Compile Data Set for Download or QSAR

Found 169 hits Enz. Inhib. hit(s) with all data for entry = 2625   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194437 (US9200016, 119 | US9902710, Compound 119) Show SMILES COCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H24N4O5S/c1-30-13-20-18-11-22(32-3)21(31-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(23(14)26-16)27-33(24,28)29/h4-8,10-12,27H,9,13H2,1-3H3,(H2,24,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194477 (US9200016, 159 | US9902710, Compound 159) Show SMILES COc1cc2cncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC Show InChI InChI=1S/C21H20N4O4S/c1-28-19-9-15-12-23-11-14(17(15)10-20(19)29-2)8-16-7-6-13-4-3-5-18(21(13)24-16)25-30(22,26)27/h3-7,9-12,25H,8H2,1-2H3,(H2,22,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194402 (US9200016, 84 | US9902710, Compound 84) Show SMILES CCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H24N4O4S/c1-4-19-18-12-22(31-3)21(30-2)11-17(18)15(13-25-19)10-16-9-8-14-6-5-7-20(23(14)26-16)27-32(24,28)29/h5-9,11-13,27H,4,10H2,1-3H3,(H2,24,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194474 (US9200016, 156 | US9902710, Compound 156) Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC Show InChI InChI=1S/C22H22N4O4S/c1-13-17-10-20(29-2)21(30-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(22(14)25-16)26-31(23,27)28/h4-8,10-12,26H,9H2,1-3H3,(H2,23,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194403 (US9200016, 85 | US9902710, Compound 85) Show SMILES CCCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H26N4O4S/c1-4-6-20-19-13-23(32-3)22(31-2)12-18(19)16(14-26-20)11-17-10-9-15-7-5-8-21(24(15)27-17)28-33(25,29)30/h5,7-10,12-14,28H,4,6,11H2,1-3H3,(H2,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194392 (US9200016, 74 | US9902710, Compound 74) Show SMILES COc1cc2cncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC Show InChI InChI=1S/C22H20N2O2/c1-14-4-5-16-7-15(11-24-20(16)6-14)8-17-12-23-13-18-9-21(25-2)22(26-3)10-19(17)18/h4-7,9-13H,8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194391 (US9200016, 139 | US9200016, 73 | US9902710, Compou...) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H27N3O4/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)33-15-25(27)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H2,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194463 (US9200016, 145 | US9902710, Compound 145) Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C([O-])=O)c2cc1OC Show InChI InChI=1S/C26H20N2O5/c1-31-23-11-19-14-27-13-18(20(19)12-24(23)32-2)9-15-3-8-22-21(10-15)28-25(33-22)16-4-6-17(7-5-16)26(29)30/h3-8,10-14H,9H2,1-2H3,(H,29,30)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194436 (US9200016, 118 | US9902710, Compound 118) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCCC([O-])=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H28N2O5/c1-4-6-22-21-15-25(33-3)24(32-2)14-20(21)18(16-28-22)13-19-10-9-17-7-5-8-23(27(17)29-19)34-12-11-26(30)31/h5,7-10,14-16H,4,6,11-13H2,1-3H3,(H,30,31)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194456 (US9200016, 138 | US9902710, Compound 138) Show SMILES COc1cc2cncc(Cc3cnc4ccc(OCC(N)=O)cc4c3)c2cc1OC Show InChI InChI=1S/C23H21N3O4/c1-28-21-8-17-12-25-11-16(19(17)9-22(21)29-2)6-14-5-15-7-18(30-13-23(24)27)3-4-20(15)26-10-14/h3-5,7-12H,6,13H2,1-2H3,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194455 (US9200016, 137 | US9902710, Compound 137) Show SMILES COc1cc2cncc(Cc3cnc4ccc(O)cc4c3)c2cc1OC Show InChI InChI=1S/C21H18N2O3/c1-25-20-8-16-12-22-11-15(18(16)9-21(20)26-2)6-13-5-14-7-17(24)3-4-19(14)23-10-13/h3-5,7-12,24H,6H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194407 (US9200016, 89 | US9902710, Compound 89) Show SMILES CCc1ncc(Cc2ccc3cccc(NS(=O)(=O)CC)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H27N3O4S/c1-5-21-20-14-24(32-4)23(31-3)13-19(20)17(15-26-21)12-18-11-10-16-8-7-9-22(25(16)27-18)28-33(29,30)6-2/h7-11,13-15,28H,5-6,12H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194416 (US9200016, 98 | US9902710, Compound 98) Show SMILES CCc1ncc(Cc2cnc3ccc(NC(=O)C(N)=O)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H24N4O4/c1-4-20-19-11-23(33-3)22(32-2)10-18(19)16(13-28-20)8-14-7-15-9-17(29-25(31)24(26)30)5-6-21(15)27-12-14/h5-7,9-13H,4,8H2,1-3H3,(H2,26,30)(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194399 (US9200016, 81 | US9902710, Compound 81) Show SMILES COc1cc2cncc(Cc3ccc4n(C)c(=O)oc4c3)c2cc1OC Show InChI InChI=1S/C20H18N2O4/c1-22-16-5-4-12(7-17(16)26-20(22)23)6-13-10-21-11-14-8-18(24-2)19(25-3)9-15(13)14/h4-5,7-11H,6H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194423 (US9200016, 105 | US9902710, Compound 105) Show SMILES COc1cc2c(C)ncc(Cc3ccc4nc(C)ccc4c3)c2cc1OC Show InChI InChI=1S/C23H22N2O2/c1-14-5-7-17-9-16(6-8-21(17)25-14)10-18-13-24-15(2)19-11-22(26-3)23(27-4)12-20(18)19/h5-9,11-13H,10H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194400 (US9200016, 82 | US9902710, Compound 82) Show SMILES CCCc1ncc(Cc2ccc3n(C)c(=O)oc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H24N2O4/c1-5-6-18-17-12-22(28-4)21(27-3)11-16(17)15(13-24-18)9-14-7-8-19-20(10-14)29-23(26)25(19)2/h7-8,10-13H,5-6,9H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194487 (US9200016, 169 | US9902710, Compound 169) Show SMILES COCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H21F3N2O4/c1-31-12-19-16-9-22(33-3)21(32-2)8-15(16)14(11-29-19)6-13-7-17-18(28-10-13)4-5-20(30)23(17)24(25,26)27/h4-5,7-11,30H,6,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194418 (US9200016, 100 | US9902710, Compound 100) Show SMILES CCc1ncc(Cc2cnc3ccc(NS(N)(=O)=O)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H24N4O4S/c1-4-20-19-11-23(31-3)22(30-2)10-18(19)16(13-26-20)8-14-7-15-9-17(27-32(24,28)29)5-6-21(15)25-12-14/h5-7,9-13,27H,4,8H2,1-3H3,(H2,24,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194439 (US9200016, 121 | US9902710, Compound 121) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCc4nnn[nH]4)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H26N6O3/c1-4-6-21-20-13-24(34-3)23(33-2)12-19(20)17(14-27-21)11-18-10-9-16-7-5-8-22(26(16)28-18)35-15-25-29-31-32-30-25/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194464 (US9200016, 146 | US9902710, Compound 146) Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C(O)=O)c2cc1OC Show InChI InChI=1S/C26H20N2O5/c1-31-23-11-19-14-27-13-18(20(19)12-24(23)32-2)9-15-3-8-22-21(10-15)28-25(33-22)16-4-6-17(7-5-16)26(29)30/h3-8,10-14H,9H2,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194426 (US9200016, 108 | US9902710, Compound 108) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H26N2O5/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-27-21)11-18-10-9-16-7-5-8-22(26(16)28-18)33-15-25(29)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194440 (US9200016, 122 | US9902710, Compound 122) Show SMILES CCc1ncc(Cc2ccc3cccc(OCCC([O-])=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H26N2O5/c1-4-21-20-14-24(32-3)23(31-2)13-19(20)17(15-27-21)12-18-9-8-16-6-5-7-22(26(16)28-18)33-11-10-25(29)30/h5-9,13-15H,4,10-12H2,1-3H3,(H,29,30)/p-1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194397 (US9200016, 79 | US9902710, Compound 79) Show SMILES COc1cc2cncc(Cc3coc4ccc(C)cc4c3=O)c2cc1OC Show InChI InChI=1S/C22H19NO4/c1-13-4-5-19-18(6-13)22(24)16(12-27-19)7-14-10-23-11-15-8-20(25-2)21(26-3)9-17(14)15/h4-6,8-12H,7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194387 (US9200016, 69 | US9902710, Compound 69) Show SMILES CCCc1ncc(Cc2cnc3cc(C)ccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H26N2O2/c1-5-6-22-21-13-25(29-4)24(28-3)12-20(21)19(15-27-22)11-17-10-18-8-7-16(2)9-23(18)26-14-17/h7-10,12-15H,5-6,11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194391 (US9200016, 139 | US9200016, 73 | US9902710, Compou...) