Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM350321 ((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)isoquinol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human Btk in human Raji cells assessed as PhosY223 measured after 30 mins by cellular HTRF assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01026 BindingDB Entry DOI: 10.7270/Q2JM2FHN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM250082 (US9447106, 27b (peak 2) | US9556188, Compound 27a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02134 BindingDB Entry DOI: 10.7270/Q23F4TPF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50245586 (CHEMBL4077123) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a |
University of Science and Technology of China Curated by ChEMBL | Assay Description Irreversible inhibition of recombinant full length wild-type 3'-FLAG-tagged BTK (unknown origin) expressed in HEK293T cells assessed as reduction in ... | Eur J Med Chem 131: 107-125 (2017) Article DOI: 10.1016/j.ejmech.2017.03.001 BindingDB Entry DOI: 10.7270/Q21V5HCK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02134 BindingDB Entry DOI: 10.7270/Q23F4TPF | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50559906 (CHEMBL4798086) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human recombinant full length N-terminal His6-tagged BTK expressed in baculovirus infected Sf9 cells using fluorescein labeled Blk/Lynt... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127261 BindingDB Entry DOI: 10.7270/Q2TB1BM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM50175583 (ACP-196 | Acalabrutinib | US10239883, Example 6 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02134 BindingDB Entry DOI: 10.7270/Q23F4TPF | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267472 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267473 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267474 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267475 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267476 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267477 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267478 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267480 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267481 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267483 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267485 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267491 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267492 (4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267496 (4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267501 (4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267502 (4-(8-amino-3-((1R,5S,6S)-3-oxabicyc1o[3.1.0]hexan-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267505 (4-(8-amino-3-(tetrahydrofuran-3-yl)imidazo[1,5-a]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267507 (4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267511 (4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267512 (4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267513 (4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267514 (4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267515 (4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267516 (4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267517 ((R)-4-(8-amino-3-(1-propionylpiperidin-3-yl) imida...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267518 ((R)-ethyl 3-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267520 ((R)-4-(8-amino-3-(1-(3-methyloxetane-3 carbonyl)pi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267521 ((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3 yl)imida...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267522 ((R)-4-(8-amino-3-(1-(cyclopropanecarbonyl) piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267523 ((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3-yl)imida...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267524 ((R)-4-(8-amino-3-(1-(3-hydroxy-2-(hydroxymethyl)-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267525 ((R)-4-(8-amino-3-(piperidin-3-yl)imidazo[1,5-a]pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267527 ((R)-4-(8-amino-3-(1-(2-cyano-2-methylpropanoyl)pip...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267528 ((R)-4-(8-amino-3-(1-(3,3-difluorocyclobutanecarbon...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267532 ((R)-4-(8-amino-3-(1-(2-(3,4-dimethylphenylamino)-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267534 ((R)-4-(8-amino-3-(1-(3,3,3-trifluoro-2-oxopropanoy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267535 ((R)-4-(8-amino-3-(1-(5-methyl-1,3,4-oxadiazole-2-c...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267536 ((R)-4-(8-amino-3-(1-(6-cyanonicotinoyl)piperidin-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267537 ((R)-4-(8-amino-3-(1-(4-cyanothiophene-2-carbonyl)p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267538 ((R)-4-(8-amino-3-(1-(pyrrolidine-1-carbonyl)piperi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267547 (4-(8-amino-3-(1-aminopropan-2-yl)imidazo[1,5-a]pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267549 ((R)-4-(8-amino-3-(1-phenethylpiperidin-3-yl)imidaz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267553 ((R)-4-(8-amino-3-(1-ethylpiperidin-3-yl)imidazo[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM267555 ((R)-4-(8-amino-3-(1-(cyclopropylmethyl)piperidin-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | 7.2 | 25 |
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V. US Patent | Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (... | US Patent US9718828 (2017) BindingDB Entry DOI: 10.7270/Q2H9977T | |||||||||||
More data for this Ligand-Target Pair |
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