Compile Data Set for Download or QSAR

Found 868 hits of ph data with Target = 'Dual specificity protein kinase TTK'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141328 (US8916577, 1) Show SMILES COc1cc(Br)ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(N)=O Show InChI InChI=1S/C19H19BrN6O2/c1-26-17-12(16(25-26)18(21)27)5-3-4-10-9-22-19(24-15(10)17)23-13-7-6-11(20)8-14(13)28-2/h6-9H,3-5H2,1-2H3,(H2,21,27)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	421	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149695 (US8975267, 38) Show SMILES CSc1ncc2ccc3c(cn(CC(C)(C)CN)c3c2n1)C(N)=O Show InChI InChI=1S/C17H21N5OS/c1-17(2,8-18)9-22-7-12(15(19)23)11-5-4-10-6-20-16(24-3)21-13(10)14(11)22/h4-7H,8-9,18H2,1-3H3,(H2,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.94E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141331 (US8916577, 4) Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21 Show InChI InChI=1S/C34H42N8O2/c1-6-22-10-8-11-23(7-2)29(22)37-33(43)31-26-13-9-12-24-21-35-34(38-30(24)32(26)41(4)39-31)36-27-15-14-25(20-28(27)44-5)42-18-16-40(3)17-19-42/h8,10-11,14-15,20-21H,6-7,9,12-13,16-19H2,1-5H3,(H,37,43)(H,35,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	184	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141341 (US8916577, 5) Show SMILES COc1cc(ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(=O)N[C@H](CN)c1ccccc1)C(=O)NC1CCN(C)CC1 |r| Show InChI InChI=1S/C34H41N9O3/c1-42-16-14-24(15-17-42)37-32(44)22-12-13-26(28(18-22)46-3)39-34-36-20-23-10-7-11-25-30(41-43(2)31(25)29(23)40-34)33(45)38-27(19-35)21-8-5-4-6-9-21/h4-6,8-9,12-13,18,20,24,27H,7,10-11,14-17,19,35H2,1-3H3,(H,37,44)(H,38,45)(H,36,39,40)/t27-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	469	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141332 (US8916577, 8) Show SMILES COc1cc(ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(=O)Nc1ccccc1)N1CCN(C)CC1 Show InChI InChI=1S/C30H34N8O2/c1-36-14-16-38(17-15-36)22-12-13-24(25(18-22)40-3)33-30-31-19-20-8-7-11-23-27(35-37(2)28(23)26(20)34-30)29(39)32-21-9-5-4-6-10-21/h4-6,9-10,12-13,18-19H,7-8,11,14-17H2,1-3H3,(H,32,39)(H,31,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	353	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141333 (US8916577, 27) Show SMILES CCc1cccc(C)c1NC(=O)c1nn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21 Show InChI InChI=1S/C33H40N8O2/c1-6-22-10-7-9-21(2)28(22)36-32(42)30-25-12-8-11-23-20-34-33(37-29(23)31(25)40(4)38-30)35-26-14-13-24(19-27(26)43-5)41-17-15-39(3)16-18-41/h7,9-10,13-14,19-20H,6,8,11-12,15-18H2,1-5H3,(H,36,42)(H,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	189	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141334 (US8916577, 28) Show SMILES COc1cc(ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(=O)NC1CCCCC1)N1CCN(C)CC1 Show InChI InChI=1S/C30H40N8O2/c1-36-14-16-38(17-15-36)22-12-13-24(25(18-22)40-3)33-30-31-19-20-8-7-11-23-27(35-37(2)28(23)26(20)34-30)29(39)32-21-9-5-4-6-10-21/h12-13,18-19,21H,4-11,14-17H2,1-3H3,(H,32,39)(H,31,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	249	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141329 (US8916577, 32) Show SMILES CNC(=O)c1nn(C)c-2c1CCCc1cnc(Nc3ccc(Br)cc3OC)nc-21 Show InChI InChI=1S/C20H21BrN6O2/c1-22-19(28)17-13-6-4-5-11-10-23-20(25-16(11)18(13)27(2)26-17)24-14-8-7-12(21)9-15(14)29-3/h7-10H,4-6H2,1-3H3,(H,22,28)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	277	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141338 (US8916577, 35) Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)nc-21 Show InChI InChI=1S/C36H44N8O3/c1-6-22-10-8-11-23(7-2)30(22)40-35(46)32-27-13-9-12-25-21-37-36(41-31(25)33(27)44(4)42-32)39-28-15-14-24(20-29(28)47-5)34(45)38-26-16-18-43(3)19-17-26/h8,10-11,14-15,20-21,26H,6-7,9,12-13,16-19H2,1-5H3,(H,38,45)(H,40,46)(H,37,39,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141339 (US8916577, 43) Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)N3CCCN(C)CC3)nc-21 Show InChI InChI=1S/C36H41F3N8O3/c1-5-22-10-7-11-23(6-2)29(22)42-33(48)31-26-13-8-12-25-21-40-35(43-30(25)32(26)46(4)44-31)41-27-15-14-24(20-28(27)50-36(37,38)39)34(49)47-17-9-16-45(3)18-19-47/h7,10-11,14-15,20-21H,5-6,8-9,12-13,16-19H2,1-4H3,(H,42,48)(H,40,41,43)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	199	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141327 (US8916577, 56) Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(CC(F)(F)F)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21 Show InChI InChI=1S/C35H41F3N8O2/c1-5-22-9-7-10-23(6-2)29(22)41-33(47)31-26-12-8-11-24-20-39-34(42-30(24)32(26)46(43-31)21-35(36,37)38)40-27-14-13-25(19-28(27)48-4)45-17-15-44(3)16-18-45/h7,9-10,13-14,19-20H,5-6,8,11-12,15-18,21H2,1-4H3,(H,41,47)(H,39,40,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	862	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141326 (US8916577, 67) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCCc4c(nn(C)c4-c3n2)C(N)=O)cc1 Show InChI InChI=1S/C23H28N8O/c1-29-10-12-31(13-11-29)17-8-6-16(7-9-17)26-23-25-14-15-4-3-5-18-20(22(24)32)28-30(2)21(18)19(15)27-23/h6-9,14H,3-5,10-13H2,1-2H3,(H2,24,32)(H,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141340 (US8916577, 71) Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(CCO)c-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N(C)C)nc-21 Show InChI InChI=1S/C37H48N8O3/c1-6-24-10-8-11-25(7-2)32(24)40-36(47)34-29-13-9-12-26-23-38-37(41-33(26)35(29)45(42-34)20-21-46)39-30-15-14-28(22-31(30)48-5)44-18-16-27(17-19-44)43(3)4/h8,10-11,14-15,22-23,27,46H,6-7,9,12-13,16-21H2,1-5H3,(H,40,47)(H,38,39,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	174	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141335 (US8916577, 97) Show SMILES CCc1cccc(CC)c1NC(=O)c1c2CCCc3cnc(Nc4ccc(cc4OC)N4CCN(C)CC4)nc3-c2nn1C Show InChI InChI=1S/C34H42N8O2/c1-6-22-10-8-11-23(7-2)29(22)37-33(43)32-26-13-9-12-24-21-35-34(38-30(24)31(26)39-41(32)4)36-27-15-14-25(20-28(27)44-5)42-18-16-40(3)17-19-42/h8,10-11,14-15,20-21H,6-7,9,12-13,16-19H2,1-5H3,(H,37,43)(H,35,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	853	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141336 (US8916577, 99) Show SMILES CCc1cccc(CC)c1NC(=O)c1noc-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21 Show InChI InChI=1S/C33H39N7O3/c1-5-21-9-7-10-22(6-2)28(21)36-32(41)30-25-12-8-11-23-20-34-33(37-29(23)31(25)43-38-30)35-26-14-13-24(19-27(26)42-4)40-17-15-39(3)16-18-40/h7,9-10,13-14,19-20H,5-6,8,11-12,15-18H2,1-4H3,(H,36,41)(H,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141337 (US8916577, 101) Show SMILES CCc1cccc(CC)c1NC(=O)c1onc-2c1CCCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21 Show InChI InChI=1S/C33H39N7O3/c1-5-21-9-7-10-22(6-2)28(21)36-32(41)31-25-12-8-11-23-20-34-33(37-29(23)30(25)38-43-31)35-26-14-13-24(19-27(26)42-4)40-17-15-39(3)16-18-40/h7,9-10,13-14,19-20H,5-6,8,11-12,15-18H2,1-4H3,(H,36,41)(H,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	308	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149680 (US8975267, Ref. compound 1) Show SMILES Cn1cc(C(N)=O)c2CCc3cnc(N)nc3-c12 Show InChI InChI=1S/C12H13N5O/c1-17-5-8(11(13)18)7-3-2-6-4-15-12(14)16-9(6)10(7)17/h4-5H,2-3H2,1H3,(H2,13,18)(H2,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149681 (US8975267, Ref. compound 2) Show SMILES NC(=O)c1c([nH]c2c1ccc1cnc(N)nc21)-c1ccccc1 Show InChI InChI=1S/C17H13N5O/c18-16(23)12-11-7-6-10-8-20-17(19)22-14(10)15(11)21-13(12)9-4-2-1-3-5-9/h1-8,21H,(H2,18,23)(H2,19,20,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149682 (US8975267, Ref. compound 3) Show SMILES Cn1c(c(C(N)=O)c2CCc3cnc(N)nc3-c12)-c1ccccc1 Show InChI InChI=1S/C18H17N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-6,9H,7-8H2,1H3,(H2,19,24)(H2,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149683 (US8975267, Ref. compound 4) Show SMILES Cn1c(c(C(N)=O)c2ccc3cnc(N)nc3c12)-c1ccccc1 Show InChI InChI=1S/C18H15N5O/c1-23-15(10-5-3-2-4-6-10)13(17(19)24)12-8-7-11-9-21-18(20)22-14(11)16(12)23/h2-9H,1H3,(H2,19,24)(H2,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149684 (US8975267, 3) Show SMILES CCc1cccc(CC)c1NC(=O)c1c(C)n(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCCC3)nc-21 Show InChI InChI=1S/C39H49N7O2/c1-6-26-11-10-12-27(7-2)35(26)42-38(47)34-25(3)44(4)37-31(34)15-13-28-24-40-39(43-36(28)37)41-32-16-14-30(23-33(32)48-5)46-21-17-29(18-22-46)45-19-8-9-20-45/h10-12,14,16,23-24,29H,6-9,13,15,17-22H2,1-5H3,(H,42,47)(H,40,41,43)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	99	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149685 (US8975267, 7) Show SMILES COc1cc(ccc1Nc1ncc2CCc3c(C(N)=O)c(C)n(C)c3-c2n1)N1CCN(C)CC1 Show InChI InChI=1S/C25H31N7O2/c1-15-21(24(26)33)18-7-5-16-14-27-25(29-22(16)23(18)31(15)3)28-19-8-6-17(13-20(19)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,26,33)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149686 (US8975267, 22) Show SMILES CSc1ncc2CCc3c(cn(C(C)C)c3-c2n1)C(N)=O Show InChI InChI=1S/C15H18N4OS/c1-8(2)19-7-11(14(16)20)10-5-4-9-6-17-15(21-3)18-12(9)13(10)19/h6-8H,4-5H2,1-3H3,(H2,16,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	382	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149687 (US8975267, 25) Show SMILES CSc1ncc2CCc3c(cn(CCO)c3-c2n1)C(N)=O Show InChI InChI=1S/C14H16N4O2S/c1-21-14-16-6-8-2-3-9-10(13(15)20)7-18(4-5-19)12(9)11(8)17-14/h6-7,19H,2-5H2,1H3,(H2,15,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.44E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149688 (US8975267, 29) Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(CCO)c3c2n1 Show InChI InChI=1S/C15H16N4O2S/c1-8-11(14(16)21)10-4-3-9-7-17-15(22-2)18-12(9)13(10)19(8)5-6-20/h3-4,7,20H,5-6H2,1-2H3,(H2,16,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.94E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149689 (US8975267, 30) Show SMILES CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1 Show InChI InChI=1S/C16H18N4OS/c1-8(2)20-9(3)12(15(17)21)11-6-5-10-7-18-16(22-4)19-13(10)14(11)20/h5-8H,1-4H3,(H2,17,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	622	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149690 (US8975267, 32) Show SMILES CSc1ncc2CCc3c(cn(C4CCNCC4)c3-c2n1)C(N)=O Show InChI InChI=1S/C17H21N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h8-9,11,19H,2-7H2,1H3,(H2,18,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149691 (US8975267, 33) Show SMILES CSc1ncc2CCc3c(cn([C@@H]4CC[C@H](N)CC4)c3-c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H23N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h8-9,11-12H,2-7,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149692 (US8975267, 34) Show SMILES CSc1ncc2ccc3c(cn([C@@H]4CC[C@H](N)CC4)c3c2n1)C(N)=O |wU:15.15,12.11,(6.59,1.87,;5.05,1.92,;4.24,.61,;4.97,-.75,;4.16,-2.06,;2.62,-2.01,;1.81,-3.32,;.27,-3.27,;-.46,-1.92,;-1.96,-1.55,;-2.07,-.01,;-.64,.57,;-.28,2.07,;1.2,2.49,;1.57,3.99,;.46,5.06,;.82,6.55,;-1.02,4.63,;-1.39,3.13,;.35,-.61,;1.89,-.65,;2.7,.65,;-3.13,-2.54,;-2.86,-4.06,;-4.58,-2.02,)| Show InChI InChI=1S/C18H21N5OS/c1-25-18-21-8-10-2-7-13-14(17(20)24)9-23(16(13)15(10)22-18)12-5-3-11(19)4-6-12/h2,7-9,11-12H,3-6,19H2,1H3,(H2,20,24)/t11-,12+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	855	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149693 (US8975267, 35) Show SMILES CSc1ncc2ccc3c(cn(C4CCNCC4)c3c2n1)C(N)=O Show InChI InChI=1S/C17H19N5OS/c1-24-17-20-8-10-2-3-12-13(16(18)23)9-22(15(12)14(10)21-17)11-4-6-19-7-5-11/h2-3,8-9,11,19H,4-7H2,1H3,(H2,18,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.55E+3	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM149694 (US8975267, 36) Show SMILES CSc1ncc2ccc3c(c[nH]c3c2n1)C(N)=O Show InChI InChI=1S/C12H10N4OS/c1-18-12-15-4-6-2-3-7-8(11(13)17)5-14-10(7)9(6)16-12/h2-5,14H,1H3,(H2,13,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	814	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.r.l. US Patent					Assay Description Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...				US Patent US8975267 (2015) BindingDB Entry DOI: 10.7270/Q29C6W41
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM141330 (US8916577, 3) Show SMILES COc1cc(ccc1Nc1ncc2CCCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1 Show InChI InChI=1S/C24H30N8O2/c1-30-9-11-32(12-10-30)16-7-8-18(19(13-16)34-3)27-24-26-14-15-5-4-6-17-21(23(25)33)29-31(2)22(17)20(15)28-24/h7-8,13-14H,4-6,9-12H2,1-3H3,(H2,25,33)(H,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	194	n/a	n/a	n/a	n/a	3.0	n/a
Nerviano Medical Sciences S.R.L. US Patent					Assay Description The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...				US Patent US8916577 (2014) BindingDB Entry DOI: 10.7270/Q25719RJ
