(17)20(29)26-18/h1-6,10-11H,7-9H2,(H,24,27,28)(H,25,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of FAK (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50449314
(CHEMBL3125862)Show SMILES O=c1[nH]c(CSc2nnc(NCC3CCCO3)s2)nc2sc(cc12)-c1ccccc1 Show InChI InChI=1S/C20H19N5O2S3/c26-17-14-9-15(12-5-2-1-3-6-12)29-18(14)23-16(22-17)11-28-20-25-24-19(30-20)21-10-13-7-4-8-27-13/h1-3,5-6,9,13H,4,7-8,10-11H2,(H,21,24)(H,22,23,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of c-MET (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50449315
(CHEMBL3125863)Show SMILES Fc1ccc(Cc2cnc(NC(=O)CCc3nc4ccccc4c(=O)[nH]3)s2)cc1F Show InChI InChI=1S/C21H16F2N4O2S/c22-15-6-5-12(10-16(15)23)9-13-11-24-21(30-13)27-19(28)8-7-18-25-17-4-2-1-3-14(17)20(29)26-18/h1-6,10-11H,7-9H2,(H,24,27,28)(H,25,26,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description Inhibition of c-MET (unknown origin) by radiometric assay |
Bioorg Med Chem Lett 24: 1523-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.083 BindingDB Entry DOI: 10.7270/Q2X068JR |
More data for this Ligand-Target Pair | |