Compile Data Set for Download or QSAR

Found 272 hits Enz. Inhib. hit(s) with all data for assayid = 2 entry = 6678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145281 (US8952169, 60 | US9771376, Example 60) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:25:16:23:19.20.21,THB:15:16:23:19.20.21,25:20:23:16.24.17,24:16:19:23.22.21,24:22:19:16.25.17| Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145285 (US8952169, 64 | US9771376, Example 64) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:13.12.11,15:6:13:9.10.11,THB:15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM47139 (US8952169, 175 | US8952169, 295) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F Show InChI InChI=1S/C18H24FNO4S/c1-25(22,23)20-18(21)15-9-14(13-7-8-13)17(10-16(15)19)24-11-12-5-3-2-4-6-12/h9-10,12-13H,2-8,11H2,1H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM47141 (US8952169, 185 | US8952169, 297) Show SMILES Fc1cc(OCC2CCCCC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H27FN2O4S/c21-18-12-19(27-13-14-5-2-1-3-6-14)16(15-7-8-15)11-17(18)20(24)22-28(25,26)23-9-4-10-23/h11-12,14-15H,1-10,13H2,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145307 (US8952169, 86 | US9771376, Example 86) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1 |TLB:12:13:16:20.19.18,22:13:20:16.17.18,THB:21:13:16:20.19.18,21:19:16:13.22.14,22:17:20:13.21.14| Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.31	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145369 (US8952169, 148 | US9771376, Example 148) Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:15:6:13:9.10.11,THB:5:6:13:9.10.11,15:10:13:6.14.7,14:6:9:13.12.11,14:12:9:6.15.7| Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145470 (US8952169, 249) Show SMILES Fc1cc(OCC2(CCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H24F4N2O4S/c21-16-11-17(30-12-19(20(22,23)24)6-1-2-7-19)14(13-4-5-13)10-15(16)18(27)25-31(28,29)26-8-3-9-26/h10-11,13H,1-9,12H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145593 (US8952169, 391) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3CC3C2)cc1F Show InChI InChI=1S/C19H24FNO4S/c1-26(23,24)21-19(22)16-8-15(12-4-5-12)18(9-17(16)20)25-10-11-2-3-13-7-14(13)6-11/h8-9,11-14H,2-7,10H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145485 (US8952169, 269) Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM47137 (US8952169, 270) Show SMILES O=C(NS(=O)(=O)N1CCC1)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1 |TLB:19:20:17.18.23:24,23:18:25:22.24.21,23:22:25:17.18.19,THB:19:18:24:20.25.21| Show InChI InChI=1S/C23H31N3O4S/c27-21(25-31(28,29)26-4-1-5-26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145576 (US8952169, 373) Show SMILES CC1CCCCC1COc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)C1CC1 Show InChI InChI=1S/C21H28FNO4S/c1-13-4-2-3-5-15(13)12-27-20-11-19(22)18(10-17(20)14-6-7-14)21(24)23-28(25,26)16-8-9-16/h10-11,13-16H,2-9,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM47137 (US8952169, 270) Show SMILES O=C(NS(=O)(=O)N1CCC1)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1 |TLB:19:20:17.18.23:24,23:18:25:22.24.21,23:22:25:17.18.19,THB:19:18:24:20.25.21| Show InChI InChI=1S/C23H31N3O4S/c27-21(25-31(28,29)26-4-1-5-26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145270 (US8952169, 49) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:28:19:26:22.23.24,THB:18:19:26:22.23.24,28:23:26:19.27.20,27:19:22:26.25.24,27:25:22:19.28.20| Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145594 (US8952169, 392) Show SMILES Fc1cc(OCC2CCC3CC3C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C21H26FNO4S/c22-19-10-20(27-11-12-1-2-14-8-15(14)7-12)17(13-3-4-13)9-18(19)21(24)23-28(25,26)16-5-6-16/h9-10,12-16H,1-8,11H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145284 (US8952169, 63 | US9771376, Example 63) Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:26:17:24:20.21.22,THB:16:17:24:20.21.22,26:21:24:17.25.18,25:17:20:24.23.22,25:23:20:17.26.18| Show InChI InChI=1S/C22H29FN2O4S/c1-24-30(27,28)25-21(26)18-7-17(16-2-3-16)20(8-19(18)23)29-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16,24H,2-6,9-12H2,1H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145610 (US8952169, 413) Show SMILES CC1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CC1 |w:5.4,1.0,(-8.77,-3.18,;-7.44,-2.41,;-7.44,-.87,;-6.1,-.1,;-4.77,-.87,;-3.44,-.1,;-2.1,-.87,;-.77,-.1,;-.77,1.44,;.56,2.21,;.56,3.75,;1.9,1.44,;1.9,-.1,;.56,-.87,;.56,-2.41,;-.21,-3.75,;1.33,-3.75,;3.23,2.21,;3.23,3.75,;4.56,1.44,;5.9,2.21,;5.13,3.54,;6.67,3.54,;7.23,1.44,;8,.1,;8.77,1.44,;-4.77,-2.41,;-6.1,-3.18,)| Show InChI InChI=1S/C21H28FNO4S/c1-13-2-4-14(5-3-13)12-27-20-11-19(22)18(10-17(20)15-6-7-15)21(24)23-28(25,26)16-8-9-16/h10-11,13-16H,2-9,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145516 (US8952169, 312 | US8952169, 430 | US8952169, 433) Show SMILES Fc1cc(OCC23CCCCC2C3(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C21H24F3NO4S/c22-16-10-17(29-11-20-8-2-1-3-18(20)21(20,23)24)14(12-4-5-12)9-15(16)19(26)25-30(27,28)13-6-7-13/h9-10,12-13,18H,1-8,11H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145442 (US8952169, 221) Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H26F4N2O4S/c22-17-12-18(31-13-20(21(23,24)25)7-2-1-3-8-20)15(14-5-6-14)11-16(17)19(28)26-32(29,30)27-9-4-10-27/h11-12,14H,1-10,13H2,(H,26,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145641 (US8952169, 446) Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C21H25F4NO4S/c22-17-11-18(30-12-20(21(23,24)25)8-2-1-3-9-20)15(13-4-5-13)10-16(17)19(27)26-31(28,29)14-6-7-14/h10-11,13-14H,1-9,12H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145276 (US8952169, 55) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC2C3CC4CC(C3)CC2C4)c(c1)C1CC1 |TLB:12:13:15:17.18.19,THB:13:21:17:15.14.19,13:14:17:21.20.22,20:21:15:17.18.19,20:18:15:21.13.22,(7.75,1.73,;6.42,2.5,;5.65,3.84,;7.19,3.84,;5.08,1.73,;3.75,2.5,;3.75,4.04,;2.41,1.73,;1.08,2.5,;-.25,1.73,;-.25,.19,;-1.59,-.58,;-2.92,.19,;-4.25,-.58,;-5.58,.19,;-6.92,-.58,;-6.92,-2.12,;-7.75,-4.02,;-6.35,-3.37,;-6.34,-.97,;-5.15,-4.04,;-4.25,-2.12,;-5.58,-2.89,;1.08,-.58,;2.41,.19,;1.08,-2.12,;.31,-3.45,;1.85,-3.45,)| Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-22(24)16-4-5-21(19(11-16)15-2-3-15)27-12-20-17-7-13-6-14(9-17)10-18(20)8-13/h4-5,11,13-15,17-18,20H,2-3,6-10,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145267 (US8952169, 46) Show SMILES CCc1cc(C(=O)NS(=O)(=O)N2CCC2)c(F)cc1OCC12CC3CC(CC(C3)C1)C2 |TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C23H31FN2O4S/c1-2-18-9-19(22(27)25-31(28,29)26-4-3-5-26)20(24)10-21(18)30-14-23-11-15-6-16(12-23)8-17(7-15)13-23/h9-10,15-17H,2-8,11-14H2,1H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145366 (US8952169, 145 | US8952169, 445 | US9771376, Examp...) