Compile Data Set for Download or QSAR

Found 125 hits Enz. Inhib. hit(s) with all data for entry = 728   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288255 (7-Chloro-5-(2-isopropyl-6-(trifluoromethyl)pyrazol...) Show SMILES CC(C)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)15-7-12-3-4-13(18(20,21)22)17(26(12)25-15)10-5-11-8-23-24-16(11)14(19)6-10/h3-9H,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288254 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C19H15ClF3N3O/c1-9(2)15-8-12-3-4-13(19(21,22)23)18(26(12)25-15)11-5-10-7-16(27)24-17(10)14(20)6-11/h3-6,8-9H,7H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288248 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H8ClF6N3O/c18-11-4-8(3-7-5-13(28)25-14(7)11)15-10(16(19,20)21)2-1-9-6-12(17(22,23)24)26-27(9)15/h1-4,6H,5H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288247 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H11F6N3O/c1-8-4-10(5-9-6-14(28)25-15(8)9)16-12(17(19,20)21)3-2-11-7-13(18(22,23)24)26-27(11)16/h2-5,7H,6H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288246 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H10F6N4/c1-8-4-9(5-10-7-24-25-14(8)10)15-12(16(18,19)20)3-2-11-6-13(17(21,22)23)26-27(11)15/h2-7H,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288253 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O/c1-10(2)16-9-14-4-5-15(20(21,22)23)19(26(14)25-16)13-6-11(3)18-12(7-13)8-17(27)24-18/h4-7,9-10H,8H2,1-3H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288302 (7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H8ClF5N4/c17-11-4-7(3-8-6-23-24-13(8)11)14-10(15(18)19)2-1-9-5-12(16(20,21)22)25-26(9)14/h1-6,15H,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288245 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4/c17-11-4-7(3-8-6-24-25-13(8)11)14-10(15(18,19)20)2-1-9-5-12(16(21,22)23)26-27(9)14/h1-6H,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288250 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1 Show InChI InChI=1S/C19H13ClF3N3O/c20-14-6-11(5-10-7-16(27)24-17(10)14)18-13(19(21,22)23)4-3-12-8-15(9-1-2-9)25-26(12)18/h3-6,8-9H,1-2,7H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288303 (6-(Difluoromethyl)-7-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C17H11F5N4/c1-8-4-9(5-10-7-23-24-14(8)10)15-12(16(18)19)3-2-11-6-13(17(20,21)22)25-26(11)15/h2-7,16H,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288237 (6-(4-Fluorophenyl)-5-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)19-16(12-2-4-15(22)5-3-12)6-7-17-27-20(21(23,24)25)29-30(17)19/h2-10H,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288251 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-6-12(7-13-9-23-24-17(10)13)18-15(19(20,21)22)5-4-14-8-16(11-2-3-11)25-26(14)18/h4-9,11H,2-3H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288235 (5-(7-Chloro-1H-indazol-5-yl)-6-(1,1-difluoroethyl)...) Show SMILES CC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-15(18,19)9-2-3-11-24-14(16(20,21)22)26-27(11)13(9)7-4-8-6-23-25-12(8)10(17)5-7/h2-6H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288304 (5-[6-(Difluoromethyl)-4-methyl-2-(trifluoromethyl)...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C19H14F5N3O/c1-8-4-12(18(20)21)17(27-13(8)7-14(26-27)19(22,23)24)11-3-9(2)16-10(5-11)6-15(28)25-16/h3-5,7,18H,6H2,1-2H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288301 (5-[6-(Difluoromethyl)-2-(trifluoromethyl)pyrazolo[...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C18H12F5N3O/c1-8-4-10(5-9-6-14(27)24-15(8)9)16-12(17(19)20)3-2-11-7-13(18(21,22)23)25-26(11)16/h2-5,7,17H,6H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288249 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C20H16F3N3O/c1-10-6-13(7-12-8-17(27)24-18(10)12)19-15(20(21,22)23)5-4-14-9-16(11-2-3-11)25-26(14)19/h4-7,9,11H,2-3,8H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288189 (5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-...) Show SMILES FC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(15(19,20)21)1-2-10-23-14(13(17)18)25-26(10)12/h1-5,13H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288239 (5-(6-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C22H14F4N4O/c1-11-8-14(9-13-10-18(31)28-19(11)13)20-16(12-2-4-15(23)5-3-12)6-7-17-27-21(22(24,25)26)29-30(17)20/h2-9H,10H2,1H3,(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288183 (5-(7-Chloro-1H-indazol-5-yl)-2,6-bis(trifluorometh...) Show SMILES