Compile Data Set for Download or QSAR

Found 327 hits of ec50 data for polymerid = 50000262   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327452 (1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...) Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:2.2| Show InChI InChI=1S/C25H25N5O3S/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327451 (1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...) Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C24H25N5O3S/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219622 (CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...) Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(OC(F)(F)F)c2F)ncn1 Show InChI InChI=1S/C24H18F4N6O3S/c25-21-16(2-1-3-18(21)37-24(26,27)28)17-11-38-23(32-17)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219622 (CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...) Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(OC(F)(F)F)c2F)ncn1 Show InChI InChI=1S/C24H18F4N6O3S/c25-21-16(2-1-3-18(21)37-24(26,27)28)17-11-38-23(32-17)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219613 (CHEMBL248218 | N-(4-(2-fluoro-3-(trifluoromethyl)p...) Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1 Show InChI InChI=1S/C24H18F4N6O2S/c25-21-16(2-1-3-17(21)24(26,27)28)18-11-37-23(32-18)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248023 (1-(2,6-dichloro-4-(4-(2-fluoro-3-(trifluoromethyl)...) Show SMILES OC(=O)C1CCN(CC1)c1c(Cl)cc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C23H17Cl2F4N3O3S/c24-15-8-12(9-16(25)19(15)32-6-4-11(5-7-32)21(34)35)20(33)31-22-30-17(10-36-22)13-2-1-3-14(18(13)26)23(27,28)29/h1-3,8-11H,4-7H2,(H,34,35)(H,30,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219644 (CHEMBL248390 | N-(5-chloro-4-(4-fluoro-3-(trifluor...) Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(Cl)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 Show InChI InChI=1S/C23H17ClF4N6OS/c1-34(2)18-10-17(29-11-30-18)31-14-6-3-12(4-7-14)21(35)33-22-32-19(20(24)36-22)13-5-8-16(25)15(9-13)23(26,27)28/h3-11H,1-2H3,(H,29,30,31)(H,32,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219670 (CHEMBL249471 | N-(3-(4-fluoro-3-(trifluoromethyl)p...) Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 Show InChI InChI=1S/C23H17F4N7O2S/c24-17-6-3-13(7-16(17)23(25,26)27)20-31-22(37-33-20)32-21(36)12-1-4-14(5-2-12)30-18-8-19(29-11-28-18)34-9-15(35)10-34/h1-8,11,15,35H,9-10H2,(H,28,29,30)(H,31,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50105970 (4-{N'-[1-(4-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-...) Show SMILES Cc1[nH]n(-c2ccc(cc2)C(C)(C)C)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:18.20| Show InChI InChI=1S/C24H24N4O5S/c1-14-21(23(30)28(27-14)16-11-9-15(10-12-16)24(2,3)4)25-26-22-18-8-6-5-7-17(18)20(13-19(22)29)34(31,32)33/h5-13,27,29H,1-4H3,(H,31,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells				J Med Chem 44: 3730-45 (2001) BindingDB Entry DOI: 10.7270/Q2MP52KF
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50265150 (2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1...) Show SMILES CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(=O)C(O)=O)ccc4-c3[nH]c2c1F Show InChI InChI=1S/C27H23FN2O3/c1-2-3-4-15-5-7-16(8-6-15)19-11-12-21-22-14-17-13-18(29-26(31)27(32)33)9-10-20(17)24(22)30-25(21)23(19)28/h5-13,30H,2-4,14H2,1H3,(H,29,31)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay				Bioorg Med Chem Lett 18: 5259-62 (2008) Article DOI: 10.1016/j.bmcl.2008.08.077 BindingDB Entry DOI: 10.7270/Q2ZP45ZB
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327455 (1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...) Show SMILES CNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:16.17| Show InChI InChI=1S/C25H28N6O2S/c1-14-6-8-20(12-15(14)2)31-24(33)22(17(4)29-31)16(3)27-28-25(34)30-11-10-18-13-19(23(32)26-5)7-9-21(18)30/h6-9,12-13,29H,10-11H2,1-5H3,(H,26,32)(H,28,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219654 (CHEMBL440231 | N-(4-(2-fluoro-3-(trifluoromethyl)p...) Show SMILES CN(CCO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1 Show InChI InChI=1S/C24H20F4N6O2S/c1-34(9-10-35)20-11-19(29-13-30-20)31-15-7-5-14(6-8-15)22(36)33-23-32-18(12-37-23)16-3-2-4-17(21(16)25)24(26,27)28/h2-8,11-13,35H,9-10H2,1H3,(H,29,30,31)(H,32,33,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219633 (4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...) Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1 Show InChI InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50265108 (CHEMBL498581 | N-(7-(4-butylphenyl)-6-fluoro-5,10-...) Show SMILES CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(C)=O)ccc4-c3[nH]c2c1F Show InChI InChI=1S/C27H25FN2O/c1-3-4-5-17-6-8-18(9-7-17)21-12-13-23-24-15-19-14-20(29-16(2)31)10-11-22(19)26(24)30-27(23)25(21)28/h6-14,30H,3-5,15H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay				Bioorg Med Chem Lett 18: 5259-62 (2008) Article DOI: 10.1016/j.bmcl.2008.08.077 BindingDB Entry DOI: 10.7270/Q2ZP45ZB
