Compile Data Set for Download or QSAR

Found 115 hits of ph data with Target = 'cGMP-specific 3',5'-cyclic phosphodiesterase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14392 (3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...) Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1 Show InChI InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14393 (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...) Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)=O Show InChI InChI=1S/C23H30N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,16H,5-9,12-13H2,1-4H3,(H,25,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14394 (5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyrid...) Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)C(C)=O Show InChI InChI=1S/C24H26N6O3/c1-4-6-11-33-24-18(12-16(13-26-24)15(3)31)22-27-20-19(5-2)30(29-21(20)23(32)28-22)14-17-9-7-8-10-25-17/h7-10,12-13H,4-6,11,14H2,1-3H3,(H,27,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14400 (5-(5-acetyl-2-propoxypyridin-3-yl)-3-ethyl-2-(1-me...) Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C)C1)C(C)=O Show InChI InChI=1S/C21H26N6O3/c1-5-7-30-21-15(8-13(9-22-21)12(3)28)19-23-17-16(6-2)27(14-10-26(4)11-14)25-18(17)20(29)24-19/h8-9,14H,5-7,10-11H2,1-4H3,(H,23,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14396 (5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1 Show InChI InChI=1S/C23H29N5O4/c1-4-6-17-20-21(27(3)26-17)23(30)25-22(24-20)16-13-15(7-8-19(16)32-5-2)18(29)14-28-9-11-31-12-10-28/h7-8,13H,4-6,9-12,14H2,1-3H3,(H,24,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14397 (5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(C)=O Show InChI InChI=1S/C19H22N4O3/c1-5-7-14-16-17(23(4)22-14)19(25)21-18(20-16)13-10-12(11(3)24)8-9-15(13)26-6-2/h8-10H,5-7H2,1-4H3,(H,20,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14398 (5-(5-Acetyl-2-propoxy-3-pyridinyl)-3-ethyl-2-[(1-m...) Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(Cc3nccn3C)nc2c(=O)[nH]1)C(C)=O Show InChI InChI=1S/C22H25N7O3/c1-5-9-32-22-15(10-14(11-24-22)13(3)30)20-25-18-16(6-2)29(27-19(18)21(31)26-20)12-17-23-7-8-28(17)4/h7-8,10-11H,5-6,9,12H2,1-4H3,(H,25,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14399 (2-(azetidin-3-yl)-5-(5-acetyl-2-propoxypyridin-3-y...) Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CNC1)C(C)=O Show InChI InChI=1S/C20H24N6O3/c1-4-6-29-20-14(7-12(8-22-20)11(3)27)18-23-16-15(5-2)26(13-9-21-10-13)25-17(16)19(28)24-18/h7-8,13,21H,4-6,9-10H2,1-3H3,(H,23,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14395 (5-[2-Butoxy-5-(1-hydroxyethyl)-3-pyridinyl]-3-ethy...) Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)O Show InChI InChI=1S/C23H32N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,14,16,30H,5-9,12-13H2,1-4H3,(H,25,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	n/a	n/a	825	n/a	n/a	n/a	n/a	7.4	30
Pfizer					Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...				J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM23620 (2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...) Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	24
University of North Carolina					Assay Description Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.				J Biol Chem 287: 11788-97 (2012) Article DOI: 10.1074/jbc.M111.326777 BindingDB Entry DOI: 10.7270/Q2K9364D
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM92338 (Wyq16#) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)NC(=O)OC(C)C Show InChI InChI=1S/C21H27N5O6S/c1-6-8-15-17-18(26(5)24-15)20(27)23-19(22-17)14-11-13(9-10-16(14)31-7-2)33(29,30)25-21(28)32-12(3)4/h9-12H,6-8H2,1-5H3,(H,25,28)(H,22,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	24
