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Compile Data Set for Download or QSAR

Found 44 hits of ec50 data for polymerid = 2740,50006942   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568115
PNG
(CHEMBL4864190)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-n1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12
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n/an/an/an/a 70n/an/an/an/a


TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111386
PNG
(CHEMBL3604792)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C21H19F2N3O/c22-19-11-15(12-20(23)21(19)27)18-13-25-6-5-17(18)14-1-3-16(4-2-14)26-9-7-24-8-10-26/h1-6,11-13,24,27H,7-10H2
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n/an/an/an/a 140n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50248765
PNG
(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Show SMILES Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)
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n/an/an/an/a 150n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by western blotting analysis


Nat Chem Biol 3: 156-60 (2007)


Article DOI: 10.1038/nchembio859
BindingDB Entry DOI: 10.7270/Q22B8Z60
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111384
PNG
(CHEMBL3604794)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2
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n/an/an/an/a 210n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568114
PNG
(CHEMBL4857399)
Show SMILES Oc1c(F)cc(Nc2ncc3ccn(-c4ccc(cc4)N4CCOCC4)c3n2)cc1F
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TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111385
PNG
(CHEMBL3604793)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3
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n/an/an/an/a 340n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111377
PNG
(CHEMBL3604885)
Show SMILES Cc1ccc(cc1)-c1nc(N)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H13F2N3O/c1-9-2-4-10(5-3-9)15-12(8-21-17(20)22-15)11-6-13(18)16(23)14(19)7-11/h2-8,23H,1H3,(H2,20,21,22)
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n/an/an/an/a 360n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111381
PNG
(CHEMBL3604881)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(N)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H22F2N4O/c1-27-6-8-28(9-7-27)16-4-2-14(3-5-16)17-12-21(25)26-13-18(17)15-10-19(23)22(29)20(24)11-15/h2-5,10-13,29H,6-9H2,1H3,(H2,25,26)
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n/an/an/an/a 440n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111394
PNG
(CHEMBL3604784)
Show SMILES NCCOc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H16F2N2O2/c20-17-9-13(10-18(21)19(17)24)16-11-23-6-4-15(16)12-2-1-3-14(8-12)25-7-5-22/h1-4,6,8-11,24H,5,7,22H2
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n/an/an/an/a 490n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111373
PNG
(CHEMBL3604889)
Show SMILES CC(C)CCN1[C@H](C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 |r|
Show InChI InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)/t11-/m1/s1
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n/an/an/an/a 500n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111380
PNG
(CHEMBL3604882)
Show SMILES CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C23H24F2N4O/c1-26-22-13-18(19(14-27-22)16-11-20(24)23(30)21(25)12-16)15-3-5-17(6-4-15)29-9-7-28(2)8-10-29/h3-6,11-14,30H,7-10H2,1-2H3,(H,26,27)
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n/an/an/an/a 580n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111374
PNG
(CHEMBL3604888)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C24H27F2N5O/c1-15(2)28-24-27-14-19(17-12-20(25)23(32)21(26)13-17)22(29-24)16-4-6-18(7-5-16)31-10-8-30(3)9-11-31/h4-7,12-15,32H,8-11H2,1-3H3,(H,27,28,29)
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n/an/an/an/a 610n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111378
PNG
(CHEMBL3604884)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc(Nc2ccc(C)cc2)ncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C29H28F2N4O/c1-19-3-7-22(8-4-19)33-28-17-24(25(18-32-28)21-15-26(30)29(36)27(31)16-21)20-5-9-23(10-6-20)35-13-11-34(2)12-14-35/h3-10,15-18,36H,11-14H2,1-2H3,(H,32,33)
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n/an/an/an/a 690n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111376
PNG
(CHEMBL3604886)
Show SMILES CNc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H15F2N3O/c1-10-3-5-11(6-4-10)16-13(9-22-18(21-2)23-16)12-7-14(19)17(24)15(20)8-12/h3-9,24H,1-2H3,(H,21,22,23)
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n/an/an/an/a 690n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568104
PNG
(CHEMBL4858257 | US11851436, Compound A1-2)
Show SMILES CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12
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TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111393
PNG
(CHEMBL3604785)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)-c1cn[nH]c1
Show InChI InChI=1S/C20H13F2N3O/c21-18-7-14(8-19(22)20(18)26)17-11-23-5-4-16(17)13-3-1-2-12(6-13)15-9-24-25-10-15/h1-11,26H,(H,24,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111388
PNG
(CHEMBL3604790)
Show SMILES COc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO2/c1-23-13-4-2-11(3-5-13)14-6-7-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111391
PNG
(CHEMBL3604787)
Show SMILES CN1CCN(CC1)c1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C22H21F2N3O/c1-26-7-9-27(10-8-26)17-4-2-3-15(11-17)18-5-6-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-6,11-14,28H,7-10H2,1H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568113
PNG
(CHEMBL4873445)
Show SMILES CC(C)CCn1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc12
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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111368
PNG
(CHEMBL3604775)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C15H10F2N2O2/c16-12-5-9(6-13(17)15(12)21)14-11(7-18-19-14)8-1-3-10(20)4-2-8/h1-7,20-21H,(H,18,19)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111375
PNG
(CHEMBL3604887)
Show SMILES CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C20H19F2N3O/c1-11(2)24-20-23-10-15(14-8-16(21)19(26)17(22)9-14)18(25-20)13-6-4-12(3)5-7-13/h4-11,26H,1-3H3,(H,23,24,25)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111389
PNG
(CHEMBL3604789)
Show SMILES Cc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO/c1-11-2-4-12(5-3-11)14-6-7-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3
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n/an/an/an/a 1.60E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568106
PNG
(CHEMBL4849660 | US11851436, Compound A1-4)
Show SMILES Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(CCN5CCOCC5)cc4)c3n2)cc1F
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n/an/an/an/a 1.90E+3n/an/an/an/a


TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111387
PNG
(CHEMBL3604791)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C19H14F2N2O2/c1-22-19(25)12-4-2-11(3-5-12)14-6-7-23-10-15(14)13-8-16(20)18(24)17(21)9-13/h2-10,24H,1H3,(H,22,25)
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n/an/an/an/a 2.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111364
PNG
(CHEMBL3604779)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1C1CCOCC1
Show InChI InChI=1S/C16H15F2NO2/c17-14-7-11(8-15(18)16(14)20)13-9-19-4-1-12(13)10-2-5-21-6-3-10/h1,4,7-10,20H,2-3,5-6H2
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n/an/an/an/a 2.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111392
PNG
(CHEMBL3604786)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-5-4-17(18)14-2-1-3-16(10-14)25-6-8-27-9-7-25/h1-5,10-13,26H,6-9H2
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n/an/an/an/a 2.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111379
PNG
(CHEMBL3604883)
Show SMILES CC(C)CNc1cc(-c2ccc(cc2)N2CCN(C)CC2)c(cn1)-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C26H30F2N4O/c1-17(2)15-29-25-14-21(22(16-30-25)19-12-23(27)26(33)24(28)13-19)18-4-6-20(7-5-18)32-10-8-31(3)9-11-32/h4-7,12-14,16-17,33H,8-11,15H2,1-3H3,(H,29,30)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM25017
PNG
(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)
Show SMILES CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12
Show InChI InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
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n/an/an/an/a 2.60E+3n/an/an/an/a


TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111372
PNG
(CHEMBL3604771)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccc(O)cc1
Show InChI InChI=1S/C15H12N2O2/c18-12-5-1-10(2-6-12)14-9-16-17-15(14)11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111369
PNG
(CHEMBL3604774)
Show SMILES Nc1n[nH]c(c1-c1ccccc1)-c1ccc(O)cc1
Show InChI InChI=1S/C15H13N3O/c16-15-13(10-4-2-1-3-5-10)14(17-18-15)11-6-8-12(19)9-7-11/h1-9,19H,(H3,16,17,18)
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n/an/an/an/a 3.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111361
PNG
(CHEMBL3604782)
Show SMILES Cc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO/c1-11-3-2-4-12(7-11)14-5-6-21-10-15(14)13-8-16(19)18(22)17(20)9-13/h2-10,22H,1H3
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n/an/an/an/a 4.10E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111365
PNG
(CHEMBL3604778)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccccc1
Show InChI InChI=1S/C17H11F2NO/c18-15-8-12(9-16(19)17(15)21)14-10-20-7-6-13(14)11-4-2-1-3-5-11/h1-10,21H
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n/an/an/an/a 4.20E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111383
PNG
(CHEMBL3604795)
Show SMILES COc1ccc(cn1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H12F2N2O2/c1-23-16-3-2-10(8-21-16)12-4-5-20-9-13(12)11-6-14(18)17(22)15(19)7-11/h2-9,22H,1H3
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n/an/an/an/a 5.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111395
PNG
(CHEMBL3604783)
Show SMILES COc1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C18H13F2NO2/c1-23-13-4-2-3-11(7-13)14-5-6-21-10-15(14)12-8-16(19)18(22)17(20)9-12/h2-10,22H,1H3
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n/an/an/an/a 5.60E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111366
PNG
(CHEMBL3604777)
Show SMILES Oc1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C17H11F2NO2/c18-15-7-11(8-16(19)17(15)22)14-9-20-6-5-13(14)10-1-3-12(21)4-2-10/h1-9,21-22H
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n/an/an/an/a 6.40E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111367
PNG
(CHEMBL3604776)
Show SMILES Oc1ccc(cc1)-c1ccncc1-c1ccc(O)cc1
Show InChI InChI=1S/C17H13NO2/c19-14-5-1-12(2-6-14)16-9-10-18-11-17(16)13-3-7-15(20)8-4-13/h1-11,19-20H
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n/an/an/an/a 9.30E+3n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50324684
PNG
(3-(1-(4-amino-6-(2-fluoroacetyl)-5-p-tolyl-7H-pyrr...)
Show SMILES C[C+]1C=C(C)C2=Cc3ccc(CCC(=O)NCCCCCC(=O)NCCCCNC(=O)OCCCn4c(C(=O)CF)c(-c5ccc(C)cc5)c5c(N)ncnc45)n3[B-](F)(F)C12 |t:2,5|
Show InChI InChI=1S/C44H54BF3N8O5/c1-28-11-13-31(14-12-28)38-39-42(49)53-27-54-43(39)55(41(38)35(57)26-46)22-9-23-61-44(60)52-21-8-7-20-50-36(58)10-5-4-6-19-51-37(59)18-17-32-15-16-33-25-34-29(2)24-30(3)40(34)45(47,48)56(32)33/h11-16,24-25,27,40H,4-10,17-23,26H2,1-3H3,(H,50,58)(H,51,59)(H,52,60)(H2,49,53,54)
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n/an/an/an/a 1.00E+4n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by western blotting analysis


Nat Chem Biol 3: 156-60 (2007)


Article DOI: 10.1038/nchembio859
BindingDB Entry DOI: 10.7270/Q22B8Z60
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111390
PNG
(CHEMBL3604788)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10F3NO/c18-12-3-1-10(2-4-12)13-5-6-21-9-14(13)11-7-15(19)17(22)16(20)8-11/h1-9,22H
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n/an/an/an/a 1.04E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50568112
PNG
(CHEMBL4851452)
Show SMILES COC(=O)CCCc1ccc(cc1)-n1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc12
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n/an/an/an/a 1.39E+4n/an/an/an/a


TBA

Assay Description
Inhibition of RSK2 in human MOLM-13 assessed as reduction in cell viability measured after 72 hrs by MTS assay


Citation and Details

Article DOI: 10.1016/j.bmc.2021.116220
BindingDB Entry DOI: 10.7270/Q2H70KKB
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111370
PNG
(CHEMBL3604773)
Show SMILES Oc1ccc(cc1)-c1cn[nH]c1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-11(7-9-13)14-10-16-17-15(14)12-4-2-1-3-5-12/h1-10,18H,(H,16,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111382
PNG
(CHEMBL3604796)
Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cnccc1-c1ccc(F)cc1
Show InChI InChI=1S/C17H10Cl2FNO/c18-15-7-11(8-16(19)17(15)22)14-9-21-6-5-13(14)10-1-3-12(20)4-2-10/h1-9,22H
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111362
PNG
(CHEMBL3604781)
Show SMILES CC(C)c1ccncc1-c1cc(F)c(O)c(F)c1
Show InChI InChI=1S/C14H13F2NO/c1-8(2)10-3-4-17-7-11(10)9-5-12(15)14(18)13(16)6-9/h3-8,18H,1-2H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111363
PNG
(CHEMBL3604780)
Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1C1CCNCC1
Show InChI InChI=1S/C16H16F2N2O/c17-14-7-11(8-15(18)16(14)21)13-9-20-6-3-12(13)10-1-4-19-5-2-10/h3,6-10,19,21H,1-2,4-5H2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Mus musculus)
BDBM50111371
PNG
(CHEMBL3604772)
Show SMILES Oc1ccc(cc1)-c1[nH]ncc1-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c18-13-8-6-12(7-9-13)15-14(10-16-17-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>2.00E+4n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...


J Med Chem 58: 6766-83 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00450
BindingDB Entry DOI: 10.7270/Q21C1ZN6
More data for this
Ligand-Target Pair