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Compile Data Set for Download or QSAR

Found 105 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 7077   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172902
PNG
(US9096579, 4)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(N)=O
Show InChI InChI=1S/C18H17N7O/c1-10-5-12(6-11-7-14(17(19)26)23-16(10)11)22-18-20-4-3-13(24-18)15-8-25(2)9-21-15/h3-9,23H,1-2H3,(H2,19,26)(H,20,22,24)
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173073
PNG
(US9096579, 175)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)-c1nnco1
Show InChI InChI=1S/C19H16N8O/c1-11-5-13(6-12-7-15(24-17(11)12)18-26-22-10-28-18)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,20,23,25)
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n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172906
PNG
(US9096579, 8)
Show SMILES CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C19H19N7O/c1-11-6-13(7-12-8-15(18(27)20-2)24-17(11)12)23-19-21-5-4-14(25-19)16-9-26(3)10-22-16/h4-10,24H,1-3H3,(H,20,27)(H,21,23,25)
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173054
PNG
(US9096579, 156)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccccn1
Show InChI InChI=1S/C24H22N8O/c1-15-9-18(29-24-26-8-6-19(31-24)21-13-32(2)14-28-21)10-16-11-20(30-22(15)16)23(33)27-12-17-5-3-4-7-25-17/h3-11,13-14,30H,12H2,1-2H3,(H,27,33)(H,26,29,31)
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n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173018
PNG
(US9096579, 120)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2n1C
Show InChI InChI=1S/C27H25N9O/c1-16-10-18(31-27-28-9-8-19(34-27)22-14-35(2)15-30-22)11-17-12-21(33-25(16)17)26(37)29-13-24-32-20-6-4-5-7-23(20)36(24)3/h4-12,14-15,33H,13H2,1-3H3,(H,29,37)(H,28,31,34)
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n/an/a 1.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172901
PNG
(US9096579, 3)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C22H23ClN8O/c1-29-5-7-31(8-6-29)21(32)18-10-14-9-15(11-16(23)20(14)27-18)26-22-24-4-3-17(28-22)19-12-30(2)13-25-19/h3-4,9-13,27H,5-8H2,1-2H3,(H,24,26,28)
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n/an/a 1.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173008
PNG
(US9096579, 110)
Show SMILES CCn1ccc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1
Show InChI InChI=1S/C24H25N9O/c1-4-33-8-6-17(31-33)12-26-23(34)20-11-16-10-18(9-15(2)22(16)29-20)28-24-25-7-5-19(30-24)21-13-32(3)14-27-21/h5-11,13-14,29H,4,12H2,1-3H3,(H,26,34)(H,25,28,30)
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n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173016
PNG
(US9096579, 118)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccnn1C
Show InChI InChI=1S/C23H23N9O/c1-14-8-16(28-23-24-6-5-18(30-23)20-12-31(2)13-26-20)9-15-10-19(29-21(14)15)22(33)25-11-17-4-7-27-32(17)3/h4-10,12-13,29H,11H2,1-3H3,(H,25,33)(H,24,28,30)
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n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173063
PNG
(US9096579, 165)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cccnc1
Show InChI InChI=1S/C24H22N8O/c1-15-8-18(29-24-26-7-5-19(31-24)21-13-32(2)14-28-21)9-17-10-20(30-22(15)17)23(33)27-12-16-4-3-6-25-11-16/h3-11,13-14,30H,12H2,1-2H3,(H,27,33)(H,26,29,31)
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n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173010
PNG
(US9096579, 112)
Show SMILES Cc1c(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)cnn1C
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(29-24-25-6-5-19(31-24)21-12-32(3)13-27-21)8-16-9-20(30-22(14)16)23(34)26-10-17-11-28-33(4)15(17)2/h5-9,11-13,30H,10H2,1-4H3,(H,26,34)(H,25,29,31)
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173071
PNG
(US9096579, 173)
