Compile Data Set for Download or QSAR

Found 331 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 2449   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366340 (US9873693, Compound 268) Show SMILES Clc1ccc(Cn2cc(Cl)cc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc1 Show InChI InChI=1S/C24H22Cl2N4O2/c25-18-8-6-16(7-9-18)14-30-15-19(26)12-21(24(30)32)23(31)28-10-2-1-4-17-13-29-22-20(17)5-3-11-27-22/h3,5-9,11-13,15H,1-2,4,10,14H2,(H,27,29)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366341 (US9873693, Compound 269) Show SMILES Clc1ccc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc1Cl Show InChI InChI=1S/C24H22Cl2N4O2/c25-20-9-8-16(13-21(20)26)15-30-12-4-7-19(24(30)32)23(31)28-10-2-1-5-17-14-29-22-18(17)6-3-11-27-22/h3-4,6-9,11-14H,1-2,5,10,15H2,(H,27,29)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366187 (US9873693, Compound 110 | US9873693, Compound 270 ...) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C24H22F2N4O2/c25-20-9-8-16(13-21(20)26)15-30-12-4-7-19(24(30)32)23(31)28-10-2-1-5-17-14-29-22-18(17)6-3-11-27-22/h3-4,6-9,11-14H,1-2,5,10,15H2,(H,27,29)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366343 (US9873693, Compound 271) Show SMILES Fc1cc(Cn2cccc(C(=O)NCCCCc3c[nH]c4ncccc34)c2=O)cc(F)c1F Show InChI InChI=1S/C24H21F3N4O2/c25-19-11-15(12-20(26)21(19)27)14-31-10-4-7-18(24(31)33)23(32)29-8-2-1-5-16-13-30-22-17(16)6-3-9-28-22/h3-4,6-7,9-13H,1-2,5,8,14H2,(H,28,30)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366344 (US9873693, Compound 272) Show SMILES Clc1cccc(Cn2cccc(C(=O)NCc3nc(cs3)-c3c[nH]c4ncccc34)c2=O)c1 Show InChI InChI=1S/C24H18ClN5O2S/c25-16-5-1-4-15(10-16)13-30-9-3-7-18(24(30)32)23(31)28-12-21-29-20(14-33-21)19-11-27-22-17(19)6-2-8-26-22/h1-11,14H,12-13H2,(H,26,27)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366345 (US9873693, Compound 273) Show SMILES Clc1ccc(Cn2cc(Cl)cc(C(=O)NCc3nc(cs3)-c3c[nH]c4ncccc34)c2=O)cc1 Show InChI InChI=1S/C24H17Cl2N5O2S/c25-15-5-3-14(4-6-15)11-31-12-16(26)8-18(24(31)33)23(32)29-10-21-30-20(13-34-21)19-9-28-22-17(19)2-1-7-27-22/h1-9,12-13H,10-11H2,(H,27,28)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366240 (US9873693, Compound 163) Show SMILES Fc1cc(Cn2cccc(C(=O)NC(COc3ccc4[nH]c(=O)[nH]c4c3)c3cccnc3)c2=O)cc(F)c1F Show InChI InChI=1S/C27H18F3N5O4/c28-19-9-15(10-20(29)24(19)30)13-35-8-2-4-18(26(35)37)25(36)32-23(16-3-1-7-31-12-16)14-39-17-5-6-21-22(11-17)34-27(38)33-21/h1-12,23H,13-14H2,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366241 (US9873693, Compound 164) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(ccn3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C26H19F2N5O2/c27-22-6-5-16(11-23(22)28)15-33-10-2-4-20(26(33)35)25(34)32-13-18-12-17(7-9-29-18)21-14-31-24-19(21)3-1-8-30-24/h1-12,14H,13,15H2,(H,30,31)(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366242 (US9873693, Compound 165) Show SMILES [O-][n+]1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H19F2N5O3/c27-22-6-5-16(10-23(22)28)13-32-8-2-4-20(26(32)35)25(34)31-11-17-9-18(15-33(36)14-17)21-12-30-24-19(21)3-1-7-29-24/h1-10,12,14-15H,11,13H2,(H,29,30)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366243 (US9873693, Compound 166) Show SMILES Fc1cc(Cn2cccc(C(=O)NC\C=C\c3ccc4CC(=O)Nc4c3)c2=O)cc(F)c1F Show InChI InChI=1S/C24H18F3N3O3/c25-18-9-15(10-19(26)22(18)27)13-30-8-2-4-17(24(30)33)23(32)28-7-1-3-14-5-6-16-12-21(31)29-20(16)11-14/h1-6,8-11H,7,12-13H2,(H,28,32)(H,29,31)/b3-1+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366245 (US9873693, Compound 168) Show SMILES Fc1cc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)C3CC3)c2=O)cc(F)c1F |r| Show InChI InChI=1S/C25H19F3N4O4/c26-17-8-13(9-18(27)22(17)28)11-32-7-1-2-16(24(32)34)23(33)29-21(14-3-4-14)12-36-15-5-6-19-20(10-15)31-25(35)30-19/h1-2,5-10,14,21H,3-4,11-12H2,(H,29,33)/t21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366246 (US9873693, Compound 169) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCOc3ccc4[nH]c(=O)[nH]c4c3F)c2=O)cc1F Show InChI InChI=1S/C22H17F3N4O4/c23-14-4-3-12(10-15(14)24)11-29-8-1-2-13(21(29)31)20(30)26-7-9-33-17-6-5-16-19(18(17)25)28-22(32)27-16/h1-6,8,10H,7,9,11H2,(H,26,30)(H2,27,28,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366190 (US9873693, Compound 113 | US9873693, Compound 274) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCOc3ccc4[nH]c(=O)[nH]c4c3)c2=O)cc1F Show InChI InChI=1S/C22H18F2N4O4/c23-16-5-3-13(10-17(16)24)12-28-8-1-2-15(21(28)30)20(29)25-7-9-32-14-4-6-18-19(11-14)27-22(31)26-18/h1-6,8,10-11H,7,9,12H2,(H,25,29)(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366156 (US9873693, Compound 79) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)C(=O)NC3CC3)c2=O)cc1F Show InChI InChI=1S/C31H25F2N5O3/c32-26-9-6-19(12-27(26)33)17-38-10-2-5-23(31(38)41)30(40)36-14-18-3-1-4-20(11-18)25-16-35-28-24(25)13-21(15-34-28)29(39)37-22-7-8-22/h1-6,9-13,15-16,22H,7-8,14,17H2,(H,34,35)(H,36,40)(H,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366157 (US9873693, Compound 80) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)C(F)(F)F)c2=O)cc1F Show InChI InChI=1S/C28H19F5N4O2/c29-23-7-6-17(10-24(23)30)15-37-8-2-5-20(27(37)39)26(38)36-12-16-3-1-4-18(9-16)22-14-35-25-21(22)11-19(13-34-25)28(31,32)33/h1-11,13-14H,12,15H2,(H,34,35)(H,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366158 (US9873693, Compound 81) Show SMILES Oc1ccc(cc1CNC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C27H20F2N4O3/c28-22-7-5-16(11-23(22)29)15-33-10-2-4-20(27(33)36)26(35)32-13-18-12-17(6-8-24(18)34)21-14-31-25-19(21)3-1-9-30-25/h1-12,14,34H,13,15H2,(H,30,31)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366159 (US9873693, Compound 82) Show SMILES Oc1ccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc1-c1c[nH]c2ncccc12 Show InChI InChI=1S/C27H20F2N4O3/c28-22-7-5-17(12-23(22)29)15-33-10-2-4-19(27(33)36)26(35)32-13-16-6-8-24(34)20(11-16)21-14-31-25-18(21)3-1-9-30-25/h1-12,14,34H,13,15H2,(H,30,31)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366160 (US9873693, Compound 83) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(OS(=O)(=O)c4ccccc4)cc(c3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C33H24F2N4O5S/c34-29-11-10-21(16-30(29)35)20-39-13-5-9-27(33(39)41)32(40)38-18-22-14-23(28-19-37-31-26(28)8-4-12-36-31)17-24(15-22)44-45(42,43)25-6-2-1-3-7-25/h1-17,19H,18,20H2,(H,36,37)(H,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366161 (US9873693, Compound 84) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(OC4CCCCC4)cc(c3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C33H30F2N4O3/c34-29-11-10-21(16-30(29)35)20-39-13-5-9-27(33(39)41)32(40)38-18-22-14-23(28-19-37-31-26(28)8-4-12-36-31)17-25(15-22)42-24-6-2-1-3-7-24/h4-5,8-17,19,24H,1-3,6-7,18,20H2,(H,36,37)(H,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366162 (US9873693, Compound 85) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(OC4CCCC4)cc(c3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C32H28F2N4O3/c33-28-10-9-20(15-29(28)34)19-38-12-4-8-26(32(38)40)31(39)37-17-21-13-22(16-24(14-21)41-23-5-1-2-6-23)27-18-36-30-25(27)7-3-11-35-30/h3-4,7-16,18,23H,1-2,5-6,17,19H2,(H,35,36)(H,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366247 (US9873693, Compound 170) Show SMILES Fc1cc(Cn2cccc(C(=O)NC\C=C\c3ccc4[nH]c(=O)[nH]c4c3)c2=O)cc(F)c1F Show InChI InChI=1S/C23H17F3N4O3/c24-16-9-14(10-17(25)20(16)26)12-30-8-2-4-15(22(30)32)21(31)27-7-1-3-13-5-6-18-19(11-13)29-23(33)28-18/h1-6,8-11H,7,12H2,(H,27,31)(H2,28,29,33)/b3-1+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366248 (US9873693, Compound 171) Show SMILES [O-][n+]1ccc(cc1CNC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H19F2N5O3/c27-22-6-5-16(11-23(22)28)15-32-9-2-4-20(26(32)35)25(34)31-13-18-12-17(7-10-33(18)36)21-14-30-24-19(21)3-1-8-29-24/h1-12,14H,13,15H2,(H,29,30)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366196 (US9873693, Compound 119 | US9873693, Compound 276) Show SMILES Cn1c2ccc(OCCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc2[nH]c1=O Show InChI InChI=1S/C23H20F2N4O4/c1-28-20-7-5-15(12-19(20)27-23(28)32)33-10-8-26-21(30)16-3-2-9-29(22(16)31)13-14-4-6-17(24)18(25)11-14/h2-7,9,11-12H,8,10,13H2,1H3,(H,26,30)(H,27,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366202 (US9873693, Compound 125 | US9873693, Compound 277) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3nnc(o3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C23H16F2N6O3/c24-17-6-5-13(9-18(17)25)12-31-8-2-4-15(23(31)33)21(32)28-11-19-29-30-22(34-19)16-10-27-20-14(16)3-1-7-26-20/h1-10H,11-12H2,(H,26,27)(H,28,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366163 (US9873693, Compound 86) Show SMILES CN1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C33H31F2N5O3/c1-39-12-8-24(9-13-39)43-25-15-22(14-23(17-25)28-19-37-31-26(28)4-2-10-36-31)18-38-32(41)27-5-3-11-40(33(27)42)20-21-6-7-29(34)30(35)16-21/h2-7,10-11,14-17,19,24H,8-9,12-13,18,20H2,1H3,(H,36,37)(H,38,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366164 (US9873693, Compound 87) Show SMILES Cn1nc(NC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c2cc(ccc12)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C28H20F2N6O2/c1-35-24-9-7-17(21-14-32-25-18(21)4-2-10-31-25)13-20(24)26(34-35)33-27(37)19-5-3-11-36(28(19)38)15-16-6-8-22(29)23(30)12-16/h2-14H,15H2,1H3,(H,31,32)(H,33,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366165 (US9873693, Compound 88) Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C37H37F2N5O5/c1-37(2,3)49-36(47)43-14-10-26(11-15-43)48-27-17-24(16-25(19-27)30-21-41-33-28(30)6-4-12-40-33)20-42-34(45)29-7-5-13-44(35(29)46)22-23-8-9-31(38)32(39)18-23/h4-9,12-13,16-19,21,26H,10-11,14-15,20,22H2,1-3H3,(H,40,41)(H,42,45)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366166 (US9873693, Compound 89) Show SMILES CNC(=O)c1cc(c[nH]1)-c1cccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c1 Show InChI InChI=1S/C26H22F2N4O3/c1-29-25(34)23-12-19(14-30-23)18-5-2-4-16(10-18)13-31-24(33)20-6-3-9-32(26(20)35)15-17-7-8-21(27)22(28)11-17/h2-12,14,30H,13,15H2,1H3,(H,29,34)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366167 (US9873693, Compound 90) Show SMILES Oc1cnc2[nH]cc(-c3cccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)c3)c2c1 Show InChI InChI=1S/C27H20F2N4O3/c28-23-7-6-17(10-24(23)29)15-33-8-2-5-20(27(33)36)26(35)32-12-16-3-1-4-18(9-16)22-14-31-25-21(22)11-19(34)13-30-25/h1-11,13-14,34H,12,15H2,(H,30,31)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366168 (US9873693, Compound 91) Show SMILES COc1cnc2[nH]cc(-c3ccc(CNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)s3)c2c1 Show InChI InChI=1S/C26H20F2N4O3S/c1-35-16-10-19-20(13-30-24(19)29-11-16)23-7-5-17(36-23)12-31-25(33)18-3-2-8-32(26(18)34)14-15-4-6-21(27)22(28)9-15/h2-11,13H,12,14H2,1H3,(H,29,30)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366169 (US9873693, Compound 92) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3ccc(OCCN4CCOCC4)c(c3)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C33H31F2N5O4/c34-28-7-5-23(18-29(28)35)21-40-10-2-4-25(33(40)42)32(41)38-19-22-6-8-30(44-16-13-39-11-14-43-15-12-39)26(17-22)27-20-37-31-24(27)3-1-9-36-31/h1-10,17-18,20H,11-16,19,21H2,(H,36,37)(H,38,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366350 (US9873693, Compound 278) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cc(ccc3F)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C27H19F3N4O2/c28-22-8-6-17(21-14-32-25-19(21)3-1-9-31-25)12-18(22)13-33-26(35)20-4-2-10-34(27(20)36)15-16-5-7-23(29)24(30)11-16/h1-12,14H,13,15H2,(H,31,32)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366351 (US9873693, Compound 279) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCOc3cc4[nH]c(=O)[nH]c4cn3)c2=O)cc1F Show InChI InChI=1S/C21H17F2N5O4/c22-14-4-3-12(8-15(14)23)11-28-6-1-2-13(20(28)30)19(29)24-5-7-32-18-9-16-17(10-25-18)27-21(31)26-16/h1-4,6,8-10H,5,7,11H2,(H,24,29)(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366352 (US9873693, Compound 280) Show SMILES CC(C)n1c2ccc(OCCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc2[nH]c1=O Show InChI InChI=1S/C25H24F2N4O4/c1-15(2)31-22-8-6-17(13-21(22)29-25(31)34)35-11-9-28-23(32)18-4-3-10-30(24(18)33)14-16-5-7-19(26)20(27)12-16/h3-8,10,12-13,15H,9,11,14H2,1-2H3,(H,28,32)(H,29,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366170 (US9873693, Compound 93) Show SMILES CN(=O)C1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12 |(.7,-5.39,;.7,-3.85,;2.03,-3.08,;-.64,-3.08,;-1.97,-3.85,;-3.3,-3.08,;-3.3,-1.54,;-1.97,-.77,;-.64,-1.54,;-4.64,-.77,;-4.64,.77,;-3.3,1.54,;-3.3,3.08,;-1.97,3.85,;-.64,3.08,;.7,3.85,;.7,5.39,;2.03,3.08,;2.03,1.54,;3.36,.77,;4.7,1.54,;4.7,3.08,;6.03,3.85,;7.36,3.08,;7.36,1.54,;8.7,.77,;10.03,1.54,;11.37,.77,;10.03,3.08,;11.37,3.85,;8.7,3.85,;3.36,3.85,;3.36,5.39,;-4.64,3.85,;-5.97,3.08,;-5.97,1.54,;-7.31,3.85,;-7.78,5.31,;-9.32,5.31,;-9.8,3.85,;-11.2,3.22,;-11.37,1.69,;-10.12,.79,;-8.71,1.41,;-8.55,2.94,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366171 (US9873693, Compound 94) Show SMILES CS(=O)(=O)N1CCC(CC1)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C33H31F2N5O5S/c1-46(43,44)40-12-8-24(9-13-40)45-25-15-22(14-23(17-25)28-19-37-31-26(28)4-2-10-36-31)18-38-32(41)27-5-3-11-39(33(27)42)20-21-6-7-29(34)30(35)16-21/h2-7,10-11,14-17,19,24H,8-9,12-13,18,20H2,1H3,(H,36,37)(H,38,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366172 (US9873693, Compound 95) Show SMILES CCn1nc(NC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c2cc(ccc12)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C29H22F2N6O2/c1-2-37-25-10-8-18(22-15-33-26-19(22)5-3-11-32-26)14-21(25)27(35-37)34-28(38)20-6-4-12-36(29(20)39)16-17-7-9-23(30)24(31)13-17/h3-15H,2,16H2,1H3,(H,32,33)(H,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366173 (US9873693, Compound 96) Show SMILES OC(=O)Cn1nc(NC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)c2cc(ccc12)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C29H20F2N6O4/c30-22-7-5-16(11-23(22)31)14-36-10-2-4-19(29(36)41)28(40)34-27-20-12-17(6-8-24(20)37(35-27)15-25(38)39)21-13-33-26-18(21)3-1-9-32-26/h1-13H,14-15H2,(H,32,33)(H,38,39)(H,34,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366174 (US9873693, Compound 97) Show SMILES Nc1ncccc1-c1ccc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)s1 Show InChI InChI=1S/C23H18F2N4O2S/c24-18-7-5-14(11-19(18)25)13-29-10-2-4-17(23(29)31)22(30)28-12-15-6-8-20(32-15)16-3-1-9-27-21(16)26/h1-11H,12-13H2,(H2,26,27)(H,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366175 (US9873693, Compound 98) Show SMILES CC(C)Oc1cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)cc(c1)-c1c[nH]c2ncc(F)cc12 Show InChI InChI=1S/C30H25F3N4O3/c1-17(2)40-22-9-19(8-20(11-22)25-15-35-28-24(25)12-21(31)14-34-28)13-36-29(38)23-4-3-7-37(30(23)39)16-18-5-6-26(32)27(33)10-18/h3-12,14-15,17H,13,16H2,1-2H3,(H,34,35)(H,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366249 (US9873693, Compound 172) Show SMILES OC(=O)c1cc(cc(CNC(=O)c2cccn(Cc3ccc(F)c(F)c3)c2=O)n1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C27H19F2N5O4/c28-21-6-5-15(9-22(21)29)14-34-8-2-4-19(26(34)36)25(35)32-12-17-10-16(11-23(33-17)27(37)38)20-13-31-24-18(20)3-1-7-30-24/h1-11,13H,12,14H2,(H,30,31)(H,32,35)(H,37,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366250 (US9873693, Compound 173) Show SMILES C[C@H](COc1ccc2[nH]c(=O)[nH]c2c1)NC(=O)c1cccn(Cc2cc(F)c(F)c(F)c2)c1=O |r| Show InChI InChI=1S/C23H17F3N4O4/c1-12(11-34-14-4-5-18-19(9-14)29-23(33)28-18)27-21(31)15-3-2-6-30(22(15)32)10-13-7-16(24)20(26)17(25)8-13/h2-9,12H,10-11H2,1H3,(H,27,31)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366251 (US9873693, Compound 174) Show