Compile Data Set for Download or QSAR

Found 293 hits of ec50 data for polymerid = 49000363,49000366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005363 ((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...) Show SMILES Cc1noc(n1)C1CN2CCC1C2 |TLB:4:6:12:10.9| Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)				J Med Chem 35: 911-6 (1992) BindingDB Entry DOI: 10.7270/Q2S75F81
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261732 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005363 ((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...) Show SMILES Cc1noc(n1)C1CN2CCC1C2 |TLB:4:6:12:10.9| Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)				J Med Chem 35: 911-6 (1992) BindingDB Entry DOI: 10.7270/Q2S75F81
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005363 ((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...) Show SMILES Cc1noc(n1)C1CN2CCC1C2 |TLB:4:6:12:10.9| Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)				J Med Chem 35: 911-6 (1992) BindingDB Entry DOI: 10.7270/Q2S75F81
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464175 (CHEMBL4247625) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCOC[C@H]2O)cn1 |r| Show InChI InChI=1S/C24H26N6O3/c1-29-8-5-17-16(11-15-3-4-18(25-13-15)19-6-9-30(2)28-19)12-21(26-23(17)29)24(32)27-20-7-10-33-14-22(20)31/h3-6,8-9,12-13,20,22,31H,7,10-11,14H2,1-2H3,(H,27,32)/t20-,22-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261731 (1-Fluoro-N-((1S,2S)-2-hydroxycyclohexyl)-4-((6-(1-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C27H27FN4O2/c1-32-16-19(15-30-32)23-11-10-17(14-29-23)12-18-13-22(26(28)21-7-3-2-6-20(18)21)27(34)31-24-8-4-5-9-25(24)33/h2-3,6-7,10-11,13-16,24-25,33H,4-5,8-9,12H2,1H3,(H,31,34)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112163 (CHEMBL3608419) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C24H25N5O3/c1-28-13-18(11-26-28)17-6-4-16(5-7-17)12-29-14-19(23-21(29)3-2-9-25-23)24(31)27-20-15-32-10-8-22(20)30/h2-7,9,11,13-14,20,22,30H,8,10,12,15H2,1H3,(H,27,31)/t20-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261728 (1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- y...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)c(F)c1 |r| Show InChI InChI=1S/C27H25F2N3O3/c1-32-14-19(13-30-32)16-6-7-17(23(28)12-16)10-18-11-22(26(29)21-5-3-2-4-20(18)21)27(34)31-24-8-9-35-15-25(24)33/h2-7,11-14,24-25,33H,8-10,15H2,1H3,(H,31,34)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464175 (CHEMBL4247625) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCOC[C@H]2O)cn1 |r| Show InChI InChI=1S/C24H26N6O3/c1-29-8-5-17-16(11-15-3-4-18(25-13-15)19-6-9-30(2)28-19)12-21(26-23(17)29)24(32)27-20-7-10-33-14-22(20)31/h3-6,8-9,12-13,20,22,31H,7,10-11,14H2,1-2H3,(H,27,32)/t20-,22-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112166 (CHEMBL3608422) Show SMILES CNC(=O)c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc23)cc1 |r| Show InChI InChI=1S/C22H24N4O4/c1-23-21(28)15-6-4-14(5-7-15)11-26-12-16(20-18(26)3-2-9-24-20)22(29)25-17-13-30-10-8-19(17)27/h2-7,9,12,17,19,27H,8,10-11,13H2,1H3,(H,23,28)(H,25,29)/t17-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112165 (CHEMBL3608421) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc23)cc1F |r| Show InChI InChI=1S/C24H24FN5O3/c1-29-12-16(10-27-29)17-5-4-15(9-19(17)25)11-30-13-18(23-21(30)3-2-7-26-23)24(32)28-20-14-33-8-6-22(20)31/h2-5,7,9-10,12-13,20,22,31H,6,8,11,14H2,1H3,(H,28,32)/t20-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261730 (1-fluoro-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-py...