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50264952 (6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroi...) Show SMILES Cc1cc(ccc1F)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O Show InChI InChI=1S/C23H15F2NO2/c1-11-8-12(3-7-19(11)24)15-5-6-17-18-10-14-9-13(23(27)28)2-4-16(14)21(18)26-22(17)20(15)25/h2-9,26H,10H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay				Bioorg Med Chem Lett 18: 5259-62 (2008) Article DOI: 10.1016/j.bmcl.2008.08.077 BindingDB Entry DOI: 10.7270/Q2ZP45ZB
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50263454 (9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[...) Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1 Show InChI InChI=1S/C27H25NO3/c1-2-3-4-16-5-7-17(8-6-16)18-9-11-20-21-12-10-19-13-23(27(30)31)25(29)15-22(19)26(21)28-24(20)14-18/h5-9,11,13-15,28-29H,2-4,10,12H2,1H3,(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327457 (1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...) Show SMILES CCNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:17.18| Show InChI InChI=1S/C26H30N6O2S/c1-6-27-24(33)20-8-10-22-19(14-20)11-12-31(22)26(35)29-28-17(4)23-18(5)30-32(25(23)34)21-9-7-15(2)16(3)13-21/h7-10,13-14,30H,6,11-12H2,1-5H3,(H,27,33)(H,29,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219621 (4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-d...) Show SMILES FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3CCOc12 Show InChI InChI=1S/C23H16F3N5O2S/c24-23(25,26)16-3-1-2-15-19-17(9-11-33-20(15)16)34-22(30-19)31-21(32)13-4-6-14(7-5-13)29-18-8-10-27-12-28-18/h1-8,10,12H,9,11H2,(H,27,28,29)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248580 (6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-flu...) Show SMILES NC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C22H18ClF4N5O2S/c23-15-8-12(9-29-19(15)32-6-4-11(5-7-32)18(28)33)20(34)31-21-30-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H2,28,33)(H,30,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219659 ((Z)-N-(4-(3,4-difluorophenyl)thiazol-2-yl)-4-((2,4...) Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccc(F)c(F)c1 |w:7.8,t:1| Show InChI InChI=1S/C20H11F2N3O3S2/c21-13-6-5-12(8-14(13)22)15-9-29-19(23-15)24-17(26)11-3-1-10(2-4-11)7-16-18(27)25-20(28)30-16/h1-9H,(H,23,24,26)(H,25,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219614 (CHEMBL249672 | N-(3-(4-fluoro-3-(trifluoromethyl)p...) Show SMILES CN(C(CO)NO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 |w:2.4| Show InChI InChI=1S/C23H20F4N8O3S/c1-35(19(10-36)33-38)18-9-17(28-11-29-18)30-14-5-2-12(3-6-14)21(37)32-22-31-20(34-39-22)13-4-7-16(24)15(8-13)23(25,26)27/h2-9,11,19,33,36,38H,10H2,1H3,(H,28,29,30)(H,31,32,34,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219619 (CHEMBL248428 | N-(3-(4-fluoro-3-(trifluoromethyl)p...) Show SMILES OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 Show InChI InChI=1S/C22H17F4N7O2S/c23-16-6-3-13(9-15(16)22(24,25)26)19-31-21(36-33-19)32-20(35)12-1-4-14(5-2-12)30-18-10-17(27-7-8-34)28-11-29-18/h1-6,9-11,34H,7-8H2,(H2,27,28,29,30)(H,31,32,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327456 (CHEMBL1257847 | N'-(1-(1-(3,4-dimethylphenyl)-3-me...) Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(=O)N1CCOCC1)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C28H32N6O3S/c1-17-5-7-23(15-18(17)2)34-27(36)25(20(4)31-34)19(3)29-30-28(38)33-10-9-21-16-22(6-8-24(21)33)26(35)32-11-13-37-14-12-32/h5-8,15-16,31H,9-14H2,1-4H3,(H,30,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219625 (CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...) Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1 Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at TPO receptor				Bioorg Med Chem Lett 18: 3000-6 (2008) Article DOI: 10.1016/j.bmcl.2008.03.052 BindingDB Entry DOI: 10.7270/Q2474BRS
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219625 (CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...) Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1 Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50377376 (CHEMBL408853) Show SMILES Nc1nc(cs1)-c1cccc(OC(F)(F)F)c1F Show InChI InChI=1S/C10H6F4N2OS/c11-8-5(6-4-18-9(15)16-6)2-1-3-7(8)17-10(12,13)14/h1-4H,(H2,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at TPO receptor				Bioorg Med Chem Lett 18: 3000-6 (2008) Article DOI: 10.1016/j.bmcl.2008.03.052 BindingDB Entry DOI: 10.7270/Q2474BRS
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248531 (1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...) Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human TPO receptor expressed in rat BaF3 cells				Bioorg Med Chem Lett 20: 4069-72 (2010) Article DOI: 10.1016/j.bmcl.2010.05.087 BindingDB Entry DOI: 10.7270/Q2W66MQW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219679 (CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...) Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248531 (1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...) Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219679 (CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...) Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at TPO receptor				Bioorg Med Chem Lett 18: 3000-6 (2008) Article DOI: 10.1016/j.bmcl.2008.03.052 BindingDB Entry DOI: 10.7270/Q2474BRS
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248581 (5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...) Show SMILES NS(=O)(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C21H18ClF4N5O3S2/c22-15-8-11(9-28-18(15)31-6-4-12(5-7-31)36(27,33)34)19(32)30-20-29-16(10-35-20)13-2-1-3-14(17(13)23)21(24,25)26/h1-3,8-10,12H,4-7H2,(H2,27,33,34)(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50263334 (9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...) Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1 Show InChI InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327454 (1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...) Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:2.2| Show InChI InChI=1S/C26H27N5O3S/c1-15(23-16(2)29-31(24(23)32)21-10-8-17-5-3-6-18(17)14-21)27-28-26(35)30-12-4-7-19-13-20(25(33)34)9-11-22(19)30/h8-11,13-14,29H,3-7,12H2,1-2H3,(H,28,35)(H,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219650 (CHEMBL247041 | N-(4-(2-fluoro-3-isobutylphenyl)thi...) Show SMILES CC(C)Cc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1F Show InChI InChI=1S/C24H22FN5OS/c1-15(2)12-17-4-3-5-19(22(17)25)20-13-32-24(29-20)30-23(31)16-6-8-18(9-7-16)28-21-10-11-26-14-27-21/h3-11,13-15H,12H2,1-2H3,(H,26,27,28)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50264951 (6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2...) Show SMILES CCCc1ccc(cc1)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O Show InChI InChI=1S/C25H20FNO2/c1-2-3-14-4-6-15(7-5-14)18-10-11-20-21-13-17-12-16(25(28)29)8-9-19(17)23(21)27-24(20)22(18)26/h4-12,27H,2-3,13H2,1H3,(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay				Bioorg Med Chem Lett 18: 5259-62 (2008) Article DOI: 10.1016/j.bmcl.2008.08.077 BindingDB Entry DOI: 10.7270/Q2ZP45ZB
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248106 (CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine) Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O |w:16.18| Show InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219643 (CHEMBL246847 | N-(4-(2-fluoro-3-(trifluoromethyl)p...) Show SMILES COc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1 Show InChI InChI=1S/C22H15F4N5O2S/c1-33-18-9-17(27-11-28-18)29-13-7-5-12(6-8-13)20(32)31-21-30-16(10-34-21)14-3-2-4-15(19(14)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248106 (CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine) Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O |w:16.18| Show InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay				Bioorg Med Chem Lett 18: 5259-62 (2008) Article DOI: 10.1016/j.bmcl.2008.08.077 BindingDB Entry DOI: 10.7270/Q2ZP45ZB
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50105947 (3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(3-trifluorometh...) Show SMILES Cc1[nH]n(-c2cccc(c2)C(F)(F)F)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:18.20| Show InChI InChI=1S/C21H15F3N4O5S/c1-11-18(20(30)28(27-11)13-6-4-5-12(9-13)21(22,23)24)25-26-19-15-8-3-2-7-14(15)17(10-16(19)29)34(31,32)33/h2-10,27,29H,1H3,(H,31,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells				J Med Chem 44: 3730-45 (2001) BindingDB Entry DOI: 10.7270/Q2MP52KF
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50105963 (4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-...) Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:16.18| Show InChI InChI=1S/C22H20N4O5S/c1-12-8-9-15(10-13(12)2)26-22(28)20(14(3)25-26)23-24-21-17-7-5-4-6-16(17)19(11-18(21)27)32(29,30)31/h4-11,25,27H,1-3H3,(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells				J Med Chem 44: 3730-45 (2001) BindingDB Entry DOI: 10.7270/Q2MP52KF
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50263455 (2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benz...) Show SMILES CCCOc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1 Show InChI InChI=1S/C26H23NO4/c1-2-11-31-18-7-3-15(4-8-18)16-5-9-19-20-10-6-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-5,7-9,12-14,27-28H,2,6,10-11H2,1H3,(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327458 (1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...) Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:1.0,3.2| Show InChI InChI=1S/C24H25N5O4/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219715 (CHEMBL245794 | N-(4-(2-fluoro-3-(trifluoromethyl)p...) Show SMILES Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1 Show InChI InChI=1S/C22H15F4N5OS/c1-12-9-18(28-11-27-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(10-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248582 ((4R)-1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl...) Show SMILES C[C@H]1CN(CC1C(O)=O)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F |r| Show InChI InChI=1S/C22H17ClF4N4O3S/c1-10-7-31(8-13(10)20(33)34)18-15(23)5-11(6-28-18)19(32)30-21-29-16(9-35-21)12-3-2-4-14(17(12)24)22(25,26)27/h2-6,9-10,13H,7-8H2,1H3,(H,33,34)(H,29,30,32)/t10-,13?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50263457 (2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benz...) Show SMILES CCCOc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1 Show InChI InChI=1S/C26H23NO4/c1-2-10-31-18-5-3-4-15(11-18)16-6-8-19-20-9-7-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-6,8,11-14,27-28H,2,7,9-10H2,1H3,(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219698 (4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-f...) Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 Show InChI InChI=1S/C22H17F4N7OS/c1-33(2)18-10-17(27-11-28-18)29-14-6-3-12(4-7-14)20(34)31-21-30-19(32-35-21)13-5-8-16(23)15(9-13)22(24,25)26/h3-11H,1-2H3,(H,27,28,29)(H,30,31,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50325421 (4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene...) Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc(C)cc1 |w:2.2| Show InChI InChI=1S/C25H20FN3O3S/c1-14-3-10-19(11-4-14)29-21-12-9-18(26)13-20(21)22(24(29)30)15(2)27-28-23(33)16-5-7-17(8-6-16)25(31)32/h3-13,22H,1-2H3,(H,28,33)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs				Bioorg Med Chem Lett 20: 5062-4 (2010) Article DOI: 10.1016/j.bmcl.2010.07.040 BindingDB Entry DOI: 10.7270/Q21836P8
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50219675 (4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-f...) Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(C)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1 Show InChI InChI=1S/C24H20F4N6OS/c1-13-21(15-6-9-18(25)17(10-15)24(26,27)28)32-23(36-13)33-22(35)14-4-7-16(8-5-14)31-19-11-20(34(2)3)30-12-29-19/h4-12H,1-3H3,(H,29,30,31)(H,32,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Pfizer Global Research & Development Curated by ChEMBL					Assay Description Agonist activity at human TPOr expressed in BaF3 cells by reporter assay				Bioorg Med Chem Lett 17: 5447-54 (2007) Article DOI: 10.1016/j.bmcl.2007.07.038 BindingDB Entry DOI: 10.7270/Q2Q52PBC
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50327459 (1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...) Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:1.0,3.2| Show InChI InChI=1S/C25H25N5O4/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co, Ltd Curated by ChEMBL					Assay Description Inhibition of human TPOR expressed in human BaF3 cells				Bioorg Med Chem Lett 20: 5670-2 (2010) Article DOI: 10.1016/j.bmcl.2010.08.028 BindingDB Entry DOI: 10.7270/Q2DR2VRW
					More data for this Ligand-Target Pair
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50248024 (1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...) Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Br)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C22H17BrF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...				Bioorg Med Chem Lett 19: 1428-30 (2009) Article DOI: 10.1016/j.bmcl.2009.01.032 BindingDB Entry DOI: 10.7270/Q2T43SZN
					More data for this Ligand-Target Pair

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