Compile Data Set for Download or QSAR

Found 372 hits Enz. Inhib. hit(s) with all data for entry = 650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285634 (3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.488	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285598 (3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.669	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285537 (3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.51	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285634 (3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.59	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285538 (N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...) Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12Cl2N4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285534 (3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...) Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.89	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285572 (3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.97	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM285598 (3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM285534 (3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...) Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.35	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285534 (3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...) Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 Show InChI InChI=1S/C17H12ClFN6O/c1-24-9-11(8-21-24)22-17(26)15-16(10-4-5-12(18)13(19)7-10)25-14(23-15)3-2-6-20-25/h2-9H,1H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.77	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285598 (3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| Show InChI InChI=1S/C17H14ClFN4O/c1-9-4-5-10(7-11(9)18)16-15(17(24)21-13-8-12(13)19)22-14-3-2-6-20-23(14)16/h2-7,12-13H,8H2,1H3,(H,21,24)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.82	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285572 (3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.91	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285568 (N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...) Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(9-13(10)18)16-15(17(23)20-12-6-7-12)21-14-3-2-8-19-22(14)16/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285556 (3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...) Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-19-16(23)14-15(10-5-6-11(17)12(18)9-10)22-13(21-14)4-3-8-20-22/h3-6,8-9H,2,7H2,1H3,(H,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285537 (3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285536 (3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)| Show InChI InChI=1S/C16H11ClF2N4O/c17-10-7-11(18)9(6-12(10)19)15-14(16(24)21-8-3-4-8)22-13-2-1-5-20-23(13)15/h1-2,5-8H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.83	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285574 (US10077269, Example 47 | US10669279, Example 47 | ...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)15-14(16(24)22-5-2-6-22)21-12-3-1-4-20-23(12)15/h1,3-4,7-8H,2,5-6H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285571 (3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F Show InChI InChI=1S/C16H10ClF3N4O/c17-9-4-3-8(6-10(9)18)14-13(15(25)22-11-7-16(11,19)20)23-12-2-1-5-21-24(12)14/h1-6,11H,7H2,(H,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.92	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285576 (US10077269, Example 49 | US10669279, Example 49 | ...) Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H15ClN4O/c1-11-5-6-12(10-13(11)18)16-15(17(23)21-8-3-9-21)20-14-4-2-7-19-22(14)16/h2,4-7,10H,3,8-9H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285626 (3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...) Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)| Show InChI InChI=1S/C15H11ClF2N4O/c1-2-19-15(23)13-14(22-12(21-13)4-3-5-20-22)8-6-11(18)9(16)7-10(8)17/h3-7H,2H2,1H3,(H,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.58	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285540 (US10077269, Example 13 | US10669279, Example 13 | ...