BindingDB PrimarySearch

Found 182 hits of ec50 data for polymerid = 50000606,50001237,50001880,50002487,50002529
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557812 (US11365181, Compound 03058) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463341 (CHEMBL4238783) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50465773 (CHEMBL4277250) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Activation of human Kv7.4 by patch clamp method				Bioorg Med Chem Lett 28: 3793-3797 (2018) Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463349 (CHEMBL4250878) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557809 (US11365181, Compound 03043) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463346 (CHEMBL4250403) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463345 (CHEMBL4247074) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463342 (CHEMBL4247002) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557815 (US11365181, Compound 03066) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50592357 (CHEMBL5185685) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557810 (US11365181, Compound 03044) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	57	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557818 (US11365181, Compound A (WO2014/048165 A1)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557807 (US11365181, Compound 03034) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50526877 (CHEMBL4545892) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
University Federico II of Naples Curated by ChEMBL					Assay Description Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay				J Med Chem 63: 163-185 (2020) Article DOI: 10.1021/acs.jmedchem.9b00796 BindingDB Entry DOI: 10.7270/Q2KW5KG2
University Federico II of Naples Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50526876 (CHEMBL4457044) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
University Federico II of Naples Curated by ChEMBL					Assay Description Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay				J Med Chem 63: 163-185 (2020) Article DOI: 10.1021/acs.jmedchem.9b00796 BindingDB Entry DOI: 10.7270/Q2KW5KG2
University Federico II of Naples Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50592357 (CHEMBL5185685) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	87	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557803 (US11365181, Compound 03026) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	88	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557819 (US11365181, Compound B (WO2008/024398 A2)) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	98	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50465774 (CHEMBL4287894) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Activation of human Kv7.4 by patch clamp method				Bioorg Med Chem Lett 28: 3793-3797 (2018) Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50526877 (CHEMBL4545892) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
University Federico II of Naples Curated by ChEMBL					Assay Description Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay				J Med Chem 63: 163-185 (2020) Article DOI: 10.1021/acs.jmedchem.9b00796 BindingDB Entry DOI: 10.7270/Q2KW5KG2
University Federico II of Naples Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463347 (CHEMBL4246596) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50272438 (CHEMBL4128096) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 1731-1735 (2018) Article DOI: 10.1016/j.bmcl.2018.04.040 BindingDB Entry DOI: 10.7270/Q25X2CFM
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463339 (CHEMBL4250839) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557804 (US11365181, Compound 03027) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	147	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50143558 (CHEMBL41355 \| EZOGABINE \| N-(2-amino-4-(4-fluorobe...) Show SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	<150	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Activity at Kv 7.2 channel expressed in cloned CHO cells by [86Rb] efflux assay				J Med Chem 50: 2576-82 (2007) Article DOI: 10.1021/jm060989l BindingDB Entry DOI: 10.7270/Q2PR7ZRH
NeuroSearch A/S Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50465777 (CHEMBL4288707) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Activation of human Kv7.4 by patch clamp method				Bioorg Med Chem Lett 28: 3793-3797 (2018) Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50395486 (CHEMBL2163660) Show SMILES Clc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay				J Med Chem 55: 6975-9 (2012) Article DOI: 10.1021/jm300700v BindingDB Entry DOI: 10.7270/Q2KD2017
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50272437 (CHEMBL4125892) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 1731-1735 (2018) Article DOI: 10.1016/j.bmcl.2018.04.040 BindingDB Entry DOI: 10.7270/Q25X2CFM
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463344 (CHEMBL4246564) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557811 (US11365181, Compound 03049) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Homo sapiens (Human))	BDBM50390916 (CHEMBL2070953) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557805 (US11365181, Compound 03028) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	272	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463348 (CHEMBL4246239) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50463338 (CHEMBL4244768) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50592355 (CHEMBL5200636) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50272436 (CHEMBL4126113) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 1731-1735 (2018) Article DOI: 10.1016/j.bmcl.2018.04.040 BindingDB Entry DOI: 10.7270/Q25X2CFM
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 5 (Homo sapiens (Human))	BDBM50526876 (CHEMBL4457044) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
University Federico II of Naples Curated by ChEMBL					Assay Description Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay				J Med Chem 63: 163-185 (2020) Article DOI: 10.1021/acs.jmedchem.9b00796 BindingDB Entry DOI: 10.7270/Q2KW5KG2
University Federico II of Naples Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50143558 (CHEMBL41355 \| EZOGABINE \| N-(2-amino-4-(4-fluorobe...) Show SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 3004-3008 (2018) Article DOI: 10.1016/j.bmcl.2018.05.019 BindingDB Entry DOI: 10.7270/Q2H997WB
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50143558 (CHEMBL41355 \| EZOGABINE \| N-(2-amino-4-(4-fluorobe...) Show SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Nanjing University of Technology Curated by ChEMBL					Assay Description Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay				Bioorg Med Chem Lett 28: 1731-1735 (2018) Article DOI: 10.1016/j.bmcl.2018.04.040 BindingDB Entry DOI: 10.7270/Q25X2CFM
Nanjing University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50395488 (CHEMBL1572950) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay				J Med Chem 55: 6975-9 (2012) Article DOI: 10.1021/jm300700v BindingDB Entry DOI: 10.7270/Q2KD2017
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM557808 (US11365181, Compound 03039) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	409	n/a	n/a	n/a	n/a
TBA					Assay Description Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2BC42RQ
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Homo sapiens (Human))	BDBM50390878 (CHEMBL2070970) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50395493 (CHEMBL2164065) Show SMILES Fc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay				J Med Chem 55: 6975-9 (2012) Article DOI: 10.1021/jm300700v BindingDB Entry DOI: 10.7270/Q2KD2017
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 5 (Homo sapiens (Human))	BDBM50592360 (CHEMBL4549229) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Homo sapiens (Human))	BDBM50390895 (CHEMBL2070988) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	600	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50121051 (CHEMBL3621437) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	625	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Activation of human Kv7.4 expressed in CHOK1 cells				Bioorg Med Chem Lett 25: 4941-4 (2015) Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50526876 (CHEMBL4457044) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	630	n/a	n/a	n/a	n/a
University Federico II of Naples Curated by ChEMBL					Assay Description Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay				J Med Chem 63: 163-185 (2020) Article DOI: 10.1021/acs.jmedchem.9b00796 BindingDB Entry DOI: 10.7270/Q2KW5KG2
University Federico II of Naples Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 4 (Homo sapiens (Human))	BDBM50592360 (CHEMBL4549229) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	660	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 2 (Homo sapiens (Human))	BDBM50130610 ((E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-ph...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	690	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Effective concentration against Potassium voltage gated channel, KQT-like subfamily, member 2 expressed in SH-SY5Y human neuroblastoma cells				J Med Chem 46: 3778-81 (2003) Article DOI: 10.1021/jm034111v BindingDB Entry DOI: 10.7270/Q2RJ4K66
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Homo sapiens (Human))	BDBM50390922 (CHEMBL2070954) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay				Bioorg Med Chem Lett 22: 5936-41 (2012) Article DOI: 10.1016/j.bmcl.2012.07.060 BindingDB Entry DOI: 10.7270/Q25T3MKN
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair

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