Show SMILES Cc1nnc(o1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(24-18(11)13)19-27-26-12(2)29-19)23-20-21-5-4-15(25-20)17-9-28(3)10-22-17/h4-10,24H,1-3H3,(H,21,23,25)
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n/an/a 2.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173035
PNG
(US9096579, 137)
Show SMILES Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)[nH]n1
Show InChI InChI=1S/C23H23N9O/c1-13-6-16(27-23-24-5-4-18(29-23)20-11-32(3)12-26-20)8-15-9-19(28-21(13)15)22(33)25-10-17-7-14(2)30-31-17/h4-9,11-12,28H,10H2,1-3H3,(H,25,33)(H,30,31)(H,24,27,29)
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n/an/a 2.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172904
PNG
(US9096579, 6)
Show SMILES CN(C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Cl)c2[nH]1
Show InChI InChI=1S/C19H18ClN7O/c1-26(2)18(28)15-7-11-6-12(8-13(20)17(11)24-15)23-19-21-5-4-14(25-19)16-9-27(3)10-22-16/h4-10,24H,1-3H3,(H,21,23,25)
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n/an/a 2.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172908
PNG
(US9096579, 10)
Show SMILES CN(C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C3CC3)c2[nH]1
Show InChI InChI=1S/C22H23N7O/c1-28(2)21(30)18-9-14-8-15(10-16(13-4-5-13)20(14)26-18)25-22-23-7-6-17(27-22)19-11-29(3)12-24-19/h6-13,26H,4-5H2,1-3H3,(H,23,25,27)
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n/an/a 2.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173021
PNG
(US9096579, 123)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccncc2[nH]1
Show InChI InChI=1S/C25H22N10O/c1-14-7-16(30-25-27-6-4-18(34-25)21-12-35(2)13-29-21)8-15-9-19(33-23(14)15)24(36)28-11-22-31-17-3-5-26-10-20(17)32-22/h3-10,12-13,33H,11H2,1-2H3,(H,28,36)(H,31,32)(H,27,30,34)
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n/an/a 2.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173019
PNG
(US9096579, 121)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C25H22FN7O/c1-15-9-18(30-25-27-8-7-20(32-25)22-13-33(2)14-29-22)10-17-11-21(31-23(15)17)24(34)28-12-16-5-3-4-6-19(16)26/h3-11,13-14,31H,12H2,1-2H3,(H,28,34)(H,27,30,32)
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n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173072
PNG
(US9096579, 174)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NNC=O
Show InChI InChI=1S/C19H18N8O2/c1-11-5-13(6-12-7-15(24-17(11)12)18(29)26-22-10-28)23-19-20-4-3-14(25-19)16-8-27(2)9-21-16/h3-10,24H,1-2H3,(H,22,28)(H,26,29)(H,20,23,25)
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n/an/a 2.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172927
PNG
(US9096579, 29)
Show SMILES CC(C)n1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCN(C)CC2)n1
Show InChI InChI=1S/C24H27ClN8O/c1-15(2)33-13-21(27-14-33)19-4-5-26-24(30-19)28-17-10-16-11-20(29-22(16)18(25)12-17)23(34)32-8-6-31(3)7-9-32/h4-5,10-15,29H,6-9H2,1-3H3,(H,26,28,30)
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n/an/a 3.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173028
PNG
(US9096579, 130)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nccs1
Show InChI InChI=1S/C22H20N8OS/c1-13-7-15(27-22-24-4-3-16(29-22)18-11-30(2)12-26-18)8-14-9-17(28-20(13)14)21(31)25-10-19-23-5-6-32-19/h3-9,11-12,28H,10H2,1-2H3,(H,25,31)(H,24,27,29)
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n/an/a 3.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173069
PNG
(US9096579, 171)
Show SMILES Cc1noc(n1)-c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C20H18N8O/c1-11-6-14(7-13-8-16(25-18(11)13)19-23-12(2)27-29-19)24-20-21-5-4-15(26-20)17-9-28(3)10-22-17/h4-10,25H,1-3H3,(H,21,24,26)
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n/an/a 3.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173005
PNG
(US9096579, 107)
Show SMILES Cc1cnc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)s1
