Compile Data Set for Download or QSAR

Found 1099 hits of ph data with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208973 (US9266881, 12-1) Show SMILES Cn1cc(nc1CCn1nc2cccc(N3CCOCC3)n2c1=O)-c1ccccc1 Show InChI InChI=1S/C22H24N6O2/c1-25-16-18(17-6-3-2-4-7-17)23-19(25)10-11-27-22(29)28-20(24-27)8-5-9-21(28)26-12-14-30-15-13-26/h2-9,16H,10-15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.410	-53.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208974 (US9266881, B-1) Show SMILES Cn1cc(nc1CCn1nc2cccc(-c3ccncc3)n2c1=O)-c1ccccc1 Show InChI InChI=1S/C23H20N6O/c1-27-16-19(17-6-3-2-4-7-17)25-21(27)12-15-28-23(30)29-20(8-5-9-22(29)26-28)18-10-13-24-14-11-18/h2-11,13-14,16H,12,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2	-49.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208959 (US9266881, 6-1) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(N3CCOCC3)n12 Show InChI InChI=1S/C21H21N5O2/c27-21-25(11-10-17-9-8-16-4-1-2-5-18(16)22-17)23-19-6-3-7-20(26(19)21)24-12-14-28-15-13-24/h1-9H,10-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.5	-49.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208958 (US9266881, 5-1) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3ccncc3)n12 Show InChI InChI=1S/C22H17N5O/c28-22-26(15-12-18-9-8-16-4-1-2-5-19(16)24-18)25-21-7-3-6-20(27(21)22)17-10-13-23-14-11-17/h1-11,13-14H,12,15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4.40	-47.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208972 (US9266881, 11-4) Show SMILES Cn1cc(nc1CCn1nc2cccc(Br)n2c1=O)-c1ccccc1 Show InChI InChI=1S/C18H16BrN5O/c1-22-12-14(13-6-3-2-4-7-13)20-16(22)10-11-23-18(25)24-15(19)8-5-9-17(24)21-23/h2-9,12H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.20	-46.5	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208964 (US9266881, A-1) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3cccnc3)n12 Show InChI InChI=1S/C22H17N5O/c28-22-26(14-12-18-11-10-16-5-1-2-7-19(16)24-18)25-21-9-3-8-20(27(21)22)17-6-4-13-23-15-17/h1-11,13,15H,12,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9	-45.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208960 (US9266881, 7-2) Show SMILES COc1ccc(CC(C)(O)c2cccc3nn(CCc4ccc5ccccc5n4)c(=O)n23)cc1 Show InChI InChI=1S/C27H26N4O3/c1-27(33,18-19-10-14-22(34-2)15-11-19)24-8-5-9-25-29-30(26(32)31(24)25)17-16-21-13-12-20-6-3-4-7-23(20)28-21/h3-15,33H,16-18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11	-45.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208970 (US9266881, A-7) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(NCc3cccnc3)n12 Show InChI InChI=1S/C23H20N6O/c30-23-28(14-12-19-11-10-18-6-1-2-7-20(18)26-19)27-22-9-3-8-21(29(22)23)25-16-17-5-4-13-24-15-17/h1-11,13,15,25H,12,14,16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12	-45.2	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208966 (US9266881, A-3) Show SMILES Cc1ccc(cc1)-c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12 Show InChI InChI=1S/C24H20N4O/c1-17-9-11-19(12-10-17)22-7-4-8-23-26-27(24(29)28(22)23)16-15-20-14-13-18-5-2-3-6-21(18)25-20/h2-14H,15-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17	-44.3	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208969 (US9266881, A-6) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(N3CCCCC3)n12 Show InChI InChI=1S/C22H23N5O/c28-22-26(16-13-18-12-11-17-7-2-3-8-19(17)23-18)24-20-9-6-10-21(27(20)22)25-14-4-1-5-15-25/h2-3,6-12H,1,4-5,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19	-44.1	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208968 (US9266881, A-5) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3ccccc3)n12 Show InChI InChI=1S/C23H18N4O/c28-23-26(16-15-19-14-13-17-7-4-5-10-20(17)24-19)25-22-12-6-11-21(27(22)23)18-8-2-1-3-9-18/h1-14H,15-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20	-43.