Compile Data Set for Download or QSAR

Found 185 hits Enz. Inhib. hit(s) with all data for entry = 3145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392936 (US10301306, Example 134) Show SMILES OCc1cccc(c1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C27H21FN4O2/c28-22-5-4-20(21(13-22)14-29)15-32-23-8-11-31-27(34)25(23)24(19-3-1-2-17(12-19)16-33)26(32)18-6-9-30-10-7-18/h1-7,9-10,12-13,33H,8,11,15-16H2,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392938 (US10301306, Example 136) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(Cl)c(Cl)c2)c(c1)C#N Show InChI InChI=1S/C26H17Cl2FN4O/c27-20-4-2-16(12-21(20)28)23-24-22(7-10-32-26(24)34)33(25(23)15-5-8-31-9-6-15)14-17-1-3-19(29)11-18(17)13-30/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392939 (US10301306, Example 137) Show SMILES Oc1ccccc1-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 |(-2.63,1.99,;-1.54,3.08,;-1.94,4.57,;-.85,5.66,;.63,5.26,;1.03,3.77,;-.06,2.68,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.52,-3.48,;3.61,-4.57,;3.21,-6.05,;4.3,-7.14,;1.72,-6.45,;.58,-5.38,;-.91,-5.78,;-2.41,-6.1,;-.56,-.05,;-2.1,-.05,;-2.87,1.28,;-4.41,1.28,;-5.18,-.05,;-4.41,-1.39,;-2.87,-1.39,)| Show InChI InChI=1S/C26H19FN4O2/c27-19-6-5-17(18(13-19)14-28)15-31-21-9-12-30-26(33)24(21)23(20-3-1-2-4-22(20)32)25(31)16-7-10-29-11-8-16/h1-8,10-11,13,32H,9,12,15H2,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392940 (US10301306, Example 138) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cc(Cl)cc(Cl)c2)c(c1)C#N Show InChI InChI=1S/C26H17Cl2FN4O/c27-19-9-17(10-20(28)12-19)23-24-22(5-8-32-26(24)34)33(25(23)15-3-6-31-7-4-15)14-16-1-2-21(29)11-18(16)13-30/h1-4,6-7,9-12H,5,8,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392942 (US10301306, Example 140) Show SMILES COc1cc(ccn1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H20FN5O2/c1-34-22-13-17(6-10-30-22)23-24-21(7-11-31-26(24)33)32(25(23)16-4-8-29-9-5-16)15-18-2-3-20(27)12-19(18)14-28/h2-6,8-10,12-13H,7,11,15H2,1H3,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392943 (US10301306, Example 141) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3ccoc3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H17FN4O2/c25-19-2-1-16(18(11-19)12-26)13-29-20-5-9-28-24(30)22(20)21(17-6-10-31-14-17)23(29)15-3-7-27-8-4-15/h1-4,6-8,10-11,14H,5,9,13H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392944 (US10301306, Example 142) Show SMILES Cc1csc(c1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C25H19FN4OS/c1-15-10-21(32-14-15)23-22-20(6-9-29-25(22)31)30(24(23)16-4-7-28-8-5-16)13-17-2-3-19(26)11-18(17)12-27/h2-5,7-8,10-11,14H,6,9,13H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392816 (5-Fluoro-2-((4-oxo-2-(pyridin-4-yl)-3-(thiophen-2-...) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3cccs3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H17FN4OS/c25-18-4-3-16(17(12-18)13-26)14-29-19-7-10-28-24(30)21(19)22(20-2-1-11-31-20)23(29)15-5-8-27-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392953 (US10301306, Example 151) Show SMILES CC(C)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(cc1F)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C29H25F5N4O/c1-16(2)37-24-13-18(9-11-35-24)27-25(17-4-7-21(30)8-5-17)26-23(10-12-36-28(26)39)38(27)15-19-3-6-20(14-22(19)31)29(32,33)34/h3-9,11,13-14,16H,10,12,15H2,1-2H3,(H,35,37)(H,36,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392955 (3-(4-Fluorophenyl)-7,7-dimethyl-2-(pyridin-4-yl)-6...) Show SMILES