Compile Data Set for Download or QSAR

Found 88 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1686   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13390 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COCc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-32-19-31-16-27(32)28(23-9-6-20(14-29)7-10-23)34-18-25-11-8-21(15-30)13-26(25)24-5-3-4-22(12-24)17-33-2/h3-13,16,19,28H,17-18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13389 (4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...) Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13384 (4-{[(R)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)...) Show SMILES COc1cccc(c1)-c1cc(ccc1CO[C@@H](c1cncn1C)c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3/t27-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13405 (3-(3-chlorophenyl)-4-{[(4-cyano-3-fluorophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(C#N)c(F)c1 Show InChI InChI=1S/C26H18ClFN4O/c1-32-16-31-14-25(32)26(19-7-8-20(13-30)24(28)11-19)33-15-21-6-5-17(12-29)9-23(21)18-3-2-4-22(27)10-18/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13415 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NCc1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21F2N5O/c1-34-17-32-15-26(34)27(21-5-2-18(12-30)3-6-21)35-16-22-7-4-19(13-31)10-25(22)33-14-20-8-23(28)11-24(29)9-20/h2-11,15,17,27,33H,14,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13388 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES CCOc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-3-33-25-6-4-5-23(14-25)26-13-21(16-30)9-12-24(26)18-34-28(27-17-31-19-32(27)2)22-10-7-20(15-29)8-11-22/h4-14,17,19,28H,3,18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13383 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13418 (A313326 Analogue 65 | N-(3-chlorophenyl)-5-cyano-2...) Show SMILES Cn1cncc1C(OCc1ccc(cc1C(=O)Nc1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20ClN5O2/c1-33-17-31-15-25(33)26(20-8-5-18(13-29)6-9-20)35-16-21-10-7-19(14-30)11-24(21)27(34)32-23-4-2-3-22(28)12-23/h2-12,15,17,26H,16H2,1H3,(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13406 (3-(3-chlorophenyl)-4-{[(4-cyano-2-fluorophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1F)C#N Show InChI InChI=1S/C26H18ClFN4O/c1-32-16-31-14-25(32)26(22-8-6-18(13-30)10-24(22)28)33-15-20-7-5-17(12-29)9-23(20)19-3-2-4-21(27)11-19/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13375 (4-({[4-chloro-2-(3-chlorophenyl)phenyl]methoxy}(1-...) Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(18-7-5-17(13-28)6-8-18)31-15-20-9-10-22(27)12-23(20)19-3-2-4-21(26)11-19/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13393 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19F3N4O2/c1-34-17-33-15-25(34)26(21-5-2-18(13-31)3-6-21)35-16-22-7-4-19(14-32)12-24(22)20-8-10-23(11-9-20)36-27(28,29)30/h2-12,15,17,26H,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.840	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13386 (3-(2H-1,3-benzodioxol-5-yl)-4-{[(4-cyanophenyl)(1-...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H20N4O3/c1-31-16-30-14-24(31)27(20-5-2-18(12-28)3-6-20)32-15-22-7-4-19(13-29)10-23(22)21-8-9-25-26(11-21)34-17-33-25/h2-11,14,16,27H,15,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.870	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13382 (3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H19ClN4O/c1-31-17-30-15-25(31)26(20-8-5-18(13-28)6-9-20)32-16-22-10-7-19(14-29)11-24(22)21-3-2-4-23(27)12-21/h2-12,15,17,26H,16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.870	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13412 (A313326 Analogue 60a | N-(5-cyano-2-{[(4-cyanophen...