Compile Data Set for Download or QSAR

Found 256 hits of ec50 data for polymerid = 49000764,8284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50138784 ((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...) Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50138783 (4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...) Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50138783 (4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...) Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50138783 (4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...) Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Activation of human metabotropic glutamate 8 receptor expressed in golden hamster AV12-664 cells				J Med Chem 61: 10040-10052 (2018) Article DOI: 10.1021/acs.jmedchem.8b01120 BindingDB Entry DOI: 10.7270/Q2SJ1Q0B
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50138783 (4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...) Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50220011 (CHEMBL243925 | L-(+)-2-amino-4-thiophosphonobutyri...) Show SMILES N[C@@H](CCP(O)(O)=S)C(O)=O Show InChI InChI=1S/C4H10NO4PS/c5-3(4(6)7)1-2-10(8,9)11/h3H,1-2,5H2,(H,6,7)(H2,8,9,11)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Université Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production				J Med Chem 50: 4656-64 (2007) Article DOI: 10.1021/jm070400y BindingDB Entry DOI: 10.7270/Q2XP74NQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Activation of human metabotropic glutamate 8 receptor expressed in golden hamster AV12-664 cells				J Med Chem 61: 10040-10052 (2018) Article DOI: 10.1021/acs.jmedchem.8b01120 BindingDB Entry DOI: 10.7270/Q2SJ1Q0B
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283487 (CHEMBL4162576) Show SMILES Clc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1 Show InChI InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	125	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	128	n/a	n/a	n/a	n/a
Université Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production				J Med Chem 50: 4656-64 (2007) Article DOI: 10.1021/jm070400y BindingDB Entry DOI: 10.7270/Q2XP74NQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50552330 (CHEMBL4745982) Show SMILES Cc1ccoc1C(=O)Nc1cc(C)c(cc1F)N1C(=O)c2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	189	n/a	n/a	n/a	n/a
TBA					Assay Description Positive allosteric modulation of mGluR8 (unknown origin) by calcium mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127724 BindingDB Entry DOI: 10.7270/Q2WS8XWG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50004881 ((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...) Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	240	n/a	n/a	n/a	n/a
Universite Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...				J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM82006 (D-AP4 | D-APB | US9212196, L-AP4) Show SMILES N[C@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Universite Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...				J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255396 (CHEMBL4067923) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(o1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C9H13N2O8P/c10-5(8(12)13)3-4-20(17,18)9(14)6-1-2-7(19-6)11(15)16/h1-2,5,9,14H,3-4,10H2,(H,12,13)(H,17,18)/t5-,9?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50217031 ((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...) Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
University Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production				J Med Chem 50: 3585-95 (2007) Article DOI: 10.1021/jm070262c BindingDB Entry DOI: 10.7270/Q23R0SMQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255292 (CHEMBL4061423) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1csc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C9H13N2O7PS/c10-6(8(12)13)1-2-19(17,18)9(14)5-3-7(11(15)16)20-4-5/h3-4,6,9,14H,1-2,10H2,(H,12,13)(H,17,18)/t6-,9?