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208957 (US9266881, 4-1) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2c(cccn12)-c1ncco1 Show InChI InChI=1S/C20H15N5O2/c26-20-24-11-3-5-16(19-21-10-13-27-19)18(24)23-25(20)12-9-15-8-7-14-4-1-2-6-17(14)22-15/h1-8,10-11,13H,9,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	22	-43.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208967 (US9266881, A-4) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3cncs3)n12 Show InChI InChI=1S/C20H15N5OS/c26-20-24(11-10-15-9-8-14-4-1-2-5-16(14)22-15)23-19-7-3-6-17(25(19)20)18-12-21-13-27-18/h1-9,12-13H,10-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23	-43.6	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208954 (US9266881, 1-6) Show SMILES Brc1cccn2c1nn(CCc1ccc3ccccc3n1)c2=O Show InChI InChI=1S/C17H13BrN4O/c18-14-5-3-10-21-16(14)20-22(17(21)23)11-9-13-8-7-12-4-1-2-6-15(12)19-13/h1-8,10H,9,11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	37	-42.4	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208955 (US9266881, 2-4) Show SMILES Brc1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12 Show InChI InChI=1S/C17H13BrN4O/c18-15-6-3-7-16-20-21(17(23)22(15)16)11-10-13-9-8-12-4-1-2-5-14(12)19-13/h1-9H,10-11H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	59	-41.3	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208971 (US9266881, A-8) Show SMILES CC(C)(O)c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12 Show InChI InChI=1S/C20H20N4O2/c1-20(2,26)17-8-5-9-18-22-23(19(25)24(17)18)13-12-15-11-10-14-6-3-4-7-16(14)21-15/h3-11,26H,12-13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	72	-40.8	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208965 (US9266881, A-2) Show SMILES Cc1cccn2c1nn(CCc1ccc3ccccc3n1)c2=O Show InChI InChI=1S/C18H16N4O/c1-13-5-4-11-21-17(13)20-22(18(21)23)12-10-15-9-8-14-6-2-3-7-16(14)19-15/h2-9,11H,10,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	74	-40.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208961 (US9266881, 8-2) Show SMILES O=C(Nc1cccnc1)c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12 Show InChI InChI=1S/C23H18N6O2/c30-22(26-18-6-4-13-24-15-18)20-8-3-9-21-27-28(23(31)29(20)21)14-12-17-11-10-16-5-1-2-7-19(16)25-17/h1-11,13,15H,12,14H2,(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	97	-40.0	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208963 (US9266881, 10-4) Show SMILES O=c1n(CCc2ccc3ncccc3n2)nc2c(cccn12)-c1ccncc1 Show InChI InChI=1S/C21H16N6O/c28-21-26-13-2-3-17(15-7-11-22-12-8-15)20(26)25-27(21)14-9-16-5-6-18-19(24-16)4-1-10-23-18/h1-8,10-13H,9,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	103	-39.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208956 (US9266881, 3-4) Show SMILES Brc1ccc2nn(CCc3ccc4ccccc4n3)c(=O)n2c1 Show InChI InChI=1S/C17H13BrN4O/c18-13-6-8-16-20-22(17(23)21(16)11-13)10-9-14-7-5-12-3-1-2-4-15(12)19-14/h1-8,11H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	155	-38.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208962 (US9266881, 9-1) Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2ccc(cn12)-c1cccnc1 Show InChI InChI=1S/C22H17N5O/c28-22-26-15-18(17-5-3-12-23-14-17)8-10-21(26)25-27(22)13-11-19-9-7-16-4-1-2-6-20(16)24-19/h1-10,12,14-15H,11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	510	-35.9	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM208975 (US9266881, 13-6) Show SMILES O=c1n(C[C@@H]2C[C@H]2c2ccccn2)nc2cccc(N3CCOCC3)n12 |r| Show InChI InChI=1S/C19H21N5O2/c25-19-23(13-14-12-15(14)16-4-1-2-7-20-16)21-17-5-3-6-18(24(17)19)22-8-10-26-11-9-22/h1-7,14-15H,8-13H2/t14-,15+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	546	-35.7	n/a	n/a	n/a	n/a	n/a	7.2	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...				