Compile Data Set for Download or QSAR

Found 126 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 8190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236019 (US9365562, 57) Show SMILES Cc1nc(Cc2cc(F)ccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C26H24F2N8/c1-15-29-23(35-13-18(14-35)26-32-21-6-4-5-7-22(21)34(26)3)12-25(30-15)36-24(31-16(2)33-36)11-17-10-19(27)8-9-20(17)28/h4-10,12,18H,11,13-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0650	-58.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236020 (US9365562, 58) Show SMILES Cc1nc(Cc2ccc(F)cc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C26H25FN8/c1-16-28-23(34-14-19(15-34)26-31-21-6-4-5-7-22(21)33(26)3)13-25(29-16)35-24(30-17(2)32-35)12-18-8-10-20(27)11-9-18/h4-11,13,19H,12,14-15H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.120	-56.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236035 (US9365562, 73) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccnn2C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C24H26N10O/c1-15-26-16(2)34(30-15)22-11-21(28-24(29-22)35-14-18-9-10-25-32(18)4)33-12-17(13-33)23-27-19-7-5-6-8-20(19)31(23)3/h5-11,17H,12-14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.130	-56.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235985 (US9365562, 23) Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H22N8S/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.200	-55.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236018 (US9365562, 56) Show SMILES Cc1nc(-c2c(F)cccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C |(-6.46,-3.49,;-5.96,-2.03,;-6.8,-.72,;-5.9,.53,;-6.29,2.02,;-7.78,2.41,;-8.87,1.33,;-8.18,3.9,;-7.09,4.99,;-5.6,4.59,;-5.21,3.11,;-3.72,3.5,;-4.43,.05,;-4.43,-1.49,;-3.1,.82,;-1.76,.05,;-.43,.82,;-.43,2.36,;-1.76,3.19,;-1.76,4.73,;-3.1,2.36,;.9,.05,;1.3,-1.43,;2.79,-1.04,;2.39,.45,;4.12,-1.81,;4.28,-3.34,;5.79,-3.66,;6.56,-4.99,;8.1,-4.99,;8.87,-3.66,;8.1,-2.32,;6.56,-2.32,;5.53,-1.18,;5.85,.33,)| Show InChI InChI=1S/C25H22F2N8/c1-14-28-21(34-12-16(13-34)24-31-19-9-4-5-10-20(19)33(24)3)11-22(29-14)35-25(30-15(2)32-35)23-17(26)7-6-8-18(23)27/h4-11,16H,12-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.240	-54.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236039 (US9365562, 77) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1ccnc1C)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H24N10/c1-14-25-16(3)33(29-14)21-11-20(27-23(28-21)32-10-9-24-15(32)2)31-12-17(13-31)22-26-18-7-5-6-8-19(18)30(22)4/h5-11,17H,12-13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	-54.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236010 (US9365562, 48) Show SMILES Cc1nc(CN2CCCC2=O)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C24H27N9O/c1-15-25-20(32-12-17(13-32)24-28-18-7-4-5-8-19(18)30(24)3)11-21(26-15)33-22(27-16(2)29-33)14-31-10-6-9-23(31)34/h4-5,7-8,11,17H,6,9-10,12-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.260	-54.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236029 (US9365562, 67) Show SMILES CCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H21F3N8/c1-4-16-25-12(2)29-32(16)18-9-17(27-20(28-18)21(22,23)24)31-10-13(11-31)19-26-14-7-5-6-8-15(14)30(19)3/h5-9,13H,4,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.280	-54.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236041 (US9365562, 79) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H19N9/c1-12-22-13(2)29(26-12)19-8-18(24-17(9-21)25-19)28-10-14(11-28)20-23-15-6-4-5-7-16(15)27(20)3/h4-8,14H,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.280	-54.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236034 (US9365562, 72) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2nccs2)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H23N9OS/c1-14-25-15(2)32(29-14)20-10-19(27-23(28-20)33-13-21-24-8-9-34-21)31-11-16(12-31)22-26-17-6-4-5-7-18(17)30(22)3/h4-10,16H,11-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.280	-54.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236040 (US9365562, 78) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CCCC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H27N9/c1-15-24-16(2)32(28-15)21-12-20(26-23(27-21)30-10-6-7-11-30)31-13-17(14-31)22-25-18-8-4-5-9-19(18)29(22)3/h4-5,8-9,12,17H,6-7,10-11,13-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.290	-54.