Found 372 hits Enz. Inhib. hit(s) with all data for entry = 650 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285634
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 | PDB
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.488 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285598
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <0.669 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285537
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.51 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285634
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285538
(N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285534
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <1.89 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285572
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.97 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
(Homo sapiens (Human)) | BDBM285598
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
(Homo sapiens (Human)) | BDBM285534
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.35 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285534
(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)Show SMILES Cn1cc(NC(=O)c2nc3cccnn3c2-c2ccc(Cl)c(F)c2)cn1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285598
(3-(3-chloro-4-methylphenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES Cc1ccc(cc1Cl)-c1c(nc2cccnn12)C(=O)N[C@@H]1C[C@@H]1F |r| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.82 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285572
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.91 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285568
(N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285556
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.48 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285537
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285536
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.83 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285574
(US10077269, Example 47 | US9598421, Example 47 | a...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285571
(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.92 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285576
(US10077269, Example 49 | US9598421, Example 49 | a...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285626
(3-(4-chloro-2,5-difluoro-phenyl)-N-ethylimidazo[1,...)Show SMILES CCNC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1F |(4.83,-4.93,;4.06,-3.6,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.58 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285540
(US10077269, Example 13 | US9598421, Example 13 | a...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.63 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
(Homo sapiens (Human)) | BDBM285634
(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.69 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285551
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)N2CCC2)c(F)cc1C#N |(-2.3,-23.34,;-3.79,-23.74,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,;-6.77,-24.54,;-8.25,-24.93,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,)| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.04 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285556
(3-(4-chloro-3-fluorophenyl)-N-propylimidazo[1,2-b]...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285540
(US10077269, Example 13 | US9598421, Example 13 | a...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285612
(3-(4-chloro-3-fluorophenyl)-N-(1H-pyrazol-4-yl)imi...)Show SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)Nc1cn[nH]c1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285613
(US10077269, Example 83 | US9598421, Example 83 | a...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.39 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285603
(US10077269, Example 76 | US9598421, Example 76 | a...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285627
(3-(4-chloro-5-fluoro-2-methylphenyl)-N-(propan-2-y...)Show SMILES CC(C)NC(=O)c1nc2cccnn2c1-c1cc(F)c(Cl)cc1C |(4.83,-2.26,;4.06,-3.6,;4.83,-4.93,;2.52,-3.6,;1.75,-2.26,;2.52,-.93,;.21,-2.26,;-.7,-3.51,;-2.16,-3.03,;-3.49,-3.8,;-4.83,-3.03,;-4.83,-1.49,;-3.49,-.72,;-2.16,-1.49,;-.7,-1.02,;-.3,.47,;1.19,.87,;1.59,2.36,;3.08,2.75,;.5,3.44,;.9,4.93,;-.99,3.05,;-1.39,1.56,;-2.87,1.16,)| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.48 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285622
(3-(4-cyano-2,5-difluorophenyl)-N-cyclopropylimidaz...)Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1C#N |(2.79,1.73,;1.31,1.33,;.91,-.16,;-.58,-.56,;-.98,-2.04,;-.07,-3.29,;-.98,-4.54,;-2.44,-4.06,;-3.78,-4.83,;-5.11,-4.06,;-5.11,-2.52,;-3.78,-1.75,;-2.44,-2.52,;1.47,-3.29,;2.24,-1.96,;2.24,-4.62,;3.78,-4.62,;5.11,-5.39,;5.11,-3.85,;-1.67,.53,;-3.16,.13,;-1.27,2.02,;.21,2.51,;.59,4.01,;.97,5.5,)| | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.52 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285547
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-8.25,-24.93,;-6.77,-24.54,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,;-3.79,-23.74,;-2.3,-23.34,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,)| | PDB
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UniChem
