Compile Data Set for Download or QSAR

Found 120 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345367 (1-cyclobutyl-4-(1-tetralin-6-ylsulfonyl-4,5-dihydr...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCCc2c1 |c:6| Show InChI InChI=1S/C21H30N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h8-9,16,19H,1-7,10-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345355 (1-cyclobutyl-4-[1-[4-(3-thienyl)phenyl]sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccsc1 |c:6| Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,20-6-4-17(5-7-20)18-8-15-28-16-18)25-10-9-22-21(25)24-13-11-23(12-14-24)19-2-1-3-19/h4-8,15-16,19H,1-3,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.0210	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345352 (4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H28N4O3S/c28-21-8-4-18(5-9-21)19-6-10-22(11-7-19)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20,28H,1-3,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0210	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345354 (1-cyclobutyl-4-[1-[4-(2-thienyl)phenyl]sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cccs1 |c:6| Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,19-8-6-17(7-9-19)20-5-2-16-28-20)25-11-10-22-21(25)24-14-12-23(13-15-24)18-3-1-4-18/h2,5-9,16,18H,1,3-4,10-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0270	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345410 (1-cyclobutyl-4-(1-indan-5-ylsulfonyl-4,5-dihydroim...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCc2c1 |c:6| Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-7-16-3-1-4-17(16)15-19)24-10-9-21-20(24)23-13-11-22(12-14-23)18-5-2-6-18/h7-8,15,18H,1-6,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345351 (3-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES Oc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H28N4O3S/c28-21-6-1-3-19(17-21)18-7-9-22(10-8-18)31(29,30)27-12-11-24-23(27)26-15-13-25(14-16-26)20-4-2-5-20/h1,3,6-10,17,20,28H,2,4-5,11-16H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345393 (1-cyclobutyl-4-[1-[4-(1,1-dimethylpropyl)phenyl]su...) Show SMILES CCC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:18| Show InChI InChI=1S/C22H34N4O2S/c1-4-22(2,3)18-8-10-20(11-9-18)29(27,28)26-13-12-23-21(26)25-16-14-24(15-17-25)19-6-5-7-19/h8-11,19H,4-7,12-17H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345350 (2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES Oc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H28N4O3S/c28-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19,28H,3-5,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345376 (US10202354, Example 41) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](N=C1N1CCN(CC1)C1CCC1)C1CC1 |r,c:16| Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345408 (1-cyclobutyl-4-[1-[(6-methoxy-2-naphthyl)sulfonyl]...) Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:20| Show InChI InChI=1S/C22H28N4O3S/c1-29-20-7-5-18-16-21(8-6-17(18)15-20)30(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)19-3-2-4-19/h5-8,15-16,19H,2-4,9-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345409 (1-[1-[(6-chloro-2-naphthyl)sulfonyl]-4,5-dihydroim...) Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:19| Show InChI InChI=1S/C21H25ClN4O2S/c22-18-6-4-17-15-20(7-5-16(17)14-18)29(27,28)26-9-8-23-21(26)25-12-10-24(11-13-25)19-2-1-3-19/h4-7,14-15,19H,1-3,8-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345366 (1-cyclobutyl-4-(1-((4-isopropylphenyl)sulfonyl)-4,...) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:16| Show InChI InChI=1S/C20H30N4O2S/c1-16(2)17-6-8-19(9-7-17)27(25,26)24-11-10-21-20(24)23-14-12-22(13-15-23)18-4-3-5-18/h6-9,16,18H,3-5,10-15H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0430	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345360 (1-cyclobutyl-4-[1-[4-(2-fluorophenyl)phe-nyl]sulfo...) Show SMILES Fc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H27FN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0460	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345377 (US10202354, Example 42) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](N=C1N1CCN(CC1)C1CCC1)C1CC1 |r,c:16| Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0470	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345349 (1-cyclobutyl-4-[1-(4-phenylphenyl)sulfonyl-4,5-dih...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1 |c:6| Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-9-20(10-12-22)19-5-2-1-3-6-19)27-14-13-24-23(27)26-17-15-25(16-18-26)21-7-4-8-21/h1-3,5-6,9-12,21H,4,7-8,13-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0480	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345364 (1-cyclobutyl-4-[1-[4-(2-methylpyrazol-3-yl)phenyl]...) Show SMILES Cn1nccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:20| Show InChI InChI=1S/C21H28N6O2S/c1-24-20(9-10-23-24)17-5-7-19(8-6-17)30(28,29)27-12-11-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-10,18H,2-4,11-16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345380 (2-(4-cyclobutylpiperazin-1-yl)-3-(4-isopropylpheny...) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CC2(CCCC2)N=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C24H36N4O2S/c1-19(2)20-8-10-22(11-9-20)31(29,30)28-18-24(12-3-4-13-24)25-23(28)27-16-14-26(15-17-27)21-6-5-7-21/h8-11,19,21H,3-7,12-18H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345389 (1-cyclobutyl-4-[1-(3-phenylphenyl)sulfonyl-4,5-dih...