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236012 (US9365562, 50) Show SMILES Cc1nc(-c2ccccc2Cl)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C25H23ClN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.350	-54.0	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236032 (US9365562, 70) Show SMILES CC(C)Oc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H26N8O/c1-13(2)31-22-25-19(10-20(26-22)30-15(4)23-14(3)27-30)29-11-16(12-29)21-24-17-8-6-7-9-18(17)28(21)5/h6-10,13,16H,11-12H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.380	-53.8	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236033 (US9365562, 71) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccno2)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H23N9O2/c1-14-25-15(2)32(29-14)21-10-20(27-23(28-21)33-13-17-8-9-24-34-17)31-11-16(12-31)22-26-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236026 (US9365562, 64) Show SMILES CCc1nc(C)nn1-c1cc(nc(OC)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H24N8O/c1-5-17-22-13(2)26-29(17)19-10-18(24-21(25-19)30-4)28-11-14(12-28)20-23-15-8-6-7-9-16(15)27(20)3/h6-10,14H,5,11-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.400	-53.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236000 (US9365562, 38) Show SMILES CCCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H26N8/c1-5-8-19-25-15(3)27-30(19)21-11-20(23-14(2)24-21)29-12-16(13-29)22-26-17-9-6-7-10-18(17)28(22)4/h6-7,9-11,16H,5,8,12-13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.410	-53.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236023 (US9365562, 61) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H24N8/c1-13-23-14(2)30(27-13)20-10-19(25-21(26-20)15-8-9-15)29-11-16(12-29)22-24-17-6-4-5-7-18(17)28(22)3/h4-7,10,15-16H,8-9,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.460	-53.3	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236036 (US9365562, 74) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccon2)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H23N9O2/c1-14-24-15(2)32(28-14)21-10-20(26-23(27-21)33-13-17-8-9-34-29-17)31-11-16(12-31)22-25-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.490	-53.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236005 (US9365562, 43) Show SMILES COC(=O)CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C23H26N8O2/c1-14-24-20(11-21(25-14)31-19(26-15(2)28-31)9-10-22(32)33-4)30-12-16(13-30)23-27-17-7-5-6-8-18(17)29(23)3/h5-8,11,16H,9-10,12-13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.490	-53.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235968 (US9365562, 6) Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H23N7/c1-14-10-23-29(11-14)20-9-19(25-21(26-20)15-7-8-15)28-12-16(13-28)22-24-17-5-3-4-6-18(17)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.530	-52.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235995 (US9365562, 33) Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H22N8/c1-13-10-22-29(26-13)19-9-18(24-20(25-19)14-7-8-14)28-11-15(12-28)21-23-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.540	-52.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235964 (US9365562, 2) Show SMILES Cc1cnn(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H21N7/c1-13-9-21-27(10-13)19-8-18(22-14(2)23-19)26-11-15(12-26)20-24-16-6-4-5-7-17(16)25(20)3/h4-10,15H,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.610	-52.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236038 (US9365562, 76) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1cccn1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H22N10/c1-14-24-15(2)32(28-14)20-11-19(26-22(27-20)31-10-6-9-23-31)30-12-16(13-30)21-25-17-7-4-5-8-18(17)29(21)3/h4-11,16H,12-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.610	-52.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235970 (US9365562, 8) Show SMILES Cc1cn(nc1C)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H23N7/c1-13-10-28(25-14(13)2)20-9-19(22-15(3)23-20)27-11-16(12-27)21-24-17-7-5-6-8-18(17)26(21)4/h5-10,16H,11-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.630	-52.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235976 (US9365562, 14) Show SMILES CC(C)c1ccn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H25N7/c1-14(2)17-9-10-29(26-17)21-11-20(23-15(3)24-21)28-12-16(13-28)22-25-18-7-5-6-8-19(18)27(22)4/h5-11,14,16H,12-13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	-52.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236037 (US9365562, 75) Show SMILES Cc1noc(COc2nc(cc(n2)-n2nc(C)nc2C)N2CC(C2)c2nc3ccccc3n2C)n1 Show InChI InChI=1S/C23H24N10O2/c1-13-24-15(3)33(29-13)20-9-19(27-23(28-20)34-12-21-25-14(2)30-35-21)32-10-16(11-32)22-26-17-7-5-6-8-18(17)31(22)4/h5-9,16H,10-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.700	-52.3	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235975 (US9365562, 13) Show SMILES Cc1nc(cc(n1)-n1ccc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H23N7/c1-14-23-20(11-21(24-14)29-10-9-17(26-29)15-7-8-15)28-12-16(13-28)22-25-18-5-3-4-6-19(18)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.740	-52.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236024 (US9365562, 62) Show SMILES COc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H22N8O/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.760	-52.0	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235973 (US9365562, 11) Show SMILES Cc1nc(cc(n1)-n1ccc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H18F3N7/c1-12-24-17(9-18(25-12)30-8-7-16(27-30)20(21,22)23)29-10-13(11-29)19-26-14-5-3-4-6-15(14)28(19)2/h3-9,13H,10-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.760	-52.0	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235997 (US9365562, 35) Show SMILES CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H24N8/c1-5-18-24-14(3)26-29(18)20-10-19(22-13(2)23-20)28-11-15(12-28)21-25-16-8-6-7-9-17(16)27(21)4/h6-10,15H,5,11-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.810	-51.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235966 (US9365562, 4) Show SMILES COc1nc(cc(n1)-n1cc(C)cn1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H21N7O/c1-13-9-21-27(10-13)18-8-17(23-20(24-18)28-3)26-11-14(12-26)19-22-15-6-4-5-7-16(15)25(19)2/h4-10,14H,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.820	-51.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236059 (US9365562, 97) Show SMILES Cc1ccc(nc1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H19F3N6/c1-13-7-8-15(26-10-13)17-9-19(29-21(28-17)22(23,24)25)31-11-14(12-31)20-27-16-5-3-4-6-18(16)30(20)2/h3-10,14H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.900	-51.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235971 (US9365562, 9) Show SMILES Cc1nn(c(C)c1C)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H25N7/c1-13-14(2)26-29(15(13)3)21-10-20(23-16(4)24-21)28-11-17(12-28)22-25-18-8-6-7-9-19(18)27(22)5/h6-10,17H,11-12H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.930	-51.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236028 (US9365562, 66) Show SMILES COCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H21F3N8O/c1-12-25-18(11-33-3)32(29-12)17-8-16(27-20(28-17)21(22,23)24)31-9-13(10-31)19-26-14-6-4-5-7-15(14)30(19)2/h4-8,13H,9-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.940	-51.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236003 (US9365562, 41) Show SMILES C[C@@H](O)Cc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C |r| Show InChI InChI=1S/C22H26N8O/c1-13(31)9-20-25-15(3)27-30(20)21-10-19(23-14(2)24-21)29-11-16(12-29)22-26-17-7-5-6-8-18(17)28(22)4/h5-8,10,13,16,31H,9,11-12H2,1-4H3/t13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-51.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236056 (US9365562, 94) Show SMILES Cc1ccc(nc1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H22N6/c1-14-8-9-17(23-11-14)19-10-21(25-15(2)24-19)28-12-16(13-28)22-26-18-6-4-5-7-20(18)27(22)3/h4-11,16H,12-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	-51.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235994 (US9365562, 32) Show SMILES Cc1cn(nn1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H22N8/c1-13-10-29(26-25-13)19-9-18(23-20(24-19)14-7-8-14)28-11-15(12-28)21-22-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.10	-51.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236061 (US9365562, 99) Show SMILES Cc1nc(cc(n1)-c1ccc(Cl)cn1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H19ClN6/c1-13-24-18(16-8-7-15(22)10-23-16)9-20(25-13)28-11-14(12-28)21-26-17-5-3-4-6-19(17)27(21)2/h3-10,14H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.10	-51.