Found 14 hits Enz. Inhib. hit(s) with all data for assayid = 13 entry = 50036796 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074893
(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC Show InChI InChI=1S/C34H30N4O5/c1-3-42-29-15-23-14-24(19-39)28(20-40)32(27(23)17-30(29)43-4-2)21-11-13-36-31(16-21)38-34(41)26-10-6-5-9-25(26)33(37-38)22-8-7-12-35-18-22/h5-18,39-40H,3-4,19-20H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074898
(2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...)Show SMILES COc1cc2cc(CO)cc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C31H24N4O4/c1-38-27-14-22-12-19(18-36)13-25(26(22)16-28(27)39-2)20-9-11-33-29(15-20)35-31(37)24-8-4-3-7-23(24)30(34-35)21-6-5-10-32-17-21/h3-17,36H,18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074897
(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)Show SMILES CCOc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-16-26-22(14-28(29)41-2)13-23(18-38)27(19-39)31(26)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074896
(2-[4-(6-Ethoxy-2,3-bis-hydroxymethyl-7-methoxy-nap...)Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-14-22-13-23(18-38)27(19-39)31(26(22)16-28(29)41-2)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074889
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4ccc3=O)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-24-12-19-11-20(15-31)22(16-32)28(21(19)14-25(24)35-2)18-9-10-29-26(13-18)30-23-6-4-3-5-17(23)7-8-27(30)33/h3-14,31-32H,15-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074886
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccncc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-21-13-22(17-37)26(18-38)30(25(21)16-28(27)41-2)20-9-12-34-29(15-20)36-32(39)24-6-4-3-5-23(24)31(35-36)19-7-10-33-11-8-19/h3-16,37-38H,17-18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074901
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)15-28(27)41-2)19-9-11-34-29(14-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-10-33-16-20/h3-16,37-38H,17-18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074894
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccccn4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-20-13-21(17-37)25(18-38)30(24(20)16-28(27)41-2)19-10-12-34-29(15-19)36-32(39)23-8-4-3-7-22(23)31(35-36)26-9-5-6-11-33-26/h3-16,37-38H,17-18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074895
(2-[4-(2,3-Bis-hydroxymethyl-naphthalen-1-yl)-pyrid...)Show SMILES OCc1cc2ccccc2c(c1CO)-c1ccnc(c1)-n1nc(-c2cccnc2)c2ccccc2c1=O Show InChI InChI=1S/C30H22N4O3/c35-17-22-14-19-6-1-2-8-23(19)28(26(22)18-36)20-11-13-32-27(15-20)34-30(37)25-10-4-3-9-24(25)29(33-34)21-7-5-12-31-16-21/h1-16,35-36H,17-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074884
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ncc4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C27H23N3O5/c1-34-23-10-18-9-19(14-31)22(15-32)26(21(18)12-24(23)35-2)16-7-8-28-25(11-16)30-27(33)20-6-4-3-5-17(20)13-29-30/h3-13,31-32H,14-15H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074887
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074903
(2-[5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccc(nc3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)14-28(27)41-2)19-9-10-29(34-16-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-11-33-15-20/h3-16,37-38H,17-18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50074890
(4'-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen...)Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccccc3=O)c2cc1OC Show InChI InChI=1S/C24H22N2O5/c1-30-20-10-16-9-17(13-27)19(14-28)24(18(16)12-21(20)31-2)15-6-7-25-22(11-15)26-8-4-3-5-23(26)29/h3-12,27-28H,13-14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tanabe Seiyaku Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung |
J Med Chem 42: 1088-99 (1999)
Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH |
More data for this Ligand-Target Pair | |