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Compile Data Set for Download or QSAR

Found 219 hits Enz. Inhib. hit(s) with all data for entry = 937   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225896
PNG
(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Show SMILES Cc1c[nH]nc1C1CCCN(C1)c1ccc2ncnc(N)c2n1
Show InChI InChI=1/C16H19N7/c1-10-7-20-22-14(10)11-3-2-6-23(8-11)13-5-4-12-15(21-13)16(17)19-9-18-12/h4-5,7,9,11H,2-3,6,8H2,1H3,(H,20,22)(H2,17,18,19)
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n/an/a 6.20n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225896
PNG
(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Show SMILES Cc1c[nH]nc1C1CCCN(C1)c1ccc2ncnc(N)c2n1
Show InChI InChI=1/C16H19N7/c1-10-7-20-22-14(10)11-3-2-6-23(8-11)13-5-4-12-15(21-13)16(17)19-9-18-12/h4-5,7,9,11H,2-3,6,8H2,1H3,(H,20,22)(H2,17,18,19)
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n/an/a 6.20n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225896
PNG
(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Show SMILES Cc1c[nH]nc1C1CCCN(C1)c1ccc2ncnc(N)c2n1
Show InChI InChI=1/C16H19N7/c1-10-7-20-22-14(10)11-3-2-6-23(8-11)13-5-4-12-15(21-13)16(17)19-9-18-12/h4-5,7,9,11H,2-3,6,8H2,1H3,(H,20,22)(H2,17,18,19)
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n/an/a 6.20n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225896
PNG
(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Show SMILES Cc1c[nH]nc1C1CCCN(C1)c1ccc2ncnc(N)c2n1
Show InChI InChI=1/C16H19N7/c1-10-7-20-22-14(10)11-3-2-6-23(8-11)13-5-4-12-15(21-13)16(17)19-9-18-12/h4-5,7,9,11H,2-3,6,8H2,1H3,(H,20,22)(H2,17,18,19)
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n/an/a 6.20n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299544
PNG
(N-[3-(4-amino- pyrido[3,2-d] pyrimidin- 6-yl)-5-fl...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(NC(=O)CN2CCCC2)c1
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n/an/a 7.25n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299546
PNG
(3-(4-aminopyrido [3,2-d]pyrimidin- 6-yl)phenol | U...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(O)c1
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n/an/a 11n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299256
PNG
(6-(2-fluoro-4-pyridyl)pyrido[3,2-d]pyrimidin-4-ami...)
Show SMILES Nc1ncnc2ccc(nc12)-c1ccnc(F)c1
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n/an/a 11.5n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011536
PNG
(CHEMBL3262587 | US9592235, Example 184 | US9855269...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(F)c1
Show InChI InChI=1S/C13H9FN4/c14-9-3-1-2-8(6-9)10-4-5-11-12(18-10)13(15)17-7-16-11/h1-7H,(H2,15,16,17)
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n/an/a 11.8n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299492
PNG
(2-(4-amino- quinazolin- 6-yl)phenyl | US9592235, E...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(O)c1
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n/an/a 14.7n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299462
PNG
(6-(amino-5-fluoro- phenyl)pyrido [3,2-d]pyrimidin-...)
Show SMILES Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2n1
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n/an/a 16.9n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299383
PNG
(6-(3-chloro- phenyl)pyrido [3,2-d] pyrimidin-4- am...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(Cl)c1
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n/an/a 19.7n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011561
PNG