Show InChI InChI=1S/C23H22N8OS/c1-13-6-16(28-23-24-5-4-17(30-23)19-11-31(3)12-27-19)7-15-8-18(29-21(13)15)22(32)26-10-20-25-9-14(2)33-20/h4-9,11-12,29H,10H2,1-3H3,(H,26,32)(H,24,28,30)
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n/an/a 3.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173043
PNG
(US9096579, 145)
Show SMILES Cc1nn(C)cc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C24H25N9O/c1-14-7-18(28-24-25-6-5-19(30-24)21-12-32(3)13-27-21)8-16-9-20(29-22(14)16)23(34)26-10-17-11-33(4)31-15(17)2/h5-9,11-13,29H,10H2,1-4H3,(H,26,34)(H,25,28,30)
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n/an/a 3.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173060
PNG
(US9096579, 162)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nccn1C
Show InChI InChI=1S/C23H23N9O/c1-14-8-16(28-23-25-5-4-17(30-23)19-12-31(2)13-27-19)9-15-10-18(29-21(14)15)22(33)26-11-20-24-6-7-32(20)3/h4-10,12-13,29H,11H2,1-3H3,(H,26,33)(H,25,28,30)
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n/an/a 3.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173046
PNG
(US9096579, 148)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCS(=O)(=O)CC2)n1
Show InChI InChI=1S/C21H20ClN7O3S/c1-28-11-18(24-12-28)16-2-3-23-21(27-16)25-14-8-13-9-17(26-19(13)15(22)10-14)20(30)29-4-6-33(31,32)7-5-29/h2-3,8-12,26H,4-7H2,1H3,(H,23,25,27)
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n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173039
PNG
(US9096579, 141)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NC[C@H]1CCCO1 |r|
Show InChI InChI=1/C23H25N7O2/c1-14-8-16(27-23-24-6-5-18(29-23)20-12-30(2)13-26-20)9-15-10-19(28-21(14)15)22(31)25-11-17-4-3-7-32-17/h5-6,8-10,12-13,17,28H,3-4,7,11H2,1-2H3,(H,25,31)(H,24,27,29)/t17-/s2
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n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173061
PNG
(US9096579, 163)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cccnn1
Show InChI InChI=1S/C23H21N9O/c1-14-8-17(28-23-24-7-5-18(30-23)20-12-32(2)13-26-20)9-15-10-19(29-21(14)15)22(33)25-11-16-4-3-6-27-31-16/h3-10,12-13,29H,11H2,1-2H3,(H,25,33)(H,24,28,30)
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n/an/a 3.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173026
PNG
(US9096579, 128)
Show SMILES CCn1nccc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C24H25N9O/c1-4-33-18(5-8-28-33)12-26-23(34)20-11-16-10-17(9-15(2)22(16)30-20)29-24-25-7-6-19(31-24)21-13-32(3)14-27-21/h5-11,13-14,30H,4,12H2,1-3H3,(H,26,34)(H,25,29,31)
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n/an/a 3.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173055
PNG
(US9096579, 157)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cc[nH]n1
Show InChI InChI=1S/C22H21N9O/c1-13-7-16(27-22-23-5-4-17(29-22)19-11-31(2)12-25-19)8-14-9-18(28-20(13)14)21(32)24-10-15-3-6-26-30-15/h3-9,11-12,28H,10H2,1-2H3,(H,24,32)(H,26,30)(H,23,27,29)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173070
PNG
(US9096579, 172)
Show SMILES CC(=O)NNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C20H20N8O2/c1-11-6-14(7-13-8-16(24-18(11)13)19(30)27-26-12(2)29)23-20-21-5-4-15(25-20)17-9-28(3)10-22-17/h4-10,24H,1-3H3,(H,26,29)(H,27,30)(H,21,23,25)
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n/an/a 4.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173052
PNG
(US9096579, 154)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCC1CCOCC1
Show InChI InChI=1S/C24H27N7O2/c1-15-9-18(28-24-25-6-3-19(30-24)21-13-31(2)14-27-21)10-17-11-20(29-22(15)17)23(32)26-12-16-4-7-33-8-5-16/h3,6,9-11,13-14,16,29H,4-5,7-8,12H2,1-2H3,(H,26,32)(H,25,28,30)
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n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172999
PNG
(US9096579, 101)
Show SMILES COc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)N(C)C