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccs1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C24H19N5O3S2/c1-29-16-27-14-22(29)24(19-7-4-17(12-25)5-8-19)32-15-20-9-6-18(13-26)11-21(20)28-34(30,31)23-3-2-10-33-23/h2-11,14,16,24,28H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.880	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13377 (4-({[4-chloro-2-(3-methoxyphenyl)phenyl]methoxy}(1...) Show SMILES COc1cccc(c1)-c1cc(Cl)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C26H22ClN3O2/c1-30-17-29-15-25(30)26(19-8-6-18(14-28)7-9-19)32-16-21-10-11-22(27)13-24(21)20-4-3-5-23(12-20)31-2/h3-13,15,17,26H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.910	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13380 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc2ccccc12)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(24-12-9-21(16-31)10-13-24)35-19-25-14-11-22(17-32)15-28(25)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13391 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(22-6-3-19(14-28)4-7-22)33-17-23-8-5-20(15-29)13-25(23)21-9-11-24(32-2)12-10-21/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13404 (4-{[(3-chloro-4-cyanophenyl)(1-methyl-1H-imidazol-...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(C#N)c(Cl)c1)C#N Show InChI InChI=1S/C27H21ClN4O2/c1-32-17-31-15-26(32)27(20-8-9-21(14-30)25(28)12-20)34-16-22-7-6-18(13-29)10-24(22)19-4-3-5-23(11-19)33-2/h3-12,15,17,27H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13395 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H18F2N4O/c1-32-16-31-14-25(32)26(19-5-2-17(12-29)3-6-19)33-15-20-7-4-18(13-30)8-24(20)21-9-22(27)11-23(28)10-21/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13413 (A313326 Analogue 60b) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H23N5O3S/c1-19-3-11-24(12-4-19)36(33,34)31-25-13-21(15-29)7-10-23(25)17-35-27(26-16-30-18-32(26)2)22-8-5-20(14-28)6-9-22/h3-13,16,18,27,31H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13407 (3-(3-chlorophenyl)-4-{[(1-methyl-1H-imidazol-5-yl)...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H19ClF3N3O/c1-33-16-32-14-24(33)25(18-7-9-21(10-8-18)26(28,29)30)34-15-20-6-5-17(13-31)11-23(20)19-3-2-4-22(27)12-19/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13396 (4-({[2-(3-methoxyphenyl)-4-nitrophenyl]methoxy}(1-...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O Show InChI InChI=1S/C26H22N4O4/c1-29-17-28-15-25(29)26(19-8-6-18(14-27)7-9-19)34-16-21-10-11-22(30(31)32)13-24(21)20-4-3-5-23(12-20)33-2/h3-13,15,17,26H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13378 (4-({[4-chloro-2-(3-ethoxyphenyl)phenyl]methoxy}(1-...) Show SMILES CCOc1cccc(c1)-c1cc(Cl)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H24ClN3O2/c1-3-32-24-6-4-5-21(13-24)25-14-23(28)12-11-22(25)17-33-27(26-16-30-18-31(26)2)20-9-7-19(15-29)8-10-20/h4-14,16,18,27H,3,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13394 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H22N4O/c1-19-3-8-22(9-4-19)25-13-21(15-29)7-12-24(25)17-32-27(26-16-30-18-31(26)2)23-10-5-20(14-28)6-11-23/h3-13,16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13387 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H18F2N4O3/c1-33-16-32-14-23(33)26(19-5-2-17(12-30)3-6-19)34-15-21-7-4-18(13-31)10-22(21)20-8-9-24-25(11-20)36-27(28,29)35-24/h2-11,14,16,26H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13392 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES CCOc1ccc(cc1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H24N4O2/c1-3-33-25-12-10-22(11-13-25)26-14-21(16-30)6-9-24(26)18-34-28(27-17-31-19-32(27)2)23-7-4-20(15-29)5-8-23/h4-14,17,19,28H,3,18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13379 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20N4O/c1-30-18-29-16-25(30)26(22-10-7-19(14-27)8-11-22)31-17-23-12-9-20(15-28)13-24(23)21-5-3-2-4-6-21/h2-13,16,18,26H,17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13402 (4-({[4-formyl-2-(3-methoxyphenyl)phenyl]methoxy}(1...) Show SMILES COc1cccc(c1)-c1cc(C=O)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H23N3O3/c1-30-18-29-15-26(30)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(16-31)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,15-16,18,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13409 (3-(2H-1,3-benzodioxol-5-yl)-4-{[(4-cyanophenyl)(1,...) Show SMILES Cc1ncc(C(OCc2ccc(cc2-c2ccc3OCOc3c2)C#N)c2ccc(cc2)C#N)n1C Show InChI InChI=1S/C28H22N4O3/c1-18-31-15-25(32(18)2)28(21-6-3-19(13-29)4-7-21)33-16-23-8-5-20(14-30)11-24(23)22-9-10-26-27(12-22)35-17-34-26/h3-12,15,28H,16-17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13403 (4-{[(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)met...