University of North Carolina					Assay Description Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.				J Biol Chem 287: 11788-97 (2012) Article DOI: 10.1074/jbc.M111.326777 BindingDB Entry DOI: 10.7270/Q2K9364D
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	24
University of North Carolina					Assay Description Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.				J Biol Chem 287: 11788-97 (2012) Article DOI: 10.1074/jbc.M111.326777 BindingDB Entry DOI: 10.7270/Q2K9364D
					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM123687 (US8741907, 3 | US9067945, 2) Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. 2 uL portions of the diluted substa...				US Patent US8741907 (2014) BindingDB Entry DOI: 10.7270/Q21V5CNH
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150176 (US8980904, 1) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C25H25ClN4O3/c1-32-22-8-7-17(9-21(22)26)15-33-24-20(23(31)27-11-16-5-3-2-4-6-16)12-28-25(29-24)30-13-18-10-19(18)14-30/h2-9,12,18-19H,10-11,13-15H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.172	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150181 (US8980904, 6) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccc(F)cc2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C25H24ClFN4O3/c1-33-22-7-4-16(8-21(22)26)14-34-24-20(23(32)28-10-15-2-5-19(27)6-3-15)11-29-25(30-24)31-12-17-9-18(17)13-31/h2-8,11,17-18H,9-10,12-14H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0750	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150178 (US8980904, 3) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C23H23ClN6O3/c1-32-19-4-3-14(7-18(19)24)13-33-22-17(21(31)27-10-20-25-5-2-6-26-20)9-28-23(29-22)30-11-15-8-16(15)12-30/h2-7,9,15-16H,8,10-13H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150179 (US8980904, 4) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccn2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C24H24ClN5O3/c1-32-21-6-5-15(8-20(21)25)14-33-23-19(22(31)27-10-18-4-2-3-7-26-18)11-28-24(29-23)30-12-16-9-17(16)13-30/h2-8,11,16-17H,9-10,12-14H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0280	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150177 (US8980904, 2) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccc2)N2C3CCC2COC3)cc1Cl Show InChI InChI=1S/C26H27ClN4O4/c1-33-23-10-7-18(11-22(23)27)14-35-25-21(24(32)28-12-17-5-3-2-4-6-17)13-29-26(30-25)31-19-8-9-20(31)16-34-15-19/h2-7,10-11,13,19-20H,8-9,12,14-16H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.01	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150182 (US8980904, 7) Show SMILES COc1ccc(COc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-3.8,;-8.05,-4.57,;-6.72,-3.8,;-5.33,-4.55,;-4,-3.78,;-4,-2.24,;-2.67,-1.47,;-1.33,-2.24,;,-1.47,;,.07,;1.33,.84,;2.67,.07,;2.67,-1.47,;1.33,-2.24,;1.33,-3.78,;,-4.55,;2.67,-4.55,;4,-3.78,;4,-2.24,;5.33,-1.47,;6.67,-2.24,;8,-1.47,;6.67,-3.78,;5.33,-4.55,;1.33,2.38,;2.58,3.29,;2.1,4.75,;1.33,6.09,;.56,4.75,;.09,3.29,;-5.33,-1.47,;-6.67,-2.24,;-8,-1.47,)| Show InChI InChI=1S/C24H29ClN4O4/c1-32-21-7-2-14(8-20(21)25)13-33-23-19(22(31)27-17-3-5-18(30)6-4-17)10-26-24(28-23)29-11-15-9-16(15)12-29/h2,7-8,10,15-18,30H,3-6,9,11-13H2,1H3,(H,27,31)/t15?,16?,17-,18-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.739	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150183 (US8980904, 8) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CC3)CC2)cc1Cl Show InChI InChI=1S/C25H27ClN6O3/c1-34-20-4-3-17(13-19(20)26)16-35-23-18(22(33)29-15-21-27-9-2-10-28-21)14-30-24(31-23)32-11-7-25(5-6-25)8-12-32/h2-4,9-10,13-14H,5-8,11-12,15-16H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.476	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150180 (US8980904, 5) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2cnc(C)cn2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C24H25ClN6O3/c1-14-7-27-18(8-26-14)9-28-22(32)19-10-29-24(31-11-16-6-17(16)12-31)30-23(19)34-13-15-3-4-21(33-2)20(25)5-15/h3-5,7-8,10,16-17H,6,9,11-13H2,1-2H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.529	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150184 (US8980904, 9) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccn2)N2CCC3(CC3)CC2)cc1Cl Show InChI InChI=1S/C26H28ClN5O3/c1-34-22-6-5-18(14-21(22)27)17-35-24-20(23(33)29-15-19-4-2-3-11-28-19)16-30-25(31-24)32-12-9-26(7-8-26)10-13-32/h2-6,11,14,16H,7-10,12-13,15,17H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.186	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150185 (US8980904, 10) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccc2)N2CCC3(CC3)CC2)cc1Cl Show InChI InChI=1S/C27H29ClN4O3/c1-34-23-8-7-20(15-22(23)28)18-35-25-21(24(33)29-16-19-5-3-2-4-6-19)17-30-26(31-25)32-13-11-27(9-10-27)12-14-32/h2-8,15,17H,9-14,16,18H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.14	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150186 (US8980904, 11) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCCN2CCOCC2)N2CCC3(CC3)CC2)cc1Cl Show InChI InChI=1S/C26H34ClN5O4/c1-34-22-3-2-19(16-21(22)27)18-36-24-20(23(33)28-8-11-31-12-14-35-15-13-31)17-29-25(30-24)32-9-6-26(4-5-26)7-10-32/h2-3,16-17H,4-15,18H2,1H3,(H,28,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.935	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150188 (US8980904, 13) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCCN2CCOCC2)N2CC3CC3C2)cc1Cl Show InChI InChI=1S/C24H30ClN5O4/c1-32-21-3-2-16(10-20(21)25)15-34-23-19(22(31)26-4-5-29-6-8-33-9-7-29)12-27-24(28-23)30-13-17-11-18(17)14-30/h2-3,10,12,17-18H,4-9,11,13-15H2,1H3,(H,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.213	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150189 (US8980904, 14) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccc2)N2CCCC22CC2)cc1Cl Show InChI InChI=1S/C26H27ClN4O3/c1-33-22-9-8-19(14-21(22)27)17-34-24-20(23(32)28-15-18-6-3-2-4-7-18)16-29-25(30-24)31-13-5-10-26(31)11-12-26/h2-4,6-9,14,16H,5,10-13,15,17H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.98	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150190 (US8980904, 15) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccccc2)N2CCC3(CC3)C2)cc1Cl Show InChI InChI=1S/C26H27ClN4O3/c1-33-22-8-7-19(13-21(22)27)16-34-24-20(23(32)28-14-18-5-3-2-4-6-18)15-29-25(30-24)31-12-11-26(17-31)9-10-26/h2-8,13,15H,9-12,14,16-17H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.119	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150187 (US8980904, 12) Show SMILES COc1ccc(COc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)CC2)cc1Cl |r,wU:17.17,wD:20.21,(-9.38,-4.16,;-8.05,-4.93,;-6.72,-4.16,;-5.33,-4.9,;-4,-4.13,;-4,-2.59,;-2.67,-1.82,;-1.33,-2.59,;,-1.82,;,-.28,;1.33,.49,;2.67,-.28,;2.67,-1.82,;1.33,-2.59,;1.33,-4.13,;,-4.9,;2.67,-4.9,;4,-4.13,;4,-2.59,;5.33,-1.82,;6.67,-2.59,;8,-1.82,;6.67,-4.13,;5.33,-4.9,;1.33,2.03,;2.67,2.8,;2.67,4.34,;1.33,5.11,;2.1,6.44,;.56,6.44,;,4.34,;,2.8,;-5.33,-1.82,;-6.67,-2.59,;-8,-1.82,)| Show InChI InChI=1S/C26H33ClN4O4/c1-34-22-7-2-17(14-21(22)27)16-35-24-20(23(33)29-18-3-5-19(32)6-4-18)15-28-25(30-24)31-12-10-26(8-9-26)11-13-31/h2,7,14-15,18-19,32H,3-6,8-13,16H2,1H3,(H,29,33)/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.719	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150191 (US8980904, 17) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ccc(F)cc2)N2CCC3(CC3)C2)cc1Cl Show InChI InChI=1S/C26H26ClFN4O3/c1-34-22-7-4-18(12-21(22)27)15-35-24-20(23(33)29-13-17-2-5-19(28)6-3-17)14-30-25(31-24)32-11-10-26(16-32)8-9-26/h2-7,12,14H,8-11,13,15-16H2,1H3,(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.08	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150192 (US8980904, 18) Show SMILES COc1ccc(COc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CC3)C2)cc1Cl Show InChI InChI=1S/C24H25ClN6O3/c1-33-19-4-3-16(11-18(19)25)14-34-22-17(21(32)28-13-20-26-8-2-9-27-20)12-29-23(30-22)31-10-7-24(15-31)5-6-24/h2-4,8-9,11-12H,5-7,10,13-15H2,1H3,(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.44	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM150193 (US8980904, 19) Show SMILES COc1ccc(COc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl |r,wU:17.17,wD:20.21,(-9.34,-3.88,;-8,-4.65,;-6.67,-3.88,;-5.33,-4.65,;-4,-3.88,;-4,-2.34,;-2.67,-1.57,;-1.33,-2.34,;,-1.57,;,-.03,;1.33,.74,;2.67,-.03,;2.67,-1.57,;1.33,-2.34,;1.33,-3.88,;,-4.65,;2.67,-4.65,;4,-3.88,;4,-2.34,;5.33,-1.57,;6.67,-2.34,;8,-1.57,;6.67,-3.88,;5.33,-4.65,;1.33,2.28,;.09,3.19,;.56,4.65,;2.1,4.65,;3.44,5.42,;2.1,6.19,;2.58,3.19,;-5.33,-1.57,;-6.67,-2.34,;-8,-1.57,)| Show InChI InChI=1S/C25H31ClN4O4/c1-33-21-7-2-16(12-20(21)26)14-34-23-19(22(32)28-17-3-5-18(31)6-4-17)13-27-24(29-23)30-11-10-25(15-30)8-9-25/h2,7,12-13,17-18,31H,3-6,8-11,14-15H2,1H3,(H,28,32)/t17-,18-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.08	n/a	n/a	n/a	n/a	7.5	30
Xuanzhu Pharma Co., Ltd. US Patent					Assay Description A sample to be tested is precisely weighed, dissolved by adding DMSO, mixed sufficiently to form 10 mM solution. The above mother solution is diluted...				US Patent US8980904 (2015) BindingDB Entry DOI: 10.7270/Q24M9389
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157136 (US9023849, 2) Show SMILES CC1(C)C(=O)Nc2nc(ncc12)-n1nc(Cc2c(F)ccc(F)c2F)c2cc(Cl)ccc12 Show InChI InChI=1S/C22H15ClF3N5O/c1-22(2)13-9-27-21(29-19(13)28-20(22)32)31-17-6-3-10(23)7-12(17)16(30-31)8-11-14(24)4-5-15(25)18(11)26/h3-7,9H,8H2,1-2H3,(H,27,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157137 (US9023849, 3) Show SMILES CC1(C)C(=O)Nc2nc(nc(I)c12)-n1nc(Cc2ccccc2F)c2ccccc12 Show InChI InChI=1S/C22H17FIN5O/c1-22(2)17-18(24)25-21(27-19(17)26-20(22)30)29-16-10-6-4-8-13(16)15(28-29)11-12-7-3-5-9-14(12)23/h3-10H,11H2,1-2H3,(H,25,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	690	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157138 (US9023849, 5) Show SMILES CC1(C)C(=O)Nc2nc(ncc12)-n1nc(Cc2ccccc2F)c2ccccc12 Show InChI InChI=1S/C22H18FN5O/c1-22(2)15-12-24-21(26-19(15)25-20(22)29)28-18-10-6-4-8-14(18)17(27-28)11-13-7-3-5-9-16(13)23/h3-10,12H,11H2,1-2H3,(H,24,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157139 (US9023849, 6) Show SMILES CC1(C)C(=O)Nc2nc(nc(I)c12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12 Show InChI InChI=1S/C22H16F2IN5O/c1-22(2)17-18(25)26-21(28-19(17)27-20(22)31)30-16-8-7-12(23)10-13(16)15(29-30)9-11-5-3-4-6-14(11)24/h3-8,10H,9H2,1-2H3,(H,26,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	690	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157140 (US9023849, 8) Show SMILES CC1(C)C(=O)Nc2nc(ncc12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12 Show InChI InChI=1S/C22H17F2N5O/c1-22(2)15-11-25-21(27-19(15)26-20(22)30)29-18-8-7-13(23)10-14(18)17(28-29)9-12-5-3-4-6-16(12)24/h3-8,10-11H,9H2,1-2H3,(H,25,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	400	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157141 (US9023849, 9) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-n1nc(Cc2ccccc2F)c2ncc(F)cc12 Show InChI InChI=1S/C20H15F2N7O/c1-20(2)16-17(24-18(20)30)25-19(27-26-16)29-14-8-11(21)9-23-15(14)13(28-29)7-10-5-3-4-6-12(10)22/h3-6,8-9H,7H2,1-2H3,(H,24,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	85	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157142 (US9023849, 10) Show SMILES CC1(C)C(=O)Nc2nc(nc(I)c12)-c1nn(Cc2ccccc2F)c2CCCc12 Show InChI