Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22376 ((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505369 (CHEMBL4440757) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22375 ((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22391 ((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22385 ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 31.6 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22385 ((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 34 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505372 (CHEMBL4447391) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50605641 (CHEMBL5177743) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00235 BindingDB Entry DOI: 10.7270/Q23J3J2Q | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22379 ((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22382 ((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 70 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22374 ((3aS,6aR)-4-methyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 90 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418312 (CHEMBL1765932) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50511467 (CHEMBL4551205) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00235 BindingDB Entry DOI: 10.7270/Q23J3J2Q | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505367 (CHEMBL4565513) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22378 ((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22388 ((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 150 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418306 (CHEMBL1765955) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 158 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22377 ((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418304 (CHEMBL1765953) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22386 ((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 230 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418303 (CHEMBL1765959) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418313 (CHEMBL1765945) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418308 (CHEMBL1765933) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418310 (CHEMBL1765962) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418309 (CHEMBL1765956) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 251 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418325 (CHEMBL1765958) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418307 (CHEMBL1765934) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 316 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22383 ((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 320 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22389 ((3aS,6aR)-N-(3-fluorophenyl)-5-hexyl-4-phenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 330 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418326 (CHEMBL1765961) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418305 (CHEMBL1765960) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50468000 (CHEMBL4288251) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Agonist activity at recombinant full length human LRH1 expressed in HeLa cells after 24 hrs by dual-glo luciferase reporter gene assay | ACS Med Chem Lett 9: 1051-1056 (2018) Article DOI: 10.1021/acsmedchemlett.8b00361 BindingDB Entry DOI: 10.7270/Q2WW7MCP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50544057 (CHEMBL4637563) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Agonist activity at LRH1 (unknown origin) by luciferase reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127293 BindingDB Entry DOI: 10.7270/Q2GH9NH4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22373 ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 430 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505380 (CHEMBL4541939) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418316 (CHEMBL1765966) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418303 (CHEMBL1765959) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505369 (CHEMBL4440757) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505376 (CHEMBL4461328) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at recombinant human LRH1 ligand binding domain (300 to 537 residues) expressed in Escherichia coli BL21 cells assessed as increase ... | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22373 ((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418329 (CHEMBL1765951) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418311 (CHEMBL1765931) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505378 (CHEMBL4558553) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505371 (CHEMBL4455426) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505366 (CHEMBL4452061) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505376 (CHEMBL4461328) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50505370 (CHEMBL4460749) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Emory University School of Medicine Curated by ChEMBL | Assay Description Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assay | J Med Chem 62: 11022-11034 (2019) Article DOI: 10.1021/acs.jmedchem.9b00753 BindingDB Entry DOI: 10.7270/Q2XK8JT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418321 (CHEMBL1765963) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM22390 ((3aS,6aR)-N-(4-chlorophenyl)-5-hexyl-4-phenyl-1,2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | 7.5 | 22 |
University of Southampton | Assay Description The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv... | J Med Chem 49: 6652-5 (2006) Article DOI: 10.1021/jm060990k BindingDB Entry DOI: 10.7270/Q2930RGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 5 group A member 2 (Homo sapiens (Human)) | BDBM50418330 (CHEMBL1765938) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | J Med Chem 54: 2266-81 (2011) Article DOI: 10.1021/jm1014296 BindingDB Entry DOI: 10.7270/Q29Z957P | |||||||||||
More data for this Ligand-Target Pair |
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