US Patent US9266881 (2016) BindingDB Entry DOI: 10.7270/Q2154FVR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119848 (US8691986, 14) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ncc(Cl)cc2n1 Show InChI InChI=1S/C23H18ClFN6O/c1-26-23(32)16-3-2-13(8-17(16)25)21-22(28-7-6-27-21)14-11-31(12-14)20-5-4-18-19(30-20)9-15(24)10-29-18/h2-10,14H,11-12H2,1H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119847 (US8691986, 13) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1 Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119846 (US8691986, 12) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)c(Cl)cc2n1 Show InChI InChI=1S/C23H17ClF2N6O/c1-27-22(33)15-3-2-12(6-17(15)25)20-21(29-5-4-28-20)14-10-32(11-14)23-30-9-13-7-18(26)16(24)8-19(13)31-23/h2-9,14H,10-11H2,1H3,(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119845 (US8691986, 11) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)ccc2n1 Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-4-2-13(9-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-8-16(24)3-5-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16.6	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119844 (US8691986, 10) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(Cl)cc2n1 Show InChI InChI=1S/C23H18ClFN6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.90	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119843 (US8691986, 9) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(F)cc2n1 Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.9	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119842 (US8691986, 8) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1 Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119841 (US8691986, 7) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119840 (US8691986, 6) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccccc2n1 Show InChI InChI=1S/C23H19FN6O/c1-25-22(31)17-7-6-14(10-18(17)24)20-21(27-9-8-26-20)16-12-30(13-16)23-28-11-15-4-2-3-5-19(15)29-23/h2-11,16H,12-13H2,1H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.60	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119839 (US8691986, 5) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cccc(F)c2n1 Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)19-7-5-18(15-21(19)28)25-24(30-11-12-31-25)17-9-13-33(14-10-17)22-8-6-16-3-2-4-20(27)23(16)32-22/h2-8,11-12,15,17H,9-10,13-14H2,1H3,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119838 (US8691986, 4) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cc(F)ccc2n1 Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-5-2-18(15-21(20)28)25-24(30-10-11-31-25)16-8-12-33(13-9-16)23-7-3-17-14-19(27)4-6-22(17)32-23/h2-7,10-11,14-16H,8-9,12-13H2,1H3,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119837 (US8691986, 3) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccccc2n1 Show InChI InChI=1S/C26H24FN5O/c1-28-26(33)20-8-6-19(16-21(20)27)25-24(29-12-13-30-25)18-10-14-32(15-11-18)23-9-7-17-4-2-3-5-22(17)31-23/h2-9,12-13,16,18H,10-11,14-15H2,1H3,(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119836 (US8691986, 2) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(F)cc2n1 Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.30	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119835 (US8691986, 1) Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(Cl)cc2n1 Show InChI InChI=1S/C26H23ClFN5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28.7	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119851 (US8691986, 15 | US9718803, 30.2) Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119850 (US8691986, 17 | US9718803, 5.19) Show SMILES CNC(=O)c1cccc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C24H21N5O/c1-25-24(30)18-7-4-6-17(13-18)22-23(27-12-11-26-22)19-14-29(15-19)21-10-9-16-5-2-3-8-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM119849 (US8691986, 16 | US9718803, 30.4) Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.2	25
Amgen Inc. US Patent					Assay Description IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...				US Patent US8691986 (2014) BindingDB Entry DOI: 10.7270/Q26T0K9T
