BindingDB PrimarySearch

Found 20 hits of ec50 data for polymerid = 2103,2104
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Substance-P receptor (Homo sapiens (Human))	BDBM50413782 (CHEMBL1627325) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0490	n/a	n/a	n/a	n/a
National Institute of Neuroscienc Curated by ChEMBL					Assay Description Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization				J Med Chem 52: 4068-71 (2009) Article DOI: 10.1021/jm900604g BindingDB Entry DOI: 10.7270/Q2445NQD
National Institute of Neuroscienc Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50001450 ((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0575	n/a	n/a	n/a	n/a
National Institute of Neuroscienc Curated by ChEMBL					Assay Description Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization				J Med Chem 52: 4068-71 (2009) Article DOI: 10.1021/jm900604g BindingDB Entry DOI: 10.7270/Q2445NQD
National Institute of Neuroscienc Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50001450 ((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche AG Curated by ChEMBL					Assay Description Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins				J Med Chem 55: 5061-76 (2012) Article DOI: 10.1021/jm2017072 BindingDB Entry DOI: 10.7270/Q2959JP4
F. Hoffmann-La Roche AG Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087851 (CHEMBL384518 \| LysProSerProAspArgPheTyrGlyLeuMet) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description Agonist activity at bfSPR to produce increase in intracellular [Ca2+]				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50001450 ((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087851 (CHEMBL384518 \| LysProSerProAspArgPheTyrGlyLeuMet) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50001450 ((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description Agonist activity at bfSPR to produce increase in intracellular [Ca2+]				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50030211 ((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Technische Universität München Curated by ChEMBL					Assay Description Tested for the biological activity and selectivity against NK-1 receptor				J Med Chem 37: 2145-52 (1994) BindingDB Entry DOI: 10.7270/Q2NG4PNN
Technische Universität München Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50030213 ((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Technische Universität München Curated by ChEMBL					Assay Description Tested for the biological activity and selectivity against NK-1 receptor				J Med Chem 37: 2145-52 (1994) BindingDB Entry DOI: 10.7270/Q2NG4PNN
Technische Universität München Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087852 (CHEMBL263185 \| His-Asn-Pro-Ala-Ser-Phe-Ile-Gly-Leu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	13.5	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description Agonist activity at bfSPR to produce increase in intracellular [Ca2+]				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087852 (CHEMBL263185 \| His-Asn-Pro-Ala-Ser-Phe-Ile-Gly-Leu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087850 (CHEMBL415159 \| TyrLysSerAspSerPheTyrGlyLeuMet) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50087850 (CHEMBL415159 \| TyrLysSerAspSerPheTyrGlyLeuMet) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Marshall University School of Medicine and Huntington VA Medical Center Curated by ChEMBL					Assay Description Agonist activity at bfSPR to produce increase in intracellular [Ca2+]				J Med Chem 43: 1741-53 (2000) BindingDB Entry DOI: 10.7270/Q27D2TCJ
					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50140771 (((2R,3R)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24.4	n/a	n/a	n/a	n/a
Tom's of Maine Curated by ChEMBL					Assay Description Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells				J Nat Prod 69: 432-5 (2006) Article DOI: 10.1021/np058114h BindingDB Entry DOI: 10.7270/Q2V98907
Tom's of Maine Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50030212 ((S)-2-{2-[(2R,5S,8R)-5,8-Dibenzyl-2-(3-guanidino-p...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Technische Universität München Curated by ChEMBL					Assay Description Tested for the biological activity and selectivity against NK-1 receptor				J Med Chem 37: 2145-52 (1994) BindingDB Entry DOI: 10.7270/Q2NG4PNN
Technische Universität München Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50559988 (CHEMBL4794099) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127353 BindingDB Entry DOI: 10.7270/Q2SB49F8
TBA					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50559987 (CHEMBL4750714) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127353 BindingDB Entry DOI: 10.7270/Q2SB49F8
TBA					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50030214 ((S)-2-{2-[(6R,9S,12R)-6,9-Dibenzyl-12-(3-guanidino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Technische Universität München Curated by ChEMBL					Assay Description Tested for the biological activity and selectivity against NK-1 receptor				J Med Chem 37: 2145-52 (1994) BindingDB Entry DOI: 10.7270/Q2NG4PNN
Technische Universität München Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50261729 (6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at NK1 receptor (unknown origin)				Bioorg Med Chem Lett 18: 4267-74 (2008) Article DOI: 10.1016/j.bmcl.2008.06.096 BindingDB Entry DOI: 10.7270/Q21C1WQ8
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Substance-P receptor (Homo sapiens (Human))	BDBM50456633 (CHEMBL4215185) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.50E+5	n/a	n/a	n/a	n/a
Universidad de Sevilla Curated by ChEMBL					Assay Description Partial agonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as IP1 accumulation measured after 30 mins by H...				Eur J Med Chem 138: 644-660 (2017) Article DOI: 10.1016/j.ejmech.2017.06.056 BindingDB Entry DOI: 10.7270/Q2930WSH
Universidad de Sevilla Curated by ChEMBL					More data for this Ligand-Target Pair