Compile Data Set for Download or QSAR

Found 319 hits of ph data with Target = 'Diacylglycerol O-acyltransferase 2'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275027 (N2-(tert-butyl)-N8-((trans)-2- phenylcyclopropyl)-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)N[C@H]1CC1c1ccccc1 |r| Show InChI InChI=1S/C31H32F3N3O2/c1-30(2,3)36-29(39)37-15-14-23-22(20-10-7-11-21(16-20)31(32,33)34)12-13-24(26(23)18-37)28(38)35-27-17-25(27)19-8-5-4-6-9-19/h4-13,16,25,27H,14-15,17-18H2,1-3H3,(H,35,38)(H,36,39)/t25?,27-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275028 (N2-(tert-butyl)-N8-(imidazo[1,2-a]pyridin-3- ylmet...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cnc2ccccn12 Show InChI InChI=1S/C30H30F3N5O2/c1-29(2,3)36-28(40)37-14-12-23-22(19-7-6-8-20(15-19)30(31,32)33)10-11-24(25(23)18-37)27(39)35-17-21-16-34-26-9-4-5-13-38(21)26/h4-11,13,15-16H,12,14,17-18H2,1-3H3,(H,35,39)(H,36,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53.4	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275029 (N2-(tert-butyl)-N8-((4-methyl-1,2,5- oxadiazol-3-y...) Show SMILES Cc1nonc1CNC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C26H28F3N5O3/c1-15-22(33-37-32-15)13-30-23(35)20-9-8-18(16-6-5-7-17(12-16)26(27,28)29)19-10-11-34(14-21(19)20)24(36)31-25(2,3)4/h5-9,12H,10-11,13-14H2,1-4H3,(H,30,35)(H,31,36)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275030 (N2-(tert-butyl)-N8-((1-methyl-1H-imidazol- 2-yl)me...) Show SMILES Cn1ccnc1CNC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C27H30F3N5O2/c1-26(2,3)33-25(37)35-12-10-20-19(17-6-5-7-18(14-17)27(28,29)30)8-9-21(22(20)16-35)24(36)32-15-23-31-11-13-34(23)4/h5-9,11,13-14H,10,12,15-16H2,1-4H3,(H,32,36)(H,33,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	474	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275031 (N2-(tert-butyl)-N8-(((trans)-2- phenylcyclopropyl)...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NC[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C32H34F3N3O2/c1-31(2,3)37-30(40)38-15-14-25-24(21-10-7-11-23(16-21)32(33,34)35)12-13-26(28(25)19-38)29(39)36-18-22-17-27(22)20-8-5-4-6-9-20/h4-13,16,22,27H,14-15,17-19H2,1-3H3,(H,36,39)(H,37,40)/t22-,27-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	528	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275004 (N8-(2-(1H-1,2,4-triazol-5-yl)ethyl)-N2-(tert- buty...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1ncn[nH]1 Show InChI InChI=1S/C26H29F3N6O2/c1-25(2,3)33-24(37)35-12-10-19-18(16-5-4-6-17(13-16)26(27,28)29)7-8-20(21(19)14-35)23(36)30-11-9-22-31-15-32-34-22/h4-8,13,15H,9-12,14H2,1-3H3,(H,30,36)(H,33,37)(H,31,32,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	959	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275033 (N8-(2-(4H-1,2,4-triazol-4-yl)ethyl)-N2-(tert- buty...