BindingDB PrimarySearch

Found 16 hits of ec50 data for polymerid = 2153,3627
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50454163 (CHEMBL4215022) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Medical University of Warsaw Curated by ChEMBL					Assay Description Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgamma...				Bioorg Med Chem 26: 527-535 (2018) Article DOI: 10.1016/j.bmc.2017.12.016 BindingDB Entry DOI: 10.7270/Q2DF6TTS
Medical University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50511105 (GWP-42004 \| Gwp42004 \| O-4394 \| THCV \| Tetrahydroc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.40	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00965 BindingDB Entry DOI: 10.7270/Q2057KWP
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50454165 (CHEMBL4218720) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Medical University of Warsaw Curated by ChEMBL					Assay Description Agonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes after 90 mins by microbeta scintillation counting based [35S]GTPgamma...				Bioorg Med Chem 26: 527-535 (2018) Article DOI: 10.1016/j.bmc.2017.12.016 BindingDB Entry DOI: 10.7270/Q2DF6TTS
Medical University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50039564 (CHEMBL83597 \| [3-((R)-1-Methyl-pyrrolidin-2-ylmeth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50036286 ((R)-(-)-10-methyl-11-hydroxyaporphine \| (R)-6,10-d...) Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1ccc(C)c(O)c-31 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptami...				J Med Chem 38: 647-58 (1995) BindingDB Entry DOI: 10.7270/Q2HX1BQH
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50454165 (CHEMBL4218720) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
Medical University of Warsaw Curated by ChEMBL					Assay Description Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation af...				Bioorg Med Chem 26: 527-535 (2018) Article DOI: 10.1016/j.bmc.2017.12.016 BindingDB Entry DOI: 10.7270/Q2DF6TTS
Medical University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50039565 (CHEMBL314213 \| [3-(2-Dimethylamino-ethyl)-1H-indol...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50039566 ((3-Nitro-pyridin-2-yl)-(3-(R)-1-pyrrolidin-2-ylmet...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	323	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding				J Med Chem 51: 4529-38 (2008) Article DOI: 10.1021/jm800176x BindingDB Entry DOI: 10.7270/Q2Q81CWG
Università di Catania Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50262582 (2-[[3-[4-(Pyridin-2-yl)-1-piperazinyl]propyl]thio]...) Show SMILES C(CSc1nc2ccccc2s1)CN1CCN(CC1)c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	323	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding				J Med Chem 51: 4529-38 (2008) Article DOI: 10.1021/jm800176x BindingDB Entry DOI: 10.7270/Q2Q81CWG
Università di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50454163 (CHEMBL4215022) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	631	n/a	n/a	n/a	n/a
Medical University of Warsaw Curated by ChEMBL					Assay Description Antagonist activity at 5-HT1A receptor in Sprague-Dawley rat hippocampal membranes assessed as inhibition of 8-OH-DPAT-induced receptor activation af...				Bioorg Med Chem 26: 527-535 (2018) Article DOI: 10.1016/j.bmc.2017.12.016 BindingDB Entry DOI: 10.7270/Q2DF6TTS
Medical University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50039567 (CHEMBL84942 \| [3-(1-Methyl-pyrrolidin-3-yl)-1H-ind...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	885	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50262833 (3-amino-6-ethyl-2-(3-(4-(pyrimidin-2-yl)piperazin-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS binding				J Med Chem 51: 4529-38 (2008) Article DOI: 10.1021/jm800176x BindingDB Entry DOI: 10.7270/Q2Q81CWG
Università di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor				J Med Chem 37: 2509-12 (1994) BindingDB Entry DOI: 10.7270/Q2S181JQ
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50016013 ((R)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...) Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(O)c-31 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Ability to inhibit 5-HT sensitive,forskolin-stimulated adenylyl cyclase(FSC) activity in rat hippocampal membranes mediated through 5-hydroxytryptami...				J Med Chem 38: 647-58 (1995) BindingDB Entry DOI: 10.7270/Q2HX1BQH
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair