Found 42 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50043770 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446091
(CHEMBL3108867)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)cc1Cl Show InChI InChI=1S/C17H13Cl2N3O3S2/c18-14-6-1-11(9-15(14)19)10-16(23)21-12-2-4-13(5-3-12)27(24,25)22-17-20-7-8-26-17/h1-9H,10H2,(H,20,22)(H,21,23) | UniProtKB/SwissProt
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446089
(CHEMBL3108869)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl Show InChI InChI=1S/C16H12Cl2N4O3S2/c17-13-6-1-10(7-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446090
(CHEMBL3108868)Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)cc1Cl Show InChI InChI=1S/C17H13ClFN3O3S2/c18-14-9-11(1-6-15(14)19)10-16(23)21-12-2-4-13(5-3-12)27(24,25)22-17-20-7-8-26-17/h1-9H,10H2,(H,20,22)(H,21,23) | UniProtKB/SwissProt
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| CHEMBL
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446100
(CHEMBL3108858)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccon2)cc1Cl Show InChI InChI=1S/C17H13Cl2N3O4S/c18-14-6-1-11(9-15(14)19)10-17(23)20-12-2-4-13(5-3-12)27(24,25)22-16-7-8-26-21-16/h1-9H,10H2,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446088
(CHEMBL3108870)Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl Show InChI InChI=1S/C16H12ClFN4O3S2/c17-13-7-10(1-6-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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| n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446129
(CHEMBL1394402)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446095
(CHEMBL3108863)Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)cc1 Show InChI InChI=1S/C21H16Cl2N2O5S/c22-18-10-1-13(11-19(18)23)12-20(26)24-15-6-8-17(9-7-15)31(29,30)25-16-4-2-14(3-5-16)21(27)28/h1-11,25H,12H2,(H,24,26)(H,27,28) | UniProtKB/SwissProt
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| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446111
(CHEMBL3108848)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(F)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C18H15ClFN3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-16(20)15(19)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446102
(CHEMBL3108856)Show SMILES OS(=O)(=O)c1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C14H11Cl2NO4S/c15-12-6-1-9(7-13(12)16)8-14(18)17-10-2-4-11(5-3-10)22(19,20)21/h1-7H,8H2,(H,17,18)(H,19,20,21) | UniProtKB/SwissProt
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National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446097
(CHEMBL3108861)Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1 Show InChI InChI=1S/C21H16Cl2N2O5S/c22-18-9-4-13(10-19(18)23)11-20(26)24-15-5-7-17(8-6-15)31(29,30)25-16-3-1-2-14(12-16)21(27)28/h1-10,12,25H,11H2,(H,24,26)(H,27,28) | UniProtKB/SwissProt
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| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446112
(CHEMBL3108847)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(F)c3)cc2)no1 Show InChI InChI=1S/C18H15ClFN3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446099
(CHEMBL3108859)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccn[nH]2)cc1Cl Show InChI InChI=1S/C17H14Cl2N4O3S/c18-14-6-1-11(9-15(14)19)10-17(24)21-12-2-4-13(5-3-12)27(25,26)23-16-7-8-20-22-16/h1-9H,10H2,(H,21,24)(H2,20,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446094
(CHEMBL3108864)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cncnc2)cc1Cl Show InChI InChI=1S/C18H14Cl2N4O3S/c19-16-6-1-12(7-17(16)20)8-18(25)23-13-2-4-15(5-3-13)28(26,27)24-14-9-21-11-22-10-14/h1-7,9-11,24H,8H2,(H,23,25) | UniProtKB/SwissProt
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| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446113
(CHEMBL3108846)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(c3)C(F)(F)F)cc2)no1 Show InChI InChI=1S/C19H15ClF3N3O4S/c1-11-8-17(25-30-11)26-31(28,29)14-5-3-13(4-6-14)24-18(27)10-12-2-7-16(20)15(9-12)19(21,22)23/h2-9H,10H2,1H3,(H,24,27)(H,25,26) | UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446098
(CHEMBL3108860)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)n(C)n1 Show InChI InChI=1S/C19H18Cl2N4O3S/c1-12-9-18(25(2)23-12)24-29(27,28)15-6-4-14(5-7-15)22-19(26)11-13-3-8-16(20)17(21)10-13/h3-10,24H,11H2,1-2H3,(H,22,26) | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446124
(CHEMBL3108835)Show SMILES CN(C(=O)Cc1ccc(Cl)c(Cl)c1)c1ccc(cc1)S(=O)(=O)Nc1cc(C)on1 Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-9-18(22-28-12)23-29(26,27)15-6-4-14(5-7-15)24(2)19(25)11-13-3-8-16(20)17(21)10-13/h3-10H,11H2,1-2H3,(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446115
