Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50236430 ((R)-N-(2-(1-(4-chlorobenzyl)pyrrolidin-3-ylamino)-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50153942 (CHEMBL435499 | N-({[1-(4-Chloro-benzyl)-piperidin-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 54 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506122 (CHEMBL4531005) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 135 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as pEC50 for CCL2-stimulated [35S]GT... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50506124 (CHEMBL4544504) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 148 | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Non-competitive insurmountable antagonist activity at human CCR2 expressed in human U2OS cell membranes assessed as EC50 for CCL2-stimulated [35S]GTP... | J Med Chem 62: 11035-11053 (2019) Article DOI: 10.1021/acs.jmedchem.9b00742 BindingDB Entry DOI: 10.7270/Q2QR51DD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50409951 (CHEMBL2096789) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50153938 (CHEMBL181432 | N-{[1-(4-Chloro-benzyl)-piperidin-3...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 610 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50409950 (CHEMBL2096788) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50409950 (CHEMBL2096788) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
Deltagen Research Laboratories Curated by ChEMBL | Assay Description Inhibition of MCP-1 induced chemotaxis in THP-1 cells | Bioorg Med Chem Lett 14: 5413-6 (2004) Article DOI: 10.1016/j.bmcl.2004.08.009 BindingDB Entry DOI: 10.7270/Q2W958PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50255479 (CHEMBL4067429) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Neurosciences Therapeutic Area Unit , GSK Pharmaceuticals R&D , 898 Halei Road, Zhangjiang Hi-Tech Park , Pudong , Shanghai 201203 , P. R. China. Curated by ChEMBL | Assay Description Agonist activity at CCR2 (unknown origin) | J Med Chem 61: 2518-2532 (2018) Article DOI: 10.1021/acs.jmedchem.7b01854 BindingDB Entry DOI: 10.7270/Q2959M1F | |||||||||||
More data for this Ligand-Target Pair |