| US Patent
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Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285616
(US10077269, Example 86 | US9598421, Example 86 | a...)Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
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UniChem
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| n/a | n/a | 5.83 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285602
(N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 | PDB
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| n/a | n/a | 5.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285613
(US10077269, Example 83 | US9598421, Example 83 | a...) | PDB
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Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285547
(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nc2cccnn12)C(=O)N1CCC1 |(-8.25,-24.93,;-6.77,-24.54,;-6.37,-23.05,;-4.88,-22.65,;-4.48,-21.16,;-4.16,-19.66,;-3.79,-23.74,;-2.3,-23.34,;-4.19,-25.23,;-5.68,-25.62,;-6.08,-27.11,;-5.17,-28.36,;-6.08,-29.6,;-7.54,-29.13,;-8.87,-29.9,;-10.21,-29.13,;-10.21,-27.59,;-8.87,-26.82,;-7.54,-27.59,;-3.63,-28.36,;-2.86,-27.02,;-2.86,-29.69,;-3.26,-31.18,;-1.77,-31.58,;-1.37,-30.09,)| | PDB
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Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
(Homo sapiens (Human)) | BDBM285537
(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...) | PDB
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Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285563
(3-(3-chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285603
(US10077269, Example 76 | US9598421, Example 76 | a...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
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| US Patent
| n/a | n/a | 7.09 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285574
(US10077269, Example 47 | US9598421, Example 47 | a...)Show SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
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Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285616
(US10077269, Example 86 | US9598421, Example 86 | a...)Show SMILES FC1(F)Oc2ccc(cc2O1)-c1c(nc2cccnn12)C(=O)N1CCC1 | PDB
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UniChem
| US Patent
| n/a | n/a | 7.72 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285614
(US10077269, Example 84 | US9598421, Example 84 | a...) | PDB
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UniChem
| US Patent
| n/a | n/a | 7.84 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285611
(3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...) | PDB
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UniChem
| US Patent
| n/a | n/a | 7.86 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285568
(N-cyclopropyl-3-(3-fluoro-4-methylphenyl)imidazo[1...) | PDB
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| n/a | n/a | 8.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285611
(3-(4-chloro-3-fluorophenyl)-N-ethylimidazo[1,2-b]p...) | PDB
GoogleScholar
AffyNet
| PC cid
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UniChem
| US Patent
| n/a | n/a | 9.34 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285602
(N-cyclopropyl-3-[2-(difluoro-methoxy)pyridin-4-yl]...)Show SMILES FC(F)Oc1cc(ccn1)-c1c(nc2cccnn12)C(=O)NC1CC1 | PDB
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UniChem
| US Patent
| n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM285536
(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)Show SMILES Fc1cc(-c2c(nc3cccnn23)C(=O)NC2CC2)c(F)cc1Cl |(8.76,-6.6,;7.27,-7,;6.88,-8.49,;5.39,-8.89,;4.99,-10.38,;5.89,-11.62,;4.99,-12.87,;3.52,-12.39,;2.19,-13.16,;.86,-12.39,;.86,-10.85,;2.19,-10.08,;3.52,-10.85,;7.44,-11.62,;8.21,-10.29,;8.21,-12.96,;9.75,-12.96,;11.08,-13.73,;11.08,-12.19,;4.3,-7.8,;2.81,-8.2,;4.7,-6.31,;6.19,-5.91,;6.58,-4.43,)| | PDB
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| US Patent
| n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285595
(3-(4-chloro-2-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)cc1F |r,wU:3.4,1.0,(5.5,-1.78,;4.73,-3.11,;4.73,-4.65,;3.39,-3.88,;1.85,-3.88,;1.08,-2.55,;1.85,-1.21,;-.46,-2.55,;-1.36,-3.79,;-2.83,-3.32,;-4.16,-4.09,;-5.5,-3.32,;-5.5,-1.78,;-4.16,-1.01,;-2.83,-1.78,;-1.36,-1.3,;-.96,.19,;.52,.59,;.92,2.07,;-.17,3.16,;.23,4.65,;-1.66,2.76,;-2.05,1.28,;-3.54,.88,)| | PDB
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| PC cid
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UniChem
| US Patent
| n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285529
(3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...) | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
(Homo sapiens (Human)) | BDBM285557
(3-(4-chlorophenyl)-N-(2-methylcyclopropyl)imidazo[...) | PDB
GoogleScholar
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1
(Homo sapiens (Human)) | BDBM285572
(3-(4-chloro-3-fluorophenyl)-N-[(1R,2S)-2-fluorocyc...)Show SMILES F[C@H]1C[C@H]1NC(=O)c1nc2cccnn2c1-c1ccc(Cl)c(F)c1 |r| | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| |
US Patent US10077269 (2018)
BindingDB Entry DOI: 10.7270/Q2P84DX5 |
More data for this
Ligand-Target Pair | |
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