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Found 243 hits of ph data with Target = 'Sodium-dependent dopamine transporter'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22170
PNG
((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES O[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-31-14-16-32(17-15-31)21-27(33)20-22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m0/s1
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 0.75 -48.4n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22172
PNG
((2S)-1-{4-[2-(diphenylmethoxy)ethyl]piperazin-1-yl...)
Show SMILES O[C@H](CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H34N2O2/c31-27(22-24-10-4-1-5-11-24)23-30-18-16-29(17-19-30)20-21-32-28(25-12-6-2-7-13-25)26-14-8-3-9-15-26/h1-15,27-28,31H,16-23H2/t27-/m0/s1
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 2.30 -45.8n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22180
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2S)-2-...)
Show SMILES F[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H31F3N2O/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-32-14-16-33(17-15-32)21-27(31)20-22-4-2-1-3-5-22/h1-13,27-28H,14-21H2/t27-/m0/s1
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 2.70 -45.5n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22169
PNG
((1R)-3-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES O[C@H](CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 |r|
Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-21-20-32-18-16-31(17-19-32)15-14-27(33)22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m1/s1
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 3 -45.2n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22165
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2
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 3.70 -44.7n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22167
PNG
(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)pip...)
Show SMILES C(CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1
Show InChI InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2
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 3.70 -44.7n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170440
PNG
(US9085531, 40)
Show SMILES CN1CC(c2ccc3sccc3c2)c2ccccc2C1
Show InChI InChI=1S/C18H17NS/c1-19-11-15-4-2-3-5-16(15)17(12-19)13-6-7-18-14(10-13)8-9-20-18/h2-10,17H,11-12H2,1H3
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 3.80n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170440
PNG
(US9085531, 40)
Show SMILES CN1CC(c2ccc3sccc3c2)c2ccccc2C1
Show InChI InChI=1S/C18H17NS/c1-19-11-15-4-2-3-5-16(15)17(12-19)13-6-7-18-14(10-13)8-9-20-18/h2-10,17H,11-12H2,1H3
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 3.80n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170446
PNG
(US9085531, 49)
Show SMILES CN1CC(c2ccc3[nH]ccc3c2)c2ccccc2C1
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 3.80n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22186
PNG
(4-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazi...)
Show SMILES CC(O)(CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H34F2N2O2/c1-29(34,25-5-3-2-4-6-25)15-16-32-17-19-33(20-18-32)21-22-35-28(23-7-11-26(30)12-8-23)24-9-13-27(31)14-10-24/h2-14,28,34H,15-22H2,1H3
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 4 -44.6n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22168
PNG
((1S)-3-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES O[C@@H](CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 |r|
Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-21-20-32-18-16-31(17-19-32)15-14-27(33)22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m0/s1
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 4.40 -44.3n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170454
PNG
(US9085531, 102)
Show SMILES CN(C)Cc1ccc2C(CN(C)Cc2c1)c1ccc2sccc2c1
Show InChI InChI=1S/C21H24N2S/c1-22(2)12-15-4-6-19-18(10-15)13-23(3)14-20(19)16-5-7-21-17(11-16)8-9-24-21/h4-11,20H,12-14H2,1-3H3
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 4.40n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170442
PNG
(US9085531, 19)
Show SMILES CN1CC(c2ccccc2C1)c1cccc2ccoc12
Show InChI InChI=1S/C18H17NO/c1-19-11-14-5-2-3-7-15(14)17(12-19)16-8-4-6-13-9-10-20-18(13)16/h2-10,17H,11-12H2,1H3
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 4.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170444
PNG
(US9085531, 14)
Show SMILES CN1CC(c2ccc3occc3c2)c2ccccc2C1
Show InChI InChI=1S/C18H17NO/c1-19-11-15-4-2-3-5-16(15)17(12-19)13-6-7-18-14(10-13)8-9-20-18/h2-10,17H,11-12H2,1H3
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 4.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60502
PNG
(BDBM50054534 | US9085531, 44)
Show SMILES CN1CC(c2ccccc2C1)c1cccc2sccc12
Show InChI InChI=1S/C18H17NS/c1-19-11-13-5-2-3-6-14(13)17(12-19)15-7-4-8-18-16(15)9-10-20-18/h2-10,17H,11-12H2,1H3
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 4.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22187
PNG
(4-{4-[2-(diphenylmethoxy)ethyl]piperazin-1-yl}-2-p...)
Show SMILES CC(O)(CCN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H36N2O2/c1-29(32,27-15-9-4-10-16-27)17-18-30-19-21-31(22-20-30)23-24-33-28(25-11-5-2-6-12-25)26-13-7-3-8-14-26/h2-16,28,32H,17-24H2,1H3
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 7 -43.3n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170445
PNG
(US9085531, 17)
Show SMILES CN1CC(c2ccc3ccoc3c2)c2ccccc2C1
Show InChI InChI=1S/C18H17NO/c1-19-11-15-4-2-3-5-16(15)17(12-19)14-7-6-13-8-9-20-18(13)10-14/h2-10,17H,11-12H2,1H3
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 7.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170452
PNG
(US9085531, 97)
Show SMILES CN1CC(c2ccc3sccc3c2)c2ccc(cc2C1)-c1cccnn1
Show InChI InChI=1S/C22H19N3S/c1-25-13-18-12-16(21-3-2-9-23-24-21)4-6-19(18)20(14-25)15-5-7-22-17(11-15)8-10-26-22/h2-12,20H,13-14H2,1H3
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 8.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60509
PNG
(US9085531, 125)
Show SMILES CN1Cc2ccccc2C(C1Cl)c1ccc2[nH]ncc2c1
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 11.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22171
PNG
((2R)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES O[C@@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H32F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-31-14-16-32(17-15-31)21-27(33)20-22-4-2-1-3-5-22/h1-13,27-28,33H,14-21H2/t27-/m1/s1
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 12 -42.0n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170441
PNG
(US9085531, 2)
Show SMILES CN1CC(c2cc3ccccc3o2)c2ccccc2C1
Show InChI InChI=1S/C18H17NO/c1-19-11-14-7-2-4-8-15(14)16(12-19)18-10-13-6-3-5-9-17(13)20-18/h2-10,16H,11-12H2,1H3
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 13.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170441
PNG
(US9085531, 2)
Show SMILES CN1CC(c2cc3ccccc3o2)c2ccccc2C1
Show InChI InChI=1S/C18H17NO/c1-19-11-14-7-2-4-8-15(14)16(12-19)18-10-13-6-3-5-9-17(13)20-18/h2-10,16H,11-12H2,1H3
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 13.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170439
PNG
(US9085531, 21)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccccc2C1
Show InChI InChI=1S/C18H17NS/c1-19-11-14-7-2-4-8-15(14)16(12-19)18-10-13-6-3-5-9-17(13)20-18/h2-10,16H,11-12H2,1H3
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 14.3n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22174
PNG
(1-[(2S)-2-benzylpropyl]-4-{2-[bis(4-fluorophenyl)m...)
Show SMILES C[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C29H34F2N2O/c1-23(21-24-5-3-2-4-6-24)22-33-17-15-32(16-18-33)19-20-34-29(25-7-11-27(30)12-8-25)26-9-13-28(31)14-10-26/h2-14,23,29H,15-22H2,1H3/t23-/m0/s1
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 17 -41.2n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22175
PNG
(1-[(2R)-2-benzylpropyl]-4-{2-[bis(4-fluorophenyl)m...)
Show SMILES C[C@@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C29H34F2N2O/c1-23(21-24-5-3-2-4-6-24)22-33-17-15-32(16-18-33)19-20-34-29(25-7-11-27(30)12-8-25)26-9-13-28(31)14-10-26/h2-14,23,29H,15-22H2,1H3/t23-/m1/s1
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 17 -41.2n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22184
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCC(=C)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C29H32F2N2O/c1-23(24-5-3-2-4-6-24)15-16-32-17-19-33(20-18-32)21-22-34-29(25-7-11-27(30)12-8-25)26-9-13-28(31)14-10-26/h2-14,29H,1,15-22H2
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 18 -41.1n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170456
PNG
(US9085531, 119)
Show SMILES CN1CC(c2ccc3cc[nH]c3c2)c2ccccc2C1
