Found 29 hits Enz. Inhib. hit(s) with all data for entry = 1908 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347063
(US10202390, Example 18)Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC1CC1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C20H19N9/c1-2-5-28-12-18(26-27-28)15-10-22-17(7-16(15)25-14-3-4-14)19-11-23-20-6-13(8-21)9-24-29(19)20/h6-7,9-12,14H,2-5H2,1H3,(H,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347074
(US10202390, Example 29)Show SMILES CC(C)(O)CCc1cc(n[nH]1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C25H28N8O2/c1-25(2,34)6-3-18-9-23(32-31-18)19-13-27-21(10-22(19)30-17-4-7-35-8-5-17)20-14-29-33-15-16(11-26)12-28-24(20)33/h9-10,12-15,17,34H,3-8H2,1-2H3,(H,27,30)(H,31,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347061
(3-(4-(isopropylamino)-5-(1-(tetrahydro-2H-pyran-4-...)Show SMILES CC(C)Nc1cc(ncc1-c1cn(nn1)C1CCOCC1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C22H23N9O/c1-14(2)27-18-8-19(21-12-25-22-7-15(9-23)10-26-31(21)22)24-11-17(18)20-13-30(29-28-20)16-3-5-32-6-4-16/h7-8,10-14,16H,3-6H2,1-2H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347062
(US10202390, Example 17)Show SMILES CC(C)Nc1cc(ncc1-c1cn(nn1)C1CN(C1)C(C)=O)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C22H22N10O/c1-13(2)27-18-5-19(21-9-25-22-4-15(6-23)7-26-32(21)22)24-8-17(18)20-12-31(29-28-20)16-10-30(11-16)14(3)33/h4-5,7-9,12-13,16H,10-11H2,1-3H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347058
(US10202390, Example 13)Show SMILES CC(C)Nc1cc(ncc1-n1cc(CCC(C)(C)O)nn1)-c1cnn2cc(Cl)cnc12 Show InChI InChI=1S/C21H25ClN8O/c1-13(2)26-18-7-17(16-9-25-30-11-14(22)8-24-20(16)30)23-10-19(18)29-12-15(27-28-29)5-6-21(3,4)31/h7-13,31H,5-6H2,1-4H3,(H,23,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347072
(3-(5-(1-(3-hydroxy-3-methylbutyl)-1H-pyrazol-4-yl)...)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CCC(C)(C)O)c1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C23H26N8O/c1-15(2)29-19-8-20(21-13-26-22-7-16(9-24)10-28-31(21)22)25-12-18(19)17-11-27-30(14-17)6-5-23(3,4)32/h7-8,10-15,32H,5-6H2,1-4H3,(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347064
(US10202390, Example 19)Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC1CC1)-c1cnc2cc(Cl)cnn12 Show InChI InChI=1S/C19H19ClN8/c1-2-5-27-11-17(25-26-27)14-9-21-16(7-15(14)24-13-3-4-13)18-10-22-19-6-12(20)8-23-28(18)19/h6-11,13H,2-5H2,1H3,(H,21,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347067
(US10202390, Example 22)Show SMILES CC(C)Nc1cc(ncc1-n1cc(CCC(C)(C)O)nn1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C22H25N9O/c1-14(2)27-18-8-17(20-12-25-21-7-15(9-23)10-26-31(20)21)24-11-19(18)30-13-16(28-29-30)5-6-22(3,4)32/h7-8,10-14,32H,5-6H2,1-4H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347070
(US10202390, Example 25)Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1N[C@H]1CC[C@H](F)C1)-c1cnn2cc(cnc12)C#N |r| Show InChI InChI=1S/C24H26FN9O/c1-24(2,35)6-5-18-14-33(32-31-18)22-12-27-20(8-21(22)30-17-4-3-16(25)7-17)19-11-29-34-13-15(9-26)10-28-23(19)34/h8,10-14,16-17,35H,3-7H2,1-2H3,(H,27,30)/t16-,17-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347073
(US10202390, Example 28)Show SMILES CC(C)Nc1cc(ncc1-c1cc([nH]n1)C1CCOCC1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C23H24N8O/c1-14(2)28-19-9-21(22-13-26-23-7-15(10-24)11-27-31(22)23)25-12-17(19)20-8-18(29-30-20)16-3-5-32-6-4-16/h7-9,11-14,16H,3-6H2,1-2H3,(H,25,28)(H,29,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347060