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)-c1ccccc1 |c:6| Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-4-8-20(18-22)19-6-2-1-3-7-19)27-13-12-24-23(27)26-16-14-25(15-17-26)21-9-5-10-21/h1-4,6-8,11,18,21H,5,9-10,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345363 (1-cyclobutyl-4-[1-[4-(1-methylpyrazol-3-yl)phenyl]...) Show SMILES Cn1ccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:20| Show InChI InChI=1S/C21H28N6O2S/c1-24-11-9-20(23-24)17-5-7-19(8-6-17)30(28,29)27-12-10-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-9,11,18H,2-4,10,12-16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345400 (1-cyclobutyl-4-[1-(4-phenoxyphenyl)sulfonyl-4,5-di...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(Oc2ccccc2)cc1 |c:6| Show InChI InChI=1S/C23H28N4O3S/c28-31(29,22-11-9-21(10-12-22)30-20-7-2-1-3-8-20)27-14-13-24-23(27)26-17-15-25(16-18-26)19-5-4-6-19/h1-3,7-12,19H,4-6,13-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345359 (1-cyclobutyl-4-[1-[4- | US10202354, Example 24) Show SMILES COc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:22| Show InChI InChI=1S/C24H30N4O3S/c1-31-23-8-3-2-7-22(23)19-9-11-21(12-10-19)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)20-5-4-6-20/h2-3,7-12,20H,4-6,13-18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345336 (2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1C#N |c:6| Show InChI InChI=1S/C24H27N5O2S/c25-18-20-4-1-2-7-23(20)19-8-10-22(11-9-19)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)21-5-3-6-21/h1-2,4,7-11,21H,3,5-6,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0530	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345381 ((R)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](C)N=C1N1CCN(CC1)C1CCC1 |r,c:17| Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0540	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345369 (1-cyclobutyl-4-[1-(4-cyclopropylphenyl)sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)C1CC1 |c:6| Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-6-17(7-9-19)16-4-5-16)24-11-10-21-20(24)23-14-12-22(13-15-23)18-2-1-3-18/h6-9,16,18H,1-5,10-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0580	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345365 (5-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cncnc1 |c:6| Show InChI InChI=1S/C21H26N6O2S/c28-30(29,20-6-4-17(5-7-20)18-14-22-16-23-15-18)27-9-8-24-21(27)26-12-10-25(11-13-26)19-2-1-3-19/h4-7,14-16,19H,1-3,8-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345396 (1-cyclobutyl-4-[1-(2-naphthylsulfonyl)-4,5-dihydro...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H26N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h1-2,4-5,8-9,16,19H,3,6-7,10-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0620	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345414 (5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...) Show SMILES Cn1ccc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:18| Show InChI InChI=1S/C20H27N5O2S/c1-22-9-7-16-15-18(5-6-19(16)22)28(26,27)25-10-8-21-20(25)24-13-11-23(12-14-24)17-3-2-4-17/h5-7,9,15,17H,2-4,8,10-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0620	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345362 (1-cyclobutyl-4-[1-[4-(4-fluorophenyl)phe-nyl]sulfo...) Show SMILES Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H27FN4O2S/c24-20-8-4-18(5-9-20)19-6-10-22(11-7-19)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)21-2-1-3-21/h4-11,21H,1-3,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0710	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345344 (1-cyclobutyl-4-[1-[4-(m-tolyl)phenyl]sulfonyl-4,5-...) Show SMILES Cc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C24H30N4O2S/c1-19-4-2-5-21(18-19)20-8-10-23(11-9-20)31(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)22-6-3-7-22/h2,4-5,8-11,18,22H,3,6-7,12-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0740	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345413 (1-cyclobutyl-4-[1-[(6-methyl-2-naphthyl)sulfonyl]-...) Show SMILES Cc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:19| Show InChI InChI=1S/C22H28N4O2S/c1-17-5-6-19-16-21(8-7-18(19)15-17)29(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)20-3-2-4-20/h5-8,15-16,20H,2-4,9-14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0770	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345343 (1-cyclobutyl-4-[1-[4-(o-tolyl)phenyl]sulfonyl-4,5-...) Show SMILES Cc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C24H30N4O2S/c1-19-5-2-3-8-23(19)20-9-11-22(12-10-20)31(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-6-4-7-21/h2-3,5,8-12,21H,4,6-7,13-18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0770	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345338 (1-cyclobutyl-4-[1-[4-(4-methoxyphenyl)phe-nyl]sulf...) Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:22| Show InChI InChI=1S/C24H30N4O3S/c1-31-22-9-5-19(6-10-22)20-7-11-23(12-8-20)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-3-2-4-21/h5-12,21H,2-4,13-18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345388 (1-[4-tert-butylphenyl)sulfonyl-4,5-dihydroimidazol...) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:17| Show InChI InChI=1S/C21H32N4O2S/c1-21(2,3)17-7-9-19(10-8-17)28(26,27)25-12-11-22-20(25)24-15-13-23(14-16-24)18-5-4-6-18/h7-10,18H,4-6,11-16H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0810	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345356 (1-[1-[4-(2-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...) Show SMILES Clc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H27ClN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0840	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345370 (1-cyclobutyl-4-[1-(3-cyclopropylphenyl)sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)C1CC1 |c:6| Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-6-1-3-17(15-19)16-7-8-16)24-10-9-21-20(24)23-13-11-22(12-14-23)18-4-2-5-18/h1,3,6,15-16,18H,2,4-5,7-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0870	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345391 (1-cyclobutyl-4-[1-(3,5-dimethylphenyl)sulfonyl-4,5...) Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:15| Show InChI InChI=1S/C19H28N4O2S/c1-15-12-16(2)14-18(13-15)26(24,25)23-7-6-20-19(23)22-10-8-21(9-11-22)17-4-3-5-17/h12-14,17H,3-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0880	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345405 (N-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:17| Show InChI InChI=1S/C19H27N5O3S/c1-15(25)21-16-5-7-18(8-6-16)28(26,27)24-10-9-20-19(24)23-13-11-22(12-14-23)17-3-2-4-17/h5-8,17H,2-4,9-14H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0940	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345353 (1-cyclobutyl-4-[1-[4-(4-pyridyl)phenyl]sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccncc1 |c:6| Show InChI InChI=1S/C22H27N5O2S/c28-30(29,21-6-4-18(5-7-21)19-8-10-23-11-9-19)27-13-12-24-22(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20H,1-3,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0950	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345340 (4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccc(cc1)C#N |c:6| Show InChI InChI=1S/C24H27N5O2S/c25-18-19-4-6-20(7-5-19)21-8-10-23(11-9-21)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)22-2-1-3-22/h4-11,22H,1-3,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345337 (1-cyclobutyl-4-[1-[4-(3-methoxyphenyl)phe-nyl]sulf...) Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:22| Show InChI InChI=1S/C24H30N4O3S/c1-31-22-7-2-4-20(18-22)19-8-10-23(11-9-19)32(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)21-5-3-6-21/h2,4,7-11,18,21H,3,5-6,12-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0980	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345341 (1-cyclobutyl-4-[1-[4-(2-pyridyl)phenyl]sulfonyl-4,...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccn1 |c:6| Show InChI InChI=1S/C22H27N5O2S/c28-30(29,20-9-7-18(8-10-20)21-6-1-2-11-23-21)27-13-12-24-22(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.102	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345339 (1-cyclobutyl-4-[1-[4-[2-(trifluoromethyl)phe-nyl]p...) Show SMILES FC(F)(F)c1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:24| Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)22-7-2-1-6-21(22)18-8-10-20(11-9-18)34(32,33)31-13-12-28-23(31)30-16-14-29(15-17-30)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.102	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345415 (6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...) Show SMILES Cc1nc2ccc(cc2s1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:18| Show InChI InChI=1S/C19H25N5O2S2/c1-14-21-17-6-5-16(13-18(17)27-14)28(25,26)24-8-7-20-19(24)23-11-9-22(10-12-23)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.112	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345382 ((S)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...) Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](C)N=C1N1CCN(CC1)C1CCC1 |r,c:17| Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.114	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345357 (1-[1-[4-(3-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...) Show SMILES Clc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H27ClN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345416 (N-[2-chloro-4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5...) Show SMILES CC(=O)Nc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:18| Show InChI InChI=1S/C19H26ClN5O3S/c1-14(26)22-18-6-5-16(13-17(18)20)29(27,28)25-8-7-21-19(25)24-11-9-23(10-12-24)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3,(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.127	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345371 (6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...) Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2cc(ccc2c1)C#N |c:6| Show InChI InChI=1S/C22H25N5O2S/c23-16-17-4-5-19-15-21(7-6-18(19)14-17)30(28,29)27-9-8-24-22(27)26-12-10-25(11-13-26)20-2-1-3-20/h4-7,14-15,20H,1-3,8-13H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345346 (1-cyclobutyl-4-[1-[4-[3-(trifluoromethyl)phe-nyl]p...) Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:24| Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)20-4-1-3-19(17-20)18-7-9-22(10-8-18)34(32,33)31-12-11-28-23(31)30-15-13-29(14-16-30)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.134	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345402 (1-cyclobutyl-4-[1-(3,4-dichlorophenyl)sulfonyl-4,5...) Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:15| Show InChI InChI=1S/C17H22Cl2N4O2S/c18-15-5-4-14(12-16(15)19)26(24,25)23-7-6-20-17(23)22-10-8-21(9-11-22)13-2-1-3-13/h4-5,12-13H,1-3,6-11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.136	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM345361 (1-cyclobutyl-4-[1-[4-(3-fluorophenyl)phe-nyl]sulfo...) Show SMILES Fc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1 |c:21| Show InChI InChI=1S/C23H27FN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.138	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...				US Patent US10202354 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V62
					More data for this Ligand-Target Pair

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