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50034504 ((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...) Show SMILES N[C@@H]([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255406 (CHEMBL4088782) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)5-6-21(19,20)11(16)7-1-3-8(4-2-7)13(17)18/h1-4,9,11,16H,5-6,12H2,(H,14,15)(H,19,20)/t9-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283478 (CHEMBL4164141) Show SMILES COc1cc(F)c(cc1Cl)-c1c(C)nn2c(cc(C)nc12)C(F)(F)F |(37.17,-44.14,;38.18,-42.98,;37.7,-41.52,;38.73,-40.37,;38.23,-38.91,;39.26,-37.76,;36.73,-38.6,;35.71,-39.75,;36.19,-41.21,;35.16,-42.36,;36.25,-37.14,;37.15,-35.9,;38.69,-35.89,;36.24,-34.66,;34.78,-35.14,;33.45,-34.37,;32.12,-35.14,;32.12,-36.68,;30.79,-37.46,;33.45,-37.45,;34.79,-36.67,;33.45,-32.83,;34.79,-32.05,;32.12,-32.05,;33.44,-31.28,)| Show InChI InChI=1S/C16H12ClF4N3O/c1-7-4-13(16(19,20)21)24-15(22-7)14(8(2)23-24)9-5-10(17)12(25-3)6-11(9)18/h4-6H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255292 (CHEMBL4061423) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1csc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C9H13N2O7PS/c10-6(8(12)13)1-2-19(17,18)9(14)5-3-7(11(15)16)20-4-5/h3-4,6,9,14H,1-2,10H2,(H,12,13)(H,17,18)/t6-,9?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	510	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255406 (CHEMBL4088782) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(cc1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)5-6-21(19,20)11(16)7-1-3-8(4-2-7)13(17)18/h1-4,9,11,16H,5-6,12H2,(H,14,15)(H,19,20)/t9-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	560	n/a	n/a	n/a	n/a
University Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production				J Med Chem 50: 3585-95 (2007) Article DOI: 10.1021/jm070262c BindingDB Entry DOI: 10.7270/Q23R0SMQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255390 (CHEMBL4091029) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(F)c(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H14FN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	660	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50159148 (CHEMBL3786667) Show SMILES [H][C@]1(C[C@]1(C[C@H](N)C(O)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO6/c9-4(6(12)13)2-8(7(14)15)1-3(8)5(10)11/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4-,8+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	680	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay				J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283481 (CHEMBL4160675) Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F |(25.69,-48.74,;24.92,-50.08,;23.38,-50.09,;22.48,-48.85,;21.02,-49.33,;19.69,-48.56,;18.36,-49.33,;18.36,-50.87,;17.03,-51.64,;19.69,-51.64,;21.03,-50.86,;22.49,-51.33,;22.97,-52.79,;21.94,-53.94,;22.43,-55.4,;21.4,-56.55,;23.94,-55.71,;24.42,-57.17,;23.4,-58.33,;23.88,-59.79,;21.89,-58.02,;24.96,-54.56,;24.47,-53.1,;25.5,-51.95,;19.69,-47.02,;21.03,-46.24,;18.36,-46.24,;19.68,-45.48,)| Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	890	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283481 (CHEMBL4160675) Show SMILES CCc1nn2c(cc(C)nc2c1-c1cc(F)c(OC(F)F)cc1F)C(F)(F)F |(25.69,-48.74,;24.92,-50.08,;23.38,-50.09,;22.48,-48.85,;21.02,-49.33,;19.69,-48.56,;18.36,-49.33,;18.36,-50.87,;17.03,-51.64,;19.69,-51.64,;21.03,-50.86,;22.49,-51.33,;22.97,-52.79,;21.94,-53.94,;22.43,-55.4,;21.4,-56.55,;23.94,-55.71,;24.42,-57.17,;23.4,-58.33,;23.88,-59.79,;21.89,-58.02,;24.96,-54.56,;24.47,-53.1,;25.5,-51.95,;19.69,-47.02,;21.03,-46.24,;18.36,-46.24,;19.68,-45.48,)| Show InChI InChI=1S/C17H12F7N3O/c1-3-11-14(8-5-10(19)12(6-9(8)18)28-16(20)21)15-25-7(2)4-13(17(22,23)24)27(15)26-11/h4-6,16H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	891	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50283491 (CHEMBL1585091) Show SMILES COC(=O)c1ccc(cc1)-n1c(C)cc(C(=O)CSc2ccc(NC(C)=O)cc2)c1C Show InChI InChI=1S/C24H24N2O4S/c1-15-13-22(16(2)26(15)20-9-5-18(6-10-20)24(29)30-4)23(28)14-31-21-11-7-19(8-12-21)25-17(3)27/h5-13H,14H2,1-4H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50314794 ((3S)-2-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...) Show SMILES N[C@@H](CCP(O)(=O)CC(O)=O)C(O)=O |r| Show InChI InChI=1S/C6H12NO6P/c7-4(6(10)11)1-2-14(12,13)3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)(H,12,13)/t4-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	910	n/a	n/a	n/a	n/a
