Compile Data Set for Download or QSAR

Found 56 hits Enz. Inhib. hit(s) with all data for entry = 1824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145281 (US8952169, 60 | US9771376, Example 60) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:25:16:23:19.20.21,THB:15:16:23:19.20.21,25:20:23:16.24.17,24:16:19:23.22.21,24:22:19:16.25.17| Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145285 (US8952169, 64 | US9771376, Example 64) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:13.12.11,15:6:13:9.10.11,THB:15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145307 (US8952169, 86 | US9771376, Example 86) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1 |TLB:12:13:16:20.19.18,22:13:20:16.17.18,THB:21:13:16:20.19.18,21:19:16:13.22.14,22:17:20:13.21.14| Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.31	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145369 (US8952169, 148 | US9771376, Example 148) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:15:6:13:9.10.11,THB:5:6:13:9.10.11,15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM342473 (Cyclopropanesulfonic acid 4-(bicyclo[4.1.0]hept-1-...) Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C21H26FNO4S/c22-18-10-19(27-12-21-8-2-1-3-14(21)11-21)16(13-4-5-13)9-17(18)20(24)23-28(25,26)15-6-7-15/h9-10,13-15H,1-8,11-12H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145284 (US8952169, 63 | US9771376, Example 63) Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:26:17:24:20.21.22,THB:16:17:24:20.21.22,26:21:24:17.25.18,25:17:20:24.23.22,25:23:20:17.26.18| Show InChI InChI=1S/C22H29FN2O4S/c1-24-30(27,28)25-21(26)18-7-17(16-2-3-16)20(8-19(18)23)29-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16,24H,2-6,9-12H2,1H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145366 (US8952169, 145 | US8952169, 445 | US9771376, Examp...) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F |TLB:15:16:21:18.19,THB:23:22:21:18.19| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145229 (US8952169, 8 | US9771376, Example 8) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)CC2 |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-18(2)11-5-4-10(13(18)6-11)9-25-16-8-15(20)12(7-14(16)19)17(22)21-26(3,23)24/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,21,22)/t10-,11+,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145387 (US8952169, 166 | US9771376, Example 166) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-8-13(12-2-3-12)16(9-15(14)19)26-10-11-4-6-18(20,21)7-5-11/h8-9,11-12H,2-7,10H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145371 (US8952169, 150 | US9771376, Example 150) Show SMILES FC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:29:20:27:23.24.25,THB:19:20:27:23.24.25,29:24:27:20.28.21,28:20:23:27.26.25,28:26:23:20.29.21| Show InChI InChI=1S/C24H30F2N2O4S/c25-18-11-28(12-18)33(30,31)27-23(29)20-6-19(17-1-2-17)22(7-21(20)26)32-13-24-8-14-3-15(9-24)5-16(4-14)10-24/h6-7,14-18H,1-5,8-13H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145230 (US8952169, 9 | US9771376, Example 9) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2C3CC4CC(C3)CC2C4)cc1F |TLB:12:13:20:17.16.22,15:16:20:14.13.19,THB:15:14:20:17.16.22,13:14:17:20.21.22,13:21:17:14.15.19,(6.07,.01,;5.3,1.35,;4.53,2.68,;6.63,2.12,;3.97,.58,;2.63,1.35,;2.63,2.89,;1.3,.58,;1.3,-.96,;-.03,-1.73,;-.03,-3.27,;-1.37,-.96,;-2.7,-1.73,;-4.04,-.96,;-3.14,.96,;-3.14,2.5,;-4.47,3.27,;-5.8,2.5,;-5.8,.96,;-4.47,.19,;-6.63,-.94,;-5.24,-.29,;-5.22,2.11,;-1.37,.58,;-.03,1.35,;-.03,2.89,)| Show InChI InChI=1S/C18H21ClFNO4S/c1-26(23,24)21-18(22)13-7-14(19)16(8-15(13)20)25-17-11-3-9-2-10(5-11)6-12(17)4-9/h7-12,17H,2-6H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145227 (US8952169, 6 | US9771376, Example 6) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:13:14:17:21.20.19,23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145391 (US8952169, 170 | US8952169, 251 | US9771376, Examp...) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H29F3N2O4S/c25-20-9-21(33-13-23-10-14-6-16(11-23)24(26,27)17(7-14)12-23)18(15-2-3-15)8-19(20)22(30)28-34(31,32)29-4-1-5-29/h8-9,14-17H,1-7,10-13H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145368 (US8952169, 147 | US9771376, Example 147) Show SMILES O[C@H]1CCN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |r,TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C25H33FN2O5S/c26-22-9-23(33-14-25-10-15-5-16(11-25)7-17(6-15)12-25)20(18-1-2-18)8-21(22)24(30)27-34(31,32)28-4-3-19(29)13-28/h8-9,15-19,29H,1-7,10-14H2,(H,27,30)/t15?,16?,17?,19-,25?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145233 (US8952169, 12 | US9771376, Example 13) Show SMILES CC1(C)C2CCC1(C)C(C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |THB:10:8:1:5.4| Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145318 (US8952169, 97 | US9771376, Example 97) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:16:24:20:18.17.22,16:17:20:24.23.25,23:24:18:20.21.22,23:21:18:24.16.25,(8.42,2.5,;7.08,1.73,;7.08,.19,;5.75,2.5,;4.98,3.84,;6.52,3.84,;4.42,1.73,;3.08,2.5,;3.08,4.04,;1.75,1.73,;1.75,.19,;.41,-.58,;.41,-2.12,;-.92,.19,;-2.25,-.58,;-3.59,.19,;-4.92,-.58,;-6.25,.19,;-7.58,-.58,;-7.58,-2.12,;-8.42,-4.02,;-7.02,-3.37,;-7,-.97,;-5.82,-4.04,;-4.92,-2.12,;-6.25,-2.89,;-.92,1.73,;.41,2.5,;.41,4.04,)| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145257 (US8952169, 36 | US9771376, Example 36) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC2CCCCC2)cc1F Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-9-13(17)15(10-14(12)18)23-8-7-11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145231 (US8952169, 10 | US9771376, Example 10) Show SMILES C[C@@H]1[C@H]2C[C@@H](C[C@H]1Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C2(C)C |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-9-12-5-10(18(12,2)3)6-15(9)25-16-8-14(20)11(7-13(16)19)17(22)21-26(4,23)24/h7-10,12,15H,5-6H2,1-4H3,(H,21,22)/t9-,10+,12-,15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145232 (US8952169, 11 | US9771376, Example 11) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:14:15:18:22.21.20,24:15:22:18.19.20,THB:24:19:22:15.23.16,23:15:18:22.21.20,23:21:18:15.24.16| Show InChI InChI=1S/C20H25ClFNO4S/c1-28(25,26)23-19(24)15-7-16(21)18(8-17(15)22)27-3-2-20-9-12-4-13(10-20)6-14(5-12)11-20/h7-8,12-14H,2-6,9-11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145389 (US8952169, 168 | US9771376, Example 168) Show SMILES OCCCNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:29:20:27:23.24.25,THB:19:20:27:23.24.25,29:24:27:20.28.21,28:20:23:27.26.25,28:26:23:20.29.21| Show InChI InChI=1S/C24H33FN2O5S/c25-21-10-22(32-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(29)27-33(30,31)26-4-1-5-28/h9-10,15-18,26,28H,1-8,11-14H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM47138 (US8952169, 268 | US8952169, 30 | US9771376, Exampl...) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145373 (US8952169, 152 | US9771376, Example 152) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F |TLB:13:14:20:17.16.24,THB:15:14:20:17.16.24,15:16:20:14.25.19,25:14:17:20.23.24,25:23:17:14.15.19| Show InChI InChI=1S/C19H21ClF3NO4S/c1-29(26,27)24-17(25)13-4-14(20)16(5-15(13)21)28-9-18-6-10-2-11(7-18)19(22,23)12(3-10)8-18/h4-5,10-12H,2-3,6-9H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145261 (US8952169, 40 | US9771376, Example 41) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(O[C@H]2C3CC4CC2CC(Cl)(C4)C3)cc1F |r,TLB:12:13:15:22.20.23,13:14:22:18.19.17,THB:13:18:22:15.14.23,19:18:15:22.20.23,19:20:15:18.13.17| Show InChI InChI=1S/C18H20Cl2FNO4S/c1-27(24,25)22-17(23)12-4-13(19)15(5-14(12)21)26-16-10-2-9-3-11(16)8-18(20,6-9)7-10/h4-5,9-11,16H,2-3,6-8H2,1H3,(H,22,23)/t9?,10?,11?,16-,18?	