Show InChI InChI=1S/C20H21N7O2/c1-26(2)19(28)15-8-12-7-13(9-17(29-4)18(12)24-15)23-20-21-6-5-14(25-20)16-10-27(3)11-22-16/h5-11,24H,1-4H3,(H,21,23,25)
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n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173022
PNG
(US9096579, 124)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cn(C)cn1
Show InChI InChI=1S/C23H23N9O/c1-14-6-16(28-23-24-5-4-18(30-23)20-11-32(3)13-27-20)7-15-8-19(29-21(14)15)22(33)25-9-17-10-31(2)12-26-17/h4-8,10-13,29H,9H2,1-3H3,(H,25,33)(H,24,28,30)
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n/an/a 4.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173029
PNG
(US9096579, 131)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H23N9O/c1-15-9-17(30-26-27-8-7-20(34-26)22-13-35(2)14-29-22)10-16-11-21(33-24(15)16)25(36)28-12-23-31-18-5-3-4-6-19(18)32-23/h3-11,13-14,33H,12H2,1-2H3,(H,28,36)(H,31,32)(H,27,30,34)
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n/an/a 4.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173023
PNG
(US9096579, 125)
Show SMILES Cc1csc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n1
Show InChI InChI=1S/C23H22N8OS/c1-13-6-16(28-23-24-5-4-17(30-23)19-10-31(3)12-26-19)7-15-8-18(29-21(13)15)22(32)25-9-20-27-14(2)11-33-20/h4-8,10-12,29H,9H2,1-3H3,(H,25,32)(H,24,28,30)
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173050
PNG
(US9096579, 152)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCC(CC2)C#N)n1
Show InChI InChI=1S/C23H21ClN8O/c1-31-12-20(27-13-31)18-2-5-26-23(30-18)28-16-8-15-9-19(29-21(15)17(24)10-16)22(33)32-6-3-14(11-25)4-7-32/h2,5,8-10,12-14,29H,3-4,6-7H2,1H3,(H,26,28,30)
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n/an/a 5.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173025
PNG
(US9096579, 127)
Show SMILES Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)nn1C
Show InChI InChI=1S/C24H25N9O/c1-14-7-17(28-24-25-6-5-19(30-24)21-12-32(3)13-27-21)9-16-10-20(29-22(14)16)23(34)26-11-18-8-15(2)33(4)31-18/h5-10,12-13,29H,11H2,1-4H3,(H,26,34)(H,25,28,30)
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n/an/a 5.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173001
PNG
(US9096579, 103)
Show SMILES Cc1cc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)n(C)n1
Show InChI InChI=1S/C24H25N9O/c1-14-7-17(28-24-25-6-5-19(30-24)21-12-32(3)13-27-21)9-16-10-20(29-22(14)16)23(34)26-11-18-8-15(2)31-33(18)4/h5-10,12-13,29H,11H2,1-4H3,(H,26,34)(H,25,28,30)
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n/an/a 5.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173020
PNG
(US9096579, 122)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1nc2ccccc2o1
Show InChI InChI=1S/C26H22N8O2/c1-15-9-17(30-26-27-8-7-18(33-26)21-13-34(2)14-29-21)10-16-11-20(32-24(15)16)25(35)28-12-23-31-19-5-3-4-6-22(19)36-23/h3-11,13-14,32H,12H2,1-2H3,(H,28,35)(H,27,30,33)
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n/an/a 6.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173068
PNG
(US9096579, 170)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1c[nH]cn1
Show InChI InChI=1S/C22H21N9O/c1-13-5-15(28-22-24-4-3-17(30-22)19-10-31(2)12-27-19)6-14-7-18(29-20(13)14)21(32)25-9-16-8-23-11-26-16/h3-8,10-12,29H,9H2,1-2H3,(H,23,26)(H,25,32)(H,24,28,30)
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n/an/a 6.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172913
PNG
(US9096579, 15)
Show SMILES CN(C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(Br)c2[nH]1
Show InChI InChI=1S/C19H18BrN7O/c1-26(2)18(28)15-7-11-6-12(8-13(20)17(11)24-15)23-19-21-5-4-14(25-19)16-9-27(3)10-22-16/h4-10,24H,1-3H3,(H,21,23,25)
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n/an/a 6.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173036
PNG
(US9096579, 138)
