Compile Data Set for Download or QSAR

Found 60 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 6607   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM141387 (US8921319, 3) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4cccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)c4)cc3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-19-17-34(18-20-38)28-50-44(55)39-22-30-9-13-32(14-10-30)26-48-41(53)24-36-7-4-8-37(21-36)25-42(54)49-27-33-15-11-31(12-16-33)23-40(45(56)51-39)52-59(57,58)29-35-5-2-1-3-6-35/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM141391 (US8921319, 15) Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CN3CCN(CC3)CC(=O)Nc3ccc(C[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N1)cc3)cc2 |r,wU:28.29,wD:3.2,(3.08,3.56,;1.6,3.96,;1.2,5.44,;.51,2.87,;.91,1.38,;2.39,.98,;2.79,-.51,;4.28,-.9,;5.37,.18,;6.86,-.21,;7.58,-1.48,;9.07,-1.08,;6.81,-2.82,;5.55,-3.27,;4.22,-2.5,;2.89,-3.27,;2.89,-4.81,;4.22,-5.58,;5.55,-4.81,;1.4,-5.21,;.31,-4.12,;-1.02,-4.89,;.31,-2.58,;-.29,-.85,;-1.62,-1.62,;-2.96,-.85,;-2.96,.69,;-4.05,1.78,;-3.65,3.27,;-4.98,4.04,;-6.32,3.27,;-6.71,4.75,;-4.73,2.84,;-7.74,2.45,;-7.74,.91,;-9.07,.14,;-9.07,-1.4,;-7.74,-2.17,;-6.4,-1.4,;-6.4,.14,;-2.31,4.04,;-2.31,5.58,;-.98,3.27,;-1.62,1.46,;-.29,.69,;4.97,1.67,;3.48,2.07,)| Show InChI InChI=1S/C33H38N6O7S/c40-30-20-38-14-16-39(17-15-38)21-31(41)35-27-12-8-24(9-13-27)19-29(33(43)44)36-32(42)28(18-23-6-10-26(34-30)11-7-23)37-47(45,46)22-25-4-2-1-3-5-25/h1-13,28-29,37H,14-22H2,(H,34,40)(H,35,41)(H,36,42)(H,43,44)/t28-,29+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.680	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380617 (CHEMBL2016873) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)c4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-11-9-22(10-12-26)16-36-32(45)29-14-27-19-43(41-38-27)17-24-7-4-8-25(13-24)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-23-5-2-1-3-6-23/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	0.770	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380623 (CHEMBL2016870) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4cccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-17-15-30(16-18-38)26-50-44(55)39-22-32-9-5-13-36(20-32)27-48-41(53)24-34-11-4-12-35(19-34)25-42(54)49-28-37-14-6-10-33(21-37)23-40(45(56)51-39)52-59(57,58)29-31-7-2-1-3-8-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380625 (CHEMBL2016872) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r| Show InChI InChI=1S/C37H41N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-3,6-19,33-34,42H,4-5,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/t33-,34+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380626 (CHEMBL2016874) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)n4)nn3)cc1 |r| Show InChI InChI=1S/C32H34N12O4S/c33-30(34)23-11-9-21(10-12-23)15-35-31(45)28-13-26-18-43(41-38-26)16-24-7-4-8-25(36-24)17-44-19-27(39-42-44)14-29(32(46)37-28)40-49(47,48)20-22-5-2-1-3-6-22/h1-12,18-19,28-29,40H,13-17,20H2,(H3,33,34)(H,35,45)(H,37,46)/t28-,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380617 (CHEMBL2016873) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)c4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-11-9-22(10-12-26)16-36-32(45)29-14-27-19-43(41-38-27)17-24-7-4-8-25(13-24)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-23-5-2-1-3-6-23/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	2.40	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM141389 (US8921319, 10) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OC\C=C/COc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,c:19| Show InChI InChI=1S/C37H39N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-19,33-34,42H,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/b5-4-/t33-,34+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380616 (CHEMBL2016869) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r,wU:11.10,wD:40.41,(10.73,-8.05,;9.41,-8.84,;9.42,-10.38,;8.06,-8.08,;6.74,-8.86,;5.4,-8.11,;5.39,-6.57,;4.05,-5.81,;4.03,-4.27,;2.69,-3.51,;1.36,-4.3,;2.68,-1.97,;4,-1.18,;3.98,.36,;2.63,1.11,;2.61,2.65,;3.94,3.43,;5.27,2.67,;6.6,3.46,;6.58,5,;7.91,5.78,;9.25,5.02,;7.89,7.32,;6.55,8.08,;5.22,7.29,;3.88,8.05,;3.87,9.59,;5.19,10.38,;6.53,9.62,;2.53,10.35,;1.21,9.57,;-.13,10.33,;1.22,8.03,;-.11,7.25,;-.09,5.71,;1.25,4.94,;1.26,3.4,;-.07,2.63,;-1.41,3.4,;-2.73,2.62,;-2.73,1.08,;-4.06,.3,;-5.39,1.07,;-6.17,2.41,;-4.63,2.41,;-6.72,.29,;-8.06,1.05,;-8.06,2.59,;-9.4,3.35,;-10.73,2.58,;-10.72,1.03,;-9.38,.27,;-1.39,.32,;-.06,1.09,;-1.38,-1.22,;-1.42,4.93,;5.3,1.14,;6.7,-5.78,;8.04,-6.53,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-14-12-30(13-15-36)24-48-42(55)37-22-32-8-4-10-34(20-32)25-46-39(53)27-51-16-18-52(19-17-51)28-40(54)47-26-35-11-5-9-33(21-35)23-38(43(56)49-37)50-59(57,58)29-31-6-2-1-3-7-31/h1-15,20-21,37-38,50H,16-19,22-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	4.90	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM141392 (US8921319, 14) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4ccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)cc4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-12-10-22(11-13-26)16-36-32(45)29-14-27-19-43(41-38-27)17-23-6-8-24(9-7-23)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-25-4-2-1-3-5-25/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.40	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380618 (CHEMBL2016868) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)cc4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-18-16-32(17-19-38)26-50-44(55)39-22-34-8-4-10-36(20-34)27-48-41(53)24-30-12-14-31(15-13-30)25-42(54)49-28-37-11-5-9-35(21-37)23-40(45(56)51-39)52-59(57,58)29-33-6-2-1-3-7-33/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	6.90	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141388 (US8921319, 7) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccccc4CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)36-18-16-30(17-19-36)26-50-44(55)39-22-32-10-6-12-34(20-32)27-48-41(53)24-37-14-4-5-15-38(37)25-42(54)49-28-35-13-7-11-33(21-35)23-40(45(56)51-39)52-59(57,58)29-31-8-2-1-3-9-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.90	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380622 (CHEMBL2016867) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,wU:11.10,wD:38.39,(24.36,-25.86,;24.33,-24.32,;25.66,-23.53,;22.99,-23.57,;21.66,-24.36,;20.32,-23.61,;20.31,-22.07,;18.96,-21.31,;18.94,-19.77,;17.6,-19.02,;16.28,-19.81,;17.58,-17.48,;18.91,-16.7,;18.89,-15.16,;17.55,-14.4,;17.54,-12.86,;18.87,-12.08,;18.86,-10.54,;17.52,-9.78,;17.5,-8.24,;18.83,-7.46,;16.16,-7.48,;14.84,-8.27,;14.85,-9.81,;13.52,-10.58,;12.18,-9.82,;12.17,-8.29,;13.49,-7.5,;10.85,-10.59,;9.51,-9.83,;9.5,-8.29,;8.19,-10.61,;8.2,-12.15,;9.53,-12.91,;10.87,-12.14,;12.2,-12.9,;12.2,-14.43,;13.54,-15.2,;13.55,-16.74,;12.22,-17.51,;12.23,-19.05,;13.71,-18.64,;13.32,-20.13,;10.9,-19.83,;10.9,-21.37,;9.58,-22.14,;9.58,-23.68,;10.92,-24.44,;12.26,-23.66,;12.24,-22.12,;14.89,-17.5,;14.89,-19.04,;16.22,-16.72,;10.88,-15.22,;9.55,-14.46,;20.21,-12.83,;20.22,-14.37,;21.62,-21.28,;22.97,-22.02,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-16-14-34(15-17-36)26-48-42(55)37-22-30-6-10-32(11-7-30)24-46-39(53)27-51-18-20-52(21-19-51)28-40(54)47-25-33-12-8-31(9-13-33)23-38(43(56)49-37)50-59(57,58)29-35-4-2-1-3-5-35/h1-17,37-38,50H,18-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380616 (CHEMBL2016869) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r,wU:11.10,wD:40.41,(10.73,-8.05,;9.41,-8.84,;9.42,-10.38,;8.06,-8.08,;6.74,-8.86,;5.4,-8.11,;5.39,-6.57,;4.05,-5.81,;4.03,-4.27,;2.69,-3.51,;1.36,-4.3,;2.68,-1.97,;4,-1.18,;3.98,.36,;2.63,1.11,;2.61,2.65,;3.94,3.43,;5.27,2.67,;6.6,3.46,;6.58,5,;7.91,5.78,;9.25,5.02,;7.89,7.32,;6.55,8.08,;5.22,7.29,;3.88,8.05,;3.87,9.59,;5.19,10.38,;6.53,9.62,;2.53,10.35,;1.21,9.57,;-.13,10.33,;1.22,8.03,;-.11,7.25,;-.09,5.71,;1.25,4.94,;1.26,3.4,;-.07,2.63,;-1.41,3.4,;-2.73,2.62,;-2.73,1.08,;-4.06,.3,;-5.39,1.07,;-6.17,2.41,;-4.63,2.41,;-6.72,.29,;-8.06,1.05,;-8.06,2.59,;-9.4,3.35,;-10.73,2.58,;-10.72,1.03,;-9.38,.27,;-1.39,.32,;-.06,1.09,;-1.38,-1.22,;-1.42,4.93,;5.3,1.14,;6.7,-5.78,;8.04,-6.53,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-14-12-30(13-15-36)24-48-42(55)37-22-32-8-4-10-34(20-32)25-46-39(53)27-51-16-18-52(19-17-51)28-40(54)47-26-35-11-5-9-33(21-35)23-38(43(56)49-37)50-59(57,58)29-31-6-2-1-3-7-31/h1-15,20-21,37-38,50H,16-19,22-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	9.10	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141389 (US8921319, 10) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OC\C=C/COc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,c:19| Show InChI InChI=1S/C37H39N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-19,33-34,42H,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/b5-4-/t33-,34+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	9.40	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380621 (CHEMBL2016864) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4ccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)cc4)cc3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-20-18-36(19-21-38)28-50-44(55)39-22-30-10-14-34(15-11-30)26-48-41(53)24-32-6-8-33(9-7-32)25-42(54)49-27-35-16-12-31(13-17-35)23-40(45(56)51-39)52-59(57,58)29-37-4-2-1-3-5-37/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	9.40	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380626 (CHEMBL2016874) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)n4)nn3)cc1 |r| Show InChI InChI=1S/C32H34N12O4S/c33-30(34)23-11-9-21(10-12-23)15-35-31(45)28-13-26-18-43(41-38-26)16-24-7-4-8-25(36-24)17-44-19-27(39-42-44)14-29(32(46)37-28)40-49(47,48)20-22-5-2-1-3-6-22/h1-12,18-19,28-29,40H,13-17,20H2,(H3,33,34)(H,35,45)(H,37,46)/t28-,29+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	10.1	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141392 (US8921319, 14) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4ccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)cc4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-12-10-22(11-13-26)16-36-32(45)29-14-27-19-43(41-38-27)17-23-6-8-24(9-7-23)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-25-4-2-1-3-5-25/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380623 (CHEMBL2016870) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4cccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-17-15-30(16-18-38)26-50-44(55)39-22-32-9-5-13-36(20-32)27-48-41(53)24-34-11-4-12-35(19-34)25-42(54)49-28-37-14-6-10-33(21-37)23-40(45(56)51-39)52-59(57,58)29-31-7-2-1-3-8-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	