Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21216 (2-[4-(ethylsulfanyl)-1H-1,3-benzodiazol-2-yl]quino...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | -53.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM50085658 ((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | 0.830 | -48.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97464 (US8470800, A | US8609833, 17) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | 0.970 | -47.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97468 (US8470800, E) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.32 | -47.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97470 (US8470800, G) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.36 | -47.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97469 (US8470800, F) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 1.47 | -46.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 1.60 | -49.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25400 ((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | US Patent | 2.30 | -45.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97465 (US8470800, B | US8609833, 85) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2.63 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Rattus norvegicus (rat)) | BDBM106370 (9-(ortho-fluorobenzyl)-2-phenyl-azaadenine (1bis)) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Universit£ di Pisa | Assay Description For A1 adenosine receptors, 40 mg of protein were incubated for 60 min at 25°C with [3H]DPCPX 0.5 nM (Kd = 0.4 nM) and increasing concentrations... | Chem Biol Drug Des 82: 22-38 (2013) Article DOI: 10.1111/cbdd.12131 BindingDB Entry DOI: 10.7270/Q2445K4Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97466 (US8470800, C) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 4.05 | -44.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97471 (US8470800, H) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 8 | -43.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25400 ((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 9 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM97467 (US8470800, D | US8609833, 93) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 10.6 | -42.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
Inotek Pharmaceuticals Corporation US Patent | Assay Description Radioligand binding assay using adenosine receptor. | US Patent US8470800 (2013) BindingDB Entry DOI: 10.7270/Q2SQ8Z0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21220 ((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 14 | -44.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM86761 (CAS_35920-39-9 | NECA | NSC_448222) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | 14 | -44.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM50011300 (CHEMBL2398482 | US9133197, 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 27 | -43.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. US Patent | Assay Description Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c... | US Patent US9133197 (2015) BindingDB Entry DOI: 10.7270/Q2542MB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21215 (2-(1H-1,3-benzodiazol-2-yl)quinoxaline | 2-(1H-ben...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM181010 (US9133197, 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 51 | -41.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. US Patent | Assay Description Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c... | US Patent US9133197 (2015) BindingDB Entry DOI: 10.7270/Q2542MB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM181013 (US9133197, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 120 | -39.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. US Patent | Assay Description Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c... | US Patent US9133197 (2015) BindingDB Entry DOI: 10.7270/Q2542MB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM50011301 (CHEMBL2398486 | US9133197, 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | US Patent | 197 | -38.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. US Patent | Assay Description Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c... | US Patent US9133197 (2015) BindingDB Entry DOI: 10.7270/Q2542MB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM181014 (US9133197, 6) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 216 | -38.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. US Patent | Assay Description Competition binding experiments have been performed incubating membranes from CHO-K1 cells stably transfected with the human adenosine A1 receptor (c... | US Patent US9133197 (2015) BindingDB Entry DOI: 10.7270/Q2542MB7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21174 (CHEMBL398272 | N-[2-(furan-2-yl)-6-(1,3-thiazol-2-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 220 | -37.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21172 (CHEMBL251975 | N-[2-(furan-2-yl)-6-(1H-pyrazol-1-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 270 | -37.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21180 (2-(4-methylpiperazin-1-yl)-N-[6-(pyridin-2-yl)-2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 389 | -36.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21177 (N-[6-(5-methyl-1H-pyrazol-1-yl)-2-(5-methylfuran-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 390 | -36.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25398 (Bivalent derivative, 12e | N-[5-(2-{[6-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 436 | -35.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21227 (2-mercaptopyrimidine analogue, 5f | N-[6-methoxy-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 486 | -36.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21233 (2-mercaptopyrimidine analogue, 5l | N-{6-[(3-chlor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 582 | -35.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21179 (N-[2-(5-methylfuran-2-yl)-6-(1,3-thiazol-2-yl)pyri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 720 | -34.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21176 (N-[2-(5-methylfuran-2-yl)-6-(1H-pyrazol-1-yl)pyrim...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 850 | -34.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21178 (JMC511730 Compound 1 | N-[6-(3,5-dimethyl-1H-pyraz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 850 | -34.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21185 (2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 850 | -34.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 890 | -34.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM198126 ((2S,3S,4R,5R)-5-[2-chloro-6-[(3-iodophenyl)methyla...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 890 | -34.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21186 (2-(4-methylpiperazin-1-yl)-N-[6-(1H-pyrazol-1-yl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 930 | -34.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25397 ((2R,3R,4S,5R)-2-{6-[(4-{[2-(3-amino-4-hydroxypheny...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.01E+3 | -33.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM198129 (4-amino-6-alkyloxy-2-benzylthiopyrimidines (6)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.20E+3 | -33.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM198127 (4-amino-6-alkyloxy-2-benzylthiopyrimidines (4)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.24E+3 | -33.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21229 (2-mercaptopyrimidine analogue, 5h | N-[6-propoxy-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.46E+3 | -33.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21175 (CHEMBL252171 | N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.70E+3 | -32.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21182 (CHEMBL270761 | N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1.70E+3 | -32.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21232 (2-mercaptopyrimidine analogue, 5k | N-{6-[(2-chlor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.84E+3 | -32.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita di Napoli | Assay Description The membranes prepared from CHO cells transfected with human adenosine A1 receptors were used in binding assays. Nonspecific binding was determined i... | J Med Chem 51: 1764-70 (2008) Article DOI: 10.1021/jm701159t BindingDB Entry DOI: 10.7270/Q2MP51JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25399 (Bivalent derivative, 18 | N-[5-(1-{9-[(2R,3R,4S,5R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.91E+3 | -32.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25396 (Bivalent derivative, 12c | N-[5-(2-{[4-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.91E+3 | -32.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM198128 (4-amino-6-alkyloxy-2-benzylthiopyrimidines (5)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.95E+3 | -32.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Università di Napoli Federico II | Assay Description Aliquots of cell membranes (30 ug proteins) were incubated at 25 °C for 180 min in 500 uL of binding buffer (50 mM Tris-HCl, 2 mM MgCl2, 2 units/... | Chem Biol Drug Des 88: 724-729 (2016) Article DOI: 10.1111/cbdd.12801 BindingDB Entry DOI: 10.7270/Q25M64JG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM25394 (Bivalent derivative, 12a | N-[5-(2-{[2-({9-[(2R,3R...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 1.98E+3 | -32.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Monash University | Assay Description The displacement of [3H]DPCPX binding from the A1AR was determined using DDT1 MF-2 cell membranes. Nonspecific binding was determined in parallel ass... | J Med Chem 51: 6128-37 (2008) Article DOI: 10.1021/jm800613s BindingDB Entry DOI: 10.7270/Q26M3554 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21188 (N-[6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-(1,3-thiazol...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.00E+3 | -32.2 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Neuroscience | Assay Description The membranes prepared from Flp-In HEK cells transfected with adenosine receptors were used in binding assays. Nonspecific binding was determined in ... | J Med Chem 51: 1719-29 (2008) Article DOI: 10.1021/jm701185v BindingDB Entry DOI: 10.7270/Q2W66J2J | |||||||||||
More data for this Ligand-Target Pair |
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