(3-(4-(isopropylamino)-5-(4-propyl-1H-1,2,3-triazol...)Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C20H21N9/c1-4-5-15-12-28(27-26-15)18-10-22-16(7-17(18)25-13(2)3)19-11-23-20-6-14(8-21)9-24-29(19)20/h6-7,9-13H,4-5H2,1-3H3,(H,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347056
(2-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-N-isopro...)Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnn2cc(Cl)cnc12 Show InChI InChI=1S/C19H21ClN8/c1-4-5-14-11-27(26-25-14)18-9-21-16(6-17(18)24-12(2)3)15-8-23-28-10-13(20)7-22-19(15)28/h6-12H,4-5H2,1-3H3,(H,21,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347068
(US10202390, Example 23)Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(Cl)cnc12 Show InChI InChI=1S/C23H27ClN8O2/c1-23(2,33)6-3-17-14-31(30-29-17)21-12-25-19(9-20(21)28-16-4-7-34-8-5-16)18-11-27-32-13-15(24)10-26-22(18)32/h9-14,16,33H,3-8H2,1-2H3,(H,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347059
(US10202390, Example 14)Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1COC1)-c1cnn2cc(Cl)cnc12 Show InChI InChI=1S/C21H23ClN8O2/c1-21(2,31)4-3-14-10-29(28-27-14)19-8-23-17(5-18(19)26-15-11-32-12-15)16-7-25-30-9-13(22)6-24-20(16)30/h5-10,15,31H,3-4,11-12H2,1-2H3,(H,23,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347057
(US10202390, Example 12)Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C20H21N9/c1-4-5-15-12-28(27-26-15)19-10-22-17(6-18(19)25-13(2)3)16-9-24-29-11-14(7-21)8-23-20(16)29/h6,8-13H,4-5H2,1-3H3,(H,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347071
(US10202390, Example 26)Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1COC1)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C22H23N9O2/c1-22(2,32)4-3-15-11-30(29-28-15)20-9-24-18(5-19(20)27-16-12-33-13-16)17-8-26-31-10-14(6-23)7-25-21(17)31/h5,7-11,16,32H,3-4,12-13H2,1-2H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347065
(US10202390, Example 20)Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(Cl)cnn12 Show InChI InChI=1S/C19H21ClN8/c1-4-5-27-11-17(25-26-27)14-9-21-16(7-15(14)24-12(2)3)18-10-22-19-6-13(20)8-23-28(18)19/h6-12H,4-5H2,1-3H3,(H,21,24) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347069
(US10202390, Example 24)Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CC(F)(F)C1)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C23H23F2N9O/c1-22(2,35)4-3-15-13-33(32-31-15)20-11-27-18(5-19(20)30-16-6-23(24,25)7-16)17-10-29-34-12-14(8-26)9-28-21(17)34/h5,9-13,16,35H,3-4,6-7H2,1-2H3,(H,27,30) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347066
(US10202390, Example 21)Show SMILES COC(=O)N1CCC(n2cc(nn2)-c2cnc(cc2NC2CC2)-c2cnc3cc(Cl)cnn23)[C@](C)(O)C1 |r| Show InChI InChI=1S/C24H26ClN9O3/c1-24(36)13-32(23(35)37-2)6-5-21(24)33-12-19(30-31-33)16-10-26-18(8-17(16)29-15-3-4-15)20-11-27-22-7-14(25)9-28-34(20)22/h7-12,15,21,36H,3-6,13H2,1-2H3,(H,26,29)/t21?,24-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347048
(US10202390, Example 3)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(c1)C1CCOCC1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C23H24N8O/c1-15(2)29-20-8-21(22-13-26-23-7-16(9-24)10-28-31(22)23)25-12-19(20)17-11-27-30(14-17)18-3-5-32-6-4-18/h7-8,10-15,18H,3-6H2,1-2H3,(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347051