FC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C15H6ClF6N5/c16-9-4-6(3-7-5-23-25-11(7)9)12-8(14(17,18)19)1-2-10-24-13(15(20,21)22)26-27(10)12/h1-5H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288218 (5-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-6-(triflu...) Show SMILES CC(C)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)16-23-13-4-3-11(17(19,20)21)15(26(13)25-16)9-5-10-7-22-24-14(10)12(18)6-9/h3-8H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288256 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4/c1-10(2)16-8-14-4-5-15(19(20,21)22)18(26(14)25-16)12-6-11(3)17-13(7-12)9-23-24-17/h4-10H,1-3H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288294 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...) Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1 Show InChI InChI=1S/C18H14ClF2N5/c1-8-4-12(16(20)21)15(26-18(8)23-17(25-26)9-2-3-9)10-5-11-7-22-24-14(11)13(19)6-10/h4-7,9,16H,2-3H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288198 (5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(13(17)18)1-2-10-23-14(15(19,20)21)25-26(10)12/h1-5,13H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288307 (7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-4-...) Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F Show InChI InChI=1S/C17H10ClF5N4/c1-7-2-10(16(19)20)15(27-12(7)5-13(26-27)17(21,22)23)8-3-9-6-24-25-14(9)11(18)4-8/h2-6,16H,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288224 (5-(7-Chloro-1H-indazol-5-yl)-2-(1,1-difluoroethyl)...) Show SMILES CC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-15(18,19)14-24-11-3-2-9(16(20,21)22)13(27(11)26-14)7-4-8-6-23-25-12(8)10(17)5-7/h2-6H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288305 (6-(Difluoromethyl)-4-methyl-7-(7-methyl-1H-indazol...) Show SMILES Cc1cc(C(F)F)c(-c2cc(C)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F Show InChI InChI=1S/C18H13F5N4/c1-8-4-12(17(19)20)16(27-13(8)6-14(26-27)18(21,22)23)10-3-9(2)15-11(5-10)7-24-25-15/h3-7,17H,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288244 (2-Cyclopropyl-6-(4-fluorophenyl)-5-(7-methyl-1H-in...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C1CC1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H18FN5/c1-13-10-16(11-17-12-25-27-21(13)17)22-19(14-4-6-18(24)7-5-14)8-9-20-26-23(15-2-3-15)28-29(20)22/h4-12,15H,2-3H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288257 (7-Chloro-5-(2-cyclopropyl-8-methyl-6-(trifluoromet...) Show SMILES Cc1cc(c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14ClF3N4O/c1-8-4-12(19(21,22)23)16(27-18(8)25-17(26-27)9-2-3-9)11-5-10-7-14(28)24-15(10)13(20)6-11/h4-6,9H,2-3,7H2,1H3,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288220 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(trif...) Show SMILES FC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C17H11ClF3N5/c18-12-6-9(5-10-7-22-24-14(10)12)15-11(17(19,20)21)3-4-13-23-16(8-1-2-8)25-26(13)15/h3-8H,1-2H2,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288260 (5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-8-...) Show SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)F)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-6-2-9(16(20,21)22)12(27-15(6)24-14(26-27)13(18)19)7-3-8-5-23-25-11(8)10(17)4-7/h2-5,13H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.126	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288199 (6-(Difluoromethyl)-5-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C16H10F5N5/c1-7-4-8(5-9-6-22-24-12(7)9)13-10(14(17)18)2-3-11-23-15(16(19,20)21)25-26(11)13/h2-6,14H,1H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288275 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...) Show SMILES CCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1 Show InChI InChI=1S/C19H16ClF2N5/c1-2-9-6-13(17(21)22)16(27-19(9)24-18(26-27)10-3-4-10)11-5-12-8-23-25-15(12)14(20)7-11/h5-8,10,17H,2-4H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288258 (2-Cyclopropyl-8-methyl-5-(7-methyl-1H-indazol-5-yl...) Show SMILES Cc1cc(c(-c2cc(C)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H16F3N5/c1-9-5-12(7-13-8-23-25-15(9)13)16-14(19(20,21)22)6-10(2)18-24-17(11-3-4-11)26-27(16)18/h5-8,11H,3-4H2,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288262 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-8-ethyl...) Show SMILES CCc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15ClF3N5/c1-2-9-6-13(19(21,22)23)16(28-18(9)25-17(27-28)10-3-4-10)11-5-12-8-24-26-15(12)14(20)7-11/h5-8,10H,2-4H2,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288286 (7-Ethyl-5-(8-methyl-2,6-bis(trifluoromethyl)-[1,2,...) Show SMILES CCc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C19H14F6N4O/c1-3-9-5-11(6-10-7-13(30)26-14(9)10)15-12(18(20,21)22)4-8(2)16-27-17(19(23,24)25)28-29(15)16/h4-6H,3,7H2,1-2H3,(H,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288193 (2-(Difluoromethyl)-6-(trifluoromethyl)-5-(7-(trifl...) Show SMILES FC(F)c1nc2ccc(c(-c3cc(c4[nH]ncc4c3)C(F)(F)F)n2n1)C(F)(F)F Show InChI InChI=1S/C16H7F8N5/c17-13(18)14-26-10-2-1-8(15(19,20)21)12(29(10)28-14)6-3-7-5-25-27-11(7)9(4-6)16(22,23)24/h1-5,13H,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288285 (7-Chloro-5-(2-ethyl-8-methyl-6-(trifluoromethyl)- ...) Show SMILES Cc1cc(c(-c2cc3CC(=O)Nc3c(Cl)c2)n2nc(nc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H9ClF6N4O/c1-6-2-9(16(19,20)21)13(28-14(6)26-15(27-28)17(22,23)24)8-3-7-5-11(29)25-12(7)10(18)4-8/h2-4H,5H2,1H3,(H,25,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.158	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288230 (5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difl...) Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C17H12ClF2N5/c18-12-6-9(5-10-7-21-23-14(10)12)15-11(16(19)20)3-4-13-22-17(8-1-2-8)24-25(13)15/h3-8,16H,1-2H2,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288215 (2-Cyclopropyl-8-fluoro-5-(7-methyl-1H-indazol-5-yl...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(cc(F)c2nc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C18H13F4N5/c1-8-4-10(5-11-7-23-25-14(8)11)15-12(18(20,21)22)6-13(19)17-24-16(9-2-3-9)26-27(15)17/h4-7,9H,2-3H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288188 (5-(7-Chloro-1H-indazol-5-yl)-8-methyl-2,6-bis(trif...) Show SMILES Cc1cc(c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C16H8ClF6N5/c1-6-2-9(15(18,19)20)12(28-13(6)25-14(27-28)16(21,22)23)7-3-8-5-24-26-11(8)10(17)4-7/h2-5H,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288184 (5-(7-Methyl-1H-indazol-5-yl)-2,6-bis(trifluorometh...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C16H9F6N5/c1-7-4-8(5-9-6-23-25-12(7)9)13-10(15(17,18)19)2-3-11-24-14(16(20,21)22)26-27(11)13/h2-6H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288243 (2-Ethyl-6-(4-fluorophenyl)-5-(7-methyl-1H-indazol-...) Show SMILES CCc1nc2ccc(-c3ccc(F)cc3)c(-c3cc(C)c4[nH]ncc4c3)n2n1 Show InChI InChI=1S/C22H18FN5/c1-3-19-25-20-9-8-18(14-4-6-17(23)7-5-14)22(28(20)27-19)15-10-13(2)21-16(11-15)12-24-26-21/h4-12H,3H2,1-2H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288265 (5-(7-Chloro-1H-indazol-5-yl)-8-methyl-2-propyl-6- ...) Show SMILES CCCc1nc2c(C)cc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C18H15ClF3N5/c1-3-4-14-24-17-9(2)5-12(18(20,21)22)16(27(17)26-14)10-6-11-8-23-25-15(11)13(19)7-10/h5-8H,3-4H2,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288281 (5-(2-Cyclopropyl-8-methyl-6-(trifluoromethyl)- | U...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2nc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C20H17F3N4O/c1-9-5-13(7-12-8-15(28)24-16(9)12)17-14(20(21,22)23)6-10(2)19-25-18(11-3-4-11)26-27(17)19/h5-7,11H,3-4,8H2,1-2H3,(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288259 (5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...) Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-6-2-9(13(18)19)12(27-14(6)24-15(26-27)16(20,21)22)7-3-8-5-23-25-11(8)10(17)4-7/h2-5,13H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288200 (7-Chloro-5-(6-(difluoromethyl)-2-(trifluoromethyl)...) Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C16H8ClF5N4O/c17-9-4-7(3-6-5-11(27)24-12(6)9)13-8(14(18)19)1-2-10-23-15(16(20,21)22)25-26(10)13/h1-4,14H,5H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288185 (5-(2,6-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]...) Show SMILES FC(F)(F)c1nc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4O/c17-9-4-7(3-6-5-11(28)25-12(6)9)13-8(15(18,19)20)1-2-10-24-14(16(21,22)23)26-27(10)13/h1-4H,5H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288259 (5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...) Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-6-2-9(13(18)19)12(27-14(6)24-15(26-27)16(20,21)22)7-3-8-5-23-25-11(8)10(17)4-7/h2-5,13H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.251	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair

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