Found 8 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 50044144 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50005711
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C |r| Show InChI InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM19149
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 459 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50293358
(CHEMBL556332 | N-Hydroxy-E-3-(4'-hydroxybiphenyl-4...)Show InChI InChI=1S/C15H13NO3/c17-14-8-6-13(7-9-14)12-4-1-11(2-5-12)3-10-15(18)16-19/h1-10,17,19H,(H,16,18)/b10-3+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50005730
(CHEMBL3235790)Show SMILES ONC(=O)\C=C\c1ccc(c(Cl)c1)-c1ccc(CC#N)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:25:26:24.23.29:30,THB:25:24:26.31.27:30,27:26:23:29.28.30,27:28:25.26.31:23| Show InChI InChI=1S/C27H27ClN2O2/c28-25-12-17(2-6-26(31)30-32)1-5-23(25)22-4-3-21(7-8-29)24(13-22)27-14-18-9-19(15-27)11-20(10-18)16-27/h1-6,12-13,18-20,32H,7,9-11,14-16H2,(H,30,31)/b6-2+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50293361
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50293369
(CHEMBL538364 | E,E-5-(4'-Methoxybiphenyl-4-yl)-pen...)Show InChI InChI=1S/C18H17NO3/c1-22-17-12-10-16(11-13-17)15-8-6-14(7-9-15)4-2-3-5-18(20)19-21/h2-13,21H,1H3,(H,19,20)/b4-2+,5-3+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50005732
(CHEMBL3235787)Show SMILES COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(\C=C\C=C\C(=O)NO)cc1 |TLB:11:12:10.9.15:16,THB:11:10:12.17.13:16,13:12:9:15.14.16,13:14:11.12.17:9| Show InChI InChI=1S/C28H31NO3/c1-32-26-11-10-24(23-8-6-19(7-9-23)4-2-3-5-27(30)29-31)15-25(26)28-16-20-12-21(17-28)14-22(13-20)18-28/h2-11,15,20-22,31H,12-14,16-18H2,1H3,(H,29,30)/b4-2+,5-3+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
Polyamine deacetylase HDAC10
(Homo sapiens (Human)) | BDBM50005744
(CHEMBL3235463)Show SMILES ONC(=O)\C=C\c1ccc(cc1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2 |TLB:22:23:21.20.26:27,THB:22:21:23.28.24:27,24:23:20:26.25.27,24:25:22.23.28:20| Show InChI InChI=1S/C25H27NO3/c27-23-7-6-21(20-4-1-16(2-5-20)3-8-24(28)26-29)12-22(23)25-13-17-9-18(14-25)11-19(10-17)15-25/h1-8,12,17-19,27,29H,9-11,13-15H2,(H,26,28)/b8-3+ | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description
Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrate |
Eur J Med Chem 79: 251-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.021
BindingDB Entry DOI: 10.7270/Q2V989KV |
More data for this
Ligand-Target Pair | |
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