Compile Data Set for Download or QSAR

Found 87 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187126 (US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...) Show SMILES CCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187169 (US9670181, 48 6,7-dimethoxy-4-((6-methoxy-2-(methy...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-6-8-23-20-15-25(34-5)24(33-4)14-19(20)21(27(31)30-23)13-17-11-16-12-18(32-3)9-10-22(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187210 (US9670181, 86 4-((6-ethoxy-2-(ethylamino)-7-fluoro...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H32FN3O4/c1-6-9-22-19-14-26(35-5)25(34-4)13-18(19)20(28(33)32-22)11-17-10-16-12-24(36-8-3)21(29)15-23(16)31-27(17)30-7-2/h10,12-15H,6-9,11H2,1-5H3,(H,30,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187169 (US9670181, 48 6,7-dimethoxy-4-((6-methoxy-2-(methy...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-6-8-23-20-15-25(34-5)24(33-4)14-19(20)21(27(31)30-23)13-17-11-16-12-18(32-3)9-10-22(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187160 (US9670181, 40 1-ethyl-4-((2-(ethylamino)-6-methoxy...) Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O4/c1-6-21-19-14-24(33-5)23(32-4)13-18(19)20(26(30)29-21)12-16-10-15-11-17(31-3)8-9-22(15)28-25(16)27-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187209 (US9670181, 85 1-ethyl-6,7-dimethoxy-4-((6-methoxyq...) Show SMILES CCc1nc(O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O4/c1-5-20-18-12-23(30-4)22(29-3)11-17(18)19(24(27)26-20)9-14-8-15-10-16(28-2)6-7-21(15)25-13-14/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187127 (US9670181, 7 4-(dibenzo[b,d]furan-2-ylmethyl)-6,7-...) Show SMILES CCCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H25NO4/c1-4-7-22-19-15-26(31-3)25(30-2)14-18(19)21(27(29)28-22)13-16-10-11-24-20(12-16)17-8-5-6-9-23(17)32-24/h5-6,8-12,14-15H,4,7,13H2,1-3H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187162 (US9670181, 42 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...) Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-6-10-28-26-17(11-16-12-18(32-3)8-9-23(16)29-26)13-21-19-14-24(33-4)25(34-5)15-20(19)22(7-2)30-27(21)31/h8-9,11-12,14-15H,6-7,10,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187174 (US9670181, 53 4-((2-(isopropylamino)-6-methoxyquin...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H33N3O4/c1-7-8-24-21-15-26(35-6)25(34-5)14-20(21)22(28(32)31-24)13-18-11-17-12-19(33-4)9-10-23(17)30-27(18)29-16(2)3/h9-12,14-16H,7-8,13H2,1-6H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM187126 (US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...) Show SMILES CCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187184 (US9670181, 62 6,7-dimethoxy-4-((6-(methylamino)-[1...) Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H27N3O5/c1-5-6-19-17-11-22(32-4)21(31-3)10-16(17)18(26(30)29-19)8-15-7-14-9-23-24(34-13-33-23)12-20(14)28-25(15)27-2/h7,9-12H,5-6,8,13H2,1-4H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187186 (US9670181, 64 4-((6-(ethylamino)-[1,3]dioxolo[4,5-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187206 (US9670181, 82 1-ethyl-4-((2-(ethylamino)-7-fluoro-...) Show SMILES CCNc1nc2cc(F)c(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H28FN3O4/c1-6-20-17-12-24(34-5)23(33-4)11-16(17)18(26(31)30-20)9-15-8-14-10-22(32-3)19(27)13-21(14)29-25(15)28-7-2/h8,10-13H,6-7,9H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187192 (US9670181, 69 N-(2-((3-((1-ethyl-3-hydroxy-6,7-dim...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H32N4O5/c1-6-23-21-15-26(37-5)25(36-4)14-20(21)22(28(34)32-23)13-18-11-17-12-19(35-3)7-8-24(17)31-27(18)30-10-9-29-16(2)33/h7-8,11-12,14-15H,6,9-10,13H2,1-5H3,(H,29,33)(H,30,31)(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187155 (US9670181, 35 4-((2-(ethylamino)-6-methylquinolin-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O3/c1-6-8-23-20-15-25(33-5)24(32-4)14-19(20)21(27(31)30-23)13-18-12-17-11-16(3)9-10-22(17)29-26(18)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187173 (US9670181, 52 6,7-dimethoxy-4-((6-methoxy-2-(propy...) Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H33N3O4/c1-6-8-24-21-16-26(35-5)25(34-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(33-3)9-10-23(17)30-27(18)29-11-7-2/h9-10,12-13,15-16H,6-8,11,14H2,1-5H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187208 (US9670181, 84 6,7-dimethoxy-4-((6-methoxyquinolin-...) Show SMILES CCCc1nc(O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H26N2O4/c1-5-6-22-19-13-24(31-4)23(30-3)12-18(19)20(25(28)27-22)10-15-9-16-11-17(29-2)7-8-21(16)26-14-15/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187159 (US9670181, 39 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H27N3O4/c1-6-20-18-13-23(32-5)22(31-4)12-17(18)19(25(29)28-20)11-15-9-14-10-16(30-3)7-8-21(14)27-24(15)26-2/h7-10,12-13H,6,11H2,1-5H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187212 (US9670181, 88 N-(2-((6-ethoxy-3-((3-hydroxy-6,7-di...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C30H36N4O5/c1-6-8-26-23-17-28(38-5)27(37-4)16-22(23)24(30(36)34-26)15-20-13-19-14-21(39-7-2)9-10-25(19)33-29(20)32-12-11-31-18(3)35/h9-10,13-14,16-17H,6-8,11-12,15H2,1-5H3,(H,31,35)(H,32,33)(H,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187189 (US9670181, 67 4-((2-(ethylamino)-6-methoxyquinolin...) Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(COC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O5/c1-6-27-25-16(9-15-10-17(32-3)7-8-21(15)28-25)11-20-18-12-23(33-4)24(34-5)13-19(18)22(14-31-2)29-26(20)30/h7-10,12-13H,6,11,14H2,1-5H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187154 (US9670181, 34 6,7-dimethoxy-4-((6-methyl-2-(methyl...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(C)ccc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O3/c1-6-7-22-19-14-24(32-5)23(31-4)13-18(19)20(26(30)29-22)12-17-11-16-10-15(2)8-9-21(16)28-25(17)27-3/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187201 (US9670181, 77 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCOC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O5/c1-6-22-20-15-25(35-5)24(34-4)14-19(20)21(27(31)30-22)13-17-11-16-12-18(33-3)7-8-23(16)29-26(17)28-9-10-32-2/h7-8,11-12,14-15H,6,9-10,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187182 (US9670181, 61 1-ethyl-6,7-dimethoxy-4-((6-(methyla...) Show SMILES CCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H25N3O5/c1-5-18-16-10-21(31-4)20(30-3)9-15(16)17(25(29)28-18)7-14-6-13-8-22-23(33-12-32-22)11-19(13)27-24(14)26-2/h6,8-11H,5,7,12H2,1-4H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187200 (US9670181, 76 6,7-dimethoxy-4-((6-methoxy-2-((2-me...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCOC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H33N3O5/c1-6-7-24-21-16-26(36-5)25(35-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(34-3)8-9-23(17)30-27(18)29-10-11-33-2/h8-9,12-13,15-16H,6-7,10-11,14H2,1-5H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187193 (US9670181, 70 4-((2-(ethylamino)-7-fluoro-6-methox...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H30FN3O4/c1-6-8-21-18-13-25(35-5)24(34-4)12-17(18)19(27(32)31-21)10-16-9-15-11-23(33-3)20(28)14-22(15)30-26(16)29-7-2/h9,11-14H,6-8,10H2,1-5H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187181 (US9670181, 60 6,7-dimethoxy-1-methyl-4-((6-(methyl...) Show SMILES CNc1nc2cc3OCOc3cc2cc1Cc1c(O)nc(C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H23N3O5/c1-12-15-8-19(29-3)20(30-4)9-16(15)17(24(28)26-12)6-14-5-13-7-21-22(32-11-31-21)10-18(13)27-23(14)25-2/h5,7-10H,6,11H2,1-4H3,(H,25,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187197 (US9670181, 73 N-(2-((3-((3-hydroxy-6,7-dimethoxy-1...) Show SMILES COc1ccc2nc(NCCNC(C)=O)c(Cc3c(O)nc(C)c4cc(OC)c(OC)cc34)cc2c1 Show InChI InChI=1S/C27H30N4O5/c1-15-20-13-24(35-4)25(36-5)14-21(20)22(27(33)30-15)12-18-10-17-11-19(34-3)6-7-23(17)31-26(18)29-9-8-28-16(2)32/h6-7,10-11,13-14H,8-9,12H2,1-5H3,(H,28,32)(H,29,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187158 (US9670181, 38 6,7-dimethoxy-4-((6-methoxy-2-(propy...) Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O4/c1-6-9-27-25-17(10-16-11-18(31-3)7-8-22(16)29-25)12-21-20-14-24(33-5)23(32-4)13-19(20)15(2)28-26(21)30/h7-8,10-11,13-14H,6,9,12H2,1-5H3,(H,27,29)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187204 (US9670181, 80 6,7-dimethoxy-4-((2-methylquinolin-6...) Show SMILES CCCc1nc(O)c(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H26N2O3/c1-5-6-22-19-14-24(30-4)23(29-3)13-18(19)20(25(28)27-22)12-16-8-10-21-17(11-16)9-7-15(2)26-21/h7-11,13-14H,5-6,12H2,1-4H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187163 (US9670181, 43 1-ethyl-4-((2-(isopropylamino)-6-met...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-7-22-20-14-25(34-6)24(33-5)13-19(20)21(27(31)30-22)12-17-10-16-11-18(32-4)8-9-23(16)29-26(17)28-15(2)3/h8-11,13-15H,7,12H2,1-6H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187211 (US9670181, 87 N-(2-((6-(cyclopropylmethoxy)-3-((1-...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OCC4CC4)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C31H36N4O5/c1-5-26-24-16-29(39-4)28(38-3)15-23(24)25(31(37)35-26)14-21-12-20-13-22(40-17-19-6-7-19)8-9-27(20)34-30(21)33-11-10-32-18(2)36/h8-9,12-13,15-16,19H,5-7,10-11,14,17H2,1-4H3,(H,32,36)(H,33,34)(H,35,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187152 (US9670181, 32 6,7-dimethoxy-4-((7-methoxyquinolin-...) Show SMILES CCCc1nc(O)c(Cc2cnc3cc(OC)ccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C25H26N2O4/c1-5-6-21-19-13-24(31-4)23(30-3)12-18(19)20(25(28)27-21)10-15-9-16-7-8-17(29-2)11-22(16)26-14-15/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187176 (US9670181, 55 N-(2-((3-((3-hydroxy-6,7-dimethoxy-1...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C29H34N4O5/c1-6-7-25-22-16-27(38-5)26(37-4)15-21(22)23(29(35)33-25)14-19-12-18-13-20(36-3)8-9-24(18)32-28(19)31-11-10-30-17(2)34/h8-9,12-13,15-16H,6-7,10-11,14H2,1-5H3,(H,30,34)(H,31,32)(H,33,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187170 (US9670181, 49 4-((6-ethoxy-2-(ethylamino)quinolin-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)ccc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H33N3O4/c1-6-9-24-21-16-26(34-5)25(33-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(35-8-3)10-11-23(17)30-27(18)29-7-2/h10-13,15-16H,6-9,14H2,1-5H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187161 (US9670181, 41 4-((6-ethoxy-2-(ethylamino)quinolin-...) Show SMILES CCNc1nc2ccc(OCC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-6-22-20-15-25(33-5)24(32-4)14-19(20)21(27(31)30-22)13-17-11-16-12-18(34-8-3)9-10-23(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187148 (US9670181, 28 4-((5-ethoxyquinolin-3-yl)methyl)-6,...) Show SMILES CCOc1cccc2ncc(Cc3c(O)nc(C)c4cc(OC)c(OC)cc34)cc12 Show InChI InChI=1S/C24H24N2O4/c1-5-30-21-8-6-7-20-19(21)10-15(13-25-20)9-18-17-12-23(29-4)22(28-3)11-16(17)14(2)26-24(18)27/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187157 (US9670181, 37 6,7-dimethoxy-4-((6-methoxy-2-(methy...) Show SMILES CNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H25N3O4/c1-13-17-11-21(30-4)22(31-5)12-18(17)19(24(28)26-13)10-15-8-14-9-16(29-3)6-7-20(14)27-23(15)25-2/h6-9,11-12H,10H2,1-5H3,(H,25,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187198 (US9670181, 74 6,7-dimethoxy-1-propyl-4-(quinolin-3...) Show SMILES CCCc1nc(O)c(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O3/c1-4-7-21-18-13-23(29-3)22(28-2)12-17(18)19(24(27)26-21)11-15-10-16-8-5-6-9-20(16)25-14-15/h5-6,8-10,12-14H,4,7,11H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187205 (US9670181, 81 1-ethyl-6,7-dimethoxy-4-((2-methylqu...) Show SMILES CCc1nc(O)c(Cc2ccc3nc(C)ccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O3/c1-5-20-18-13-23(29-4)22(28-3)12-17(18)19(24(27)26-20)11-15-7-9-21-16(10-15)8-6-14(2)25-21/h6-10,12-13H,5,11H2,1-4H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187164 (US9670181, 44 4-((2-(benzylamino)-6-methoxyquinoli...