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(Cl)cc1)C#N Show InChI InChI=1S/C26H22ClN3O2/c1-30-17-29-15-25(30)26(19-8-10-22(27)11-9-19)32-16-21-7-6-18(14-28)12-24(21)20-4-3-5-23(13-20)31-2/h3-13,15,17,26H,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13408 (3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1,2-dimethy...) Show SMILES Cc1ncc(C(OCc2ccc(cc2-c2cccc(Cl)c2)C#N)c2ccc(cc2)C#N)n1C Show InChI InChI=1S/C27H21ClN4O/c1-18-31-16-26(32(18)2)27(21-9-6-19(14-29)7-10-21)33-17-23-11-8-20(15-30)12-25(23)22-4-3-5-24(28)13-22/h3-13,16,27H,17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13417 (5-cyano-2-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5...) Show SMILES Cn1cncc1C(OCc1ccc(cc1C(=O)Nc1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21N5O2/c1-32-18-30-16-25(32)26(21-10-7-19(14-28)8-11-21)34-17-22-12-9-20(15-29)13-24(22)27(33)31-23-5-3-2-4-6-23/h2-13,16,18,26H,17H2,1H3,(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13414 (A313326 Analogue 60c | N-(5-cyano-2-{[(4-cyanophen...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccc2ccccc12)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H23N5O3S/c1-35-20-33-18-28(35)30(24-12-9-21(16-31)10-13-24)38-19-25-14-11-22(17-32)15-27(25)34-39(36,37)29-8-4-6-23-5-2-3-7-26(23)29/h2-15,18,20,30,34H,19H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13410 (3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1,3-thiazol...) Show SMILES Clc1cccc(c1)-c1cc(ccc1COC(c1cncs1)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C25H16ClN3OS/c26-22-3-1-2-20(11-22)23-10-18(13-28)6-9-21(23)15-30-25(24-14-29-16-31-24)19-7-4-17(12-27)5-8-19/h1-11,14,16,25H,15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13376 (4-({[4-chloro-2-(4-chlorophenyl)phenyl]methoxy}(1-...) Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1ccc(Cl)cc1)c1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(19-4-2-17(13-28)3-5-19)31-15-20-8-11-22(27)12-23(20)18-6-9-21(26)10-7-18/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13416 (A313326 Analogue 62 | N-(5-cyano-2-{[(4-cyanopheny...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NC(=O)c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21N5O2/c1-32-18-30-16-25(32)26(21-10-7-19(14-28)8-11-21)34-17-23-12-9-20(15-29)13-24(23)31-27(33)22-5-3-2-4-6-22/h2-13,16,18,26H,17H2,1H3,(H,31,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13381 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1cccc2cccnc12)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(23-10-7-20(15-30)8-11-23)35-18-24-12-9-21(16-31)14-26(24)25-6-2-4-22-5-3-13-33-28(22)25/h2-14,17,19,29H,18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13374 (4-({[4-chloro-2-(2-chlorophenyl)phenyl]methoxy}(1-...) Show SMILES Cn1cncc1C(OCc1ccc(Cl)cc1-c1ccccc1Cl)c1ccc(cc1)C#N Show InChI InChI=1S/C25H19Cl2N3O/c1-30-16-29-14-24(30)25(18-8-6-17(13-28)7-9-18)31-15-19-10-11-20(26)12-22(19)21-4-2-3-5-23(21)27/h2-12,14,16,25H,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13399 (A313326 Analogue 36 | N-(4-{[(4-cyanophenyl)(1-met...) Show SMILES COCC(=O)Nc1ccc(COC(c2cncn2C)c2ccc(cc2)C#N)c(c1)-c1cccc(OC)c1 Show InChI InChI=1S/C29H28N4O4/c1-33-19-31-16-27(33)29(21-9-7-20(15-30)8-10-21)37-17-23-11-12-24(32-28(34)18-35-2)14-26(23)22-5-4-6-25(13-22)36-3/h4-14,16,19,29H,17-18H2,1-3H3,(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13400 (A313326 Analogue 