(CHEMBL3108844)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)cc3)cc2)no1 Show InChI InChI=1S/C18H16ClN3O4S/c1-12-10-17(21-26-12)22-27(24,25)16-8-6-15(7-9-16)20-18(23)11-13-2-4-14(19)5-3-13/h2-10H,11H2,1H3,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446093
(CHEMBL3108865)Show SMILES Oc1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1 Show InChI InChI=1S/C20H16Cl2N2O4S/c21-18-9-4-13(10-19(18)22)11-20(26)23-14-5-7-17(8-6-14)29(27,28)24-15-2-1-3-16(25)12-15/h1-10,12,24-25H,11H2,(H,23,26) | UniProtKB/SwissProt
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PubMed
| n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446106
(CHEMBL3108852)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc4ccccc4c3)cc2)no1 Show InChI InChI=1S/C22H19N3O4S/c1-15-12-21(24-29-15)25-30(27,28)20-10-8-19(9-11-20)23-22(26)14-16-6-7-17-4-2-3-5-18(17)13-16/h2-13H,14H2,1H3,(H,23,26)(H,24,25) | UniProtKB/SwissProt
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| n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446120
(CHEMBL3108839)Show SMILES CN(c1cc(C)on1)S(=O)(=O)c1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-9-18(23-28-12)24(2)29(26,27)15-6-4-14(5-7-15)22-19(25)11-13-3-8-16(20)17(21)10-13/h3-10H,11H2,1-2H3,(H,22,25) | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446116
(CHEMBL3108843)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3cccc(Cl)c3)cc2)no1 Show InChI InChI=1S/C18H16ClN3O4S/c1-12-9-17(21-26-12)22-27(24,25)16-7-5-15(6-8-16)20-18(23)11-13-3-2-4-14(19)10-13/h2-10H,11H2,1H3,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446122
(CHEMBL3108837)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(cc2)C(=O)NCc2ccc(Cl)c(Cl)c2)no1 Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)18(24)21-10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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UniChem
| Article
PubMed
| n/a | n/a | 2.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446118
(CHEMBL3108841)Show SMILES Cc1cc(NS(=O)(=O)Cc2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-8-18(23-28-12)24-29(26,27)11-13-2-5-15(6-3-13)22-19(25)10-14-4-7-16(20)17(21)9-14/h2-9H,10-11H2,1H3,(H,22,25)(H,23,24) | UniProtKB/SwissProt
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| n/a | n/a | 3.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446110
(CHEMBL3108849)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(C)c(F)c3)cc2)no1 Show InChI InChI=1S/C19H18FN3O4S/c1-12-3-4-14(10-17(12)20)11-19(24)21-15-5-7-16(8-6-15)28(25,26)23-18-9-13(2)27-22-18/h3-10H,11H2,1-2H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446109
(CHEMBL3108850)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(C)c(C)c3)cc2)no1 Show InChI InChI=1S/C20H21N3O4S/c1-13-4-5-16(10-14(13)2)12-20(24)21-17-6-8-18(9-7-17)28(25,26)23-19-11-15(3)27-22-19/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446104
(CHEMBL3108854)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)CCc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-10-18(23-28-12)24-29(26,27)15-6-4-14(5-7-15)22-19(25)9-3-13-2-8-16(20)17(21)11-13/h2,4-8,10-11H,3,9H2,1H3,(H,22,25)(H,23,24) | UniProtKB/SwissProt
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| n/a | n/a | 6.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446092
(CHEMBL3108866)Show SMILES CN(C)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1 Show InChI InChI=1S/C22H21Cl2N3O3S/c1-27(2)18-5-3-4-17(14-18)26-31(29,30)19-9-7-16(8-10-19)25-22(28)13-15-6-11-20(23)21(24)12-15/h3-12,14,26H,13H2,1-2H3,(H,25,28) | UniProtKB/SwissProt
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| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446127
(CHEMBL3108832)Show SMILES Cc1cc(NS(=O)(=O)C2CCN(CC2)C(=O)Cc2ccc(Cl)c(Cl)c2)no1 Show InChI InChI=1S/C17H19Cl2N3O4S/c1-11-8-16(20-26-11)21-27(24,25)13-4-6-22(7-5-13)17(23)10-12-2-3-14(18)15(19)9-12/h2-3,8-9,13H,4-7,10H2,1H3,(H,20,21) | UniProtKB/SwissProt
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| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446114
(CHEMBL3108845)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)cc3Cl)cc2)no1 Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)15-6-4-14(5-7-15)21-18(24)9-12-2-3-13(19)10-16(12)20/h2-8,10H,9H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446101
(CHEMBL3108857)Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccccc2)cc1Cl Show InChI InChI=1S/C20H16Cl2N2O3S/c21-18-11-6-14(12-19(18)22)13-20(25)23-15-7-9-17(10-8-15)28(26,27)24-16-4-2-1-3-5-16/h1-12,24H,13H2,(H,23,25) | UniProtKB/SwissProt
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| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446128