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCc2ccccc2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C31H31N3O4/c1-5-26-24-17-29(38-4)28(37-3)16-23(24)25(31(35)34-26)15-21-13-20-14-22(36-2)11-12-27(20)33-30(21)32-18-19-9-7-6-8-10-19/h6-14,16-17H,5,15,18H2,1-4H3,(H,32,33)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187207 (US9670181, 83 N-(2-((6-(cyclopropylmethoxy)-3-((3-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC4CC4)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C32H38N4O5/c1-5-6-28-25-17-30(40-4)29(39-3)16-24(25)26(32(38)36-28)15-22-13-21-14-23(41-18-20-7-8-20)9-10-27(21)35-31(22)34-12-11-33-19(2)37/h9-10,13-14,16-17,20H,5-8,11-12,15,18H2,1-4H3,(H,33,37)(H,34,35)(H,36,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187167 (US9670181, 47 4-((2-(ethylamino)-6-methoxyquinolin...) Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(C(C)C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H31N3O4/c1-7-28-26-17(10-16-11-18(32-4)8-9-22(16)29-26)12-21-19-13-23(33-5)24(34-6)14-20(19)25(15(2)3)30-27(21)31/h8-11,13-15H,7,12H2,1-6H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187139 (US9670181, 19 1-ethyl-6,7-dimethoxy-4-(naphthalen-...) Show SMILES CCc1nc(O)c(Cc2ccc3ccccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H23NO3/c1-4-21-19-14-23(28-3)22(27-2)13-18(19)20(24(26)25-21)12-15-9-10-16-7-5-6-8-17(16)11-15/h5-11,13-14H,4,12H2,1-3H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187151 (US9670181, 31 1-ethyl-6,7-dimethoxy-4-((7-methoxyq...) Show SMILES CCc1nc(O)c(Cc2cnc3cc(OC)ccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O4/c1-5-20-18-12-23(30-4)22(29-3)11-17(18)19(24(27)26-20)9-14-8-15-6-7-16(28-2)10-21(15)25-13-14/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187153 (US9670181, 33 6,7-dimethoxy-1-methyl-4-((6-methyl-...) Show SMILES CNc1nc2ccc(C)cc2cc1Cc1c(O)nc(C)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H25N3O3/c1-13-6-7-20-15(8-13)9-16(23(25-3)27-20)10-19-18-12-22(30-5)21(29-4)11-17(18)14(2)26-24(19)28/h6-9,11-12H,10H2,1-5H3,(H,25,27)(H,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187137 (US9670181, 17 6,7-dimethoxy-1-methyl-4-(naphthalen...) Show SMILES COc1cc2c(C)nc(O)c(Cc3ccc4ccccc4c3)c2cc1OC Show InChI InChI=1S/C23H21NO3/c1-14-18-12-21(26-2)22(27-3)13-19(18)20(23(25)24-14)11-15-8-9-16-6-4-5-7-17(16)10-15/h4-10,12-13H,11H2,1-3H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187188 (US9670181, 66 4-((2-ethyl-6-methoxyquinolin-3-yl)m...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H30N2O4/c1-6-8-24-20-15-26(33-5)25(32-4)14-19(20)21(27(30)29-24)13-17-11-16-12-18(31-3)9-10-23(16)28-22(17)7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187147 (US9670181, 27 6,7-dimethoxy-4-((5-methoxyquinolin-...) Show SMILES COc1cc2c(C)nc(O)c(Cc3cnc4cccc(OC)c4c3)c2cc1OC Show InChI InChI=1S/C23H22N2O4/c1-13-15-10-21(28-3)22(29-4)11-16(15)17(23(26)25-13)8-14-9-18-19(24-12-14)6-5-7-20(18)27-2/h5-7,9-12H,8H2,1-4H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187150 (US9670181, 30 4-((7-ethoxyquinolin-3-yl)methyl)-6,...) Show SMILES CCOc1ccc2cc(Cc3c(O)nc(C)c4cc(OC)c(OC)cc34)cnc2c1 Show InChI InChI=1S/C24H24N2O4/c1-5-30-17-7-6-16-8-15(13-25-21(16)10-17)9-20-19-12-23(29-4)22(28-3)11-18(19)14(2)26-24(20)27/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187175 (US9670181, 54 6,7-dimethoxy-4-((6-methoxy-2-((2,2,...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H28F3N3O4/c1-5-6-22-19-13-24(37-4)23(36-3)12-18(19)20(26(34)33-22)11-16-9-15-10-17(35-2)7-8-21(15)32-25(16)31-14-27(28,29)30/h7-10,12-13H,5-6,11,14H2,1-4H3,(H,31,32)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair

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