Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50396483 (PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50146588 (CHEMBL3764145) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50146590 (CHEMBL3765068) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50146591 (CHEMBL3763692) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50146587 (CHEMBL3764571) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM50146589 (CHEMBL3765683) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description Inhibition of wild-type B-Raf (unknown origin) using MEK1 K97M as substrate preincubated for 90 mins followed by substrate addition measured after 1 ... | Eur J Med Chem 108: 623-43 (2016) Article DOI: 10.1016/j.ejmech.2015.12.001 BindingDB Entry DOI: 10.7270/Q2Z60QX5 | |||||||||||
More data for this Ligand-Target Pair |