InChI=1S/C21H19FIN5O/c1-21(2)15-17(23)24-19(25-18(15)26-20(21)29)16-12-7-5-9-14(12)28(27-16)10-11-6-3-4-8-13(11)22/h3-4,6,8H,5,7,9-10H2,1-2H3,(H,24,25,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	480	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157143 (US9023849, 11) Show SMILES CC1(C)C(=O)Nc2nc(ncc12)-c1nn(Cc2ccccc2F)c2CCCc12 Show InChI InChI=1S/C21H20FN5O/c1-21(2)14-10-23-19(24-18(14)25-20(21)28)17-13-7-5-9-16(13)27(26-17)11-12-6-3-4-8-15(12)22/h3-4,6,8,10H,5,7,9,11H2,1-2H3,(H,23,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157144 (US9023849, 12) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2CCCc12 Show InChI InChI=1S/C20H19FN6O/c1-20(2)16-18(23-19(20)28)22-17(25-24-16)15-12-7-5-9-14(12)27(26-15)10-11-6-3-4-8-13(11)21/h3-4,6,8H,5,7,9-10H2,1-2H3,(H,22,23,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157145 (US9023849, 15) Show SMILES Cc1ncc2c(nn(Cc3ccccc3F)c2n1)-c1ncc2c(NC(=O)C2(C)C)n1 Show InChI InChI=1S/C21H18FN7O/c1-11-23-8-13-16(18-24-9-14-17(26-18)27-20(30)21(14,2)3)28-29(19(13)25-11)10-12-6-4-5-7-15(12)22/h4-9H,10H2,1-3H3,(H,24,26,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	310	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157146 (US9023849, 16) Show SMILES Cc1ncc2c(nn(Cc3ccccc3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1 Show InChI InChI=1S/C20H17FN8O/c1-10-22-8-12-14(16-24-17-15(26-27-16)20(2,3)19(30)25-17)28-29(18(12)23-10)9-11-6-4-5-7-13(11)21/h4-8H,9H2,1-3H3,(H,24,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157147 (US9023849, 17) Show SMILES Cc1ncc2c(nn(Cc3cccc(F)c3F)c2n1)-c1ncc2c(NC(=O)C2(C)C)n1 Show InChI InChI=1S/C21H17F2N7O/c1-10-24-7-12-16(18-25-8-13-17(27-18)28-20(31)21(13,2)3)29-30(19(12)26-10)9-11-5-4-6-14(22)15(11)23/h4-8H,9H2,1-3H3,(H,25,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	230	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157148 (US9023849, 18) Show SMILES Cc1ncc2c(nn(Cc3cccc(F)c3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1 Show InChI InChI=1S/C20H16F2N8O/c1-9-23-7-11-14(16-25-17-15(27-28-16)20(2,3)19(31)26-17)29-30(18(11)24-9)8-10-5-4-6-12(21)13(10)22/h4-7H,8H2,1-3H3,(H,25,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157149 (US9023849, 19) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncncc12 Show InChI InChI=1S/C19H15FN8O/c1-19(2)14-16(24-18(19)29)23-15(26-25-14)13-11-7-21-9-22-17(11)28(27-13)8-10-5-3-4-6-12(10)20/h3-7,9H,8H2,1-2H3,(H,23,24,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	370	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157150 (US9023849, 21) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12 Show InChI InChI=1S/C21H16F2N6O/c1-21(2)17-18(24-19(21)30)25-20(27-26-17)29-16-8-7-12(22)10-13(16)15(28-29)9-11-5-3-4-6-14(11)23/h3-8,10H,9H2,1-2H3,(H,24,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157151 (US9023849, 22) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-n1nc(CCC(F)(F)C(F)(F)F)c2cc(F)ccc12 Show InChI InChI=1S/C18H14F6N6O/c1-16(2)12-13(25-14(16)31)26-15(28-27-12)30-11-4-3-8(19)7-9(11)10(29-30)5-6-17(20,21)18(22,23)24/h3-4,7H,5-6H2,1-2H3,(H,25,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157152 (US9023849, 23) Show SMILES CCc1nc(nc2NC(=O)C(C)(C)c12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12 Show InChI InChI=1S/C24H21F2N5O/c1-4-17-20-21(28-22(32)24(20,2)3)29-23(27-17)31-19-10-9-14(25)12-15(19)18(30-31)11-13-7-5-6-8-16(13)26/h5-10,12H,4,11H2,1-3H3,(H,27,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	440	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157153 (US9023849, 24) Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12 Show InChI InChI=1S/C21H16ClFN6O/c1-21(2)17-19(25-20(21)30)24-18(27-26-17)16-13-8-7-12(22)9-15(13)29(28-16)10-11-5-3-4-6-14(11)23/h3-9H,10H2,1-2H3,(H,24,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair

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