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCn1cnnc1 Show InChI InChI=1S/C26H29F3N6O2/c1-25(2,3)33-24(37)35-11-9-20-19(17-5-4-6-18(13-17)26(27,28)29)7-8-21(22(20)14-35)23(36)30-10-12-34-15-31-32-16-34/h4-8,13,15-16H,9-12,14H2,1-3H3,(H,30,36)(H,33,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	178	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275034 (N8-(1-(1,3,4-thiadiazol-2-yl)ethyl)-N2-(tert- buty...) Show SMILES CC(NC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C)c1nncs1 Show InChI InChI=1S/C26H28F3N5O2S/c1-15(23-33-30-14-37-23)31-22(35)20-9-8-18(16-6-5-7-17(12-16)26(27,28)29)19-10-11-34(13-21(19)20)24(36)32-25(2,3)4/h5-9,12,14-15H,10-11,13H2,1-4H3,(H,31,35)(H,32,36)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	659	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275035 (N2-(tert-butyl)-N8-(1-(3-(pyridin-2-yl)-1,2,4- oxa...) Show SMILES CC(NC(=O)c1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C)c1nc(no1)-c1ccccn1 Show InChI InChI=1S/C31H31F3N6O4/c1-18(28-37-26(39-44-28)25-10-5-6-14-35-25)36-27(41)23-12-11-21(19-8-7-9-20(16-19)43-31(32,33)34)22-13-15-40(17-24(22)23)29(42)38-30(2,3)4/h5-12,14,16,18H,13,15,17H2,1-4H3,(H,36,41)(H,38,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	511	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275036 (N2-(tert-butyl)-N8-(imidazo[2,1-b]thiazol-6- ylmet...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cn2ccsc2n1 Show InChI InChI=1S/C28H28F3N5O3S/c1-27(2,3)34-25(38)35-10-9-21-20(17-5-4-6-19(13-17)39-28(29,30)31)7-8-22(23(21)16-35)24(37)32-14-18-15-36-11-12-40-26(36)33-18/h4-8,11-13,15H,9-10,14,16H2,1-3H3,(H,32,37)(H,34,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275037 (N2-(tert-butyl)-N8-((6,7-dihydro-5H- pyrrolo[2,1-c...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1nnc2CCCn12 Show InChI InChI=1S/C28H31F3N6O3/c1-27(2,3)33-26(39)36-13-11-20-19(17-6-4-7-18(14-17)40-28(29,30)31)9-10-21(22(20)16-36)25(38)32-15-24-35-34-23-8-5-12-37(23)24/h4,6-7,9-10,14H,5,8,11-13,15-16H2,1-3H3,(H,32,38)(H,33,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275038 (N8-(2-(1H-1,2,3-triazol-1-yl)ethyl)-N2-(tert- buty...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCCn1ccnn1 Show InChI InChI=1S/C26H29F3N6O3/c1-25(2,3)32-24(37)34-12-9-20-19(17-5-4-6-18(15-17)38-26(27,28)29)7-8-21(22(20)16-34)23(36)30-10-13-35-14-11-31-33-35/h4-8,11,14-15H,9-10,12-13,16H2,1-3H3,(H,30,36)(H,32,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.58E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275039 (N2-(tert-butyl)-N8-(2-(oxazol-5-yl)propyl)-5- (3-(...) Show SMILES CC(CNC(=O)c1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C)c1cnco1 Show InChI InChI=1S/C28H31F3N4O4/c1-17(24-14-32-16-38-24)13-33-25(36)22-9-8-20(18-6-5-7-19(12-18)39-28(29,30)31)21-10-11-35(15-23(21)22)26(37)34-27(2,3)4/h5-9,12,14,16-17H,10-11,13,15H2,1-4H3,(H,33,36)(H,34,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	867	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275040 (N2-(tert-butyl)-N8-(2-(pyridin-3-yl)propyl)-5- (3-...) Show SMILES CC(CNC(=O)c1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C)c1cccnc1 Show InChI InChI=1S/C30H33F3N4O3/c1-19(21-8-6-13-34-17-21)16-35-27(38)25-11-10-23(20-7-5-9-22(15-20)40-30(31,32)33)24-12-14-37(18-26(24)25)28(39)36-29(2,3)4/h5-11,13,15,17,19H,12,14,16,18H2,1-4H3,(H,35,38)(H,36,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275041 (N2-(tert-butyl)-N8-(pyrazolo[1,5-a]pyridin-7- ylme...