Found 5 hits of ec50 data for polymerid = 49000307,49000311,50000702,50006869 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent L-type calcium channel subunit alpha-1C
(RAT) | BDBM50283421
(((E)-Azacyclotridec-1-en-2-yl)-(2,2-diphenyl-penty...)Show SMILES CCCC(CNC1=NCCCCCCCCCCC1)(c1ccccc1)c1ccccc1 |w:7.7| Show InChI InChI=1S/C29H42N2/c1-2-23-29(26-18-12-10-13-19-26,27-20-14-11-15-21-27)25-31-28-22-16-8-6-4-3-5-7-9-17-24-30-28/h10-15,18-21H,2-9,16-17,22-25H2,1H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | n/a | n/a | 34 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding of [3H]-nitrendipine to calcium channel in rat heart membranes |
Bioorg Med Chem Lett 4: 351-354 (1994)
Article DOI: 10.1016/S0960-894X(01)80143-8 BindingDB Entry DOI: 10.7270/Q2R78F5H |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(RAT) | BDBM50283420
(((E)-Azacyclotridec-1-en-2-yl)-((1S,2S)-2-phenyl-c...)Show SMILES C1C[C@H](N=C2CCCCCCCCCCCN2)[C@@H](C1)c1ccccc1 |w:4.16| Show InChI InChI=1S/C23H36N2/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding of [3H]-nitrendipine to calcium channel in rat heart membranes |
Bioorg Med Chem Lett 4: 351-354 (1994)
Article DOI: 10.1016/S0960-894X(01)80143-8 BindingDB Entry DOI: 10.7270/Q2R78F5H |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(RAT) | BDBM50283420
(((E)-Azacyclotridec-1-en-2-yl)-((1S,2S)-2-phenyl-c...)Show SMILES C1C[C@H](N=C2CCCCCCCCCCCN2)[C@@H](C1)c1ccccc1 |w:4.16| Show InChI InChI=1S/C23H36N2/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25)/t21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determined |
Bioorg Med Chem Lett 4: 351-354 (1994)
Article DOI: 10.1016/S0960-894X(01)80143-8 BindingDB Entry DOI: 10.7270/Q2R78F5H |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(RAT) | BDBM50516235
(CHEMBL4563408)Show SMILES FC(F)Oc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)cn1 Show InChI InChI=1S/C29H24Cl2F2N8O2/c30-17-5-8-20(9-6-17)41-25(21-3-1-2-4-22(21)31)39-24-26(35-16-36-27(24)41)40-13-11-18(12-14-40)37-29(42)38-19-7-10-23(34-15-19)43-28(32)33/h1-10,15-16,18,28H,11-14H2,(H2,37,38,42) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [3H]nitrendipine from rat brain Cav1.2 dihydropyridine site after 90 mins by scintillation counting analysis |
J Med Chem 62: 6330-6345 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00727 BindingDB Entry DOI: 10.7270/Q24F1V3D |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1C
(Homo sapiens (Human)) | BDBM50538344
(CHEMBL4633246)Show SMILES Cc1c(Cc2ccc(nc2)C(F)(F)F)c[nH]c1C(=O)NC1CC1 Show InChI InChI=1S/C16H16F3N3O/c1-9-11(8-21-14(9)15(23)22-12-3-4-12)6-10-2-5-13(20-7-10)16(17,18)19/h2,5,7-8,12,21H,3-4,6H2,1H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human Cav1.2 by fluorescence based assay |
J Med Chem 63: 4929-4956 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00311 BindingDB Entry DOI: 10.7270/Q2M90D6Z |
More data for this Ligand-Target Pair | |