(US10202390, Example 6)Show SMILES CCCn1cc(cn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C21H22N8/c1-4-5-28-13-16(10-25-28)17-11-23-19(7-18(17)27-14(2)3)20-12-24-21-6-15(8-22)9-26-29(20)21/h6-7,9-14H,4-5H2,1-3H3,(H,23,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347055
(US10202390, Example 10)Show SMILES CCCn1cc(cn1)-c1cnc(cc1Nc1cnn(CC(F)F)c1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C23H20F2N10/c1-2-3-33-12-16(8-29-33)18-10-27-20(21-11-28-23-4-15(6-26)7-31-35(21)23)5-19(18)32-17-9-30-34(13-17)14-22(24)25/h4-5,7-13,22H,2-3,14H2,1H3,(H,27,32) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347054
(US10202390, Example 9)Show SMILES CCCn1cc(cn1)-c1cnc(cc1Nc1cnn(CC(F)F)c1)-c1cnc2cc(Cl)cnn12 Show InChI InChI=1S/C22H20ClF2N9/c1-2-3-32-11-14(6-28-32)17-9-26-19(20-10-27-22-4-15(23)7-30-34(20)22)5-18(17)31-16-8-29-33(12-16)13-21(24)25/h4-12,21H,2-3,13H2,1H3,(H,26,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347052
(US10202390, Example 7 | US10202390, Example 8)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(F)(F)F)c1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C20H17F3N8/c1-12(2)29-16-4-17(18-9-26-19-3-13(5-24)6-28-31(18)19)25-8-15(16)14-7-27-30(10-14)11-20(21,22)23/h3-4,6-10,12H,11H2,1-2H3,(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347052
(US10202390, Example 7 | US10202390, Example 8)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(F)(F)F)c1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C20H17F3N8/c1-12(2)29-16-4-17(18-9-26-19-3-13(5-24)6-28-31(18)19)25-8-15(16)14-7-27-30(10-14)11-20(21,22)23/h3-4,6-10,12H,11H2,1-2H3,(H,25,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347047
(2-(7-chloroimidazo[1,2-b]pyridazin-3-yl)-N-isoprop...)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(c1)C1CCOCC1)-c1cnc2cc(Cl)cnn12 Show InChI InChI=1S/C22H24ClN7O/c1-14(2)28-19-8-20(21-12-25-22-7-16(23)10-27-30(21)22)24-11-18(19)15-9-26-29(13-15)17-3-5-31-6-4-17/h7-14,17H,3-6H2,1-2H3,(H,24,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347050
(US10202390, Example 5)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(C)(C)O)c1)-c1cnc2cc(cnn12)C#N Show InChI InChI=1S/C22H24N8O/c1-14(2)28-18-6-19(20-11-25-21-5-15(7-23)8-27-30(20)21)24-10-17(18)16-9-26-29(12-16)13-22(3,4)31/h5-6,8-12,14,31H,13H2,1-4H3,(H,24,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347049
(US10202390, Example 4)Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(C)(C)O)c1)-c1cnc2cc(Cl)cnn12 Show InChI InChI=1S/C21H24ClN7O/c1-13(2)27-17-6-18(19-10-24-20-5-15(22)8-26-29(19)20)23-9-16(17)14-7-25-28(11-14)12-21(3,4)30/h5-11,13,30H,12H2,1-4H3,(H,23,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 396 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM347046
(3-(5-(4-(2-hydroxypropan-2-yl)-1H-pyrazol-1-yl)-4-...)Show SMILES CC(C)Nc1cc(ncc1-n1cc(cn1)C(C)(C)O)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C21H22N8O/c1-13(2)27-18-5-17(16-9-26-29-11-14(6-22)7-24-20(16)29)23-10-19(18)28-12-15(8-25-28)21(3,4)30/h5,7-13,30H,1-4H3,(H,23,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 578 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
TBD |
US Patent US10202390 (2019)
BindingDB Entry DOI: 10.7270/Q28W3GDC |
More data for this
Ligand-Target Pair | |
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