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cccc2ccnn12 Show InChI InChI=1S/C30H30F3N5O3/c1-29(2,3)36-28(40)37-15-13-24-23(19-6-4-9-22(16-19)41-30(31,32)33)10-11-25(26(24)18-37)27(39)34-17-21-8-5-7-20-12-14-35-38(20)21/h4-12,14,16H,13,15,17-18H2,1-3H3,(H,34,39)(H,36,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	149	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275043 (N2-(tert-butyl)-N8-((3-(pyridin-2-yl)isoxazol- 5-y...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cc(no1)-c1ccccn1 Show InChI InChI=1S/C31H30F3N5O4/c1-30(2,3)37-29(41)39-14-12-23-22(19-7-6-8-20(15-19)42-31(32,33)34)10-11-24(25(23)18-39)28(40)36-17-21-16-27(38-43-21)26-9-4-5-13-35-26/h4-11,13,15-16H,12,14,17-18H2,1-3H3,(H,36,40)(H,37,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	524	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM275044 (N2-(tert-butyl)-N8-(pyrazolo[1,5-a]pyridin-3- ylme...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1cnn2ccccc12 Show InChI InChI=1S/C30H30F3N5O3/c1-29(2,3)36-28(40)37-14-12-23-22(19-7-6-8-21(15-19)41-30(31,32)33)10-11-24(25(23)18-37)27(39)34-16-20-17-35-38-13-5-4-9-26(20)38/h4-11,13,15,17H,12,14,16,18H2,1-3H3,(H,34,39)(H,36,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274961 (US9877957, Example 1) Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c2CN(CCc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C36H41F3N4O4/c1-35(2,3)41-34(46)43-19-16-30-29(24-6-5-7-25(20-24)33(45)47-4)13-8-26(31(30)22-43)21-40-32(44)23-14-17-42(18-15-23)28-11-9-27(10-12-28)36(37,38)39/h5-13,20,23H,14-19,21-22H2,1-4H3,(H,40,44)(H,41,46)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.75	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274962 (N-(tert-butyl)-5-(3- (trifluoromethoxy)phenyl)-8-(...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)c1cc(n[nH]1)C(F)(F)F)ccc2-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C27H27F6N5O3/c1-25(2,3)35-24(40)38-10-9-19-18(15-5-4-6-17(11-15)41-27(31,32)33)8-7-16(20(19)14-38)13-34-23(39)21-12-22(37-36-21)26(28,29)30/h4-8,11-12H,9-10,13-14H2,1-3H3,(H,34,39)(H,35,40)(H,36,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274963 (US9877957, Example 3 | methyl 3-(8-((3-(tert-butyl...) Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cc(nn2C)C(C)(C)C)c2CN(CCc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C32H41N5O4/c1-31(2,3)27-17-26(36(7)35-27)28(38)33-18-22-12-13-23(20-10-9-11-21(16-20)29(39)41-8)24-14-15-37(19-25(22)24)30(40)34-32(4,5)6/h9-13,16-17H,14-15,18-19H2,1-8H3,(H,33,38)(H,34,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274964 (N-(tert-butyl)-5-(3-methoxyphenyl)-8- ((3-(trifluo...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(n[nH]2)C(F)(F)F)c2CN(CCc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C27H30F3N5O3/c1-26(2,3)32-25(37)35-11-10-20-19(16-6-5-7-18(12-16)38-4)9-8-17(21(20)15-35)14-31-24(36)22-13-23(34-33-22)27(28,29)30/h5-9,12-13H,10-11,14-15H2,1-4H3,(H,31,36)(H,32,37)(H,33,34)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.4	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274965 (N-((2-(tert-butylcarbamoyl)-5-(3- methoxyphenyl)-1...) Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2nccc3ccccc23)c2CN(CCc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C32H34N4O3/c1-32(2,3)35-31(38)36-17-15-27-25(22-9-7-10-24(18-22)39-4)13-12-23(28(27)20-36)19-34-30(37)29-26-11-6-5-8-21(26)14-16-33-29/h5-14,16,18H,15,17,19-20H2,1-4H3,(H,34,37)(H,35,38)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	135	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274966 (N2-(tert-butyl)-N8-(2-(5-chloro-1H-benzo[d]imidazo...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C31H31ClF3N5O2/c1-30(2,3)39-29(42)40-14-12-22-21(18-5-4-6-19(15-18)31(33,34)35)8-9-23(24(22)17-40)28(41)36-13-11-27-37-25-10-7-20(32)16-26(25)38-27/h4-10,15-16H,11-14,17H2,1-3H3,(H,36,41)(H,37,38)(H,39,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.9	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274967 (N2-(tert-butyl)-N8-(2-(5,6-dichloro-1H- benzo[d]im...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2cc(Cl)c(Cl)cc2[nH]1 Show InChI InChI=1S/C31H30Cl2F3N5O2/c1-30(2,3)40-29(43)41-12-10-20-19(17-5-4-6-18(13-17)31(34,35)36)7-8-21(22(20)16-41)28(42)37-11-9-27-38-25-14-23(32)24(33)15-26(25)39-27/h4-8,13-15H,9-12,16H2,1-3H3,(H,37,42)(H,38,39)(H,40,43)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.9	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274968 (N2-(tert-butyl)-N8-(2-(5-fluoro-1H- benzo[d]imidaz...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2ccc(F)cc2[nH]1 Show InChI InChI=1S/C31H31F4N5O2/c1-30(2,3)39-29(42)40-14-12-22-21(18-5-4-6-19(15-18)31(33,34)35)8-9-23(24(22)17-40)28(41)36-13-11-27-37-25-10-7-20(32)16-26(25)38-27/h4-10,15-16H,11-14,17H2,1-3H3,(H,36,41)(H,37,38)(H,39,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.9	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274969 (N8-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-N2- (tert-b...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2ccccc2[nH]1 Show InChI InChI=1S/C31H32F3N5O2/c1-30(2,3)38-29(41)39-16-14-22-21(19-7-6-8-20(17-19)31(32,33)34)11-12-23(24(22)18-39)28(40)35-15-13-27-36-25-9-4-5-10-26(25)37-27/h4-12,17H,13-16,18H2,1-3H3,(H,35,40)(H,36,37)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51.1	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274970 (N2-(tert-butyl)-N8-(isoquinolin-4-ylmethyl)- 5-(3-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cncc2ccccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-14-13-26-25(20-8-6-9-23(15-20)32(33,34)35)11-12-27(28(26)19-39)29(40)37-18-22-17-36-16-21-7-4-5-10-24(21)22/h4-12,15-17H,13-14,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66.9	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274971 (N2-(tert-butyl)-N8-quinolin-8-ylmethyl)-5- (3-(tri...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cccc2cccnc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-16-14-25-24(21-8-5-11-23(17-21)32(33,34)35)12-13-26(27(25)19-39)29(40)37-18-22-9-4-7-20-10-6-15-36-28(20)22/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67.6	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274972 (N2-(tert-butyl)-N8-(isoquinolin-5-ylmethyl)- 5-(3-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cccc2cnccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-15-13-26-25(20-6-5-9-23(16-20)32(33,34)35)10-11-27(28(26)19-39)29(40)37-18-22-8-4-7-21-17-36-14-12-24(21)22/h4-12,14,16-17H,13,15,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68.6	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274973 (N2-(tert-butyl)-N8-(2-(6-methoxy-1H- benzo[d]imida...) Show SMILES COc1ccc2nc(CCNC(=O)c3ccc(-c4cccc(OC(F)(F)F)c4)c4CCN(Cc34)C(=O)NC(C)(C)C)[nH]c2c1 Show InChI InChI=1S/C32H34F3N5O4/c1-31(2,3)39-30(42)40-15-13-23-22(19-6-5-7-21(16-19)44-32(33,34)35)9-10-24(25(23)18-40)29(41)36-14-12-28-37-26-11-8-20(43-4)17-27(26)38-28/h5-11,16-17H,12-15,18H2,1-4H3,(H,36,41)(H,37,38)(H,39,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68.9	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274975 (N2-(tert-butyl)-N8-(2-(5-methyl-1H- benzo[d]imidaz...) Show SMILES Cc1ccc2[nH]c(CCNC(=O)c3ccc(-c4cccc(c4)C(F)(F)F)c4CCN(Cc34)C(=O)NC(C)(C)C)nc2c1 Show InChI InChI=1S/C32H34F3N5O2/c1-19-8-11-26-27(16-19)38-28(37-26)12-14-36-29(41)24-10-9-22(20-6-5-7-21(17-20)32(33,34)35)23-13-15-40(18-25(23)24)30(42)39-31(2,3)4/h5-11,16-17H,12-15,18H2,1-4H3,(H,36,41)(H,37,38)(H,39,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	103	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274976 (N2-(tert-butyl)-N8-((2-methylimidazo[1,2- a]pyridi...) Show SMILES Cc1nc2ccccn2c1CNC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C Show InChI InChI=1S/C31H32F3N5O2/c1-19-26(39-14-6-5-10-27(39)36-19)17-35-28(40)24-12-11-22(20-8-7-9-21(16-20)31(32,33)34)23-13-15-38(18-25(23)24)29(41)37-30(2,3)4/h5-12,14,16H,13,15,17-18H2,1-4H3,(H,35,40)(H,37,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274977 (N2-(tert-butyl)-N8-(quinolin-5-ylmethyl)-5- (3-(tr...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cccc2ncccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-16-14-25-23(20-7-4-9-22(17-20)32(33,34)35)12-13-26(27(25)19-39)29(40)37-18-21-8-5-11-28-24(21)10-6-15-36-28/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	126	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274978 (N8-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)- N2-(tert...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1ccc2nonc2c1 Show InChI InChI=1S/C29H28F3N5O3/c1-28(2,3)34-27(39)37-12-11-21-20(18-5-4-6-19(14-18)29(30,31)32)8-9-22(23(21)16-37)26(38)33-15-17-7-10-24-25(13-17)36-40-35-24/h4-10,13-14H,11-12,15-16H2,1-3H3,(H,33,38)(H,34,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	132	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274979 (N2-(tert-butyl)-N8-(2-(imidazo[2,1-b]thiazol- 6-yl...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1cn2ccsc2n1 Show InChI InChI=1S/C29H30F3N5O2S/c1-28(2,3)35-26(39)36-12-10-22-21(18-5-4-6-19(15-18)29(30,31)32)7-8-23(24(22)17-36)25(38)33-11-9-20-16-37-13-14-40-27(37)34-20/h4-8,13-16H,9-12,17H2,1-3H3,(H,33,38)(H,35,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	133	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274980 (N2-(tert-butyl)-N8-(isoquinolin-1-ylmethyl)- 5-(3-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1nccc2ccccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-16-14-25-23(21-8-6-9-22(17-21)32(33,34)35)11-12-26(27(25)19-39)29(40)37-18-28-24-10-5-4-7-20(24)13-15-36-28/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	197	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274981 (N2-(tert-butyl)-N8-(2-(1-methyl-1H- benzo[d]imidaz...) Show SMILES Cn1c(CCNC(=O)c2ccc(-c3cccc(c3)C(F)(F)F)c3CCN(Cc23)C(=O)NC(C)(C)C)nc2ccccc12 Show InChI InChI=1S/C32H34F3N5O2/c1-31(2,3)38-30(42)40-17-15-23-22(20-8-7-9-21(18-20)32(33,34)35)12-13-24(25(23)19-40)29(41)36-16-14-28-37-26-10-5-6-11-27(26)39(28)4/h5-13,18H,14-17,19H2,1-4H3,(H,36,41)(H,38,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	205	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274982 ((R/S)-N2-(tert-butyl)-N8-(2-hydroxy-1-(6- (trifluo...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)N[C@@H](CO)c1ccc(nc1)C(F)(F)F |r| Show InChI InChI=1S/C30H30F6N4O3/c1-28(2,3)39-27(43)40-12-11-21-20(17-5-4-6-19(13-17)29(31,32)33)8-9-22(23(21)15-40)26(42)38-24(16-41)18-7-10-25(37-14-18)30(34,35)36/h4-10,13-14,24,41H,11-12,15-16H2,1-3H3,(H,38,42)(H,39,43)/t24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	214	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274983 (N2-(tert-butyl)-N8-(isoquinolin-1-ylmethyl)- 5-(3-...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(OC(F)(F)F)c1)C(=O)NCc1nccc2ccccc12 Show InChI InChI=1S/C32H31F3N4O3/c1-31(2,3)38-30(41)39-16-14-25-23(21-8-6-9-22(17-21)42-32(33,34)35)11-12-26(27(25)19-39)29(40)37-18-28-24-10-5-4-7-20(24)13-15-36-28/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	235	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274984 (N2-(tert-butyl)-N8-(2-(imidazo[1,2-a]pyridin- 2-yl...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1cn2ccccc2n1 Show InChI InChI=1S/C31H32F3N5O2/c1-30(2,3)37-29(41)39-16-13-24-23(20-7-6-8-21(17-20)31(32,33)34)10-11-25(26(24)19-39)28(40)35-14-12-22-18-38-15-5-4-9-27(38)36-22/h4-11,15,17-18H,12-14,16,19H2,1-3H3,(H,35,40)(H,37,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274985 (N8-((1,7-naphthyridin-8-yl)methyl)-N2-(tert- butyl...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1nccc2cccnc12 Show InChI InChI=1S/C31H30F3N5O2/c1-30(2,3)38-29(41)39-15-12-23-22(20-6-4-8-21(16-20)31(32,33)34)9-10-24(25(23)18-39)28(40)37-17-26-27-19(11-14-35-26)7-5-13-36-27/h4-11,13-14,16H,12,15,17-18H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	265	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274986 (N2-(tert-butyl)-N8-(2-(2-methylimidazo[2,1- b][1,3...) Show SMILES Cc1nn2cc(CCNC(=O)c3ccc(-c4cccc(c4)C(F)(F)F)c4CCN(Cc34)C(=O)NC(C)(C)C)nc2s1 Show InChI InChI=1S/C29H31F3N6O2S/c1-17-36-38-15-20(34-27(38)41-17)10-12-33-25(39)23-9-8-21(18-6-5-7-19(14-18)29(30,31)32)22-11-13-37(16-24(22)23)26(40)35-28(2,3)4/h5-9,14-15H,10-13,16H2,1-4H3,(H,33,39)(H,35,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	271	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274987 (N2-(tert-butyl)-N8-(quinolin-4-ylmethyl)-5- (3-(tr...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1ccnc2ccccc12 Show InChI InChI=1S/C32H31F3N4O2/c1-31(2,3)38-30(41)39-16-14-25-23(20-7-6-8-22(17-20)32(33,34)35)11-12-26(27(25)19-39)29(40)37-18-21-13-15-36-28-10-5-4-9-24(21)28/h4-13,15,17H,14,16,18-19H2,1-3H3,(H,37,40)(H,38,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	292	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274988 (N2-(tert-butyl)-N8-((3-cyanoisoxazol-4- yl)methyl)...