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.63	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM285634 (3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)6-8(7-11(13)19)15-14(16(24)21-9-3-4-9)22-12-2-1-5-20-23(12)15/h1-2,5-7,9H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.69	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285551 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N |(-2.3,-23.34,;-3.79,-23.74,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,;-6.77,-24.54,;-8.25,-24.93,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,)| Show InChI InChI=1S/C17H11F2N5O/c18-12-8-11(13(19)7-10(12)9-20)16-15(17(25)23-5-2-6-23)22-14-3-1-4-21-24(14)16/h1,3-4,7-8H,2,5-6H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.04	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285556 (3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...) Show SMILES CCCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C16H14ClFN4O/c1-2-7-19-16(23)14-15(10-5-6-11(17)12(18)9-10)22-13(21-14)4-3-8-20-22/h3-6,8-9H,2,7H2,1H3,(H,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.05	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285540 (US10077269, Example 13 | US10669279, Example 13 | ...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285612 (3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1 Show InChI InChI=1S/C16H10ClFN6O/c17-11-4-3-9(6-12(11)18)15-14(16(25)22-10-7-19-20-8-10)23-13-2-1-5-21-24(13)15/h1-8H,(H,19,20)(H,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285613 (US10077269, Example 83 | US10669279, Example 83 | ...) Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12Cl2N4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.39	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285603 (US10077269, Example 76 | US10669279, Example 76 | ...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.43	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285627 (3-(4-chloro-5-fluoro-2-methylphenyl)-N-(propan-2-y...) Show SMILES CC(C)NC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1C |(4.83,-2.26,;4.06,-3.6,;4.83,-4.93,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)| Show InChI InChI=1S/C17H16ClFN4O/c1-9(2)21-17(24)15-16(23-14(22-15)5-4-6-20-23)11-8-13(19)12(18)7-10(11)3/h4-9H,1-3H3,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.48	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285622 (3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidaz...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N |(2.79,1.73,;1.31,1.33,;.91,-.16,;-.58,-.56,;-.98,-2.04,;-.07,-3.29,;-.98,-4.54,;-2.44,-4.06,;-3.78,-4.83,;-5.11,-4.06,;-5.11,-2.52,;-3.78,-1.75,;-2.44,-2.52,;1.47,-3.29,;2.24,-1.96,;2.24,-4.62,;3.78,-4.62,;5.11,-5.39,;5.11,-3.85,;-1.67,.53,;-3.16,.13,;-1.27,2.02,;.21,2.51,;.59,4.01,;.97,5.5,)| Show InChI InChI=1S/C17H11F2N5O/c18-12-7-11(13(19)6-9(12)8-20)16-15(17(25)22-10-3-4-10)23-14-2-1-5-21-24(14)16/h1-2,5-7,10H,3-4H2,(H,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.52	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285547 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-8.25,-24.93,;-6.77,-24.54,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,;-3.79,-23.74,;-2.3,-23.34,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,)| Show InChI InChI=1S/C18H14FN5O/c1-11-8-12(10-20)14(19)9-13(11)17-16(18(25)23-6-3-7-23)22-15-4-2-5-21-24(15)17/h2,4-5,8-9H,3,6-7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.74	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285616 (US10077269, Example 86 | US10669279, Example 86 | ...) Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H12F2N4O3/c18-17(19)25-11-5-4-10(9-12(11)26-17)15-14(16(24)22-7-2-8-22)21-13-3-1-6-20-23(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.83	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285602 (N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.99	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285613 (US10077269, Example 83 | US10669279, Example 83 | ...) Show SMILES Clc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H12Cl2N4O/c17-11-5-4-10(9-12(11)18)15-14(16(23)21-7-2-8-21)20-13-3-1-6-19-22(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.21	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285547 (4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...) Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-8.25,-24.93,;-6.77,-24.54,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,;-3.79,-23.74,;-2.3,-23.34,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,)| Show InChI InChI=1S/C18H14FN5O/c1-11-8-12(10-20)14(19)9-13(11)17-16(18(25)23-6-3-7-23)22-15-4-2-5-21-24(15)17/h2,4-5,8-9H,3,6-7H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM285537 (3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H12ClFN4O/c17-11-6-3-9(8-12(11)18)15-14(16(23)20-10-4-5-10)21-13-2-1-7-19-22(13)15/h1-3,6-8,10H,4-5H2,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.84	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285563 (3-(3-chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...) Show SMILES Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13ClN4O/c17-11-4-1-3-10(9-11)15-14(16(22)19-12-6-7-12)20-13-5-2-8-18-21(13)15/h1-5,8-9,12H,6-7H2,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.99	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285603 (US10077269, Example 76 | US10669279, Example 76 | ...