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)cc1 |r| Show InChI InChI=1S/C27H26FN3O3/c1-31-15-20(14-29-31)18-8-6-17(7-9-18)12-19-13-23(26(28)22-5-3-2-4-21(19)22)27(33)30-24-10-11-34-16-25(24)32/h2-9,13-15,24-25,32H,10-12,16H2,1H3,(H,30,33)/t24-,25-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50064609 (6-acetoxy-8-azonia-bicyclo[3.2.1]octane | Acetic a...) Show SMILES CC(=O)OC1CC2CCCC1N2 |TLB:3:4:11:9.8.7| Show InChI InChI=1S/C9H15NO2/c1-6(11)12-9-5-7-3-2-4-8(9)10-7/h7-10H,2-5H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscari...				J Med Chem 41: 2047-55 (1998) Article DOI: 10.1021/jm9705115 BindingDB Entry DOI: 10.7270/Q2B27VZZ
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112162 (CHEMBL3608413) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCCC[C@@H]3O)c3ncccc23)c(F)c1 |r| Show InChI InChI=1S/C25H26FN5O2/c1-30-13-18(12-28-30)16-8-9-17(20(26)11-16)14-31-15-19(24-22(31)6-4-10-27-24)25(33)29-21-5-2-3-7-23(21)32/h4,6,8-13,15,21,23,32H,2-3,5,7,14H2,1H3,(H,29,33)/t21-,23-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464190 (CHEMBL4248057) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCOC[C@H]2O)cc1 |r| Show InChI InChI=1S/C25H27N5O3/c1-29-10-7-19-18(13-16-3-5-17(6-4-16)20-8-11-30(2)28-20)14-22(26-24(19)29)25(32)27-21-9-12-33-15-23(21)31/h3-8,10-11,14,21,23,31H,9,12-13,15H2,1-2H3,(H,27,32)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464189 (CHEMBL4240041) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cn1 |r| Show InChI InChI=1S/C25H28N6O2/c1-30-10-9-19-17(11-16-7-8-20(26-13-16)18-14-27-31(2)15-18)12-22(28-24(19)30)25(33)29-21-5-3-4-6-23(21)32/h7-10,12-15,21,23,32H,3-6,11H2,1-2H3,(H,29,33)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464190 (CHEMBL4248057) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCOC[C@H]2O)cc1 |r| Show InChI InChI=1S/C25H27N5O3/c1-29-10-7-19-18(13-16-3-5-17(6-4-16)20-8-11-30(2)28-20)14-22(26-24(19)29)25(32)27-21-9-12-33-15-23(21)31/h3-8,10-11,14,21,23,31H,9,12-13,15H2,1-2H3,(H,27,32)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261736 (1-fluoro-N- ((1SR,2RS)-2- hydroxy-2- methylcyclohe...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@]3(C)O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C28H29FN4O2/c1-28(35)12-6-5-9-25(28)32-27(34)23-14-19(21-7-3-4-8-22(21)26(23)29)13-18-10-11-24(30-15-18)20-16-31-33(2)17-20/h3-4,7-8,10-11,14-17,25,35H,5-6,9,12-13H2,1-2H3,(H,32,34)/t25-,28+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464189 (CHEMBL4240041) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cn1 |r| Show InChI InChI=1S/C25H28N6O2/c1-30-10-9-19-17(11-16-7-8-20(26-13-16)18-14-27-31(2)15-18)12-22(28-24(19)30)25(33)29-21-5-3-4-6-23(21)32/h7-10,12-15,21,23,32H,3-6,11H2,1-2H3,(H,29,33)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261735 (1-fluoro-N-((3S,4S)-4- hydroxytetrahydro-2H- pyran...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3COCC[C@@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-15-34-9-8-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112158 (CHEMBL3608417) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc23)c(F)c1 |r| Show InChI InChI=1S/C24H24FN5O3/c1-29-11-17(10-27-29)15-4-5-16(19(25)9-15)12-30-13-18(23-21(30)3-2-7-26-23)24(32)28-20-14-33-8-6-22(20)31/h2-5,7,9-11,13,20,22,31H,6,8,12,14H2,1H3,(H,28,32)/t20-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	51	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112161 (CHEMBL3608414) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c3ncccc23)c(F)c1 |r| Show InChI InChI=1S/C24H24FN5O3/c1-29-11-17(10-27-29)15-4-5-16(19(25)9-15)12-30-13-18(23-21(30)3-2-7-26-23)24(32)28-20-6-8-33-14-22(20)31/h2-5,7,9-11,13,20,22,31H,6,8,12,14H2,1H3,(H,28,32)/t20-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	