Compile Data Set for Download or QSAR

Found 26 hits Enz. Inhib. hit(s) with all data for entry = 838   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM294039 (Process 1 | US10106557, Compound 1) Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.470	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294042 (US10106557, Compound 8) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r| Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM294039 (Process 1 | US10106557, Compound 1) Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.01	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM294042 (US10106557, Compound 8) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r| Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.92	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r| Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.93	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM294039 (Process 1 | US10106557, Compound 1) Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.87	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM294042 (US10106557, Compound 8) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r| Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.17	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM294041 (US10106557, Compound 7) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r| Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.13	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r| Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	4.22	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294041 (US10106557, Compound 7) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r| Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.41	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r| Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	4.45	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM294043 (US10106557, Compound 30) Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r| Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.71	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294043 (US10106557, Compound 30) Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r| Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16.2	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM294041 (US10106557, Compound 7) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r| Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	16.5	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Rattus norvegicus (rat))	BDBM294043 (US10106557, Compound 30) Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r| Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21.5	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM294044 (US10106557, Compound 34) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1cncn1 |r| Show InChI InChI=1S/C18H14ClN5O4S/c19-16-4-3-15(29-16)17(25)21-6-14-12-7-27-13-5-10(23-9-20-8-22-23)1-2-11(13)24(12)18(26)28-14/h1-5,8-9,12,14H,6-7H2,(H,21,25)/t12-,14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	106	n/a	n/a	n/a	n/a	n/a	n/a	8.3	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r| Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294043 (US10106557, Compound 30) Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r| Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294042 (US10106557, Compound 8) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r| Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294041 (US10106557, Compound 7) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r| Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM294039 (Process 1 | US10106557, Compound 1) Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM294043 (US10106557, Compound 30) Show SMILES COC[C@H]1CCCN1c1ccc2N3[C@@H](COc2c1)[C@H](CNC(=O)c1ccc(Cl)s1)OC3=O |r| Show InChI InChI=1S/C22H24ClN3O5S/c1-29-11-14-3-2-8-25(14)13-4-5-15-17(9-13)30-12-16-18(31-22(28)26(15)16)10-24-21(27)19-6-7-20(23)32-19/h4-7,9,14,16,18H,2-3,8,10-12H2,1H3,(H,24,27)/t14-,16+,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.2	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM294042 (US10106557, Compound 8) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)-n1ccccc1=O |r| Show InChI InChI=1S/C21H16ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h1-9,14,16H,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.2	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) Show SMILES [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O |r| Show InChI InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.2	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM294041 (US10106557, Compound 7) Show SMILES Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCNC1=O |r| Show InChI InChI=1S/C20H19ClN4O5S/c21-17-5-4-16(31-17)18(26)23-9-15-13-10-29-14-8-11(24-7-1-6-22-19(24)27)2-3-12(14)25(13)20(28)30-15/h2-5,8,13,15H,1,6-7,9-10H2,(H,22,27)(H,23,26)/t13-,15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.2	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair
Serine protease 1 (Homo sapiens (Human))	BDBM294039 (Process 1 | US10106557, Compound 1) Show SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O Show InChI InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.2	n/a
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent					Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...				US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W
					More data for this Ligand-Target Pair