Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pepsin A (Porcine) | BDBM50022521 (Boc-Phe-His-Cha-CH2-S-Leu-NHCO(CH2)2C6H5 | CHEMBL3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1 | n/a | n/a | n/a | n/a | 1.9 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 1.9 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50025903 (4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17943 (Renin nonpeptide inhibitor, 3 | methyl (3S)-1-[(5S...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17944 (Renin nonpeptide inhibitor, 4 | methyl N-[(3R)-1-[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17945 ((2S,4S,5S)-5-amino-N-butyl-4-hydroxy-9-[(2S)-2-[(m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17946 ((2S,4S,7R)-4-amino-7-(butylcarbamoyl)-5-hydroxy-2,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17947 ((2R,4S,5S,7R)-5-amino-N-butyl-4-hydroxy-8-{[2-(3-m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17948 ((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-({[2-(3-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17949 ((2R,4S,5S,7S)-5-amino-N-butyl-4-hydroxy-7-{[4-meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17950 ((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022508 (Boc-Pro-Phe-NMe-His-Leu-OHCH2-Val-Ile-Amp | CHEMBL...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022511 (Boc-Trp-His-Sta-Ala-Sta-OMe | CHEMBL3349392) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 850 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022509 (Boc-Phe-Phe-Sta-Ala-Sta-OMe | CHEMBL3349390) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50025903 (4-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022516 (Boc-Trp-Trp-Sta-Ala-Sta-OMe | CHEMBL3142766) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17941 ((2S,4S,5S)-5-[(2S)-2-[(2S)-2-benzyl-3-[(2-methylpr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM17942 ((2R,4S,5S)-5-amino-N-butyl-4-hydroxy-2,7,7-trimeth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 2.0 | 37 |
Novartis Pharmaceuticals | Assay Description In vitro potencies of compounds against purified porcine pepsin were determined by its cleavage of substrate hemoglobin. After incubation, proteins w... | Chem Biol 7: 493-504 (2000) Article DOI: 10.1016/S1074-5521(00)00134-4 BindingDB Entry DOI: 10.7270/Q2V40SGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50421761 (CHEMBL2311113) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 2.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 2.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM912 ((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 2.0 | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity was evaluated against pepsin using porcine pepsin (sigma), porcine hemoglobin (sigma) and 0.02 M KCl-HCl buffer (pH 2) | J Med Chem 28: 1553-5 (1985) BindingDB Entry DOI: 10.7270/Q23B60QP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022520 (CHEMBL3349395 | H2N-Abu-Pro-Phe-Abu-Sta-Leu-PheOMe) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of human renin at pH 6.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50227343 (CHEMBL3349391) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 (time-dependent inhibition, T1/2>30 s) | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022512 (CHEMBL3349394 | Ibu-His-Pro-Phe-Ala-Sta-Leu-PheNH2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022517 (CHEMBL3349397 | POA-Leu-Sta-Leu-PheOMe) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022519 (CHEMBL3349393 | Ibu-His-Pro-Phe-His-Sta-Leu-PheNH2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022507 (CHEMBL3349407 | H2N-His-Pro-Phe-His-Sta-Leu-PheOMe) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 34 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022515 (CHEMBL3349396 | POA-His-Sta-Leu-PheOMe) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 67 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4.0 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022513 (CHEMBL3349389 | H2N-Phe-Gly-His-(S,S)-Sta-Ala-Phe-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pepsin A (Porcine) | BDBM50022523 (CHEMBL347185 | H2N-Phe-Gly-His-Nph-Phe-Ala-Phe-OMe) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | PubMed | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 4.0 | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibition of porcine pepsin at pH 4 | J Med Chem 31: 625-9 (1988) BindingDB Entry DOI: 10.7270/Q2B85742 | |||||||||||
More data for this Ligand-Target Pair |