59	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50356968 (CHEMBL1916225) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccc(F)cc1C |r| Show InChI InChI=1S/C21H30FN3O3/c1-3-28-21(27)24-11-8-18(9-12-24)25-10-4-5-17(14-25)23-20(26)19-7-6-16(22)13-15(19)2/h6-7,13,17-18H,3-5,8-12,14H2,1-2H3,(H,23,26)/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at rat muscarinic M1 receptor expressed in CHO cells				Bioorg Med Chem Lett 21: 6451-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.084 BindingDB Entry DOI: 10.7270/Q26W9BG8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112159 (CHEMBL3608416) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3CCOC[C@@]3(C)O)c3ncccc23)c(F)c1 |r| Show InChI InChI=1S/C25H26FN5O3/c1-25(33)15-34-9-7-22(25)29-24(32)19-14-31(21-4-3-8-27-23(19)21)13-17-6-5-16(10-20(17)26)18-11-28-30(2)12-18/h3-6,8,10-12,14,22,33H,7,9,13,15H2,1-2H3,(H,29,32)/t22-,25+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	63	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261727 (4-(4-cyanobenzyl)- 1-fluoro-N- ((3RS,4SR)-3- hydro...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(cc2)C#N)c2ccccc2c1F |r| Show InChI InChI=1S/C24H21FN2O3/c25-23-19-4-2-1-3-18(19)17(11-15-5-7-16(13-26)8-6-15)12-20(23)24(29)27-21-9-10-30-14-22(21)28/h1-8,12,21-22,28H,9-11,14H2,(H,27,29)/t21-,22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112164 (CHEMBL3608420) Show SMILES Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc23)cn1 |r| Show InChI InChI=1S/C23H24N6O3/c1-28-12-16(10-26-28)18-5-4-15(9-25-18)11-29-13-17(22-20(29)3-2-7-24-22)23(31)27-19-14-32-8-6-21(19)30/h2-5,7,9-10,12-13,19,21,30H,6,8,11,14H2,1H3,(H,27,31)/t19-,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112160 (CHEMBL3608415) Show SMILES Cn1cc(cn1)-c1ccc(Cn2nc(C(=O)N[C@H]3CCCC[C@@H]3O)c3ncccc23)c(F)c1 |r| Show InChI InChI=1S/C24H25FN6O2/c1-30-13-17(12-27-30)15-8-9-16(18(25)11-15)14-31-20-6-4-10-26-22(20)23(29-31)24(33)28-19-5-2-3-7-21(19)32/h4,6,8-13,19,21,32H,2-3,5,7,14H2,1H3,(H,28,33)/t19-,21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50263887 (1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response				Bioorg Med Chem Lett 23: 223-7 (2012) Article DOI: 10.1016/j.bmcl.2012.10.132 BindingDB Entry DOI: 10.7270/Q2TM7CF9
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50263887 (1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response				Bioorg Med Chem Lett 23: 223-7 (2012) Article DOI: 10.1016/j.bmcl.2012.10.132 BindingDB Entry DOI: 10.7270/Q2TM7CF9
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464180 (CHEMBL4240517) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cn1 |r| Show InChI InChI=1S/C25H28N6O2/c1-30-11-9-18-17(13-16-7-8-19(26-15-16)20-10-12-31(2)29-20)14-22(27-24(18)30)25(33)28-21-5-3-4-6-23(21)32/h7-12,14-15,21,23,32H,3-6,13H2,1-2H3,(H,28,33)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464180 (CHEMBL4240517) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cn1 |r| Show InChI InChI=1S/C25H28N6O2/c1-30-11-9-18-17(13-16-7-8-19(26-15-16)20-10-12-31(2)29-20)14-22(27-24(18)30)25(33)28-21-5-3-4-6-23(21)32/h7-12,14-15,21,23,32H,3-6,13H2,1-2H3,(H,28,33)/t21-,23-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	95	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261733 (1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-...) Show SMILES Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@@H]3CCOC[C@H]3O)c(F)c3ccccc23)cn1 |r| Show InChI InChI=1S/C26H25FN4O3/c1-31-14-18(13-29-31)22-7-6-16(12-28-22)10-17-11-21(25(27)20-5-3-2-4-19(17)20)26(33)30-23-8-9-34-15-24(23)32/h2-7,11-14,23-24,32H,8-10,15H2,1H3,(H,30,33)/t23-,24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464184 (CHEMBL4237601) Show SMILES Cn1ccc2c(Cc3ccc(cc3)-c3nccs3)cc(nc12)C(=O)N[C@@H]1CCOC[C@H]1O |r| Show InChI InChI=1S/C24H24N4O3S/c1-28-9-6-18-17(12-15-2-4-16(5-3-15)24-25-8-11-32-24)13-20(26-22(18)28)23(30)27-19-7-10-31-14-21(19)29/h2-6,8-9,11,13,19,21,29H,7,10,12,14H2,1H3,(H,27,30)/t19-,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464184 (CHEMBL4237601) Show SMILES Cn1ccc2c(Cc3ccc(cc3)-c3nccs3)cc(nc12)C(=O)N[C@@H]1CCOC[C@H]1O |r| Show InChI InChI=1S/C24H24N4O3S/c1-28-9-6-18-17(12-15-2-4-16(5-3-15)24-25-8-11-32-24)13-20(26-22(18)28)23(30)27-19-7-10-31-14-21(19)29/h2-6,8-9,11,13,19,21,29H,7,10,12,14H2,1H3,(H,27,30)/t19-,21-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	101	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50356969 (CHEMBL1916226) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccccc1 |r| Show InChI InChI=1S/C20H29N3O3/c1-2-26-20(25)22-13-10-18(11-14-22)23-12-6-9-17(15-23)21-19(24)16-7-4-3-5-8-16/h3-5,7-8,17-18H,2,6,9-15H2,1H3,(H,21,24)/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Partial agonist activity at rat muscarinic M1 receptor expressed in CHO cells calcium response				Bioorg Med Chem Lett 23: 223-7 (2012) Article DOI: 10.1016/j.bmcl.2012.10.132 BindingDB Entry DOI: 10.7270/Q2TM7CF9
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50356966 (CHEMBL1916224) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccccc1C |r| Show InChI InChI=1S/C21H31N3O3/c1-3-27-21(26)23-13-10-18(11-14-23)24-12-6-8-17(15-24)22-20(25)19-9-5-4-7-16(19)2/h4-5,7,9,17-18H,3,6,8,10-15H2,1-2H3,(H,22,25)/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at rat muscarinic M1 receptor expressed in CHO cells				Bioorg Med Chem Lett 21: 6451-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.084 BindingDB Entry DOI: 10.7270/Q26W9BG8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50005364 ((3S,4R)3-Methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)...) Show SMILES Cc1noc(n1)C1(C)CN2CCC1C2 |TLB:4:6:13:11.10,THB:7:6:13:11.10| Show InChI InChI=1S/C10H15N3O/c1-7-11-9(14-12-7)10(2)6-13-4-3-8(10)5-13/h8H,3-6H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by muscarinic acetylcholine receptor M1)				J Med Chem 35: 911-6 (1992) BindingDB Entry DOI: 10.7270/Q2S75F81
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261716 (4-((6-chloropyridin-3- yl)methyl)-1-fluoro-N- ((3R...) Show SMILES O[C@H]1COCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C22H20ClFN2O3/c23-20-6-5-13(11-25-20)9-14-10-17(21(24)16-4-2-1-3-15(14)16)22(28)26-18-7-8-29-12-19(18)27/h1-6,10-11,18-19,27H,7-9,12H2,(H,26,28)/t18-,19-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50356969 (CHEMBL1916226) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccccc1 |r| Show InChI InChI=1S/C20H29N3O3/c1-2-26-20(25)22-13-10-18(11-14-22)23-12-6-9-17(15-23)21-19(24)16-7-4-3-5-8-16/h3-5,7-8,17-18H,2,6,9-15H2,1H3,(H,21,24)/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at rat muscarinic M1 receptor expressed in CHO cells				Bioorg Med Chem Lett 21: 6451-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.084 BindingDB Entry DOI: 10.7270/Q26W9BG8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM261715 (4-((6-Chloropyridin-3-yl)methyl)-1-fluoro-N-((1SR,...) Show SMILES O[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cc2ccc(Cl)nc2)c2ccccc2c1F |r| Show InChI InChI=1S/C23H22ClFN2O2/c24-21-10-9-14(13-26-21)11-15-12-18(22(25)17-6-2-1-5-16(15)17)23(29)27-19-7-3-4-8-20(19)28/h1-2,5-6,9-10,12-13,19-20,28H,3-4,7-8,11H2,(H,27,29)/t19-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	137	n/a	n/a	n/a	n/a