17.4	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141390 (US8921319, 12) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1 |r| Show InChI InChI=1S/C35H43N7O6S/c36-31(37)26-17-15-24(16-18-26)22-40-34(45)29-13-4-6-19-38-32(43)27-11-8-12-28(21-27)33(44)39-20-7-5-14-30(35(46)41-29)42-49(47,48)23-25-9-2-1-3-10-25/h1-3,8-12,15-18,21,29-30,42H,4-7,13-14,19-20,22-23H2,(H3,36,37)(H,38,43)(H,39,44)(H,40,45)(H,41,46)/t29-,30+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	18	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM141388 (US8921319, 7) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccccc4CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)36-18-16-30(17-19-36)26-50-44(55)39-22-32-10-6-12-34(20-32)27-48-41(53)24-37-14-4-5-15-38(37)25-42(54)49-28-35-13-7-11-33(21-35)23-40(45(56)51-39)52-59(57,58)29-31-8-2-1-3-9-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	20.3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380620 (CHEMBL2016866) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCC(=O)NCc3cccc(CNC(=O)CC[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N2)c3)cc1 |r| Show InChI InChI=1S/C33H39N7O6S/c34-31(35)26-11-9-22(10-12-26)18-38-32(43)27-13-15-29(41)36-19-24-7-4-8-25(17-24)20-37-30(42)16-14-28(33(44)39-27)40-47(45,46)21-23-5-2-1-3-6-23/h1-12,17,27-28,40H,13-16,18-21H2,(H3,34,35)(H,36,41)(H,37,42)(H,38,43)(H,39,44)/t27-,28+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	25	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380616 (CHEMBL2016869) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r,wU:11.10,wD:40.41,(10.73,-8.05,;9.41,-8.84,;9.42,-10.38,;8.06,-8.08,;6.74,-8.86,;5.4,-8.11,;5.39,-6.57,;4.05,-5.81,;4.03,-4.27,;2.69,-3.51,;1.36,-4.3,;2.68,-1.97,;4,-1.18,;3.98,.36,;2.63,1.11,;2.61,2.65,;3.94,3.43,;5.27,2.67,;6.6,3.46,;6.58,5,;7.91,5.78,;9.25,5.02,;7.89,7.32,;6.55,8.08,;5.22,7.29,;3.88,8.05,;3.87,9.59,;5.19,10.38,;6.53,9.62,;2.53,10.35,;1.21,9.57,;-.13,10.33,;1.22,8.03,;-.11,7.25,;-.09,5.71,;1.25,4.94,;1.26,3.4,;-.07,2.63,;-1.41,3.4,;-2.73,2.62,;-2.73,1.08,;-4.06,.3,;-5.39,1.07,;-6.17,2.41,;-4.63,2.41,;-6.72,.29,;-8.06,1.05,;-8.06,2.59,;-9.4,3.35,;-10.73,2.58,;-10.72,1.03,;-9.38,.27,;-1.39,.32,;-.06,1.09,;-1.38,-1.22,;-1.42,4.93,;5.3,1.14,;6.7,-5.78,;8.04,-6.53,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-14-12-30(13-15-36)24-48-42(55)37-22-32-8-4-10-34(20-32)25-46-39(53)27-51-16-18-52(19-17-51)28-40(54)47-26-35-11-5-9-33(21-35)23-38(43(56)49-37)50-59(57,58)29-31-6-2-1-3-7-31/h1-15,20-21,37-38,50H,16-19,22-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	26.3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380623 (CHEMBL2016870) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4cccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-17-15-30(16-18-38)26-50-44(55)39-22-32-9-5-13-36(20-32)27-48-41(53)24-34-11-4-12-35(19-34)25-42(54)49-28-37-14-6-10-33(21-37)23-40(45(56)51-39)52-59(57,58)29-31-7-2-1-3-8-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	26.8	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380616 (CHEMBL2016869) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r,wU:11.10,wD:40.41,(10.73,-8.05,;9.41,-8.84,;9.42,-10.38,;8.06,-8.08,;6.74,-8.86,;5.4,-8.11,;5.39,-6.57,;4.05,-5.81,;4.03,-4.27,;2.69,-3.51,;1.36,-4.3,;2.68,-1.97,;4,-1.18,;3.98,.36,;2.63,1.11,;2.61,2.65,;3.94,3.43,;5.27,2.67,;6.6,3.46,;6.58,5,;7.91,5.78,;9.25,5.02,;7.89,7.32,;6.55,8.08,;5.22,7.29,;3.88,8.05,;3.87,9.59,;5.19,10.38,;6.53,9.62,;2.53,10.35,;1.21,9.57,;-.13,10.33,;1.22,8.03,;-.11,7.25,;-.09,5.71,;1.25,4.94,;1.26,3.4,;-.07,2.63,;-1.41,3.4,;-2.73,2.62,;-2.73,1.08,;-4.06,.3,;-5.39,1.07,;-6.17,2.41,;-4.63,2.41,;-6.72,.29,;-8.06,1.05,;-8.06,2.59,;-9.4,3.35,;-10.73,2.58,;-10.72,1.03,;-9.38,.27,;-1.39,.32,;-.06,1.09,;-1.38,-1.22,;-1.42,4.93,;5.3,1.14,;6.7,-5.78,;8.04,-6.53,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-14-12-30(13-15-36)24-48-42(55)37-22-32-8-4-10-34(20-32)25-46-39(53)27-51-16-18-52(19-17-51)28-40(54)47-26-35-11-5-9-33(21-35)23-38(43(56)49-37)50-59(57,58)29-31-6-2-1-3-7-31/h1-15,20-21,37-38,50H,16-19,22-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	31.6	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380625 (CHEMBL2016872) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r| Show InChI InChI=1S/C37H41N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-3,6-19,33-34,42H,4-5,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/t33-,34+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	34.2	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM141390 (US8921319, 12) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1 |r| Show InChI InChI=1S/C35H43N7O6S/c36-31(37)26-17-15-24(16-18-26)22-40-34(45)29-13-4-6-19-38-32(43)27-11-8-12-28(21-27)33(44)39-20-7-5-14-30(35(46)41-29)42-49(47,48)23-25-9-2-1-3-10-25/h1-3,8-12,15-18,21,29-30,42H,4-7,13-14,19-20,22-23H2,(H3,36,37)(H,38,43)(H,39,44)(H,40,45)(H,41,46)/t29-,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	38	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380623 (CHEMBL2016870) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4cccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-17-15-30(16-18-38)26-50-44(55)39-22-32-9-5-13-36(20-32)27-48-41(53)24-34-11-4-12-35(19-34)25-42(54)49-28-37-14-6-10-33(21-37)23-40(45(56)51-39)52-59(57,58)29-31-7-2-1-3-8-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	42.1	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380618 (CHEMBL2016868) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)cc4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-18-16-32(17-19-38)26-50-44(55)39-22-34-8-4-10-36(20-34)27-48-41(53)24-30-12-14-31(15-13-30)25-42(54)49-28-37-11-5-9-35(21-37)23-40(45(56)51-39)52-59(57,58)29-33-6-2-1-3-7-33/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	45.4	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM141389 (US8921319, 10) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OC\C=C/COc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,c:19| Show InChI InChI=1S/C37H39N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-19,33-34,42H,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/b5-4-/t33-,34+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM141388 (US8921319, 7) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccccc4CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)36-18-16-30(17-19-36)26-50-44(55)39-22-32-10-6-12-34(20-32)27-48-41(53)24-37-14-4-5-15-38(37)25-42(54)49-28-35-13-7-11-33(21-35)23-40(45(56)51-39)52-59(57,58)29-31-8-2-1-3-9-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	103	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380618 (CHEMBL2016868) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)cc4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-18-16-32(17-19-38)26-50-44(55)39-22-34-8-4-10-36(20-34)27-48-41(53)24-30-12-14-31(15-13-30)25-42(54)49-28-37-11-5-9-35(21-37)23-40(45(56)51-39)52-59(57,58)29-33-6-2-1-3-7-33/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	136	