Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM81374 (BODIPY-labeled probe, 4a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 17 | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM236557 (US9365572, 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 28 |
Xuanzhu Pharma Co., Ltd. US Patent | Assay Description Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES... | US Patent US9365572 (2016) BindingDB Entry DOI: 10.7270/Q20C4TNC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM81376 (Amine compound, 13a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM93207 (Kinase inhibitor, 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Washington | Assay Description Fluorescence assay used for determination of catch and release efficiency. | ACS Chem Biol 8: 691-9 (2013) Article DOI: 10.1021/cb300623a BindingDB Entry DOI: 10.7270/Q20R9N1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110198 (1-Hexyl-5-(2-hydroxybenzoyl)pyridin-2(1H)-one (28)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.81E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110199 (5-(2-Hydroxybenzoyl)-1-isopropylpyridin-2(1H)-one ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.18E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110200 (1-Cyclohexyl-5-(2-hydroxybenzoyl)pyridin-2(1H)-one...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.54E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110201 (1-[2-(Dimethylamino)ethyl]-5-(2-hydroxybenzoyl)pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.82E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110202 (5-(2,4-Dihydroxybenzoyl)-1-hexylpyridin-2(1H)-one ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.77E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110203 (t-Butyl [2-{5-(2,4-dihydroxybenzoyl)-2-oxopyridin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.78E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110204 (1-Hexyl-5-(2-hydroxy-4-methoxybenzoyl)pyridin-2(1H...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.41E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110205 (5-(2-Hydroxy-4-methoxybenzoyl)-1-isopropylpyridin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110206 (1-[2-(Dimethylamino)ethyl]-5-(2-hydroxy-4-methoxyb...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110207 (t-Butyl [2-{5-(2-hydroxy-4-methoxybenzoyl)-2-oxopy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.76E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110208 (5-(2-Hydroxy-4-methoxybenzoyl)-1-(2-hydroxyethyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.99E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110209 (5-(2,5-Dihydroxybenzoyl)-1-hexylpyridin-2(1H)-one ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110210 (5-(2,5-Dihydroxybenzoyl)-1-isopropylpyridin-2(1H)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.61E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110211 (1-Hexyl-5-(2-hydroxy-5-methoxybenzoyl)pyridin-2(1H...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.35E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110212 (1-Cyclohexyl-5-(2-hydroxy-5-methoxybenzoyl)pyridin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.48E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110213 (t-Butyl [2-{5-(2-hydroxy-5-methoxybenzoyl)-2-oxopy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110214 ((E)-5-[(2-Hydroxyphenyl)(isopropylimino)methyl]-1-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.79E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM110215 ((E)-1-Cyclohexyl-5-[(cyclohexylimino)(2-hydroxyphe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.01E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM50142887 (1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Delhi, Delhi 110007, India | Assay Description The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)... | Bioorg Chem 53: 75-82 (2014) Article DOI: 10.1016/j.bioorg.2014.02.001 BindingDB Entry DOI: 10.7270/Q2HX1BBK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase CSK (Homo sapiens (Human)) | BDBM81375 (Amine compound, 12a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16.3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Washington | Assay Description In vitro activity assay using various kinases. | Chem Biol 17: 195-206 (2010) Article DOI: 10.1016/j.chembiol.2010.01.008 BindingDB Entry DOI: 10.7270/Q2833QG7 | |||||||||||
More data for this Ligand-Target Pair |