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187186 (US9670181, 64 4-((6-(ethylamino)-[1,3]dioxolo[4,5-...) Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM125582 (US8772316, 65 | US9670181, 65 4-(dibenzo[b,d]furan...) Show SMILES CCCc1nc(N)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H26N2O3/c1-4-7-22-19-15-26(31-3)25(30-2)14-18(19)21(27(28)29-22)13-16-10-11-24-20(12-16)17-8-5-6-9-23(17)32-24/h5-6,8-12,14-15H,4,7,13H2,1-3H3,(H2,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	967	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187188 (US9670181, 66 4-((2-ethyl-6-methoxyquinolin-3-yl)m...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2CC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H30N2O4/c1-6-8-24-20-15-26(33-5)25(32-4)14-19(20)21(27(30)29-24)13-17-11-16-12-18(31-3)9-10-23(16)28-22(17)7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187189 (US9670181, 67 4-((2-(ethylamino)-6-methoxyquinolin...) Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(COC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H29N3O5/c1-6-27-25-16(9-15-10-17(32-3)7-8-21(15)28-25)11-20-18-12-23(33-4)24(34-5)13-19(18)22(14-31-2)29-26(20)30/h7-10,12-13H,6,11,14H2,1-5H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187190 (US9670181, 68 4-((2-azido-6-methoxyquinolin-3-yl)m...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2N=[N+]=[N-])c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H23N5O4/c1-5-19-17-12-22(33-4)21(32-3)11-16(17)18(24(30)27-19)10-14-8-13-9-15(31-2)6-7-20(13)26-23(14)28-29-25/h6-9,11-12H,5,10H2,1-4H3,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187192 (US9670181, 69 N-(2-((3-((1-ethyl-3-hydroxy-6,7-dim...) Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C28H32N4O5/c1-6-23-21-15-26(37-5)25(36-4)14-20(21)22(28(34)32-23)13-18-11-17-12-19(35-3)7-8-24(17)31-27(18)30-10-9-29-16(2)33/h7-8,11-12,14-15H,6,9-10,13H2,1-5H3,(H,29,33)(H,30,31)(H,32,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187193 (US9670181, 70 4-((2-(ethylamino)-7-fluoro-6-methox...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C27H30FN3O4/c1-6-8-21-18-13-25(35-5)24(34-4)12-17(18)19(27(32)31-21)10-16-9-15-11-23(33-3)20(28)14-22(15)30-26(16)29-7-2/h9,11-14H,6-8,10H2,1-5H3,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187195 (US9670181, 71 4-((2-butyl-6-methoxyquinolin-3-yl)m...) Show SMILES CCCCc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CCC)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C29H34N2O4/c1-6-8-10-24-19(13-18-14-20(33-3)11-12-25(18)30-24)15-23-21-16-27(34-4)28(35-5)17-22(21)26(9-7-2)31-29(23)32/h11-14,16-17H,6-10,15H2,1-5H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187196 (US9670181, 72 6,7-dimethoxy-4-((6-methoxy-2-(trifl...) Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2C(F)(F)F)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C26H25F3N2O4/c1-5-6-21-18-13-23(35-4)22(34-3)12-17(18)19(25(32)31-21)11-15-9-14-10-16(33-2)7-8-20(14)30-24(15)26(27,28)29/h7-10,12-13H,5-6,11H2,1-4H3,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	445	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187197 (US9670181, 73 N-(2-((3-((3-hydroxy-6,7-dimethoxy-1...) Show SMILES COc1ccc2nc(NCCNC(C)=O)c(Cc3c(O)nc(C)c4cc(OC)c(OC)cc34)cc2c1 Show InChI InChI=1S/C27H30N4O5/c1-15-20-13-24(35-4)25(36-5)14-21(20)22(27(33)30-15)12-18-10-17-11-19(34-3)6-7-23(17)31-26(18)29-9-8-28-16(2)32/h6-7,10-11,13-14H,8-9,12H2,1-5H3,(H,28,32)(H,29,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM187198 (US9670181, 74 6,7-dimethoxy-1-propyl-4-(quinolin-3...) Show SMILES CCCc1nc(O)c(Cc2cnc3ccccc3c2)c2cc(OC)c(OC)cc12 Show InChI InChI=1S/C24H24N2O3/c1-4-7-21-18-13-23(29-3)22(28-2)12-17(18)19(24(27)26-21)11-15-10-16-8-5-6-9-20(16)25-14-15/h5-6,8-10,12-14H,4,7,11H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.4	25
ALLERGAN, INC.; EXONHIT THERAPEUTICS SA US Patent					Assay Description The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...				US Patent US9670181 (2017) BindingDB Entry DOI: 10.7270/Q21Z42KJ
					More data for this Ligand-Target Pair

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