HOFFMANN-LA-ROCHE INC. US Patent					Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin...				US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50356970 (CHEMBL1916227) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1cccc(F)c1 |r| Show InChI InChI=1S/C20H28FN3O3/c1-2-27-20(26)23-11-8-18(9-12-23)24-10-4-7-17(14-24)22-19(25)15-5-3-6-16(21)13-15/h3,5-6,13,17-18H,2,4,7-12,14H2,1H3,(H,22,25)/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at rat muscarinic M1 receptor expressed in CHO cells				Bioorg Med Chem Lett 21: 6451-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.084 BindingDB Entry DOI: 10.7270/Q26W9BG8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM43821 (4-(2-benzamidoethylamino)-1-piperidinecarboxylic a...) Show SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1 Show InChI InChI=1S/C17H25N3O3/c1-2-23-17(22)20-12-8-15(9-13-20)18-10-11-19-16(21)14-6-4-3-5-7-14/h3-7,15,18H,2,8-13H2,1H3,(H,19,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2KD1W96
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM44250 (4-[2-[(4-fluorobenzoyl)amino]ethylamino]piperidine...) Show SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccc(F)cc1 Show InChI InChI=1S/C17H24FN3O3/c1-2-24-17(23)21-11-7-15(8-12-21)19-9-10-20-16(22)13-3-5-14(18)6-4-13/h3-6,15,19H,2,7-12H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	154	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2KD1W96
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM44251 (4-[2-[(3-fluorobenzoyl)amino]ethylamino]piperidine...) Show SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)c1cccc(F)c1 Show InChI InChI=1S/C17H24FN3O3/c1-2-24-17(23)21-10-6-15(7-11-21)19-8-9-20-16(22)13-4-3-5-14(18)12-13/h3-5,12,15,19H,2,6-11H2,1H3,(H,20,22)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	154	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2KD1W96
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50112157 (CHEMBL3608418) Show SMILES Cn1ncc2cc(Cn3cc(C(=O)N[C@H]4COCC[C@@H]4O)c4ncccc34)ccc12 |r| Show InChI InChI=1S/C22H23N5O3/c1-26-18-5-4-14(9-15(18)10-24-26)11-27-12-16(21-19(27)3-2-7-23-21)22(29)25-17-13-30-8-6-20(17)28/h2-5,7,9-10,12,17,20,28H,6,8,11,13H2,1H3,(H,25,29)/t17-,20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	163	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Positive allosteric modulation of rat muscarinic M1 receptor expressed in CHO cells assessed as basal and acetylcholine-stimulated Ca2+ level by FLIP...				ACS Med Chem Lett 6: 726-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00185 BindingDB Entry DOI: 10.7270/Q26W9CVM
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464179 (CHEMBL4246159) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cc1 |r| Show InChI InChI=1S/C26H29N5O2/c1-30-13-11-20-19(15-17-7-9-18(10-8-17)21-12-14-31(2)29-21)16-23(27-25(20)30)26(33)28-22-5-3-4-6-24(22)32/h7-14,16,22,24,32H,3-6,15H2,1-2H3,(H,28,33)/t22-,24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50464179 (CHEMBL4246159) Show SMILES Cn1ccc(n1)-c1ccc(Cc2cc(nc3n(C)ccc23)C(=O)N[C@@H]2CCCC[C@H]2O)cc1 |r| Show InChI InChI=1S/C26H29N5O2/c1-30-13-11-20-19(15-17-7-9-18(10-8-17)21-12-14-31(2)29-21)16-23(27-25(20)30)26(33)28-22-5-3-4-6-24(22)32/h7-14,16,22,24,32H,3-6,15H2,1-2H3,(H,28,33)/t22-,24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	182	n/a	n/a	n/a	n/a
Vanderbilt Univercity Curated by ChEMBL					Assay Description Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreate...				ACS Med Chem Lett 9: 917-922 (2018) Article DOI: 10.1021/acsmedchemlett.8b00261 BindingDB Entry DOI: 10.7270/Q2RJ4N44
					More data for this Ligand-Target Pair

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