CC1(C)CNC(=O)c2c1[nH]c(c2-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H18FN3O/c1-20(2)11-23-19(25)16-15(12-3-5-14(21)6-4-12)17(24-18(16)20)13-7-9-22-10-8-13/h3-10,24H,11H2,1-2H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392958 (N-(4-(1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-...) Show SMILES CCC(=O)Nc1cc(ccn1)-c1c(-c2ccc(F)cc2)c2c(cc[nH]c2=O)n1Cc1ccc(cc1F)C(F)(F)F Show InChI InChI=1S/C29H21F5N4O2/c1-2-24(39)37-23-13-17(9-11-35-23)27-25(16-4-7-20(30)8-5-16)26-22(10-12-36-28(26)40)38(27)15-18-3-6-19(14-21(18)31)29(32,33)34/h3-14H,2,15H2,1H3,(H,36,40)(H,35,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392959 (1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-fluoro...) Show SMILES Fc1ccc(cc1)-c1c(-c2ccncc2)n(Cc2ccc(cc2F)C(F)(F)F)c2cc[nH]c(=O)c12 Show InChI InChI=1S/C26H16F5N3O/c27-19-5-2-15(3-6-19)22-23-21(9-12-33-25(23)35)34(24(22)16-7-10-32-11-8-16)14-17-1-4-18(13-20(17)28)26(29,30)31/h1-13H,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392961 (US10301306, Example 159) Show SMILES Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(F)cc1C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C26H19F2N5O/c27-19-4-1-15(2-5-19)23-24-21(8-10-32-26(24)34)33(25(23)16-7-9-31-22(30)12-16)14-17-3-6-20(28)11-18(17)13-29/h1-7,9,11-12H,8,10,14H2,(H2,30,31)(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392962 (US10301306, Example 160) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C30H23F2N5O2/c31-22-6-3-17(4-7-22)26-27-24(10-12-35-30(27)39)37(16-20-5-8-23(32)13-21(20)15-33)28(26)19-9-11-34-25(14-19)36-29(38)18-1-2-18/h3-9,11,13-14,18H,1-2,10,12,16H2,(H,35,39)(H,34,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392902 (US10301306, Example 100 | US10301306, Example 161) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(F)cc1C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F2N5O2/c1-16(36)34-24-13-18(8-10-32-24)27-25(17-2-5-21(29)6-3-17)26-23(9-11-33-28(26)37)35(27)15-19-4-7-22(30)12-20(19)14-31/h2-8,10,12-13H,9,11,15H2,1H3,(H,33,37)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392966 (US10301306, Example 164) Show SMILES Cc1ccc(s1)-c1c2c(CCNC2=O)n(Cc2ccc(Cl)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C24H19ClFN3OS/c1-14-2-5-20(31-14)22-21-19(8-11-28-24(21)30)29(23(22)15-6-9-27-10-7-15)13-16-3-4-17(25)12-18(16)26/h2-7,9-10,12H,8,11,13H2,1H3,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392804 (3-((3-(4-Fluorophenyl)-4-oxo-2-(pyridin-4-yl)-4,5,...) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2cccc(c2)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O/c27-21-6-4-19(5-7-21)23-24-22(10-13-30-26(24)32)31(25(23)20-8-11-29-12-9-20)16-18-3-1-2-17(14-18)15-28/h1-9,11-12,14H,10,13,16H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392806 (N-(4-(3-(4-Fluorophenyl)-1-(4-methylbenzyl)-4-oxo-...) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(C)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H25FN4O2/c1-17-3-5-19(6-4-17)16-33-23-12-14-31-28(35)26(23)25(20-7-9-22(29)10-8-20)27(33)21-11-13-30-24(15-21)32-18(2)34/h3-11,13,15H,12,14,16H2,1-2H3,(H,31,35)(H,30,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392810 (N-(4-(1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-...) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C(F)(F)F)c1-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C30H23F5N4O2/c31-21-7-4-16(5-8-21)25-26-23(10-12-37-29(26)41)39(15-19-3-6-20(14-22(19)32)30(33,34)35)27(25)18-9-11-36-24(13-18)38-28(40)17-1-2-17/h3-9,11,13-14,17H,1-2,10,12,15H2,(H,37,41)(H,36,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392815 (3-(4-Fluorophenyl)-1-(4-(3-methyl-1,2,4-oxadiazol-...) Show SMILES Cc1noc(n1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C28H22FN5O2/c1-17-32-28(36-33-17)21-4-2-18(3-5-21)16-34-23-12-15-31-27(35)25(23)24(19-6-8-22(29)9-7-19)26(34)20-10-13-30-14-11-20/h2-11,13-14H,12,15-16H2,1H3,(H,31,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392816 (5-Fluoro-2-((4-oxo-2-(pyridin-4-yl)-3-(thiophen-2-...) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3cccs3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H17FN4OS/c25-18-4-3-16(17(12-18)13-26)14-29-19-7-10-28-24(30)21(19)22(20-2-1-11-31-20)23(29)15-5-8-27-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392829 (US10301306, Example 27) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1F |(-1.25,7.14,;-.85,5.66,;.63,5.26,;1.03,3.77,;-.06,2.68,;-1.54,3.08,;-1.94,4.57,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.52,-3.48,;3.61,-4.57,;3.21,-6.05,;4.3,-7.14,;1.72,-6.45,;.58,-5.38,;-.91,-5.78,;-2.4,-6.17,;-.56,-.05,;-2.1,-.05,;-2.87,1.28,;-4.41,1.28,;-5.18,-.05,;-4.41,-1.39,;-2.87,-1.39,;-2.1,-2.72,)| Show InChI InChI=1S/C26H17F3N4O/c27-18-4-1-15(2-5-18)23-24-22(8-10-32-26(24)34)33(25(23)20-7-9-31-13-21(20)29)14-16-3-6-19(28)11-17(16)12-30/h1-7,9,11,13H,8,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392836 (US10301306, Example 34) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-20-4-1-16(2-5-20)23-24-22(9-12-31-26(24)33)32(25(23)17-7-10-30-11-8-17)15-18-3-6-21(28)13-19(18)14-29/h1-8,10-11,13H,9,12,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392840 (US10301306, Example 38) Show SMILES COc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C26H22FN3O2/c1-32-21-8-2-17(3-9-21)16-30-22-12-15-29-26(31)24(22)23(18-4-6-20(27)7-5-18)25(30)19-10-13-28-14-11-19/h2-11,13-14H,12,15-16H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392843 (US10301306, Example 41) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2cc(F)cc(c2)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-19-3-1-16(2-4-19)22-23-21(7-10-33-25(23)35)34(24(22)17-5-8-32-9-6-17)14-15-11-18(26(29,30)31)13-20(28)12-15/h1-6,8-9,11-13H,7,10,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392845 (US10301306, Example 43) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-19-5-2-15(3-6-19)22-23-21(9-12-33-25(23)35)34(24(22)16-7-10-32-11-8-16)14-17-1-4-18(13-20(17)28)26(29,30)31/h1-8,10-11,13H,9,12,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392846 (US10301306, Example 44) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C25H19F2N3O/c26-19-5-1-16(2-6-19)15-30-21-11-14-29-25(31)23(21)22(17-3-7-20(27)8-4-17)24(30)18-9-12-28-13-10-18/h1-10,12-13H,11,14-15H2,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392848 (US10301306, Example 46) Show SMILES Cc1cc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)ccc1F Show InChI InChI=1S/C26H21F2N3O/c1-16-14-17(2-7-21(16)28)15-31-22-10-13-30-26(32)24(22)23(18-3-5-20(27)6-4-18)25(31)19-8-11-29-12-9-19/h2-9,11-12,14H,10,13,15H2,1H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392850 (US10301306, Example 48) Show SMILES Cc1nc(no1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C28H21F2N5O2/c1-16-33-27(34-37-16)19-2-3-20(22(30)14-19)15-35-23-10-13-32-28(36)25(23)24(17-4-6-21(29)7-5-17)26(35)18-8-11-31-12-9-18/h2-9,11-12,14H,10,13,15H2,1H3,(H,32,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392853 (US10301306, Example 51) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-20-5-3-17(4-6-20)23-24-22(9-12-31-26(24)33)32(25(23)18-7-10-30-11-8-18)15-19-2-1-16(14-29)13-21(19)28/h1-8,10-11,13H,9,12,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392855 (US10301306, Example 53) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2C(F)(F)F)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C27H18F7N3O/c28-19-5-2-15(3-6-19)22-23-21(9-12-36-25(23)38)37(24(22)16-7-10-35-11-8-16)14-17-1-4-18(26(29,30)31)13-20(17)27(32,33)34/h1-8,10-11,13H,9,12,14H2,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392857 (US10301306, Example 55) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-18-4-1-15(2-5-18)22-23-21(9-12-33-25(23)35)34(24(22)16-7-10-32-11-8-16)14-17-3-6-19(28)13-20(17)26(29,30)31/h1-8,10-11,13H,9,12,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392866 (US10301306, Example 64) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H18F3N3O/c26-18-4-1-15(2-5-18)22-23-21(9-12-30-25(23)32)31(24(22)16-7-10-29-11-8-16)14-17-3-6-19(27)13-20(17)28/h1-8,10-11,13H,9,12,14H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392867 (US10301306, Example 65) Show SMILES Cc1cc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)n(C)n1 Show InChI InChI=1S/C24H22FN5O/c1-15-13-19(29(2)28-15)14-30-20-9-12-27-24(31)22(20)21(16-3-5-18(25)6-4-16)23(30)17-7-10-26-11-8-17/h3-8,10-11,13H,9,12,14H2,1-2H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392868 (US10301306, Example 66) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccncc2)c1-c1ccncc1 Show InChI InChI=1S/C24H19FN4O/c25-19-3-1-17(2-4-19)21-22-20(9-14-28-24(22)30)29(15-16-5-10-26-11-6-16)23(21)18-7-12-27-13-8-18/h1-8,10-13H,9,14-15H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392870 (US10301306, Example 68) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccccc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O/c27-21-7-5-17(6-8-21)23-24-22(11-14-30-26(24)32)31(25(23)18-9-12-29-13-10-18)16-20-4-2-1-3-19(20)15-28/h1-10,12-13H,11,14,16H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392873 (US10301306, Example 71) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cc(F)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H17F4N3O/c26-16-3-1-14(2-4-16)22-23-21(7-10-31-25(23)33)32(24(22)15-5-8-30-9-6-15)13-18-19(28)11-17(27)12-20(18)29/h1-6,8-9,11-12H,7,10,13H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392875 (US10301306, Example 73) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cccc2C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-17-6-4-15(5-7-17)22-23-21(10-13-33-25(23)35)34(24(22)16-8-11-32-12-9-16)14-18-19(26(29,30)31)2-1-3-20(18)28/h1-9,11-12H,10,13-14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392876 (US10301306, Example 74) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(Cl)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H18ClF2N3O/c26-18-4-1-17(20(28)13-18)14-31-21-9-12-30-25(32)23(21)22(15-2-5-19(27)6-3-15)24(31)16-7-10-29-11-8-16/h1-8,10-11,13H,9,12,14H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392877 (US10301306, Example 75) Show SMILES CC(C)(C)CCn1c2CCNC(=O)c2c(c1-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H26FN3O/c1-24(2,3)11-15-28-19-10-14-27-23(29)21(19)20(16-4-6-18(25)7-5-16)22(28)17-8-12-26-13-9-17/h4-9,12-13H,10-11,14-15H2,1-3H3,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392879 (US10301306, Example 77) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cccc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-19-6-4-16(5-7-19)23-24-22(10-13-31-26(24)33)32(25(23)17-8-11-30-12-9-17)15-20-18(14-29)2-1-3-21(20)28/h1-9,11-12H,10,13,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392880 (US10301306, Example 78) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(CC2CCCC2)c1-c1ccncc1 Show InChI InChI=1S/C24H24FN3O/c25-19-7-5-17(6-8-19)21-22-20(11-14-27-24(22)29)28(15-16-3-1-2-4-16)23(21)18-9-12-26-13-10-18/h5-10,12-13,16H,1-4,11,14-15H2,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392886 (US10301306, Example 84) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cc(cc2F)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H17F3N4O/c27-18-3-1-16(2-4-18)23-24-22(7-10-32-26(24)34)33(25(23)17-5-8-31-9-6-17)14-19-20(28)11-15(13-30)12-21(19)29/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392985 (US10301306, Example 183) Show SMILES COc1cnccc1-c1c(c2c(CCNC2=O)n1Cc1cc(C)nn1C)-c1ccc(F)cc1 |(-2.87,-4.05,;-2.1,-2.72,;-2.87,-1.39,;-4.41,-1.39,;-5.18,-.05,;-4.41,1.28,;-2.87,1.28,;-2.1,-.05,;-.56,-.05,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.56,-3.71,;3.19,-5.12,;4.7,-5.44,;2.05,-6.15,;.71,-5.38,;-.69,-6.01,;-.06,2.68,;1.03,3.77,;.63,5.26,;-.85,5.66,;-1.25,7.14,;-1.94,4.57,;-1.54,3.08,)| Show InChI InChI=1S/C25H24FN5O2/c1-15-12-18(30(2)29-15)14-31-20-9-11-28-25(32)23(20)22(16-4-6-17(26)7-5-16)24(31)19-8-10-27-13-21(19)33-3/h4-8,10,12-13H,9,11,14H2,1-3H3,(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392902 (US10301306, Example 100 | US10301306, Example 161) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(F)cc1C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F2N5O2/c1-16(36)34-24-13-18(8-10-32-24)27-25(17-2-5-21(29)6-3-17)26-23(9-11-33-28(26)37)35(27)15-19-4-7-22(30)12-20(19)14-31/h2-8,10,12-13H,9,11,15H2,1H3,(H,33,37)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392903 (US10301306, Example 101) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(cc1F)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F5N4O2/c1-15(38)36-23-12-17(8-10-34-23)26-24(16-3-6-20(29)7-4-16)25-22(9-11-35-27(25)39)37(26)14-18-2-5-19(13-21(18)30)28(31,32)33/h2-8,10,12-13H,9,11,14H2,1H3,(H,35,39)(H,34,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392917 (US10301306, Example 115) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)c(F)c2)c(c1)C#N Show InChI InChI=1S/C26H17F3N4O/c27-19-3-1-17(18(11-19)13-30)14-33-22-7-10-32-26(34)24(22)23(16-2-4-20(28)21(29)12-16)25(33)15-5-8-31-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392925 (US10301306, Example 123) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cccc(c2)C(F)(F)F)c(c1)C#N Show InChI InChI=1S/C27H18F4N4O/c28-21-5-4-18(19(13-21)14-32)15-35-22-8-11-34-26(36)24(22)23(25(35)16-6-9-33-10-7-16)17-2-1-3-20(12-17)27(29,30)31/h1-7,9-10,12-13H,8,11,15H2,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392926 (US10301306, Example 124) Show SMILES COc1ccc(cn1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H20FN5O2/c1-34-22-5-3-17(14-31-22)23-24-21(8-11-30-26(24)33)32(25(23)16-6-9-29-10-7-16)15-18-2-4-20(27)12-19(18)13-28/h2-7,9-10,12,14H,8,11,15H2,1H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392929 (US10301306, Example 127) Show SMILES Oc1cccc(c1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O2/c27-20-5-4-18(19(12-20)14-28)15-31-22-8-11-30-26(33)24(22)23(17-2-1-3-21(32)13-17)25(31)16-6-9-29-10-7-16/h1-7,9-10,12-13,32H,8,11,15H2,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 185 total )  |  Next  |  Last  >>

Jump to: