Compile Data Set for Download or QSAR

Found 691 hits Enz. Inhib. hit(s) with all data for entry = 1660   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167060 (US9073876, 146 | US9732093, Compound 146) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167060 (US9073876, 146 | US9732093, Compound 146) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167191 (US9073876, 272 | US9732093, Compound 272) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167191 (US9073876, 272 | US9732093, Compound 272) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167005 (US9073876, 91 | US9732093, Compound 91) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167188 (US9073876, 269 | US9732093, Compound 269) Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167188 (US9073876, 269 | US9732093, Compound 269) Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167014 (US9073876, 100 | US9732093, Compound 100) Show SMILES COc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C19H19FN6O2/c1-27-19-25-14(21)7-16(26-19)28-18-11(10-3-2-4-10)5-6-12(17(18)20)13-8-24-15(22)9-23-13/h5-10H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167005 (US9073876, 91 | US9732093, Compound 91) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167001 (US9073876, 87 | US9732093, Compound 87) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(20-13-29-21(26)14-28-20)10-9-17(15-7-4-8-15)23(22)31-24-27-12-11-19(30-24)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167058 (US9073876, 144 | US9732093, Compound 144) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(19-13-29-20(26)14-28-19)10-9-17(15-7-4-8-15)23(22)31-21-11-12-27-24(30-21)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167058 (US9073876, 144 | US9732093, Compound 144) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(19-13-29-20(26)14-28-19)10-9-17(15-7-4-8-15)23(22)31-21-11-12-27-24(30-21)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167014 (US9073876, 100 | US9732093, Compound 100) Show SMILES COc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C19H19FN6O2/c1-27-19-25-14(21)7-16(26-19)28-18-11(10-3-2-4-10)5-6-12(17(18)20)13-8-24-15(22)9-23-13/h5-10H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167159 (US9073876, 241 | US9732093, Compound 241) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)N2CCC3(CC2)OCCCO3)c1F Show InChI InChI=1S/C26H29FN6O3/c27-23-19(20-15-31-21(28)16-30-20)6-5-18(17-3-1-4-17)24(23)36-25-29-10-7-22(32-25)33-11-8-26(9-12-33)34-13-2-14-35-26/h5-7,10,15-17H,1-4,8-9,11-14H2,(H2,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167159 (US9073876, 241 | US9732093, Compound 241) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)N2CCC3(CC2)OCCCO3)c1F Show InChI InChI=1S/C26H29FN6O3/c27-23-19(20-15-31-21(28)16-30-20)6-5-18(17-3-1-4-17)24(23)36-25-29-10-7-22(32-25)33-11-8-26(9-12-33)34-13-2-14-35-26/h5-7,10,15-17H,1-4,8-9,11-14H2,(H2,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335640 (US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...) Show SMILES CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1 Show InChI InChI=1S/C25H30FN7O3/c1-25(2,3)36-24(34)29-10-9-28-20-11-21(33-14-32-20)35-23-16(15-5-4-6-15)7-8-17(22(23)26)18-12-31-19(27)13-30-18/h7-8,11-15H,4-6,9-10H2,1-3H3,(H2,27,31)(H,29,34)(H,28,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167054 (US9073876, 140 | US9732093, Compound 140) Show SMILES Cc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C19H19FN6O/c1-10-25-15(21)7-17(26-10)27-19-12(11-3-2-4-11)5-6-13(18(19)20)14-8-24-16(22)9-23-14/h5-9,11H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167180 (US9073876, 261 | US9732093, Compound 261) Show SMILES CC(C)CNc1nccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C22H25FN6O/c1-13(2)10-28-22-25-9-8-19(29-22)30-21-15(14-4-3-5-14)6-7-16(20(21)23)17-11-27-18(24)12-26-17/h6-9,11-14H,3-5,10H2,1-2H3,(H2,24,27)(H,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335640 (US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...) Show SMILES CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1 Show InChI InChI=1S/C25H30FN7O3/c1-25(2,3)36-24(34)29-10-9-28-20-11-21(33-14-32-20)35-23-16(15-5-4-6-15)7-8-17(22(23)26)18-12-31-19(27)13-30-18/h7-8,11-15H,4-6,9-10H2,1-3H3,(H2,27,31)(H,29,34)(H,28,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167054 (US9073876, 140 | US9732093, Compound 140) Show SMILES Cc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C19H19FN6O/c1-10-25-15(21)7-17(26-10)27-19-12(11-3-2-4-11)5-6-13(18(19)20)14-8-24-16(22)9-23-14/h5-9,11H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167049 (US9073876, 135 | US9732093, Compound 135) Show SMILES CC(C)c1nccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C21H22FN5O/c1-12(2)21-24-9-8-18(27-21)28-20-14(13-4-3-5-13)6-7-15(19(20)22)16-10-26-17(23)11-25-16/h6-13H,3-5H2,1-2H3,(H2,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167049 (US9073876, 135 | US9732093, Compound 135) Show SMILES CC(C)c1nccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C21H22FN5O/c1-12(2)21-24-9-8-18(27-21)28-20-14(13-4-3-5-13)6-7-15(19(20)22)16-10-26-17(23)11-25-16/h6-13H,3-5H2,1-2H3,(H2,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167144 (US9073876, 226 | US9732093, Compound 226) Show SMILES Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1 Show InChI InChI=1S/C21H20FN5O2/c22-18-14(13-10-16-20(26-11-13)24-8-9-28-16)4-5-15(12-2-1-3-12)19(18)29-21-25-7-6-17(23)27-21/h4-7,10-12H,1-3,8-9H2,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167144 (US9073876, 226 | US9732093, Compound 226) Show SMILES Nc1ccnc(Oc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)n1 Show InChI InChI=1S/C21H20FN5O2/c22-18-14(13-10-16-20(26-11-13)24-8-9-28-16)4-5-15(12-2-1-3-12)19(18)29-21-25-7-6-17(23)27-21/h4-7,10-12H,1-3,8-9H2,(H,24,26)(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167056 (US9073876, 142 | US9732093, Compound 142) Show SMILES COCc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)nc(N)n1 Show InChI InChI=1S/C20H21FN6O2/c1-28-10-12-7-17(27-20(23)26-12)29-19-13(11-3-2-4-11)5-6-14(18(19)21)15-8-25-16(22)9-24-15/h5-9,11H,2-4,10H2,1H3,(H2,22,25)(H2,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM335835 (6-[3-(5-Aminopyrazin-2-yl)-6- cyclobutyl-2-fluorop...) Show SMILES Nc1ccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)nn1 Show InChI InChI=1S/C18H17FN6O/c19-17-12(13-8-23-15(21)9-22-13)5-4-11(10-2-1-3-10)18(17)26-16-7-6-14(20)24-25-16/h4-10H,1-3H2,(H2,20,24)(H2,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167056 (US9073876, 142 | US9732093, Compound 142) Show SMILES COCc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)nc(N)n1 Show InChI InChI=1S/C20H21FN6O2/c1-28-10-12-7-17(27-20(23)26-12)29-19-13(11-3-2-4-11)5-6-14(18(19)21)15-8-25-16(22)9-24-15/h5-9,11H,2-4,10H2,1H3,(H2,22,25)(H2,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167016 (US9073876, 102 | US9732093, Compound 102) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cccc(n2)C(F)(F)F)c1F Show InChI