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H27N3O4/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)33-15-25(27)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H2,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194486 (US9200016, 168 | US9902710, Compound 168) Show SMILES COCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H22N2O4/c1-27-13-21-19-10-23(29-3)22(28-2)9-18(19)16(12-25-21)7-14-6-15-8-17(26)4-5-20(15)24-11-14/h4-6,8-12,26H,7,13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194479 (US9200016, 161 | US9902710, Compound 161) Show SMILES COc1cc2cncc(Cc3cnc4ccc(O)c(c4c3)C(F)(F)F)c2cc1OC Show InChI InChI=1S/C22H17F3N2O3/c1-29-19-7-14-11-26-10-13(15(14)8-20(19)30-2)5-12-6-16-17(27-9-12)3-4-18(28)21(16)22(23,24)25/h3-4,6-11,28H,5H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM373566 (US9902710, Compound 48) Show SMILES COc1cc2cncc(Cc3ccc4nc(C)ccc4n3)c2cc1OC Show InChI InChI=1S/C21H19N3O2/c1-13-4-6-19-18(23-13)7-5-16(24-19)8-14-11-22-12-15-9-20(25-2)21(26-3)10-17(14)15/h4-7,9-12H,8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194462 (US9200016, 144 | US9902710, Compound 144) Show SMILES CCCc1ncc(Cc2cnc3ccc(OCC(N)=O)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H27N3O4/c1-4-5-23-21-12-25(32-3)24(31-2)11-20(21)18(14-29-23)9-16-8-17-10-19(33-15-26(27)30)6-7-22(17)28-13-16/h6-8,10-14H,4-5,9,15H2,1-3H3,(H2,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194393 (US9200016, 75 | US9902710, Compound 75) Show SMILES CCCc1ncc(Cc2ccc3cccc(OCCO)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H28N2O4/c1-4-6-22-21-15-25(31-3)24(30-2)14-20(21)18(16-27-22)13-19-10-9-17-7-5-8-23(26(17)28-19)32-12-11-29/h5,7-10,14-16,29H,4,6,11-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194435 (US9200016, 117 | US9902710, Compound 117) Show SMILES COc1cc2c(C)ncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC Show InChI InChI=1S/C23H22N2O2/c1-14-5-6-17-8-16(12-25-21(17)7-14)9-18-13-24-15(2)19-10-22(26-3)23(27-4)11-20(18)19/h5-8,10-13H,9H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194328 (US9200016, 10 | US9902710, Compound 10) Show SMILES COc1cc2cncc(Cc3ccc4oc5ccccc5c4c3)c2cc1OC Show InChI InChI=1S/C24H19NO3/c1-26-23-11-17-14-25-13-16(19(17)12-24(23)27-2)9-15-7-8-22-20(10-15)18-5-3-4-6-21(18)28-22/h3-8,10-14H,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194425 (US9200016, 107 | US9902710, Compound 107) Show SMILES CCn1c2cc(Cc3cncc4cc(OC)c(OC)cc34)ccc2oc1=O Show InChI InChI=1S/C21H20N2O4/c1-4-23-17-8-13(5-6-18(17)27-21(23)24)7-14-11-22-12-15-9-19(25-2)20(26-3)10-16(14)15/h5-6,8-12H,4,7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194468 (US9200016, 150 | US9902710, Compound 150) Show SMILES COc1cc2cncc(Cc3cnc4ccc(OCC(O)=O)cc4c3)c2cc1OC Show InChI InChI=1S/C23H20N2O5/c1-28-21-8-17-12-24-11-16(19(17)9-22(21)29-2)6-14-5-15-7-18(30-13-23(26)27)3-4-20(15)25-10-14/h3-5,7-12H,6,13H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194404 (US9200016, 86 | US9902710, Compound 86) Show SMILES CCc1ncc(Cc2ccc3cccc(NS(C)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H25N3O4S/c1-5-20-19-13-23(31-3)22(30-2)12-18(19)16(14-25-20)11-17-10-9-15-7-6-8-21(24(15)26-17)27-32(4,28)29/h6-10,12-14,27H,5,11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194485 (US9200016, 167 | US9902710, Compound 167) Show SMILES COCc1ncc(Cc2ccc3cccc(N)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H23N3O3/c1-27-13-20-18-11-22(29-3)21(28-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(24)23(14)26-16/h4-8,10-12H,9,13,24H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194461 (US9200016, 143 | US9902710, Compound 143) Show SMILES CCCc1ncc(Cc2cnc3ccc(O)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O3/c1-4-5-22-20-12-24(29-3)23(28-2)11-19(20)17(14-26-22)9-15-8-16-10-18(27)6-7-21(16)25-13-15/h6-8,10-14,27H,4-5,9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194447 (US9200016, 129 | US9902710, Compound 129) Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O3/c1-6-7-23-21-14-25(32-5)24(31-4)13-20(21)18(15-28-23)11-17-10-16-12-19(30-3)8-9-22(16)29-26(17)27-2/h8-10,12-15H,6-7,11H2,1-5H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194395 (US9200016, 77 | US9902710, Compound 77) Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O3/c1-6-8-24-22-15-26(33-5)25(32-4)14-21(22)19(16-29-24)12-18-11-17-13-20(31-3)9-10-23(17)30-27(18)28-7-2/h9-11,13-16H,6-8,12H2,1-5H3,(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194362 (US9200016, 44 | US9902710, Compound 44) Show SMILES CCCc1ncc(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O2/c1-4-7-22-20-13-24(28-3)23(27-2)12-19(20)18(15-26-22)11-16-10-17-8-5-6-9-21(17)25-14-16/h5-6,8-10,12-15H,4,7,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194401 (US9200016, 83 | US9902710, Compound 83) Show SMILES CCc1ncc(Cc2ccc3cccc(O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H22N2O3/c1-4-19-18-12-22(28-3)21(27-2)11-17(18)15(13-24-19)10-16-9-8-14-6-5-7-20(26)23(14)25-16/h5-9,11-13,26H,4,10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194394 (US9200016, 106 | US9200016, 76 | US9902710, Compou...) Show SMILES CCCc1ncc(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C29H34N4O4/c1-6-7-26-24-16-28(37-5)27(36-4)15-23(24)21(17-32-26)13-20-12-19-14-22(35-3)8-9-25(19)33-29(20)31-11-10-30-18(2)34/h8-9,12,14-17H,6-7,10-11,13H2,1-5H3,(H,30,34)(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194470 (US9200016, 152 | US9902710, Compound 152) Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(N)c4n3)c2cc1OC Show InChI InChI=1S/C22H21N3O2/c1-13-17-10-20(26-2)21(27-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(23)22(14)25-16/h4-8,10-12H,9,23H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194475 (US9200016, 157 | US9902710, Compound 157) Show SMILES COc1cc2cncc(Cc3ccc4cccc(N)c4n3)c2cc1OC Show InChI InChI=1S/C21H19N3O2/c1-25-19-9-15-12-23-11-14(17(15)10-20(19)26-2)8-16-7-6-13-4-3-5-18(22)21(13)24-16/h3-7,9-12H,8,22H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194414 (US9200016, 96 | US9902710, Compound 96) Show SMILES CCc1ncc(Cc2cnc3ccc(N)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C23H23N3O2/c1-4-20-19-11-23(28-3)22(27-2)10-18(19)16(13-26-20)8-14-7-15-9-17(24)5-6-21(15)25-12-14/h5-7,9-13H,4,8,24H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194320 (US9200016, 2 | US9902710, Compound 2) Show SMILES COc1cc2cncc(Cc3cnc4ccccc4c3)c2cc1OC Show InChI InChI=1S/C21H18N2O2/c1-24-20-9-17-13-22-12-16(18(17)10-21(20)25-2)8-14-7-15-5-3-4-6-19(15)23-11-14/h3-7,9-13H,8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194412 (US9200016, 94 | US9902710, Compound 94) Show SMILES CCc1ncc(Cc2ccc3cccc(CNS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H26N4O4S/c1-4-21-20-12-23(32-3)22(31-2)11-19(20)17(13-26-21)10-18-9-8-15-6-5-7-16(24(15)28-18)14-27-33(25,29)30/h5-9,11-13,27H,4,10,14H2,1-3H3,(H2,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194480 (US9200016, 162 | US9902710, Compound 162) Show SMILES CCCc1ncc(Cc2cnc3ccc(O)c(c3c2)C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H23F3N2O3/c1-4-5-19-17-11-23(33-3)22(32-2)10-16(17)15(13-30-19)8-14-9-18-20(29-12-14)6-7-21(31)24(18)25(26,27)28/h6-7,9-13,31H,4-5,8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194415 (US9200016, 97 | US9902710, Compound 97) Show SMILES CCc1ncc(Cc2cnc3ccc(cc3c2)N2CCCC2=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H27N3O3/c1-4-23-22-14-26(33-3)25(32-2)13-21(22)19(16-29-23)11-17-10-18-12-20(7-8-24(18)28-15-17)30-9-5-6-27(30)31/h7-8,10,12-16H,4-6,9,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM373685 (US9902710, Compound 160) Show SMILES CCCc1ncc(Cc2ccc3cccc(NC(=O)CN)c3n2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H28N4O3/c1-4-6-21-20-13-24(33-3)23(32-2)12-19(20)17(15-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)30-25(31)14-27/h5,7-10,12-13,15H,4,6,11,14,27H2,1-3H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair

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