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145261 (US8952169, 40 | US9771376, Example 41) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(O[C@H]2C3CC4CC2CC(Cl)(C4)C3)cc1F |r,TLB:12:13:15:22.20.23,13:14:22:18.19.17,THB:13:18:22:15.14.23,19:18:15:22.20.23,19:20:15:18.13.17| Show InChI InChI=1S/C18H20Cl2FNO4S/c1-27(24,25)22-17(23)12-4-13(19)15(5-14(12)21)26-16-10-2-9-3-11(16)8-18(20,6-9)7-10/h4-5,9-11,16H,2-3,6-8H2,1H3,(H,22,23)/t9?,10?,11?,16-,18?	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145243 (US8952169, 22 | US9771376, Example 22) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F Show InChI InChI=1S/C18H17ClFNO4S/c1-26(23,24)21-18(22)14-9-15(19)17(10-16(14)20)25-13-7-6-11-4-2-3-5-12(11)8-13/h6-10H,2-5H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145367 (US8952169, 146 | US9771376, Example 146) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1 |TLB:15:6:13:9.10.11,THB:5:6:13:9.10.11,15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C21H25ClFNO4S/c22-17-6-16(20(25)24-29(26,27)15-1-2-15)18(23)7-19(17)28-11-21-8-12-3-13(9-21)5-14(4-12)10-21/h6-7,12-15H,1-5,8-11H2,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145293 (US8952169, 72 | US9771376, Example 72) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:26:17:24:20.21.22,THB:26:21:24:17.25.18,16:17:24:20.21.22,25:17:20:24.23.22,25:23:20:17.26.18| Show InChI InChI=1S/C21H27ClFNO5S/c1-28-2-3-30(26,27)24-20(25)16-7-17(22)19(8-18(16)23)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,2-6,9-12H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145278 (US8952169, 57 | US9771376, Example 57) Show SMILES CC1(C)CCc2cc(OCc3cc(F)c(cc3Cl)C(=O)NS(=O)(=O)N3CCC3)ccc2O1 Show InChI InChI=1S/C22H24ClFN2O5S/c1-22(2)7-6-14-10-16(4-5-20(14)31-22)30-13-15-11-19(24)17(12-18(15)23)21(27)25-32(28,29)26-8-3-9-26/h4-5,10-12H,3,6-9,13H2,1-2H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145226 (US8952169, 5 | US9771376, Example 5) Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:21:16:23:19.20.22,21:20:15.16.17:23,THB:19:18:15:21.20.22,19:20:15:17.18.23| Show InChI InChI=1S/C19H23F2NO4S/c1-27(24,25)22-18(23)14-5-16(21)17(6-15(14)20)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.1	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145244 (US8952169, 23 | US9771376, Example 23) Show SMILES CC12CC3CC(C)(C1)CC(COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)(C3)C2 |TLB:27:9:7:4.3.2,10:9:4:7.1.2,THB:27:3:7:9.28.8,28:9:4:7.1.2,28:1:4:9.27.8| Show InChI InChI=1S/C21H27ClFNO4S/c1-19-6-13-7-20(2,9-19)11-21(8-13,10-19)12-28-17-5-16(23)14(4-15(17)22)18(25)24-29(3,26)27/h4-5,13H,6-12H2,1-3H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22.9	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145390 (US8952169, 169 | US9771376, Example 169) Show SMILES COC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C25H33FN2O5S/c1-32-19-12-28(13-19)34(30,31)27-24(29)21-7-20(18-2-3-18)23(8-22(21)26)33-14-25-9-15-4-16(10-25)6-17(5-15)11-25/h7-8,15-19H,2-6,9-14H2,1H3,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145246 (BDBM342437 | US8952169, 25) Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145247 (US8952169, 26 | US9771376, Example 26) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:25:16:23:19.20.21,THB:15:16:23:19.20.21,25:20:23:16.24.17,24:16:19:23.22.21,24:22:19:16.25.17| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-19(25)15-6-16(21)18(7-17(15)22)28-11-20-8-12-3-13(9-20)5-14(4-12)10-20/h6-7,12-14H,3-5,8-11H2,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28.1	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145347 (US8952169, 126 | US8952169, 128 | US9771376, Examp...) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F |(8,1.54,;6.67,.77,;5.9,2.1,;7.44,-.56,;5.33,,;4,.77,;4,2.31,;2.67,,;1.33,.77,;;-1.33,.77,;,-1.54,;-1.33,-2.31,;-2.67,-1.54,;-2.67,,;-4,.77,;-5.33,,;-5.33,-1.54,;-4,-2.31,;-6.67,.77,;-8,1.54,;-5.9,2.1,;-7.44,-.56,;1.33,-2.31,;2.67,-1.54,;4,-2.31,)| Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145356 (US8952169, 135 | US9771376, Example 135) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2CC3CC2C2CCCC32)cc1F |THB:14:15:18:24.20,23:24:15.16:18,21:20:15.16:18| Show InChI InChI=1S/C19H24ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-8-15(20)18(9-16(14)21)27-17-7-10-6-13(17)12-5-3-4-11(10)12/h8-13,17H,3-7H2,1-2H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145237 (US8952169, 16 | US9771376, Example 16) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F |TLB:24:14:22:17.18.19,THB:13:14:22:17.18.19,24:18:22:14.23.15,23:14:17:22.20.19,23:20:17:14.24.15,21:20:17:14.24.15| Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-17(24)13-3-14(20)16(4-15(13)21)27-10-18-5-11-2-12(6-18)8-19(22,7-11)9-18/h3-4,11-12H,2,5-10H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31.2	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145290 (US8952169, 69 | US9771376, Example 69) Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:24:15:22:18.19.20,THB:14:15:22:18.19.20,24:19:22:15.23.16,23:15:18:22.21.20,23:21:18:15.24.16| Show InChI InChI=1S/C19H24ClFN2O4S/c1-22-28(25,26)23-18(24)14-5-15(20)17(6-16(14)21)27-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13,22H,2-4,7-10H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34.3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145291 (US8952169, 70 | US9771376, Example 70) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1 |TLB:15:6:13:9.10.11,THB:5:6:13:9.10.11,15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C21H26ClFN2O4S/c22-17-7-16(20(26)24-30(27,28)25-2-1-3-25)18(23)8-19(17)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,1-6,9-12H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36.8	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145235 (US8952169, 14 | US9771376, Example 14) Show SMILES C[C@H]1[C@@H]2C[C@H](C[C@@H]1Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C2(C)C |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-9-12-5-10(18(12,2)3)6-15(9)25-16-8-14(20)11(7-13(16)19)17(22)21-26(4,23)24/h7-10,12,15H,5-6H2,1-4H3,(H,21,22)/t9-,10+,12-,15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.7	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145240 (US8952169, 19 | US9771376, Example 19) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1 |TLB:20:19:22:16.15.14,20:15:22:19.21.18,THB:12:13:16:19.20.18,21:19:16:22.14.13,21:13:16:19.20.18| Show InChI InChI=1S/C19H24ClNO4S/c1-26(23,24)21-18(22)15-2-3-17(16(20)7-15)25-11-19-8-12-4-13(9-19)6-14(5-12)10-19/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38.6	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145303 (US8952169, 82 | US9771376, Example 82) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F Show InChI InChI=1S/C15H17ClF4N2O4S/c1-22(2)27(24,25)21-13(23)9-6-10(16)12(7-11(9)17)26-8-14(4-3-5-14)15(18,19)20/h6-7H,3-5,8H2,1-2H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41.6	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145241 (US8952169, 20 | US9771376, Example 20) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCCC23CC4CC(CC(C4)C2)C3)c(Cl)c1 |TLB:13:14:17:21.20.19,23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15| Show InChI InChI=1S/C20H26ClNO4S/c1-27(24,25)22-19(23)16-2-3-18(17(21)9-16)26-5-4-20-10-13-6-14(11-20)8-15(7-13)12-20/h2-3,9,13-15H,4-8,10-12H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	56.3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145255 (US8952169, 34 | US9771376, Example 34) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F |r| Show InChI InChI=1S/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12+,14+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.8	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145327 (US8952169, 106 | US9771376, Example 106) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@@H](CC2)C(F)(F)F)cc1F |r,wU:14.13,wD:17.20,(8.67,3.36,;7.34,2.59,;6.57,3.93,;8.11,1.26,;6,1.82,;4.67,2.59,;4.67,4.13,;3.33,1.82,;3.33,.28,;2,-.49,;2,-2.03,;.67,.28,;-.67,-.49,;-2,.28,;-3.33,-.49,;-3.33,-2.03,;-4.67,-2.8,;-6,-2.03,;-6,-.49,;-4.67,.28,;-7.34,-2.8,;-8.67,-3.57,;-8.11,-1.46,;-6.57,-4.13,;.67,1.82,;2,2.59,;2,4.13,)| Show InChI InChI=1S/C16H18ClF4NO4S/c1-27(24,25)22-15(23)11-6-12(17)14(7-13(11)18)26-8-9-2-4-10(5-3-9)16(19,20)21/h6-7,9-10H,2-5,8H2,1H3,(H,22,23)/t9-,10-	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	84.7	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145360 (BDBM342455 | US8952169, 139) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC3(CCCCC3)CC2)cc1F Show InChI InChI=1S/C20H28ClFN2O4S/c1-24(2)29(26,27)23-19(25)15-12-16(21)18(13-17(15)22)28-14-6-10-20(11-7-14)8-4-3-5-9-20/h12-14H,3-11H2,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	85.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145254 (US8952169, 33 | US9771376, Example 33) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC2C3CC4CC(C3)CC2C4)cc1F |TLB:14:15:17:19.20.21,THB:15:23:19:17.16.21,15:16:19:23.22.24,22:23:17:19.20.21,22:20:17:23.15.24,(7.75,-1.15,;6.42,-1.93,;6.42,-3.47,;5.08,-1.15,;4.31,-2.49,;5.85,.18,;3.75,-.38,;2.41,-1.15,;2.41,-2.7,;1.08,-.38,;1.08,1.16,;-.25,1.93,;-.25,3.47,;-1.59,1.15,;-2.92,1.93,;-4.25,1.15,;-5.58,1.92,;-6.92,1.15,;-6.92,-.38,;-7.75,-2.29,;-6.35,-1.64,;-6.34,.76,;-5.15,-2.31,;-4.25,-.38,;-5.58,-1.16,;-1.59,-.38,;-.25,-1.15,;-.25,-2.7,)| Show InChI InChI=1S/C19H24ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-8-15(20)17(9-16(14)21)27-18-12-4-10-3-11(6-12)7-13(18)5-10/h8-13,18H,3-7H2,1-2H3,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	93.7	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM342434 (5-chloro-4-(cyclohexylmethoxy)-2-fluoro-N-(methyls...) Show SMILES CS(=O)(=O)NC(=O)c1cnc(OCC23CC4CC5(CC(C5)(C4)C2)C3)c(Cl)c1 |TLB:16:17:22:15.21.14,14:13:18:20,THB:16:15:22:18.23.17,20:17:22:15.21.14,12:13:18:20,(6.38,2.1,;5.61,3.43,;6.95,4.2,;4.84,4.77,;4.28,2.66,;2.94,3.43,;2.94,4.97,;1.61,2.66,;.28,3.43,;-1.06,2.66,;-1.06,1.12,;-2.39,.35,;-3.93,.35,;-4.7,-.98,;-6.17,-.57,;-6.94,-1.9,;-6.95,-3.44,;-5.46,-3.86,;-4.37,-4.95,;-4.39,-3.43,;-4.4,-4.97,;-5.87,-3.02,;-3.61,-2.07,;-4.7,-2.52,;.28,.35,;.28,-1.19,;1.61,1.12,)| Show InChI InChI=1S/C19H23ClN2O4S/c1-27(24,25)22-15(23)13-2-14(20)16(21-6-13)26-11-19-5-12-3-17(9-19)7-18(4-12,8-17)10-19/h2,6,12H,3-5,7-11H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145233 (US8952169, 12 | US9771376, Example 13) Show SMILES CC1(C)C2CCC1(C)C(C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |THB:10:8:1:5.4| Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145252 (US8952169, 31 | US9771376, Example 31) Show SMILES CC(Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C12CC3CC(CC(C3)C1)C2 |TLB:27:18:25:21.22.23,THB:1:18:25:21.22.23,27:22:25:18.26.19,26:18:21:25.24.23,26:24:21:18.27.19| Show InChI InChI=1S/C20H25ClFNO4S/c1-11(20-8-12-3-13(9-20)5-14(4-12)10-20)27-18-7-17(22)15(6-16(18)21)19(24)23-28(2,25)26/h6-7,11-14H,3-5,8-10H2,1-2H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145236 (US8952169, 15 | US9771376, Example 15) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC2CC2)cc1F Show InChI InChI=1S/C13H15ClFNO4S/c1-21(18,19)16-13(17)9-6-10(14)12(7-11(9)15)20-5-4-8-2-3-8/h6-8H,2-5H2,1H3,(H,16,17)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair

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