InChI=1S/C20H16F4N4O/c21-18-13(14-9-27-16(25)10-26-14)8-7-12(11-3-1-4-11)19(18)29-17-6-2-5-15(28-17)20(22,23)24/h2,5-11H,1,3-4H2,(H2,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167025 (US9073876, 111 | US9732093, Compound 111) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cccc(n2)C#N)c1F Show InChI InChI=1S/C20H16FN5O/c21-19-15(16-10-25-17(23)11-24-16)8-7-14(12-3-1-4-12)20(19)27-18-6-2-5-13(9-22)26-18/h2,5-8,10-12H,1,3-4H2,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167016 (US9073876, 102 | US9732093, Compound 102) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cccc(n2)C(F)(F)F)c1F Show InChI InChI=1S/C20H16F4N4O/c21-18-13(14-9-27-16(25)10-26-14)8-7-12(11-3-1-4-11)19(18)29-17-6-2-5-15(28-17)20(22,23)24/h2,5-11H,1,3-4H2,(H2,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM166937 (US9073876, 23 | US9732093, Compound 23) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2ccc(CC(O)=O)cc2)c1F Show InChI InChI=1S/C23H22FN3O3/c24-22-18(19-11-27-20(25)12-26-19)9-8-17(16-2-1-3-16)23(22)30-13-15-6-4-14(5-7-15)10-21(28)29/h4-9,11-12,16H,1-3,10,13H2,(H2,25,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167001 (US9073876, 87 | US9732093, Compound 87) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(20-13-29-21(26)14-28-20)10-9-17(15-7-4-8-15)23(22)31-24-27-12-11-19(30-24)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167154 (US9073876, 236 | US9732093, Compound 236) Show SMILES CN(C)c1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C21H23FN6O/c1-12-9-18(27-21(26-12)28(2)3)29-20-14(13-5-4-6-13)7-8-15(19(20)22)16-10-25-17(23)11-24-16/h7-11,13H,4-6H2,1-3H3,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167111 (US9073876, 195 | US9732093, Compound 195) Show SMILES OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1 Show InChI InChI=1S/C26H25FN2O4/c27-24-20(19-13-22-26(29-14-19)28-10-11-32-22)8-9-21(18-2-1-3-18)25(24)33-15-17-6-4-16(5-7-17)12-23(30)31/h4-9,13-14,18H,1-3,10-12,15H2,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167111 (US9073876, 195 | US9732093, Compound 195) Show SMILES OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1 Show InChI InChI=1S/C26H25FN2O4/c27-24-20(19-13-22-26(29-14-19)28-10-11-32-22)8-9-21(18-2-1-3-18)25(24)33-15-17-6-4-16(5-7-17)12-23(30)31/h4-9,13-14,18H,1-3,10-12,15H2,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167154 (US9073876, 236 | US9732093, Compound 236) Show SMILES CN(C)c1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C21H23FN6O/c1-12-9-18(27-21(26-12)28(2)3)29-20-14(13-5-4-6-13)7-8-15(19(20)22)16-10-25-17(23)11-24-16/h7-11,13H,4-6H2,1-3H3,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167180 (US9073876, 261 | US9732093, Compound 261) Show SMILES CC(C)CNc1nccc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C22H25FN6O/c1-13(2)10-28-22-25-9-8-19(29-22)30-21-15(14-4-3-5-14)6-7-16(20(21)23)17-11-27-18(24)12-26-17/h6-9,11-14H,3-5,10H2,1-2H3,(H2,24,27)(H,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167067 (US9073876, 153 | US9732093, Compound 153) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccc(cc2)C(O)=O)c1F Show InChI InChI=1S/C21H18FN3O3/c22-19-16(17-10-25-18(23)11-24-17)9-8-15(12-2-1-3-12)20(19)28-14-6-4-13(5-7-14)21(26)27/h4-12H,1-3H2,(H2,23,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167067 (US9073876, 153 | US9732093, Compound 153) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccc(cc2)C(O)=O)c1F Show InChI InChI=1S/C21H18FN3O3/c22-19-16(17-10-25-18(23)11-24-17)9-8-15(12-2-1-3-12)20(19)28-14-6-4-13(5-7-14)21(26)27/h4-12H,1-3H2,(H2,23,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167025 (US9073876, 111 | US9732093, Compound 111) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cccc(n2)C#N)c1F Show InChI InChI=1S/C20H16FN5O/c21-19-15(16-10-25-17(23)11-24-16)8-7-14(12-3-1-4-12)20(19)27-18-6-2-5-13(9-22)26-18/h2,5-8,10-12H,1,3-4H2,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167024 (US9073876, 110 | US9732093, Compound 110) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ncccc2C#N)c1F Show InChI InChI=1S/C20H16FN5O/c21-18-15(16-10-26-17(23)11-25-16)7-6-14(12-3-1-4-12)19(18)27-20-13(9-22)5-2-8-24-20/h2,5-8,10-12H,1,3-4H2,(H2,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167232 (US9073876, 313 | US9732093, Compound 313) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ncc(cn2)-c2cnc(N)nc2)c1F Show InChI InChI=1S/C22H19FN8O/c23-19-16(17-10-27-18(24)11-26-17)5-4-15(12-2-1-3-12)20(19)32-22-30-8-14(9-31-22)13-6-28-21(25)29-7-13/h4-12H,1-3H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167232 (US9073876, 313 | US9732093, Compound 313) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ncc(cn2)-c2cnc(N)nc2)c1F Show InChI InChI=1S/C22H19FN8O/c23-19-16(17-10-27-18(24)11-26-17)5-4-15(12-2-1-3-12)20(19)32-22-30-8-14(9-31-22)13-6-28-21(25)29-7-13/h4-12H,1-3H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167148 (US9073876, 230 | US9732093, Compound 230) Show SMILES Fc1c(Oc2ncccn2)c(ccc1-c1cnc2[nH]ccc2n1)C1CCC1 Show InChI InChI=1S/C20H16FN5O/c21-17-14(16-11-25-19-15(26-16)7-10-22-19)6-5-13(12-3-1-4-12)18(17)27-20-23-8-2-9-24-20/h2,5-12H,1,3-4H2,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167143 (US9073876, 225 | US9732093, Compound 225) Show SMILES Fc1c(Oc2ncccn2)c(ccc1-c1cnc2NCCOc2c1)C1CCC1 Show InChI InChI=1S/C21H19FN4O2/c22-18-15(14-11-17-20(26-12-14)23-9-10-27-17)5-6-16(13-3-1-4-13)19(18)28-21-24-7-2-8-25-21/h2,5-8,11-13H,1,3-4,9-10H2,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167148 (US9073876, 230 | US9732093, Compound 230) Show SMILES Fc1c(Oc2ncccn2)c(ccc1-c1cnc2[nH]ccc2n1)C1CCC1 Show InChI InChI=1S/C20H16FN5O/c21-17-14(16-11-25-19-15(26-16)7-10-22-19)6-5-13(12-3-1-4-12)18(17)27-20-23-8-2-9-24-20/h2,5-12H,1,3-4H2,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167024 (US9073876, 110 | US9732093, Compound 110) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ncccc2C#N)c1F Show InChI InChI=1S/C20H16FN5O/c21-18-15(16-10-26-17(23)11-25-16)7-6-14(12-3-1-4-12)19(18)27-20-13(9-22)5-2-8-24-20/h2,5-8,10-12H,1,3-4H2,(H2,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167083 (US9073876, 168 | US9732093, Compound 168) Show SMILES CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1 Show InChI InChI=1S/C21H23FN6O/c1-11(2)16-8-17(28-21(24)27-16)29-19-15(12-4-3-5-12)7-6-14(18(19)22)13-9-25-20(23)26-10-13/h6-12H,3-5H2,1-2H3,(H2,23,25,26)(H2,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167038 (US9073876, 124 | US9732093, Compound 124) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2ccnc(n2)C(F)(F)F)c1F Show InChI InChI=1S/C19H15F4N5O/c20-16-12(13-8-27-14(24)9-26-13)5-4-11(10-2-1-3-10)17(16)29-15-6-7-25-18(28-15)19(21,22)23/h4-10H,1-3H2,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167083 (US9073876, 168 | US9732093, Compound 168) Show SMILES CC(C)c1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)nc2)nc(N)n1 Show InChI InChI=1S/C21H23FN6O/c1-11(2)16-8-17(28-21(24)27-16)29-19-15(12-4-3-5-12)7-6-14(18(19)22)13-9-25-20(23)26-10-13/h6-12H,3-5H2,1-2H3,(H2,23,25,26)(H2,24,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair

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