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F |TLB:15:16:21:18.19,THB:23:22:21:18.19| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145366 (US8952169, 145 | US8952169, 445 | US9771376, Examp...) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F |TLB:15:16:21:18.19,THB:23:22:21:18.19| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145229 (US8952169, 8 | US9771376, Example 8) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)CC2 |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-18(2)11-5-4-10(13(18)6-11)9-25-16-8-15(20)12(7-14(16)19)17(22)21-26(3,23)24/h7-8,10-11,13H,4-6,9H2,1-3H3,(H,21,22)/t10-,11+,13+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145407 (US8952169, 186) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F Show InChI InChI=1S/C20H28FNO5S/c1-26-9-10-28(24,25)22-20(23)17-11-16(15-7-8-15)19(12-18(17)21)27-13-14-5-3-2-4-6-14/h11-12,14-15H,2-10,13H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145591 (US8952169, 389) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC2(CC2)CC1 Show InChI InChI=1S/C23H30FNO4S/c1-22(6-8-23(9-7-22)10-11-23)14-29-20-13-19(24)18(12-17(20)15-2-3-15)21(26)25-30(27,28)16-4-5-16/h12-13,15-16H,2-11,14H2,1H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145387 (US8952169, 166 | US9771376, Example 166) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-8-13(12-2-3-12)16(9-15(14)19)26-10-11-4-6-18(20,21)7-5-11/h8-9,11-12H,2-7,10H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145467 (US8952169, 246) Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)CCC(F)(F)CC1 Show InChI InChI=1S/C21H27F3N2O4S/c1-20(5-7-21(23,24)8-6-20)13-30-18-12-17(22)16(11-15(18)14-3-4-14)19(27)25-31(28,29)26-9-2-10-26/h11-12,14H,2-10,13H2,1H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145371 (US8952169, 150 | US9771376, Example 150) Show SMILES FC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:29:20:27:23.24.25,THB:19:20:27:23.24.25,29:24:27:20.28.21,28:20:23:27.26.25,28:26:23:20.29.21| Show InChI InChI=1S/C24H30F2N2O4S/c25-18-11-28(12-18)33(30,31)27-23(29)20-6-19(17-1-2-17)22(7-21(20)26)32-13-24-8-14-3-15(9-24)5-16(4-14)10-24/h6-7,14-18H,1-5,8-13H2,(H,27,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145269 (US8952169, 48) Show SMILES OCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:27:18:25:21.22.23,THB:17:18:25:21.22.23,27:22:25:18.26.19,26:18:21:25.24.23,26:24:21:18.27.19| Show InChI InChI=1S/C23H30FNO5S/c24-20-9-21(30-13-23-10-14-5-15(11-23)7-16(6-14)12-23)18(17-1-2-17)8-19(20)22(27)25-31(28,29)4-3-26/h8-9,14-17,26H,1-7,10-13H2,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145440 (US8952169, 219) Show SMILES Fc1cc(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:13:10.8.16,THB:15:14:10:6.7.18,7:6:13:10.8.16,7:8:13:6.17.18,17:6:10:13.14.16,17:14:10:6.7.18| Show InChI InChI=1S/C24H28F4N2O4S/c25-18-7-19(34-14-21-8-22(26)11-23(27,9-21)13-24(28,10-21)12-22)16(15-2-3-15)6-17(18)20(31)29-35(32,33)30-4-1-5-30/h6-7,15H,1-5,8-14H2,(H,29,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145445 (US8952169, 224) Show SMILES Fc1cc(OCC2(C#N)C3CC4CC(C3)CC2C4)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:7:6:10:12.13.14,5:6:10:12.13.14,THB:15:16:10:12.13.14,15:13:10:16.17.6,6:16:12:10.9.14,6:9:12:16.15.17| Show InChI InChI=1S/C25H30FN3O4S/c26-22-12-23(33-14-25(13-27)18-7-15-6-16(9-18)10-19(25)8-15)20(17-2-3-17)11-21(22)24(30)28-34(31,32)29-4-1-5-29/h11-12,15-19H,1-10,14H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145230 (US8952169, 9 | US9771376, Example 9) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2C3CC4CC(C3)CC2C4)cc1F |TLB:12:13:20:17.16.22,15:16:20:14.13.19,THB:15:14:20:17.16.22,13:14:17:20.21.22,13:21:17:14.15.19,(6.07,.01,;5.3,1.35,;4.53,2.68,;6.63,2.12,;3.97,.58,;2.63,1.35,;2.63,2.89,;1.3,.58,;1.3,-.96,;-.03,-1.73,;-.03,-3.27,;-1.37,-.96,;-2.7,-1.73,;-4.04,-.96,;-3.14,.96,;-3.14,2.5,;-4.47,3.27,;-5.8,2.5,;-5.8,.96,;-4.47,.19,;-6.63,-.94,;-5.24,-.29,;-5.22,2.11,;-1.37,.58,;-.03,1.35,;-.03,2.89,)| Show InChI InChI=1S/C18H21ClFNO4S/c1-26(23,24)21-18(22)13-7-14(19)16(8-15(13)20)25-17-11-3-9-2-10(5-11)6-12(17)4-9/h7-12,17H,2-6H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145227 (US8952169, 6 | US9771376, Example 6) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:13:14:17:21.20.19,23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15| Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-18(23)14-5-15(20)17(6-16(14)21)26-10-19-7-11-2-12(8-19)4-13(3-11)9-19/h5-6,11-13H,2-4,7-10H2,1H3,(H,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145493 (US8952169, 286) Show SMILES Fc1cc(OCC2CCC3(CC3)CC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C22H29FN2O4S/c23-19-13-20(29-14-15-4-6-22(7-5-15)8-9-22)17(16-2-3-16)12-18(19)21(26)24-30(27,28)25-10-1-11-25/h12-13,15-16H,1-11,14H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145391 (US8952169, 170 | US8952169, 251 | US9771376, Examp...) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H29F3N2O4S/c25-20-9-21(33-13-23-10-14-6-16(11-23)24(26,27)17(7-14)12-23)18(15-2-3-15)8-19(20)22(30)28-34(31,32)29-4-1-5-29/h8-9,14-17H,1-7,10-13H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145391 (US8952169, 170 | US8952169, 251 | US9771376, Examp...) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H29F3N2O4S/c25-20-9-21(33-13-23-10-14-6-16(11-23)24(26,27)17(7-14)12-23)18(15-2-3-15)8-19(20)22(30)28-34(31,32)29-4-1-5-29/h8-9,14-17H,1-7,10-13H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145368 (US8952169, 147 | US9771376, Example 147) Show SMILES O[C@H]1CCN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |r,TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C25H33FN2O5S/c26-22-9-23(33-14-25-10-15-5-16(11-25)7-17(6-15)12-25)20(18-1-2-18)8-21(22)24(30)27-34(31,32)28-4-3-19(29)13-28/h8-9,15-19,29H,1-7,10-14H2,(H,27,30)/t15?,16?,17?,19-,25?/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145233 (US8952169, 12 | US9771376, Example 13) Show SMILES CC1(C)C2CCC1(C)C(C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O |THB:10:8:1:5.4| Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145578 (US8952169, 375) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(O[C@H]2C3CC4CC2C[C@@](Cl)(C4)C3)cc1F |r,wU:15.15,22.24,TLB:14:15:19:24.22.21,15:16:24:19.20.21,25:22:19:16.15.17,23:22:19:16.15.17,THB:15:20:24:16.25.17,25:16:19:24.22.21,(7.16,-1.67,;5.83,-.9,;5.06,-2.23,;6.6,.44,;4.49,-.13,;3.16,-.9,;3.16,-2.44,;1.82,-.13,;.49,-.9,;-.84,-.13,;-2.18,-.9,;-3.72,-.9,;-2.95,-2.23,;-.84,1.41,;-2.18,2.18,;-3.66,1.78,;-3.66,.24,;-4.99,-.53,;-6.33,.24,;-6.33,1.78,;-4.99,2.55,;-5.75,1.39,;-5.76,-1.01,;-5.76,-2.55,;-7.16,-1.66,;-4.56,-1.68,;.49,2.18,;1.82,1.41,;3.16,2.18,)| Show InChI InChI=1S/C21H25ClFNO4S/c1-29(26,27)24-20(25)16-6-15(12-2-3-12)18(7-17(16)23)28-19-13-4-11-5-14(19)10-21(22,8-11)9-13/h6-7,11-14,19H,2-5,8-10H2,1H3,(H,24,25)/t11?,13?,14?,19-,21+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145318 (US8952169, 97 | US9771376, Example 97) Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:16:24:20:18.17.22,16:17:20:24.23.25,23:24:18:20.21.22,23:21:18:24.16.25,(8.42,2.5,;7.08,1.73,;7.08,.19,;5.75,2.5,;4.98,3.84,;6.52,3.84,;4.42,1.73,;3.08,2.5,;3.08,4.04,;1.75,1.73,;1.75,.19,;.41,-.58,;.41,-2.12,;-.92,.19,;-2.25,-.58,;-3.59,.19,;-4.92,-.58,;-6.25,.19,;-7.58,-.58,;-7.58,-2.12,;-8.42,-4.02,;-7.02,-3.37,;-7,-.97,;-5.82,-4.04,;-4.92,-2.12,;-6.25,-2.89,;-.92,1.73,;.41,2.5,;.41,4.04,)| Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145282 (US8952169, 61) Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(Br)c1 |TLB:22:13:20:16.17.18,THB:12:13:20:16.17.18,22:17:20:13.21.14,21:13:16:20.19.18,21:19:16:13.22.14| Show InChI InChI=1S/C19H24BrNO4S/c1-26(23,24)21-18(22)15-2-3-17(16(20)7-15)25-11-19-8-12-4-13(9-19)6-14(5-12)10-19/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145257 (US8952169, 36 | US9771376, Example 36) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC2CCCCC2)cc1F Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-9-13(17)15(10-14(12)18)23-8-7-11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145643 (US8952169, 448) Show SMILES Fc1cc(OCC2CCC(F)(F)CC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C20H25F3N2O4S/c21-17-11-18(29-12-13-4-6-20(22,23)7-5-13)15(14-2-3-14)10-16(17)19(26)24-30(27,28)25-8-1-9-25/h10-11,13-14H,1-9,12H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145481 (US8952169, 262) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145438 (US8952169, 217) Show SMILES Fc1cc(OCC2CCC(F)(F)CC2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C20H24F3NO4S/c21-17-10-18(28-11-12-5-7-20(22,23)8-6-12)15(13-1-2-13)9-16(17)19(25)24-29(26,27)14-3-4-14/h9-10,12-14H,1-8,11H2,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145460 (US8952169, 239) Show SMILES CC1(C)CCCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)C1 Show InChI InChI=1S/C22H31FN2O4S/c1-22(2)8-3-5-15(13-22)14-29-20-12-19(23)18(11-17(20)16-6-7-16)21(26)24-30(27,28)25-9-4-10-25/h11-12,15-16H,3-10,13-14H2,1-2H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145461 (US8952169, 240) Show SMILES FCC12CC3CC(C1)CC(COc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)N1CCC1)(C3)C2 |TLB:10:9:3:5.6.7,THB:1:2:5:9.8.32,8:9:3:5.6.7,8:6:3:9.33.32,33:9:5:3.2.7,33:2:5:9.8.32| Show InChI InChI=1S/C25H32F2N2O4S/c26-14-24-9-16-6-17(10-24)12-25(11-16,13-24)15-33-22-8-21(27)20(7-19(22)18-2-3-18)23(30)28-34(31,32)29-4-1-5-29/h7-8,16-18H,1-6,9-15H2,(H,28,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145231 (US8952169, 10 | US9771376, Example 10) Show SMILES C[C@@H]1[C@H]2C[C@@H](C[C@H]1Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O)C2(C)C |r| Show InChI InChI=1S/C18H23ClFNO4S/c1-9-12-5-10(18(12,2)3)6-15(9)25-16-8-14(20)11(7-13(16)19)17(22)21-26(4,23)24/h7-10,12,15H,5-6H2,1-4H3,(H,21,22)/t9-,10+,12-,15-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145232 (US8952169, 11 | US9771376, Example 11) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:14:15:18:22.21.20,24:15:22:18.19.20,THB:24:19:22:15.23.16,23:15:18:22.21.20,23:21:18:15.24.16| Show InChI InChI=1S/C20H25ClFNO4S/c1-28(25,26)23-19(24)15-7-16(21)18(8-17(15)22)27-3-2-20-9-12-4-13(10-20)6-14(5-12)11-20/h7-8,12-14H,2-6,9-11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair

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