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1conc1C#N Show InChI InChI=1S/C27H26F3N5O3/c1-26(2,3)33-25(37)35-10-9-20-19(16-5-4-6-18(11-16)27(28,29)30)7-8-21(22(20)14-35)24(36)32-13-17-15-38-34-23(17)12-31/h4-8,11,15H,9-10,13-14H2,1-3H3,(H,32,36)(H,33,37)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	314	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274989 (N2-(tert-butyl)-N8-((5-phenyl-1,2,4- oxadiazol-3-y...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1noc(n1)-c1ccccc1 Show InChI InChI=1S/C31H30F3N5O3/c1-30(2,3)37-29(41)39-15-14-23-22(20-10-7-11-21(16-20)31(32,33)34)12-13-24(25(23)18-39)27(40)35-17-26-36-28(42-38-26)19-8-5-4-6-9-19/h4-13,16H,14-15,17-18H2,1-3H3,(H,35,40)(H,37,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	326	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274990 (N2-(tert-butyl)-N8-(2-(thiazol-4-yl)ethyl)-5- (3-(...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1cscn1 Show InChI InChI=1S/C27H29F3N4O2S/c1-26(2,3)33-25(36)34-12-10-21-20(17-5-4-6-18(13-17)27(28,29)30)7-8-22(23(21)14-34)24(35)31-11-9-19-15-37-16-32-19/h4-8,13,15-16H,9-12,14H2,1-3H3,(H,31,35)(H,33,36)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	329	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274991 (N2-(tert-butyl)-N8-(pyrazolo[1,5-a]pyridin-3- ylme...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cnn2ccccc12 Show InChI InChI=1S/C30H30F3N5O2/c1-29(2,3)36-28(40)37-14-12-23-22(19-7-6-8-21(15-19)30(31,32)33)10-11-24(25(23)18-37)27(39)34-16-20-17-35-38-13-5-4-9-26(20)38/h4-11,13,15,17H,12,14,16,18H2,1-3H3,(H,34,39)(H,36,40)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	351	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274992 (N2-(tert-butyl)-N8-(2-(3,5-dimethyl-1H- pyrazol-1-...) Show SMILES Cc1cc(C)n(CCNC(=O)c2ccc(-c3cccc(c3)C(F)(F)F)c3CCN(Cc23)C(=O)NC(C)(C)C)n1 Show InChI InChI=1S/C29H34F3N5O2/c1-18-15-19(2)37(35-18)14-12-33-26(38)24-10-9-22(20-7-6-8-21(16-20)29(30,31)32)23-11-13-36(17-25(23)24)27(39)34-28(3,4)5/h6-10,15-16H,11-14,17H2,1-5H3,(H,33,38)(H,34,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	505	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274993 (N2-(tert-butyl)-N8-((5-methyl-2- phenylthiazol-4-y...) Show SMILES Cc1sc(nc1CNC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C)-c1ccccc1 Show InChI InChI=1S/C33H33F3N4O2S/c1-20-28(38-30(43-20)21-9-6-5-7-10-21)18-37-29(41)26-14-13-24(22-11-8-12-23(17-22)33(34,35)36)25-15-16-40(19-27(25)26)31(42)39-32(2,3)4/h5-14,17H,15-16,18-19H2,1-4H3,(H,37,41)(H,39,42)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	539	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human))	BDBM274994 (N2-(tert-butyl)-N8-((3-(pyridin-2-yl)-1,2,4- oxadi...) Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1nc(no1)-c1ccccn1 Show InChI InChI=1S/C30H29F3N6O3/c1-29(2,3)37-28(41)39-14-12-21-20(18-7-6-8-19(15-18)30(31,32)33)10-11-22(23(21)17-39)27(40)35-16-25-36-26(38-42-25)24-9-4-5-13-34-24/h4-11,13,15H,12,14,16-17H2,1-3H3,(H,35,40)(H,37,41)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	588	n/a	n/a	n/a	n/a	7.0	25
Merck Sharp & Dohme Corp. US Patent					Assay Description DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...				US Patent US9877957 (2018) BindingDB Entry DOI: 10.7270/Q2Z60R2C
					More data for this Ligand-Target Pair

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