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 19.8n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22177
PNG
((2R)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES N[C@@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H33F2N3O/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-32-14-16-33(17-15-32)21-27(31)20-22-4-2-1-3-5-22/h1-13,27-28H,14-21,31H2/t27-/m1/s1
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 20 -40.8n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22181
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2R)-2-...)
Show SMILES F[C@@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H31F3N2O/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-32-14-16-33(17-15-32)21-27(31)20-22-4-2-1-3-5-22/h1-13,27-28H,14-21H2/t27-/m1/s1
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 22 -40.6n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22173
PNG
((2R)-1-{4-[2-(diphenylmethoxy)ethyl]piperazin-1-yl...)
Show SMILES O[C@@H](CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H34N2O2/c31-27(22-24-10-4-1-5-11-24)23-30-18-16-29(17-19-30)20-21-32-28(25-12-6-2-7-13-25)26-14-8-3-9-15-26/h1-15,27-28,31H,16-23H2/t27-/m1/s1
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 25 -40.3n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22179
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2R)-2-...)
Show SMILES CO[C@@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C29H34F2N2O2/c1-34-28(21-23-5-3-2-4-6-23)22-33-17-15-32(16-18-33)19-20-35-29(24-7-11-26(30)12-8-24)25-9-13-27(31)14-10-25/h2-14,28-29H,15-22H2,1H3/t28-/m1/s1
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 27 -40.2n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22178
PNG
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2S)-2-...)
Show SMILES CO[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C29H34F2N2O2/c1-34-28(21-23-5-3-2-4-6-23)22-33-17-15-32(16-18-33)19-20-35-29(24-7-11-26(30)12-8-24)25-9-13-27(31)14-10-25/h2-14,28-29H,15-22H2,1H3/t28-/m0/s1
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 29 -40.0n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170457
PNG
(US9085531, 122)
Show SMILES CN1CC(c2ccc3[nH]ncc3c2)c2ccccc2C1
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 29.4n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22185
PNG
(1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylbut-3-en-1...)
Show SMILES C=C(CCN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H34N2O/c1-25(26-11-5-2-6-12-26)17-18-30-19-21-31(22-20-30)23-24-32-29(27-13-7-3-8-14-27)28-15-9-4-10-16-28/h2-16,29H,1,17-24H2
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 30 -39.9n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60506
PNG
(US9085531, 71)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccc(cc2C1)-c1cnccn1
Show InChI InChI=1S/C22H19N3S/c1-25-13-17-10-15(20-12-23-8-9-24-20)6-7-18(17)19(14-25)22-11-16-4-2-3-5-21(16)26-22/h2-12,19H,13-14H2,1H3
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 33n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170449
PNG
(US9085531, 78)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccc(CN3CCOCC3)cc2C1
Show InChI InChI=1S/C23H26N2OS/c1-24-15-19-12-17(14-25-8-10-26-11-9-25)6-7-20(19)21(16-24)23-13-18-4-2-3-5-22(18)27-23/h2-7,12-13,21H,8-11,14-16H2,1H3
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 35.4n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60512
PNG
(BDBM50054516 | US9085531, 134)
Show SMILES CN1CC(c2ccc3cnsc3c2)c2ccccc2C1
Show InChI InChI=1S/C17H16N2S/c1-19-10-14-4-2-3-5-15(14)16(11-19)12-6-7-13-9-18-20-17(13)8-12/h2-9,16H,10-11H2,1H3
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 36.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170448
PNG
(US9085531, 73)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccc(cc2C1)-c1cncnc1
Show InChI InChI=1S/C22H19N3S/c1-25-12-17-8-15(18-10-23-14-24-11-18)6-7-19(17)20(13-25)22-9-16-4-2-3-5-21(16)26-22/h2-11,14,20H,12-13H2,1H3
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 39n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22176
PNG
((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Show SMILES N[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1 |r|
Show InChI InChI=1S/C28H33F2N3O/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-19-18-32-14-16-33(17-15-32)21-27(31)20-22-4-2-1-3-5-22/h1-13,27-28H,14-21,31H2/t27-/m0/s1