(CHEMBL3262580 | US9592235, Example 174 | US9855269...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(F)c1
Show InChI InChI=1S/C14H10FN3/c15-11-3-1-2-9(6-11)10-4-5-13-12(7-10)14(16)18-8-17-13/h1-8H,(H2,16,17,18)
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n/an/a 45.9n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299537
PNG
(6-(2-methyl-4- pyridyl)pyrido [3,2-d]pyrimidin- 4-...)
Show SMILES Cc1cc(ccn1)-c1ccc2ncnc(N)c2n1
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n/an/a 50.5n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299398
PNG
(N-[3-(4-amino- quinazolin-6-yl)- 5-fluoro-phenyl]-...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCCC2)c1
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n/an/a 58.6n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225898
PNG
(MAP16 | US9592235, Example 248 | US9855269, Compou...)
Show SMILES Nc1ncnc2ccc(nc12)N1CCC(Cc2ccccn2)C1
Show InChI InChI=1/C17H18N6/c18-17-16-14(20-11-21-17)4-5-15(22-16)23-8-6-12(10-23)9-13-3-1-2-7-19-13/h1-5,7,11-12H,6,8-10H2,(H2,18,20,21)
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n/an/a 65.6n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299436
PNG
(N6-[2-(4-fluoro- phenyl)ethyl] pyrido[3,2-d] pyrim...)
Show SMILES Nc1ncnc2ccc(NCCc3ccc(F)cc3)nc12
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299617
PNG
(6-[3-(difluoro- methoxy)phenyl] pyrido[3,2-d] pyri...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(OC(F)F)c1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299523
PNG
(6-[3-(2-pyridyl)-1- piperidyl]pyrido [3,2-d]pyrimi...)
Show SMILES Nc1ncnc2ccc(nc12)N1CCCC(C1)c1ccccn1
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n/an/a 76.4n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011551
PNG
(CHEMBL3262570 | US9592235, Example 268 | US9855269...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C14H11N3/c15-14-12-8-11(10-4-2-1-3-5-10)6-7-13(12)16-9-17-14/h1-9H,(H2,15,16,17)
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011560
PNG
(CHEMBL3262579 | US9592235, Example 187 | US9855269...)
Show SMILES Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1
Show InChI InChI=1S/C14H11FN4/c15-10-3-9(4-11(16)6-10)8-1-2-13-12(5-8)14(17)19-7-18-13/h1-7H,16H2,(H2,17,18,19)
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n/an/a 84n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299592
PNG
(N6-[(3-chloro- phenyl)methyl] pyrido[3,2-d] pyrimi...)
Show SMILES Nc1ncnc2ccc(NCc3cccc(Cl)c3)nc12
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM225895
PNG
(MAP14 | US9592235, Example 192 | US9855269, Compou...)
Show SMILES CN(C)CCC(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1
Show InChI InChI=1S/C19H20FN5O/c1-25(2)6-5-18(26)24-15-8-13(7-14(20)10-15)12-3-4-17-16(9-12)19(21)23-11-22-17/h3-4,7-11H,5-6H2,1-2H3,(H,24,26)(H2,21,22,23)
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n/an/a 88.4n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299384
PNG
(6-(5-chloro-2- methyl-phenyl) quinazolin- 4-amine ...)
Show SMILES Cc1ccc(Cl)cc1-c1ccc2ncnc(N)c2c1
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n/an/a 90.5n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011564
PNG
(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H10ClN3/c15-11-3-1-2-9(6-11)10-4-5-13-12(7-10)14(16)18-8-17-13/h1-8H,(H2,16,17,18)
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n/an/a 92.7n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299619
PNG
(6-(3-methoxy- phenyl) pyrido[3,2-d] pyrimidin- 4-a...)
Show SMILES COc1cccc(c1)-c1ccc2ncnc(N)c2n1
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n/an/a 99.7n/an/an/an/an/an/a



Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299490
PNG
(N-[3-(4-amino- pyrido[3,2-d] pyrimidin-6-yl)- 5-fl...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cc(F)cc(NC(=O)CC2CCCC2)c1
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n/an/a 107n/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299488
PNG
(1-[3-(4-amino- quinazolin- 6-yl)phenyl]-3- cyclope...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)NC2CCCC2)c1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299485
PNG
(6-[3-(6-methyl-2- pyridyl)-1- piperidyl]pyrido [3,...)
Show SMILES Cc1cccc(n1)C1CCCN(C1)c1ccc2ncnc(N)c2n1
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n/an/a 145n/an/an/an/an/an/a



Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299582
PNG
(6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-a...)
Show SMILES Nc1ncnc2ccc(Oc3cccc(Cl)c3)nc12
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299412
PNG
(6-(2-methyl- 4-pyridyl) quinazolin- 4-amine | US95...)
Show SMILES Cc1cc(ccn1)-c1ccc2ncnc(N)c2c1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299494
PNG
(6-(3-ethoxy- phenyl) quinazolin- 4-amine | US95922...)
Show SMILES CCOc1cccc(c1)-c1ccc2ncnc(N)c2c1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299497
PNG
(N6-benzylpyrido [3,2-d] pyrimidine-4,6- diamine | ...)
Show SMILES Nc1ncnc2ccc(NCc3ccccc3)nc12
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299397
PNG
(1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluor...)
Show SMILES CC(=O)N1CC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011559
PNG
(CHEMBL3262578 | US9592235, Example 269 | US9855269...)
Show SMILES Nc1ccc(F)c(c1)-c1ccc2ncnc(N)c2c1
Show InChI InChI=1S/C14H11FN4/c15-12-3-2-9(16)6-10(12)8-1-4-13-11(5-8)14(17)19-7-18-13/h1-7H,16H2,(H2,17,18,19)
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299618
PNG
(6-(3-isoprapoxy- phenyl) pyrido[3,2-d] pyrimidin-4...)
Show SMILES CC(C)Oc1cccc(c1)-c1ccc2ncnc(N)c2n1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011568
PNG
(CHEMBL3262584 | US9592235, Example 186 | US9855269...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C14H9F2N3/c15-10-3-9(4-11(16)6-10)8-1-2-13-12(5-8)14(17)19-7-18-13/h1-7H,(H2,17,18,19)
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US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299411
PNG
(6-(4-pyridyl) quinazolin- 4-amine | US9592235, Exa...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccncc1
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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299536
PNG
(6-(2-ethyl-4- pyridyl)pyrido [3,2-d]pyrimidin- 4-a...)
Show SMILES CCc1cc(ccn1)-c1ccc2ncnc(N)c2n1
PDB
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299423
PNG
(N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- pyrroli...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2)c1
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299550
PNG
(6-[3-(2-pyrrolidin- 1-ylethoxy) phenyl]pyrido [3,2...)
Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(OCCN2CCCC2)c1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299365
PNG
(6-(3-chloro-5- fluoro-phenyl) quinazolin-4- amine ...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(Cl)c1
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US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011558
PNG
(CHEMBL3262577 | US9592235, Example 266 | US9855269...)
Show SMILES Nc1cc(ccc1F)-c1ccc2ncnc(N)c2c1
Show InChI InChI=1S/C14H11FN4/c15-11-3-1-9(6-12(11)16)8-2-4-13-10(5-8)14(17)19-7-18-13/h1-7H,16H2,(H2,17,18,19)
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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299545
PNG
(N-[6-(3-amino-5- fluoro-phenyl) pyrido[3,2-d] pyri...)
Show SMILES Nc1cc(F)cc(c1)-c1ccc2ncnc(NC(=O)CN3CCCC3)c2n1
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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299563
PNG
(N6-[(2-fluoro- phenyl)methyl] pyrido[3,2-d] pyrimi...)
Show SMILES Nc1ncnc2ccc(NCc3ccccc3F)nc12
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Genentech, Inc.

US Patent




US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM50011556
PNG
(CHEMBL3262575 | US9592235, Example 164 | US9855269...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H10N4/c16-8-10-2-1-3-11(6-10)12-4-5-14-13(7-12)15(17)19-9-18-14/h1-7,9H,(H2,17,18,19)
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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299435
PNG
(N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- (dimeth...)
Show SMILES CN(C)CC(=O)Nc1cccc(c1)-c1ccc2ncnc(N)c2c1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299404
PNG
(N-[3-(4-amino- quinazolin-6- yl)-5-fluoro- phenyl]...)
Show SMILES CN1CCOC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299339
PNG
(N-[3-(4-aminoquinazolin-6-yl)-5-fluoro-phenyl]-2-m...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cc(F)cc(NC(=O)CN2CCOCC2)c1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299504
PNG
(6-[3-[6-(dimethyl- amino)-2-pyridyl]- 1-piperidyl]...)
Show SMILES CN(C)c1cccc(n1)C1CCCN(C1)c1ccc2ncnc(N)c2n1
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Genentech, Inc.

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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4


(Homo sapiens (Human))
BDBM299489
PNG
(N-[3-(4-amino- quinazolin-6-yl) phenyl]-2-(2- oxop...)
Show SMILES Nc1ncnc2ccc(cc12)-c1cccc(NC(=O)CN2CCCC2=O)c1
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US Patent US9592235 (2017)


BindingDB Entry DOI: 10.7270/Q2VX0JKX
More data for this
Ligand-Target Pair
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