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380618 (CHEMBL2016868) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)cc4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-18-16-32(17-19-38)26-50-44(55)39-22-34-8-4-10-36(20-34)27-48-41(53)24-30-12-14-31(15-13-30)25-42(54)49-28-37-11-5-9-35(21-37)23-40(45(56)51-39)52-59(57,58)29-33-6-2-1-3-7-33/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	152	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM141390 (US8921319, 12) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1 |r| Show InChI InChI=1S/C35H43N7O6S/c36-31(37)26-17-15-24(16-18-26)22-40-34(45)29-13-4-6-19-38-32(43)27-11-8-12-28(21-27)33(44)39-20-7-5-14-30(35(46)41-29)42-49(47,48)23-25-9-2-1-3-10-25/h1-3,8-12,15-18,21,29-30,42H,4-7,13-14,19-20,22-23H2,(H3,36,37)(H,38,43)(H,39,44)(H,40,45)(H,41,46)/t29-,30+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	187	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380617 (CHEMBL2016873) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)c4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-11-9-22(10-12-26)16-36-32(45)29-14-27-19-43(41-38-27)17-24-7-4-8-25(13-24)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-23-5-2-1-3-6-23/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	206	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM141392 (US8921319, 14) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4ccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)cc4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-12-10-22(11-13-26)16-36-32(45)29-14-27-19-43(41-38-27)17-23-6-8-24(9-7-23)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-25-4-2-1-3-5-25/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	219	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM141389 (US8921319, 10) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OC\C=C/COc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,c:19| Show InChI InChI=1S/C37H39N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-19,33-34,42H,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/b5-4-/t33-,34+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	220	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141391 (US8921319, 15) Show SMILES OC(=O)[C@@H]1Cc2ccc(NC(=O)CN3CCN(CC3)CC(=O)Nc3ccc(C[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N1)cc3)cc2 |r,wU:28.29,wD:3.2,(3.08,3.56,;1.6,3.96,;1.2,5.44,;.51,2.87,;.91,1.38,;2.39,.98,;2.79,-.51,;4.28,-.9,;5.37,.18,;6.86,-.21,;7.58,-1.48,;9.07,-1.08,;6.81,-2.82,;5.55,-3.27,;4.22,-2.5,;2.89,-3.27,;2.89,-4.81,;4.22,-5.58,;5.55,-4.81,;1.4,-5.21,;.31,-4.12,;-1.02,-4.89,;.31,-2.58,;-.29,-.85,;-1.62,-1.62,;-2.96,-.85,;-2.96,.69,;-4.05,1.78,;-3.65,3.27,;-4.98,4.04,;-6.32,3.27,;-6.71,4.75,;-4.73,2.84,;-7.74,2.45,;-7.74,.91,;-9.07,.14,;-9.07,-1.4,;-7.74,-2.17,;-6.4,-1.4,;-6.4,.14,;-2.31,4.04,;-2.31,5.58,;-.98,3.27,;-1.62,1.46,;-.29,.69,;4.97,1.67,;3.48,2.07,)| Show InChI InChI=1S/C33H38N6O7S/c40-30-20-38-14-16-39(17-15-38)21-31(41)35-27-12-8-24(9-13-27)19-29(33(43)44)36-32(42)28(18-23-6-10-26(34-30)11-7-23)37-47(45,46)22-25-4-2-1-3-5-25/h1-13,28-29,37H,14-22H2,(H,34,40)(H,35,41)(H,36,42)(H,43,44)/t28-,29+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	320	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM141390 (US8921319, 12) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1 |r| Show InChI InChI=1S/C35H43N7O6S/c36-31(37)26-17-15-24(16-18-26)22-40-34(45)29-13-4-6-19-38-32(43)27-11-8-12-28(21-27)33(44)39-20-7-5-14-30(35(46)41-29)42-49(47,48)23-25-9-2-1-3-10-25/h1-3,8-12,15-18,21,29-30,42H,4-7,13-14,19-20,22-23H2,(H3,36,37)(H,38,43)(H,39,44)(H,40,45)(H,41,46)/t29-,30+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	