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 39 -39.3n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60503
PNG
(US9085531, 56)
Show SMILES CN1CC(c2ccc3ccccc3c2)c2c(C)cccc2C1
Show InChI InChI=1S/C21H21N/c1-15-6-5-9-19-13-22(2)14-20(21(15)19)18-11-10-16-7-3-4-8-17(16)12-18/h3-12,20H,13-14H2,1-2H3
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 39.5n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170455
PNG
(US9085531, 117)
Show SMILES CN1CC(c2cc3ccccc3o2)c2ccc(cc2C1)-c1cccnn1
Show InChI InChI=1S/C22H19N3O/c1-25-13-17-11-15(20-6-4-10-23-24-20)8-9-18(17)19(14-25)22-12-16-5-2-3-7-21(16)26-22/h2-12,19H,13-14H2,1H3
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 41.3n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22182
PNG
(3-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazi...)
Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCC(=O)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H30F2N2O2/c29-25-10-6-23(7-11-25)28(24-8-12-26(30)13-9-24)34-21-20-32-18-16-31(17-19-32)15-14-27(33)22-4-2-1-3-5-22/h1-13,28H,14-21H2
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 48 -38.8n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170453
PNG
(US9085531, 100)
Show SMILES CN1CC(c2ccc3sccc3c2)c2ccc(cc2C1)N1CCOCC1
Show InChI InChI=1S/C22H24N2OS/c1-23-14-18-13-19(24-7-9-25-10-8-24)3-4-20(18)21(15-23)16-2-5-22-17(12-16)6-11-26-22/h2-6,11-13,21H,7-10,14-15H2,1H3
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 53.4n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60513
PNG
(US9085531, 137)
Show SMILES CN1CC(c2ccc3ccccc3c2)c2ccc(cc2C1)-c1cccnn1
Show InChI InChI=1S/C24H21N3/c1-27-15-21-14-20(24-7-4-12-25-26-24)10-11-22(21)23(16-27)19-9-8-17-5-2-3-6-18(17)13-19/h2-14,23H,15-16H2,1H3
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 59.7n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170460
PNG
(US9085531, 135)
Show SMILES CN1CC(c2ccc3sncc3c2)c2ccccc2C1
Show InChI InChI=1S/C17H16N2S/c1-19-10-13-4-2-3-5-15(13)16(11-19)12-6-7-17-14(8-12)9-18-20-17/h2-9,16H,10-11H2,1H3
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 79.4n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM60514
PNG
(US9085531, 142)
Show SMILES CC1NOC(C)C1c1ccc2C(CN(C)Cc2c1)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H28N2O/c1-16-25(17(2)28-26-16)21-10-11-23-22(13-21)14-27(3)15-24(23)20-9-8-18-6-4-5-7-19(18)12-20/h4-13,16-17,24-26H,14-15H2,1-3H3
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 104n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170459
PNG
(US9085531, 130)
Show SMILES CCN1CC(c2ccc3cn[nH]c3c2)c2ccccc2C1
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 105n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170447
PNG
(US9085531, 70)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccc(cc2C1)-c1cccnn1
Show InChI InChI=1S/C22H19N3S/c1-25-13-17-11-15(20-6-4-10-23-24-20)8-9-18(17)19(14-25)22-12-16-5-2-3-7-21(16)26-22/h2-12,19H,13-14H2,1H3
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 119n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM170439
PNG
(US9085531, 21)
Show SMILES CN1CC(c2cc3ccccc3s2)c2ccccc2C1
Show InChI InChI=1S/C18H17NS/c1-19-11-14-7-2-4-8-15(14)16(12-19)18-10-13-6-3-5-9-17(13)20-18/h2-10,16H,11-12H2,1H3
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 128n/an/an/an/an/an/a7.4n/a



Albany Molecular Research, Inc.; Bristol-Myers Squibb Company

US Patent


Assay Description
In order to evaluate the relative affinity of the various compounds at the NE, DA and 5HT transporters, HEK293E cell lines were developed to express ...

US Patent US9085531 (2015)


BindingDB Entry DOI: 10.7270/Q24X56JQ
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Rattus norvegicus (rat))		BDBM22183
PNG
(3-{4-[2-(diphenylmethoxy)ethyl]piperazin-1-yl}-1-p...)
Show SMILES O=C(CCN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C28H32N2O2/c31-27(24-10-4-1-5-11-24)16-17-29-18-20-30(21-19-29)22-23-32-28(25-12-6-2-7-13-25)26-14-8-3-9-15-26/h1-15,28H,16-23H2
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Article
PubMed
 210 -35.4n/an/an/an/an/a7.44



National Taiwan University



Assay Description
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...

J Med Chem 51: 2795-806 (2008)


Article DOI: 10.1021/jm701270n
BindingDB Entry DOI: 10.7270/Q2B27SK6
More data for this
Ligand-Target Pair
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