Show SMILES CN(Cc1ccnn1C)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C24H25N9O/c1-15-9-17(28-24-25-7-6-19(30-24)21-13-31(2)14-26-21)10-16-11-20(29-22(15)16)23(34)32(3)12-18-5-8-27-33(18)4/h5-11,13-14,29H,12H2,1-4H3,(H,25,28,30)
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n/an/a 7.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173027
PNG
(US9096579, 129)
Show SMILES Cc1nc(CNC(=O)c2cc3cc(Nc4nccc(n4)-c4cn(C)cn4)cc(C)c3[nH]2)cs1
Show InChI InChI=1S/C23H22N8OS/c1-13-6-16(28-23-24-5-4-18(30-23)20-10-31(3)12-26-20)7-15-8-19(29-21(13)15)22(32)25-9-17-11-33-14(2)27-17/h4-8,10-12,29H,9H2,1-3H3,(H,25,32)(H,24,28,30)
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n/an/a 7.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172929
PNG
(US9096579, 31)
Show SMILES CC(C)Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCN(C)CC2)n1
Show InChI InChI=1S/C25H29ClN8O/c1-16(2)13-33-14-22(28-15-33)20-4-5-27-25(31-20)29-18-10-17-11-21(30-23(17)19(26)12-18)24(35)34-8-6-32(3)7-9-34/h4-5,10-12,14-16,30H,6-9,13H2,1-3H3,(H,27,29,31)
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n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172996
PNG
(US9096579, 98)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(O)=O)n1
Show InChI InChI=1S/C17H13ClN6O2/c1-24-7-14(20-8-24)12-2-3-19-17(23-12)21-10-4-9-5-13(16(25)26)22-15(9)11(18)6-10/h2-8,22H,1H3,(H,25,26)(H,19,21,23)
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n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173045
PNG
(US9096579, 147)
Show SMILES Cn1cnc(c1)-c1ccnc(Nc2cc(Cl)c3[nH]c(cc3c2)C(=O)N2CCS(=O)CC2)n1
Show InChI InChI=1S/C21H20ClN7O2S/c1-28-11-18(24-12-28)16-2-3-23-21(27-16)25-14-8-13-9-17(26-19(13)15(22)10-14)20(30)29-4-6-32(31)7-5-29/h2-3,8-12,26H,4-7H2,1H3,(H,23,25,27)
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n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173033
PNG
(US9096579, 135)
Show SMILES Cc1n[nH]cc1CNC(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C23H23N9O/c1-13-6-17(28-23-24-5-4-18(30-23)20-11-32(3)12-26-20)7-15-8-19(29-21(13)15)22(33)25-9-16-10-27-31-14(16)2/h4-8,10-12,29H,9H2,1-3H3,(H,25,33)(H,27,31)(H,24,28,30)
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n/an/a 8.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173007
PNG
(US9096579, 109)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)N1Cc2cnn(C)c2C1
Show InChI InChI=1S/C24H23N9O/c1-14-6-17(28-24-25-5-4-18(30-24)20-11-31(2)13-26-20)7-15-8-19(29-22(14)15)23(34)33-10-16-9-27-32(3)21(16)12-33/h4-9,11,13,29H,10,12H2,1-3H3,(H,25,28,30)
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n/an/a 8.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172995
PNG
(US9096579, 97)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(O)=O
Show InChI InChI=1S/C18H16N6O2/c1-10-5-12(6-11-7-14(17(25)26)22-16(10)11)21-18-19-4-3-13(23-18)15-8-24(2)9-20-15/h3-9,22H,1-2H3,(H,25,26)(H,19,21,23)
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n/an/a 9.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173017
PNG
(US9096579, 119)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCc1cscn1
Show InChI InChI=1S/C22H20N8OS/c1-13-5-15(27-22-23-4-3-17(29-22)19-9-30(2)11-25-19)6-14-7-18(28-20(13)14)21(31)24-8-16-10-32-12-26-16/h3-7,9-12,28H,8H2,1-2H3,(H,24,31)(H,23,27,29)
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n/an/a 9.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173034
PNG
(US9096579, 136)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NCC1CNC(=O)C1
Show InChI InChI=1/C23H24N8O2/c1-13-5-16(28-23-24-4-3-17(30-23)19-11-31(2)12-27-19)7-15-8-18(29-21(13)15)22(33)26-10-14-6-20(32)25-9-14/h3-5,7-8,11-12,14,29H,6,9-10H2,1-2H3,(H,25,32)(H,26,33)(H,24,28,30)
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n/an/a 9.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair
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