376	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50380620 (CHEMBL2016866) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCC(=O)NCc3cccc(CNC(=O)CC[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N2)c3)cc1 |r| Show InChI InChI=1S/C33H39N7O6S/c34-31(35)26-11-9-22(10-12-26)18-38-32(43)27-13-15-29(41)36-19-24-7-4-8-25(17-24)20-37-30(42)16-14-28(33(44)39-27)40-47(45,46)21-23-5-2-1-3-6-23/h1-12,17,27-28,40H,13-16,18-21H2,(H3,34,35)(H,36,41)(H,37,42)(H,38,43)(H,39,44)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	431	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380622 (CHEMBL2016867) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,wU:11.10,wD:38.39,(24.36,-25.86,;24.33,-24.32,;25.66,-23.53,;22.99,-23.57,;21.66,-24.36,;20.32,-23.61,;20.31,-22.07,;18.96,-21.31,;18.94,-19.77,;17.6,-19.02,;16.28,-19.81,;17.58,-17.48,;18.91,-16.7,;18.89,-15.16,;17.55,-14.4,;17.54,-12.86,;18.87,-12.08,;18.86,-10.54,;17.52,-9.78,;17.5,-8.24,;18.83,-7.46,;16.16,-7.48,;14.84,-8.27,;14.85,-9.81,;13.52,-10.58,;12.18,-9.82,;12.17,-8.29,;13.49,-7.5,;10.85,-10.59,;9.51,-9.83,;9.5,-8.29,;8.19,-10.61,;8.2,-12.15,;9.53,-12.91,;10.87,-12.14,;12.2,-12.9,;12.2,-14.43,;13.54,-15.2,;13.55,-16.74,;12.22,-17.51,;12.23,-19.05,;13.71,-18.64,;13.32,-20.13,;10.9,-19.83,;10.9,-21.37,;9.58,-22.14,;9.58,-23.68,;10.92,-24.44,;12.26,-23.66,;12.24,-22.12,;14.89,-17.5,;14.89,-19.04,;16.22,-16.72,;10.88,-15.22,;9.55,-14.46,;20.21,-12.83,;20.22,-14.37,;21.62,-21.28,;22.97,-22.02,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-16-14-34(15-17-36)26-48-42(55)37-22-30-6-10-32(11-7-30)24-46-39(53)27-51-18-20-52(21-19-51)28-40(54)47-25-33-12-8-31(9-13-33)23-38(43(56)49-37)50-59(57,58)29-35-4-2-1-3-5-35/h1-17,37-38,50H,18-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	493	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380625 (CHEMBL2016872) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r| Show InChI InChI=1S/C37H41N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-3,6-19,33-34,42H,4-5,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/t33-,34+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	510	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM141387 (US8921319, 3) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4cccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)c4)cc3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-19-17-34(18-20-38)28-50-44(55)39-22-30-9-13-32(14-10-30)26-48-41(53)24-36-7-4-8-37(21-36)25-42(54)49-27-33-15-11-31(12-16-33)23-40(45(56)51-39)52-59(57,58)29-35-5-2-1-3-6-35/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	550	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM141388 (US8921319, 7) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccccc4CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)36-18-16-30(17-19-36)26-50-44(55)39-22-32-10-6-12-34(20-32)27-48-41(53)24-37-14-4-5-15-38(37)25-42(54)49-28-35-13-7-11-33(21-35)23-40(45(56)51-39)52-59(57,58)29-31-8-2-1-3-9-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	575	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM141392 (US8921319, 14) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4ccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)cc4)nn3)cc1 |r| Show InChI InChI=1S/C33H35N11O4S/c34-31(35)26-12-10-22(11-13-26)16-36-32(45)29-14-27-19-43(41-38-27)17-23-6-8-24(9-7-23)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-25-4-2-1-3-5-25/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	