39 | methyl 4-{[(4-cyanophenyl)(1...) Show SMILES COC(=O)c1ccc(COC(c2cncn2C)c2ccc(cc2)C#N)c(c1)-c1cccc(OC)c1 Show InChI InChI=1S/C28H25N3O4/c1-31-18-30-16-26(31)27(20-9-7-19(15-29)8-10-20)35-17-23-12-11-22(28(32)34-3)14-25(23)21-5-4-6-24(13-21)33-2/h4-14,16,18,27H,17H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13411 (3-(2H-1,3-benzodioxol-5-yl)-4-{[(4-chloropyridin-3...) Show SMILES Clc1ccncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H18ClN3O3/c29-25-9-10-32-15-24(25)28(20-4-1-18(13-30)2-5-20)33-16-22-6-3-19(14-31)11-23(22)21-7-8-26-27(12-21)35-17-34-26/h1-12,15,28H,16-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Bos taurus (bovine))	BDBM13389 (4-{[(4-cyanophenyl)methoxy](1-methyl-1H-imidazol-5...) Show SMILES Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13385 (4-{[(S)-(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)...) Show SMILES COc1cccc(c1)-c1cc(ccc1CO[C@H](c1cncn1C)c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3/t27-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.0	37
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13398 (A313326 Analogue 35 | N-(4-{[(4-cyanophenyl)(1-met...) Show SMILES COc1cccc(c1)-c1cc(NS(C)(=O)=O)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C27H26N4O4S/c1-31-18-29-16-26(31)27(20-9-7-19(15-28)8-10-20)35-17-22-11-12-23(30-36(3,32)33)14-25(22)21-5-4-6-24(13-21)34-2/h4-14,16,18,27,30H,17H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13397 (4-({[4-amino-2-(3-methoxyphenyl)phenyl]methoxy}(1-...) Show SMILES COc1cccc(c1)-c1cc(N)ccc1COC(c1cncn1C)c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O2/c1-30-17-29-15-25(30)26(19-8-6-18(14-27)7-9-19)32-16-21-10-11-22(28)13-24(21)20-4-3-5-23(12-20)31-2/h3-13,15,17,26H,16,28H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Bos taurus (bovine))	BDBM13413 (A313326 Analogue 60b) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H23N5O3S/c1-19-3-11-24(12-4-19)36(33,34)31-25-13-21(15-29)7-10-23(25)17-35-27(26-16-30-18-32(26)2)22-8-5-20(14-28)6-9-22/h3-13,16,18,27,31H,17H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM13401 (4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C(O)=O Show InChI InChI=1S/C27H23N3O4/c1-30-17-29-15-25(30)26(19-8-6-18(14-28)7-9-19)34-16-22-11-10-21(27(31)32)13-24(22)20-4-3-5-23(12-20)33-2/h3-13,15,17,26H,16H2,1-2H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Bos taurus (bovine))	BDBM13414 (A313326 Analogue 60c | N-(5-cyano-2-{[(4-cyanophen...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccc2ccccc12)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H23N5O3S/c1-35-20-33-18-28(35)30(24-12-9-21(16-31)10-13-24)38-19-25-14-11-22(17-32)15-27(25)34-39(36,37)29-8-4-6-23-5-2-3-7-26(23)29/h2-15,18,20,30,34H,19H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Bos taurus (bovine))	BDBM13404 (4-{[(3-chloro-4-cyanophenyl)(1-methyl-1H-imidazol-...) Show SMILES COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(C#N)c(Cl)c1)C#N Show InChI InChI=1S/C27H21ClN4O2/c1-32-17-31-15-26(32)27(20-8-9-21(14-30)25(28)12-20)34-16-22-7-6-18(13-29)10-24(22)19-4-3-5-23(11-19)33-2/h3-12,15,17,27H,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta (Bos taurus (bovine))	BDBM13412 (A313326 Analogue 60a | N-(5-cyano-2-{[(4-cyanophen...) Show SMILES Cn1cncc1C(OCc1ccc(cc1NS(=O)(=O)c1cccs1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C24H19N5O3S2/c1-29-16-27-14-22(29)24(19-7-4-17(12-25)5-8-19)32-15-20-9-6-18(13-26)11-21(20)28-34(30,31)23-3-2-10-33-23/h2-11,14,16,24,28H,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Globe Pharmaceutical R and Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase or GGTase-I was determined by using scintillation proximity assay (SPA) technology. The assays we...				J Med Chem 47: 612-26 (2004) Article DOI: 10.1021/jm030434f BindingDB Entry DOI: 10.7270/Q2Z60M8D
					More data for this Ligand-Target Pair

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