Universite Paris Descartes Curated by ChEMBL					Assay Description Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...				J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255415 (CHEMBL4078629) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C12H14F3N2O7P/c13-12(14,15)7-5-6(1-2-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	980	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255336 (CHEMBL4064187) Show SMILES N[C@@H](CCP(O)(=O)Cc1cccc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O6P/c12-10(11(14)15)4-5-20(18,19)7-8-2-1-3-9(6-8)13(16)17/h1-3,6,10H,4-5,7,12H2,(H,14,15)(H,18,19)/t10-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50601004 (CHEMBL5202739) Show SMILES Fc1ccc(N2CCN(CC2)C(=O)c2cnc3n(CC4CC4)ncc3c2C(F)(F)F)c(F)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00593 BindingDB Entry DOI: 10.7270/Q2FB571B
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255388 (CHEMBL4093492) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cccc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50116515 (CHEMBL3609729) Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1 Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...				ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM196930 (US9212196, Derivative 26) Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(SCC(O)=O)cc1)C(O)=O |r| Show InChI InChI=1S/C13H18NO7PS/c14-10(12(17)18)5-6-22(20,21)13(19)8-1-3-9(4-2-8)23-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255389 (CHEMBL4072781) Show SMILES N[C@@H](CCP(O)(=O)[C@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50088290 (CHEMBL3427499) Show SMILES NC1(CC1(F)CP(O)(O)=O)C(O)=O Show InChI InChI=1S/C5H9FNO5P/c6-4(2-13(10,11)12)1-5(4,7)3(8)9/h1-2,7H2,(H,8,9)(H2,10,11,12)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255390 (CHEMBL4091029) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(F)c(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H14FN2O7P/c12-7-2-1-6(5-9(7)14(18)19)11(17)22(20,21)4-3-8(13)10(15)16/h1-2,5,8,11,17H,3-4,13H2,(H,15,16)(H,20,21)/t8-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255437 (CHEMBL4085750) Show SMILES N[C@@H](CCP(O)(=O)[C@@H](O)c1cccc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM50138781 ((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...) Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255388 (CHEMBL4093492) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1cccc(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C11H15N2O7P/c12-9(10(14)15)4-5-21(19,20)11(16)7-2-1-3-8(6-7)13(17)18/h1-3,6,9,11,16H,4-5,12H2,(H,14,15)(H,19,20)/t9-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50255337 (CHEMBL4063142) Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(c(c1)[N+]([O-])=O)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C12H14F3N2O7P/c13-12(14,15)7-2-1-6(5-9(7)17(21)22)11(20)25(23,24)4-3-8(16)10(18)19/h1-2,5,8,11,20H,3-4,16H2,(H,18,19)(H,23,24)/t8-,11?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques , CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France. Curated by ChEMBL					Assay Description Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...				J Med Chem 61: 1969-1989 (2018) Article DOI: 10.1021/acs.jmedchem.7b01438 BindingDB Entry DOI: 10.7270/Q2DZ0BR0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50434134 (CHEMBL2381641) Show SMILES N[C@]1(CC(=C)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h4-6H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5-,6-,9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Rattus norvegicus (Rat))	BDBM196928 (US9212196, Derivative 24) Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)c(c1)[N+]([O-])=O)C(O)=O |r| Show InChI InChI=1S/C13H17N2O10P/c14-8(12(18)19)3-4-26(23,24)13(20)7-1-2-10(25-6-11(16)17)9(5-7)15(21)22/h1-2,5,8,13,20H,3-4,6,14H2,(H,16,17)(H,18,19)(H,23,24)/t8-,13?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent					Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...				US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 256 total )  |  Next  |  Last  >>

Jump to: