Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532707 (CHEMBL4585968) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532707 (CHEMBL4585968) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532714 (CHEMBL4458009) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532714 (CHEMBL4458009) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532704 (CHEMBL4434729) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532704 (CHEMBL4434729) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532706 (CHEMBL4547419) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50532706 (CHEMBL4547419) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Via P. Giuria 9 Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assay | J Med Chem 59: 6729-38 (2016) Article DOI: 10.1021/acs.jmedchem.6b00252 BindingDB Entry DOI: 10.7270/Q28S4TCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572483 (CHEMBL4860865) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50032249 (CHEMBL3352986) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A. Moro" Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition ... | J Med Chem 57: 9983-94 (2014) Article DOI: 10.1021/jm501640e BindingDB Entry DOI: 10.7270/Q2K9394N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50567579 (Encequidar | HM-30181 | HM30181 | HM30181AK | Pgp ...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572470 (CHEMBL4861299) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572481 (CHEMBL4866156) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50370885 (CHEMBL375243) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572478 (CHEMBL4878833) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572483 (CHEMBL4860865) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50009054 (CHEMBL3237954) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass... | Eur J Med Chem 76: 558-66 (2014) Article DOI: 10.1016/j.ejmech.2014.02.051 BindingDB Entry DOI: 10.7270/Q23F4R5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572481 (CHEMBL4866156) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572482 (CHEMBL4867678) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572471 (CHEMBL4855294) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572476 (CHEMBL4870741) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50567579 (Encequidar | HM-30181 | HM30181 | HM30181AK | Pgp ...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572467 (CHEMBL4873470) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572482 (CHEMBL4867678) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572469 (CHEMBL4860692) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572480 (CHEMBL4874866) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572475 (CHEMBL4869278) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572473 (CHEMBL4849203) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572472 (CHEMBL4874542) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572479 (CHEMBL4862931) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572474 (CHEMBL4851476) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572477 (CHEMBL4852329) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572468 (CHEMBL4862848) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50567579 (Encequidar | HM-30181 | HM30181 | HM30181AK | Pgp ...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as cell growth inhibition after 3 days in presence of 200 nM paclitaxel by... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50370882 (CHEMBL222351) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50207969 (1-(2-(2-hydroxy-3-(4-o-tolylpiperazin-1-yl)propoxy...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50572467 (CHEMBL4873470) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50529862 (CHEMBL4470288) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu... | J Med Chem 62: 974-986 (2019) Article DOI: 10.1021/acs.jmedchem.8b01655 BindingDB Entry DOI: 10.7270/Q28P641C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50529862 (CHEMBL4470288) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in calcein-AM accumulation after 30 mins by calcein-AM dye based flu... | J Med Chem 62: 974-986 (2019) Article DOI: 10.1021/acs.jmedchem.8b01655 BindingDB Entry DOI: 10.7270/Q28P641C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50075373 (1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoqu...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as cell growth inhibition after 3 days in presence of 200 nM paclitaxel by... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01826 BindingDB Entry DOI: 10.7270/Q2KP85ZF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50207919 (1-(4,5-dichloro-2-(2-hydroxy-3-(4-o-tolylpiperazin...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50207961 (1-(2-(2-hydroxy-3-(4-o-tolylpiperazin-1-yl)propoxy...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50207939 (3-(4-chlorophenyl)-1-(2-(2-hydroxy-3-(4-o-tolylpip...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50207927 (1-(2-(2-hydroxy-3-(4-o-tolylpiperazin-1-yl)propoxy...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50135028 (1-(2-(2-hydroxy-3-(4-o-tolylpiperazin-1-yl)propoxy...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | J Med Chem 50: 1698-702 (2007) Article DOI: 10.1021/jm060604z BindingDB Entry DOI: 10.7270/Q2SB46JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50015306 (CHEMBL3263842) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
St. John's University Curated by ChEMBL | Assay Description Stimulation of ATPase activity of ABCB1 (unknown origin) expressed in High Five insect cell membrane assessed as ATP hydrolysis | J Med Chem 57: 4058-72 (2014) Article DOI: 10.1021/jm401966m BindingDB Entry DOI: 10.7270/Q2794671 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50022815 ((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a... | J Med Chem 58: 4529-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00085 BindingDB Entry DOI: 10.7270/Q2N29ZP5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50022815 ((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Ocean University of China Curated by ChEMBL | Assay Description Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistance | J Med Chem 56: 9057-70 (2013) Article DOI: 10.1021/jm400930e BindingDB Entry DOI: 10.7270/Q2CF9T19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50022815 ((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assay | J Med Chem 62: 8578-8608 (2019) Article DOI: 10.1021/acs.jmedchem.9b00963 BindingDB Entry DOI: 10.7270/Q28S4T5Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM50538595 (CHEMBL4645086) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences & Peking Union Medical College Curated by ChEMBL | Assay Description Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as concentration required to show half of DOX IC50 incubated for 48 hrs b... | J Med Chem 63: 5458-5476 (2020) Article DOI: 10.1021/acs.jmedchem.0c00337 BindingDB Entry DOI: 10.7270/Q2ST7TCJ | |||||||||||
More data for this Ligand-Target Pair |
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