(CHEMBL3108831)Show SMILES Cc1cc(NS(=O)(=O)c2cccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)c2)no1 Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-7-17(22-27-11)23-28(25,26)14-4-2-3-13(10-14)21-18(24)9-12-5-6-15(19)16(20)8-12/h2-8,10H,9H2,1H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446126
(CHEMBL3108833)Show SMILES Cc1cc(NS(=O)(=O)CCNC(=O)Cc2ccc(Cl)c(Cl)c2)no1 Show InChI InChI=1S/C14H15Cl2N3O4S/c1-9-6-13(18-23-9)19-24(21,22)5-4-17-14(20)8-10-2-3-11(15)12(16)7-10/h2-3,6-7H,4-5,8H2,1H3,(H,17,20)(H,18,19) | UniProtKB/SwissProt
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| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446123
(CHEMBL3108836)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NCCc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C18H17Cl2N3O3S/c1-12-10-18(22-26-12)23-27(24,25)15-5-3-14(4-6-15)21-9-8-13-2-7-16(19)17(20)11-13/h2-7,10-11,21H,8-9H2,1H3,(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446117
(CHEMBL3108842)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)no1 Show InChI InChI=1S/C18H17N3O4S/c1-13-11-17(20-25-13)21-26(23,24)16-9-7-15(8-10-16)19-18(22)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,19,22)(H,20,21) | UniProtKB/SwissProt
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| n/a | n/a | 2.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446108
(CHEMBL3108851)Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cc(C)on2)cc1C Show InChI InChI=1S/C20H21N3O5S/c1-13-10-15(4-9-18(13)27-3)12-20(24)21-16-5-7-17(8-6-16)29(25,26)23-19-11-14(2)28-22-19/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 2.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446105
(CHEMBL3108853)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C17H13Cl2N3O4S/c1-10-8-16(21-26-10)22-27(24,25)13-5-3-12(4-6-13)20-17(23)11-2-7-14(18)15(19)9-11/h2-9H,1H3,(H,20,23)(H,21,22) | UniProtKB/SwissProt
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National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446103
(CHEMBL3108855)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)C(C)(C)c3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C20H19Cl2N3O4S/c1-12-10-18(24-29-12)25-30(27,28)15-7-5-14(6-8-15)23-19(26)20(2,3)13-4-9-16(21)17(22)11-13/h4-11H,1-3H3,(H,23,26)(H,24,25) | UniProtKB/SwissProt
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| n/a | n/a | 3.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446121
(CHEMBL3108838)Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C17H15Cl2N3O5S2/c1-11-8-17(20-27-11)22-29(25,26)14-5-3-13(4-6-14)21-28(23,24)10-12-2-7-15(18)16(19)9-12/h2-9,21H,10H2,1H3,(H,20,22) | UniProtKB/SwissProt
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| n/a | n/a | >5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446119
(CHEMBL3108840)Show SMILES Cc1cc(NC(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1 Show InChI InChI=1S/C19H15Cl2N3O3/c1-11-8-17(24-27-11)23-19(26)13-3-5-14(6-4-13)22-18(25)10-12-2-7-15(20)16(21)9-12/h2-9H,10H2,1H3,(H,22,25)(H,23,24,26) | UniProtKB/SwissProt
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National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446107
(CHEMBL1873990)Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cc(C)on2)cc1OC Show InChI InChI=1S/C20H21N3O6S/c1-13-10-19(22-29-13)23-30(25,26)16-7-5-15(6-8-16)21-20(24)12-14-4-9-17(27-2)18(11-14)28-3/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | >5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446125
(CHEMBL3108834)Show SMILES Cc1cc(NC(=O)c2csc(NC(=O)Cc3ccc(Cl)c(Cl)c3)n2)no1 Show InChI InChI=1S/C16H12Cl2N4O3S/c1-8-4-13(22-25-8)20-15(24)12-7-26-16(19-12)21-14(23)6-9-2-3-10(17)11(18)5-9/h2-5,7H,6H2,1H3,(H,19,21,23)(H,20,22,24) | UniProtKB/SwissProt
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| n/a | n/a | >5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
ATP-dependent 6-phosphofructokinase
(Trypanosoma cruzi) | BDBM50446096
(CHEMBL3108862)Show SMILES CCOC(=O)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1 Show InChI InChI=1S/C23H20Cl2N2O5S/c1-2-32-23(29)16-4-3-5-18(14-16)27-33(30,31)19-9-7-17(8-10-19)26-22(28)13-15-6-11-20(24)21(25)12-15/h3-12,14,27H,2,13H2,1H3,(H,26,28) | UniProtKB/SwissProt
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| n/a | n/a | >5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description
Inhibition of Trypanosoma cruzi PFK |
ACS Med Chem Lett 5: 12-7 (2014)
Article DOI: 10.1021/ml400259d
BindingDB Entry DOI: 10.7270/Q2X34ZX7 |
More data for this
Ligand-Target Pair | |
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