SMILES Fc1cc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc(F)c1F |r| Show InChI InChI=1S/C28H19F3N4O4/c29-20-11-16(12-21(30)25(20)31)14-35-10-4-7-19(27(35)37)26(36)32-24(17-5-2-1-3-6-17)15-39-18-8-9-22-23(13-18)34-28(38)33-22/h1-13,24H,14-15H2,(H,32,36)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366119 (US9873693, Compound 245 | US9873693, Compound 42) Show SMILES Fc1ccc(Cn2cccc(C(=O)Nc3n[nH]c4ccc(cc34)-c3c[nH]c4ncccc34)c2=O)cc1F Show InChI InChI=1S/C27H18F2N6O2/c28-21-7-5-15(11-22(21)29)14-35-10-2-4-18(27(35)37)26(36)32-25-19-12-16(6-8-23(19)33-34-25)20-13-31-24-17(20)3-1-9-30-24/h1-13H,14H2,(H,30,31)(H2,32,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366120 (US9873693, Compound 246 | US9873693, Compound 43) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3nnn[nH]3)c2=O)cc1F Show InChI InChI=1S/C28H20F2N8O2/c29-23-7-6-17(10-24(23)30)15-38-8-2-5-20(28(38)40)27(39)33-12-16-3-1-4-18(9-16)22-14-32-26-21(22)11-19(13-31-26)25-34-36-37-35-25/h1-11,13-14H,12,15H2,(H,31,32)(H,33,39)(H,34,35,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366121 (US9873693, Compound 44) Show SMILES Fc1ccc(Cn2cccc(NC(=O)Cc3cccc(c3)C3CNc4ncccc34)c2=O)cc1F Show InChI InChI=1S/C27H22F2N4O2/c28-22-9-8-18(13-23(22)29)16-33-11-3-7-24(27(33)35)32-25(34)14-17-4-1-5-19(12-17)21-15-31-26-20(21)6-2-10-30-26/h1-13,21H,14-16H2,(H,30,31)(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366122 (US9873693, Compound 330 | US9873693, Compound 45) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(Br)cc34)c2=O)cc1F Show InChI InChI=1S/C27H19BrF2N4O2/c28-19-11-21-22(14-32-25(21)31-13-19)18-4-1-3-16(9-18)12-33-26(35)20-5-2-8-34(27(20)36)15-17-6-7-23(29)24(30)10-17/h1-11,13-14H,12,15H2,(H,31,32)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366123 (US9873693, Compound 331 | US9873693, Compound 46) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccsc3)c2=O)cc1F Show InChI InChI=1S/C31H22F2N4O2S/c32-27-7-6-20(12-28(27)33)17-37-9-2-5-24(31(37)39)30(38)36-14-19-3-1-4-21(11-19)26-16-35-29-25(26)13-23(15-34-29)22-8-10-40-18-22/h1-13,15-16,18H,14,17H2,(H,34,35)(H,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366124 (US9873693, Compound 332 | US9873693, Compound 47) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3cccnc3)c2=O)cc1F Show InChI InChI=1S/C32H23F2N5O2/c33-28-9-8-21(13-29(28)34)19-39-11-3-7-25(32(39)41)31(40)38-15-20-4-1-5-22(12-20)27-18-37-30-26(27)14-24(17-36-30)23-6-2-10-35-16-23/h1-14,16-18H,15,19H2,(H,36,37)(H,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 [51-360] (Homo sapiens (Human))	BDBM366125 (US9873693, Compound 333 | US9873693, Compound 48) Show SMILES Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3ccncc3)c2=O)cc1F Show InChI InChI=1S/C32H23F2N5O2/c33-28-7-6-21(14-29(28)34)19-39-12-2-5-25(32(39)41)31(40)38-16-20-3-1-4-23(13-20)27-18-37-30-26(27)15-24(17-36-30)22-8-10-35-11-9-22/h1-15,17-18H,16,19H2,(H,36,37)(H,38,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...				J Med Chem 51: 68-76 (2008) BindingDB Entry DOI: 10.7270/Q2H41TRT
					More data for this Ligand-Target Pair

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