600	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM50380621 (CHEMBL2016864) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4ccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)cc4)cc3)cc1 |r| Show InChI InChI=1S/C45H47N7O6S/c46-43(47)38-20-18-36(19-21-38)28-50-44(55)39-22-30-10-14-34(15-11-30)26-48-41(53)24-32-6-8-33(9-7-32)25-42(54)49-27-35-16-12-31(13-17-35)23-40(45(56)51-39)52-59(57,58)29-37-4-2-1-3-5-37/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	868	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380626 (CHEMBL2016874) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)n4)nn3)cc1 |r| Show InChI InChI=1S/C32H34N12O4S/c33-30(34)23-11-9-21(10-12-23)15-35-31(45)28-13-26-18-43(41-38-26)16-24-7-4-8-25(36-24)17-44-19-27(39-42-44)14-29(32(46)37-28)40-49(47,48)20-22-5-2-1-3-6-22/h1-12,18-19,28-29,40H,13-17,20H2,(H3,33,34)(H,35,45)(H,37,46)/t28-,29+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	1.86E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50380625 (CHEMBL2016872) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r| Show InChI InChI=1S/C37H41N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-3,6-19,33-34,42H,4-5,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/t33-,34+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	2.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380620 (CHEMBL2016866) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCC(=O)NCc3cccc(CNC(=O)CC[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N2)c3)cc1 |r| Show InChI InChI=1S/C33H39N7O6S/c34-31(35)26-11-9-22(10-12-26)18-38-32(43)27-13-15-29(41)36-19-24-7-4-8-25(17-24)20-37-30(42)16-14-28(33(44)39-27)40-47(45,46)21-23-5-2-1-3-6-23/h1-12,17,27-28,40H,13-16,18-21H2,(H3,34,35)(H,36,41)(H,37,42)(H,38,43)(H,39,44)/t27-,28+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	2.02E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50380622 (CHEMBL2016867) Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 |r,wU:11.10,wD:38.39,(24.36,-25.86,;24.33,-24.32,;25.66,-23.53,;22.99,-23.57,;21.66,-24.36,;20.32,-23.61,;20.31,-22.07,;18.96,-21.31,;18.94,-19.77,;17.6,-19.02,;16.28,-19.81,;17.58,-17.48,;18.91,-16.7,;18.89,-15.16,;17.55,-14.4,;17.54,-12.86,;18.87,-12.08,;18.86,-10.54,;17.52,-9.78,;17.5,-8.24,;18.83,-7.46,;16.16,-7.48,;14.84,-8.27,;14.85,-9.81,;13.52,-10.58,;12.18,-9.82,;12.17,-8.29,;13.49,-7.5,;10.85,-10.59,;9.51,-9.83,;9.5,-8.29,;8.19,-10.61,;8.2,-12.15,;9.53,-12.91,;10.87,-12.14,;12.2,-12.9,;12.2,-14.43,;13.54,-15.2,;13.55,-16.74,;12.22,-17.51,;12.23,-19.05,;13.71,-18.64,;13.32,-20.13,;10.9,-19.83,;10.9,-21.37,;9.58,-22.14,;9.58,-23.68,;10.92,-24.44,;12.26,-23.66,;12.24,-22.12,;14.89,-17.5,;14.89,-19.04,;16.22,-16.72,;10.88,-15.22,;9.55,-14.46,;20.21,-12.83,;20.22,-14.37,;21.62,-21.28,;22.97,-22.02,)| Show InChI InChI=1S/C43H51N9O6S/c44-41(45)36-16-14-34(15-17-36)26-48-42(55)37-22-30-6-10-32(11-7-30)24-46-39(53)27-51-18-20-52(21-19-51)28-40(54)47-25-33-12-8-31(9-13-33)23-38(43(56)49-37)50-59(57,58)29-35-4-2-1-3-5-35/h1-17,37-38,50H,18-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a	8.0	n/a
The Medicines Company (Leipzig) GmbH US Patent					Assay Description The inhibition constants for human plasmin (h plasmin), human plasma kallikrein (h PK), thrombin and factor Xa were determined in analogy to a previo...				US Patent US8921319 (2014) BindingDB Entry DOI: 10.7270/Q2RX99S6
					More data for this Ligand-Target Pair

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