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-9-10(4-6-19-12)14-13(15(24)22-7-2-8-22)21-11-3-1-5-20-23(11)14/h1,3-6,9,16H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.09	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285574 (US10077269, Example 47 | US10669279, Example 47 | ...) Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H11ClF2N4O/c17-13-10(18)7-9(8-11(13)19)15-14(16(24)22-5-2-6-22)21-12-3-1-4-20-23(12)15/h1,3-4,7-8H,2,5-6H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.37	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285616 (US10077269, Example 86 | US10669279, Example 86 | ...) Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C17H12F2N4O3/c18-17(19)25-11-5-4-10(9-12(11)26-17)15-14(16(24)22-7-2-8-22)21-13-3-1-6-20-23(13)15/h1,3-6,9H,2,7-8H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.72	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285614 (US10077269, Example 84 | US10669279, Example 84 | ...) Show SMILES Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)N1CCC1 Show InChI InChI=1S/C16H13ClN4O/c17-12-5-1-4-11(10-12)15-14(16(22)20-8-3-9-20)19-13-6-2-7-18-21(13)15/h1-2,4-7,10H,3,8-9H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.84	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285611 (3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...) Show SMILES CCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C15H12ClFN4O/c1-2-18-15(22)13-14(9-5-6-10(16)11(17)8-9)21-12(20-13)4-3-7-19-21/h3-8H,2H2,1H3,(H,18,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.86	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285568 (N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...) Show SMILES Cc1ccc(cc1F)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C17H15FN4O/c1-10-4-5-11(9-13(10)18)16-15(17(23)20-12-6-7-12)21-14-3-2-8-19-22(14)16/h2-5,8-9,12H,6-7H2,1H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.05	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285611 (3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...) Show SMILES CCNC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C15H12ClFN4O/c1-2-18-15(22)13-14(9-5-6-10(16)11(17)8-9)21-12(20-13)4-3-7-19-21/h3-8H,2H2,1H3,(H,18,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285602 (N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...) Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13F2N5O2/c17-16(18)25-12-8-9(5-7-19-12)14-13(15(24)21-10-3-4-10)22-11-2-1-6-20-23(11)14/h1-2,5-8,10,16H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A] (Homo sapiens (Human))	BDBM285536 (3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...) Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)| Show InChI InChI=1S/C16H11ClF2N4O/c17-10-7-11(18)9(6-12(10)19)15-14(16(24)21-8-3-4-8)22-13-2-1-5-20-23(13)15/h1-2,5-8H,3-4H2,(H,21,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285595 (3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F |r,wU:3.4,1.0,(5.5,-1.78,;4.73,-3.11,;4.73,-4.65,;3.39,-3.88,;1.85,-3.88,;1.08,-2.55,;1.85,-1.21,;-.46,-2.55,;-1.36,-3.79,;-2.83,-3.32,;-4.16,-4.09,;-5.5,-3.32,;-5.5,-1.78,;-4.16,-1.01,;-2.83,-1.78,;-1.36,-1.3,;-.96,.19,;.52,.59,;.92,2.07,;-.17,3.16,;.23,4.65,;-1.66,2.76,;-2.05,1.28,;-3.54,.88,)| Show InChI InChI=1S/C16H11ClF2N4O/c17-8-3-4-9(10(18)6-8)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285529 (3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...) Show SMILES Clc1ccc(cc1)-c1c(nc2cccnn12)C(=O)NC1CC1 Show InChI InChI=1S/C16H13ClN4O/c17-11-5-3-10(4-6-11)15-14(16(22)19-12-7-8-12)20-13-2-1-9-18-21(13)15/h1-6,9,12H,7-8H2,(H,19,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human))	BDBM285557 (3-(4-chlorophenyl)-N-(2-methylcyclopropyl)imidazo[...) Show SMILES CC1CC1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H15ClN4O/c1-10-9-13(10)20-17(23)15-16(11-4-6-12(18)7-5-11)22-14(21-15)3-2-8-19-22/h2-8,10,13H,9H2,1H3,(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair
Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (hPDE4D3) (Homo sapiens (Human))	BDBM285572 (3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...) Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C16H11ClF2N4O/c17-9-4-3-8(6-10(9)18)15-14(16(24)21-12-7-11(12)19)22-13-2-1-5-20-23(13)15/h1-6,11-12H,7H2,(H,21,24)/t11-,12+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...				US Patent US10077269 (2018) BindingDB Entry DOI: 10.7270/Q2P84DX5
					More data for this Ligand-Target Pair

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