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236022 (US9365562, 60) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H19F3N8/c1-11-24-12(2)31(28-11)17-8-16(26-19(27-17)20(21,22)23)30-9-13(10-30)18-25-14-6-4-5-7-15(14)29(18)3/h4-8,13H,9-10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.10	-51.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236013 (US9365562, 51) Show SMILES Cc1nc(-c2ccccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C25H23FN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	-50.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235993 (US9365562, 31) Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C19H17F3N8/c1-11-8-23-30(27-11)16-7-15(25-18(26-16)19(20,21)22)29-9-12(10-29)17-24-13-5-3-4-6-14(13)28(17)2/h3-8,12H,9-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	-50.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235967 (US9365562, 5) Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C20H18F3N7/c1-12-8-24-30(9-12)17-7-16(26-19(27-17)20(21,22)23)29-10-13(11-29)18-25-14-5-3-4-6-15(14)28(18)2/h3-9,13H,10-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	-50.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236008 (US9365562, 46) Show SMILES Cc1nc(COc2ccccc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C26H26N8O/c1-17-27-23(33-14-19(15-33)26-30-21-11-7-8-12-22(21)32(26)3)13-24(28-17)34-25(29-18(2)31-34)16-35-20-9-5-4-6-10-20/h4-13,19H,14-16H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.20	-50.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236049 (US9365562, 87) Show SMILES Cc1nc(cc(n1)-c1cccc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H19F3N6/c1-13-26-17(15-7-5-9-19(28-15)22(23,24)25)10-20(27-13)31-11-14(12-31)21-29-16-6-3-4-8-18(16)30(21)2/h3-10,14H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	-50.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235987 (US9365562, 25) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(CC#N)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H21N9/c1-13-23-14(2)30(27-13)20-10-19(25-18(26-20)8-9-22)29-11-15(12-29)21-24-16-6-4-5-7-17(16)28(21)3/h4-7,10,15H,8,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	-50.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236058 (US9365562, 96) Show SMILES COc1nc(cc(n1)-c1ccc(C)cn1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H22N6O/c1-14-8-9-16(23-11-14)18-10-20(26-22(25-18)29-3)28-12-15(13-28)21-24-17-6-4-5-7-19(17)27(21)2/h4-11,15H,12-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.30	-50.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235996 (US9365562, 34) Show SMILES COc1nc(cc(n1)-n1ncc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C19H20N8O/c1-12-9-20-27(24-12)17-8-16(22-19(23-17)28-3)26-10-13(11-26)18-21-14-6-4-5-7-15(14)25(18)2/h4-9,13H,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40	-50.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236030 (US9365562, 68) Show SMILES Cc1nc(C2CC2)n(n1)-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C22H21F3N8/c1-12-26-20(13-7-8-13)33(30-12)18-9-17(28-21(29-18)22(23,24)25)32-10-14(11-32)19-27-15-5-3-4-6-16(15)31(19)2/h3-6,9,13-14H,7-8,10-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40	-50.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM236021 (US9365562, 59) Show SMILES COCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C21H24N8O/c1-13-22-18(9-19(23-13)29-20(12-30-4)24-14(2)26-29)28-10-15(11-28)21-25-16-7-5-6-8-17(16)27(21)3/h5-9,15H,10-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.5	-50.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM235990 (US9365562, 28) Show SMILES Cc1cnn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C Show InChI InChI=1S/C19H20N8/c1-12-9-20-27(24-12)18-8-17(21-13(2)22-18)26-10-14(11-26)19-23-15-6-4-5-7-16(15)25(19)3/h4-9,14H,10-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.70	-50.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...				US Patent US9365562 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NQZ
					More data for this Ligand-Target Pair

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