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241303 (US10479788, Example 147 | US11046688, Example 147 ...) Show SMILES COc1cc(ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1)-c1cnn(C)c1C Show InChI InChI=1S/C24H29N7O2/c1-15-18(13-28-31(15)4)16-7-8-19(20(11-16)32-5)29-23-26-12-17-9-10-25-22(21(17)30-23)27-14-24(2,3)33-6/h7-13H,14H2,1-6H3,(H,25,27)(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241304 (US10479788, Example 148 | US11046688, Example 148 ...) Show SMILES COc1cc(ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1)-c1cnn(C)c1C Show InChI InChI=1S/C25H29N7O2/c1-16-19(13-29-32(16)3)17-5-6-20(21(11-17)33-4)30-24-27-12-18-7-9-26-23(22(18)31-24)28-14-25(2)8-10-34-15-25/h5-7,9,11-13H,8,10,14-15H2,1-4H3,(H,26,28)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241305 (US11046688, Example 149 | US9409907, 149) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(NCC(C)(C)C)c2n1)-c1cnn(C)c1 Show InChI InChI=1S/C24H29N7O/c1-15-10-25-22(27-14-24(2,3)4)21-18(15)12-26-23(30-21)29-19-8-7-16(9-20(19)32-6)17-11-28-31(5)13-17/h7-13H,14H2,1-6H3,(H,25,27)(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241306 (US10479788, Example 150 | US11046688, Example 150 ...) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(NCC(C)(C)OC)c2n1)-c1nncn1C Show InChI InChI=1S/C23H28N8O2/c1-14-10-24-20(26-12-23(2,3)33-6)19-16(14)11-25-22(29-19)28-17-8-7-15(9-18(17)32-5)21-30-27-13-31(21)4/h7-11,13H,12H2,1-6H3,(H,24,26)(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241307 (US10479788, Example 151 | US11046688, Example 151 ...) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(NCC(C)(C)C)c2n1)-c1nncn1C Show InChI InChI=1S/C23H28N8O/c1-14-10-24-20(26-12-23(2,3)4)19-16(14)11-25-22(29-19)28-17-8-7-15(9-18(17)32-6)21-30-27-13-31(21)5/h7-11,13H,12H2,1-6H3,(H,24,26)(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241308 (US10479788, Example 152 | US11046688, Example 152 ...) Show SMILES CCn1cc(cn1)-c1ccc(Nc2ncc3ccnc(NCC(C)(C)OC)c3n2)c(OC)c1 Show InChI InChI=1S/C24H29N7O2/c1-6-31-14-18(13-28-31)16-7-8-19(20(11-16)32-4)29-23-26-12-17-9-10-25-22(21(17)30-23)27-15-24(2,3)33-5/h7-14H,6,15H2,1-5H3,(H,25,27)(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241309 (US10479788, Example 153 | US11046688, Example 153 ...) Show SMILES COC1CN(C1)C(=O)c1ccc(Nc2ncc3ccnc(NCC(C)(C)C)c3n2)c(OC)c1 Show InChI InChI=1S/C24H30N6O3/c1-24(2,3)14-27-21-20-16(8-9-25-21)11-26-23(29-20)28-18-7-6-15(10-19(18)33-5)22(31)30-12-17(13-30)32-4/h6-11,17H,12-14H2,1-5H3,(H,25,27)(H,26,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241310 (US10479788, Example 154 | US11046688, Example 154 ...) Show SMILES COc1cc(ccc1Nc1ncc2ccnc(NCC3(C)CCOC3)c2n1)C1CCOCC1 Show InChI InChI=1S/C25H31N5O3/c1-25(8-12-33-16-25)15-28-23-22-19(5-9-26-23)14-27-24(30-22)29-20-4-3-18(13-21(20)31-2)17-6-10-32-11-7-17/h3-5,9,13-14,17H,6-8,10-12,15-16H2,1-2H3,(H,26,28)(H,27,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241311 (US10479788, Example 155 | US11046688, Example 155 ...) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(NCC3(C)COC3)c2n1)-c1nncn1C Show InChI InChI=1S/C23H26N8O2/c1-14-8-24-20(26-10-23(2)11-33-12-23)19-16(14)9-25-22(29-19)28-17-6-5-15(7-18(17)32-4)21-30-27-13-31(21)3/h5-9,13H,10-12H2,1-4H3,(H,24,26)(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241312 (US10479788, Example 156 | US11046688, Example 156 ...) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(NCC3(C)CCOC3)c2n1)-c1nncn1C Show InChI InChI=1S/C24H28N8O2/c1-15-10-25-21(27-12-24(2)7-8-34-13-24)20-17(15)11-26-23(30-20)29-18-6-5-16(9-19(18)33-4)22-31-28-14-32(22)3/h5-6,9-11,14H,7-8,12-13H2,1-4H3,(H,25,27)(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241313 (US10479788, Example 157 | US11046688, Example 157 ...) Show SMILES COc1cc(ccc1Nc1ncc2c(C)cnc(N3CC4(C3)CCOC4)c2n1)-c1nncn1C Show InChI InChI=1S/C24H26N8O2/c1-15-9-25-22(32-11-24(12-32)6-7-34-13-24)20-17(15)10-26-23(29-20)28-18-5-4-16(8-19(18)33-3)21-30-27-14-31(21)2/h4-5,8-10,14H,6-7,11-13H2,1-3H3,(H,26,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241314 (US10479788, Example 158 | US11046688, Example 158 ...) Show SMILES COc1cc(ccc1Nc1ncc2cc(C)nc(NCC(C)(C)OC)c2n1)-c1cnc(C)n1C Show InChI InChI=1S/C25H31N7O2/c1-15-10-18-12-27-24(31-22(18)23(29-15)28-14-25(3,4)34-7)30-19-9-8-17(11-21(19)33-6)20-13-26-16(2)32(20)5/h8-13H,14H2,1-7H3,(H,28,29)(H,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241315 (US10479788, Example 159 | US11046688, Example 159 ...) Show SMILES CCOc1cc(ccc1Nc1ncc2ccnc(N3CCC4(COC4)C3)c2n1)-c1cnn(C)c1 Show InChI InChI=1S/C25H27N7O2/c1-3-34-21-10-17(19-12-28-31(2)13-19)4-5-20(21)29-24-27-11-18-6-8-26-23(22(18)30-24)32-9-7-25(14-32)15-33-16-25/h4-6,8,10-13H,3,7,9,14-16H2,1-2H3,(H,27,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241316 (US10479788, Example 160 | US11046688, Example 160 ...) Show SMILES CCOc1cc(ccc1Nc1ncc2cc(C)nc(N3CC4(C3)CCOC4)c2n1)-c1nncn1C Show InChI InChI=1S/C25H28N8O2/c1-4-35-20-10-17(22-31-27-15-32(22)3)5-6-19(20)29-24-26-11-18-9-16(2)28-23(21(18)30-24)33-12-25(13-33)7-8-34-14-25/h5-6,9-11,15H,4,7-8,12-14H2,1-3H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241317 (US10479788, Example 163 | US11046688, Example 161 ...) Show SMILES COc1nc(ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1)-c1nnnn1C Show InChI InChI=1S/C20H24N10O2/c1-20(2,32-5)11-23-16-15-12(8-9-21-16)10-22-19(26-15)25-14-7-6-13(24-18(14)31-4)17-27-28-29-30(17)3/h6-10H,11H2,1-5H3,(H,21,23)(H,22,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241318 (US10479788, Example 162 | US11046688, Example 162 ...) Show SMILES COc1nc(ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1)-c1cnc(C)n1C Show InChI InChI=1S/C23H28N8O2/c1-14-25-12-18(31(14)4)16-7-8-17(21(28-16)32-5)29-22-26-11-15-9-10-24-20(19(15)30-22)27-13-23(2,3)33-6/h7-12H,13H2,1-6H3,(H,24,27)(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241319 (US11046688, Example 163 | US9409907, 163) Show SMILES COc1cc(ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1)-c1nnnn1C Show InChI InChI=1S/C21H25N9O2/c1-21(2,32-5)12-24-18-17-14(8-9-22-18)11-23-20(26-17)25-15-7-6-13(10-16(15)31-4)19-27-28-29-30(19)3/h6-11H,12H2,1-5H3,(H,22,24)(H,23,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM241320 (US10479788, Example 164 | US11046688, Example 164 ...) Show SMILES COc1nc(ccc1Nc1ncc2ccnc(NCC(C)(C)OC)c2n1)-c1cn(C)nc1C Show InChI InChI=1S/C23H28N8O2/c1-14-16(12-31(4)30-14)17-7-8-18(21(27-17)32-5)28-22-25-11-15-9-10-24-20(19(15)29-22)26-13-23(2,3)33-6/h7-12H,13H2,1-6H3,(H,24,26)(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.0	25
Cancer Research Technology Limited US Patent					Assay Description The enzyme reaction (total volume 10 μl) was carried out in black 384-well low volume plates containing full length MPS1 (12.5 nM or 3 nM), fluo...				US Patent US9409907 (2016) BindingDB Entry DOI: 10.7270/Q2C24VB2
					More data for this Ligand-Target Pair

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